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Boller, Danielle; Doepfner, Kathrin T; Laurentiis, Angela DE; Guerreiro, Ana S; Marinov, Marin; Shalaby, Tarek; Depledge, Paul; Robson, Anthony; Saghir, Nahid; Hayakawa, Masahiko; Kaizawa, Hiroyuki; Koizumi, Tomonobu; Ohishi, Takahide; Fattet, Sarah; Delattre, Olivier; Schweri-Olac, Anelia; Höland, Katrin; Grotzer, Michael A; Frei, Karl; Spertini, Olivier; ... (2022). Republication: Targeting PI3KC2β Impairs Proliferation and Survival in Acute Leukemia, Brain Tumours and Neuroendocrine Tumours. Anticancer research, 42(6), pp. 3217-3230. International Inst. of Anticancer Research 10.21873/anticanres.15812
Kind, Marcus Johann; Klukowska-Rötzler, Jolanta; Berezowska, Sabina Anna; Arcaro, Alexandre; Charles, Roch-Philippe (2017). Questioning the role of selected somatic PIK3C2B mutations in squamous non-small cell lung cancer oncogenesis. PLoS ONE, 12(10), e0187308. Public Library of Science 10.1371/journal.pone.0187308
Leni, Zaira; Ćwiek, Paulina; Dimitrova, Valeriya; Dulcey, Andrea S; Zamboni, Nicola; Simillion, Cedric; Rossi, Geetha; Leibundgut, Kurt; Arcaro, Alexandre (2017). 2-Deoxy-D-glucose Restore Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia via Modification of N-Linked Glycosylation in an Oxygen Tension-Independent Manner. Oxidative medicine and cellular longevity, 2017, p. 2487297. Hindawi 10.1155/2017/2487297
Arcaro, Alexandre (2015). Targeted therapies for small cell lung cancer: Where do we stand? Critical reviews in oncology, hematology, 95(2), pp. 154-164. Elsevier 10.1016/j.critrevonc.2015.03.001
Cwiek, Paulina; Leni, Zaira; Salm, Fabiana; Dimitrova, Valeriya; Styp-Rekowska, Beata; Chiriano, Gianpaolo; Carroll, Michael; Höland, Katrin; Djonov, Valentin; Scapozza, Leonardo; Guiry, Patrick; Arcaro, Alexandre (2015). RNA interference screening identifies a novel role for PCTK1/CDK16 in medulloblastoma with c-Myc amplification. OncoTarget, 6(1), pp. 116-129. Impact Journals LLC 10.18632/oncotarget.2699
Salm, Fabiana; Dimitrova, Valeriya; von Bueren, André O; Cwiek, Paulina; Rehrauer, Hubert; Djonov, Valentin; Anderle, Pascale; Arcaro, Alexandre (2015). The Phosphoinositide 3-Kinase p110α Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma. PLoS ONE, 10(4), e0123958. Public Library of Science 10.1371/journal.pone.0123958
Dimitrova, Valeriya; Arcaro, Alexandre (2015). Targeting the PI3K/AKT/mTOR signaling pathway in medulloblastoma. Current molecular medicine, 15(1), pp. 82-93. Bentham Science 10.2174/1566524015666150114115427
Arcaro, Alexandre (2015). Development of Drugs Targeting the PI3K Signalling Pathway in Leukaemias and Lymphomas. European Medical Journal Oncology, 3(1), pp. 49-58. Gorely New Media
Höland, Katrin; Boller, Danielle; Hagel, Christian; Dolski, Silvia; Treszl, András; Pardo, Olivier E.; Cwiek, Paulina; Salm, Fabiana; Leni, Zaira; Shepherd, Peter R; Styp-Rekowska, Beata; Djonov, Valentin; von Bueren, André O.; Frei, Karl; Arcaro, Alexandre (2014). Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma. PLoS ONE, 9(4), e94132. Public Library of Science 10.1371/journal.pone.0094132
Arcaro, Alexandre (2014). Targeting PI3K/mTOR Signaling in Cancer. Frontiers in oncology, 4, p. 84. Frontiers Research Foundation 10.3389/fonc.2014.00084
Fiaschetti, Giulio; Schroeder, Christina; Castelletti, Deborah; Arcaro, Alexandre; Westermann, Frank; Baumgartner, Martin; Shalaby, Tarek; Grotzer, Michael A (2014). NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma. Acta neuropathologica communications, 2, p. 39. BioMed Central 10.1186/2051-5960-2-39
Liu, Yang; Käch, Andres; Ziegler, Urs; Ong, Albert C. M.; Wallace, Darren P.; Arcaro, Alexandre; Serra, Andreas L. (2013). The role of phospholipase D in modulating the MTOR signaling pathway in polycystic kidney disease. PLoS ONE, 8(8), e73173. Public Library of Science 10.1371/journal.pone.0073173
Wojtalla, Anna; Fischer, Barbara; Kotelevets, Nataliya; Mauri, Francesco A; Sobek, Jens; Rehrauer, Hubert; Wotzkow, Carlos; Tschan, Mario P; Seckl, Michael J; Zangemeister-Wittke, Uwe; Arcaro, Alexandre (2013). Targeting the phosphoinositide 3-kinase p110-α isoform impairs cell proliferation, survival, and tumor growth in small cell lung cancer. Clinical cancer research, 19(1), pp. 96-105. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-12-1138
Arcaro, Alexandre (2013). Targeting the insulin-like growth factor-1 receptor in human cancer. Frontiers in Pharmacology, 4, p. 30. Frontiers 10.3389/fphar.2013.00030
Arcaro, Alexandre (2013). Involvement of autophagy in the response of tumor cells to PtdIns3K inhibitors: therapeutic implications. Autophagy, 9(4), pp. 607-8. Austin, Tex.: Landes Bioscience 10.4161/auto.23461
Leni, Zaira; Parakkal, Geetha; Arcaro, Alexandre (2013). Emerging metabolic targets in the therapy of hematological malignancies. BioMed research international, 2013, p. 946206. Hindawi Publishing Corporation 10.1155/2013/946206
Wojtalla, Anna; Salm, Fabiana; Christiansen, Ditte G.; Cremona, Tiziana; Cwiek, Paulina; Shalaby, Tarek; Gross, Nicole; Grotzer, Michael A.; Arcaro, Alexandre (2012). Novel agents targeting the IGF-1R/PI3K pathway impair cell proliferation and survival in subsets of medulloblastoma and neuroblastoma. PLoS ONE, 7(10), e47109. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0047109
Błajecka, Karolina; Marinov, Marin; Leitner, Laura; Uth, Kristin; Posern, Guido; Arcaro, Alexandre (2012). Phosphoinositide 3-kinase C2β regulates RhoA and the actin cytoskeleton through an interaction with Dbl. PLoS ONE, 7(9), e44945. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0044945
Boller, Danielle; Doepfner, Kathrin T; De Laurentiis, Angela; Guerreiro, Ana S; Marinov, Marin; Shalaby, Tarek; Depledge, Paul; Robson, Anthony; Saghir, Nahid; Hayakawa, Masahiko; Kaizawa, Hiroyuki; Koizumi, Tomonobu; Ohishi, Takahide; Fattet, Sarah; Delattre, Olivier; Schweri-Olac, Anelia; Höland, Katrin; Grotzer, Michael A; Frei, Karl; Spertini, Olivier; ... (2012). Targeting PI3KC2β impairs proliferation and survival in acute leukemia, brain tumours and neuroendocrine tumours. Anticancer research, 32(8), pp. 3015-27. Kapandriti: International Inst. of Anticancer Research
Grunder, Eveline; D'Ambrosio, Rocco; Fiaschetti, Giulio; Abela, Lucia; Arcaro, Alexandre; Zuzak, Tycho; Ohgaki, Hiroko; Lv, Sheng-Qing; Shalaby, Tarek; Grotzer, Michael (2011). MicroRNA-21 suppression impedes medulloblastoma cell migration. European journal of cancer, 47(16), pp. 2479-90. Amsterdam: Elsevier 10.1016/j.ejca.2011.06.041
Guerreiro, Ana S; Fattet, Sarah; Kulesza, Dorota W; Atamer, Abdullah; Elsing, Alexandra N; Shalaby, Tarek; Jackson, Shaun P; Schoenwaelder, Simone M; Grotzer, Michael A; Delattre, Olivier; Arcaro, Alexandre (2011). A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance. Molecular cancer research, 9(7), pp. 925-35. Philadelphia, Pa.: American Association for Cancer Research AACR 10.1158/1541-7786.MCR-10-0200
Wojtalla, Anna; Arcaro, Alexandre (2011). Targeting phosphoinositide 3-kinase signalling in lung cancer. Critical reviews in oncology, hematology, 80(2), pp. 278-90. Boca Raton, Fla.: Elsevier 10.1016/j.critrevonc.2011.01.007
Błajecka, Karolina; Borgström, Anna; Arcaro, Alexandre (2011). Phosphatidylinositol 3-kinase isoforms as novel drug targets. Current drug targets, 12(7), pp. 1056-81. Hilversum: Bentham Science Publishers 10.2174/138945011795677773
De Laurentiis, Angela; Pardo, Olivier E; Palamidessi, Andrea; Jackson, Shaun P; Schoenwaelder, Simone M; Reichmann, Ernst; Scita, Giorgio; Arcaro, Alexandre (2011). The catalytic class I(A) PI3K isoforms play divergent roles in breast cancer cell migration. Cellular signalling, 23(3), pp. 529-41. Amsterdam: Elsevier 10.1016/j.cellsig.2010.10.021
Castelletti, Deborah; Fiaschetti, Giulio; Di Dato, Valeria; Ziegler, Urs; Kumps, Candy; De Preter, Katleen; Zollo, Massimo; Speleman, Frank; Shalaby, Tarek; De Martino, Daniela; Berg, Thorsten; Eggert, Angelika; Arcaro, Alexandre; Grotzer, Michael A (2010). The quassinoid derivative NBT-272 targets both the AKT and ERK signaling pathways in embryonal tumors. Molecular cancer therapeutics, 9(12), pp. 3145-57. Philadelphia, Pa.: American Association for Cancer Research AACR 10.1158/1535-7163.MCT-10-0539
Shalaby, Tarek; von Bueren, André O; Hürlimann, Marie-Louise; Fiaschetti, Giulio; Castelletti, Deborah; Masayuki, Tera; Nagasawa, Kazuo; Arcaro, Alexandre; Jelesarov, Ilian; Shin-ya, Kazuo; Grotzer, Michael (2010). Disabling c-Myc in childhood medulloblastoma and atypical teratoid/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD. Molecular cancer therapeutics, 9(1), pp. 167-79. Philadelphia, Pa.: American Association for Cancer Research AACR 10.1158/1535-7163.MCT-09-0586
Marinov, Marin; Ziogas, Algirdas; Pardo, Olivier E; Tan, Liwen Terence; Dhillon, Tony; Mauri, Francesco A; Lane, Heidi A; Lemoine, Nicholas R; Zangemeister-Wittke, Uwe; Seckl, Michael J; Arcaro, Alexandre (2009). AKT/mTOR pathway activation and BCL-2 family proteins modulate the sensitivity of human small cell lung cancer cells to RAD001. Clinical cancer research, 15(4), pp. 1277-87. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-08-2166
Wu, Ming; Arcaro, Alexandre; Varga, Zsuzsanna; Vogetseder, Alexander; Le Hir, Michel; Wüthrich, Rudolf P; Serra, Andreas L (2009). Pulse mTOR inhibitor treatment effectively controls cyst growth but leads to severe parenchymal and glomerular hypertrophy in rat polycystic kidney disease. American journal of physiology - renal physiology, 297(6), F1597-605. Bethesda, Md.: American Physiological Society 10.1152/ajprenal.00430.2009
Grotzer, Michael A; Castelletti, Deborah; Fiaschetti, Giulio; Shalaby, Tarek; Arcaro, Alexandre (2009). Targeting Myc in pediatric malignancies of the central and peripheral nervous system. Current cancer drug targets, 9(2), pp. 176-88. Hilversum: Bentham Science Publishers 10.2174/156800909787580962
von Bueren, André O; Shalaby, Tarek; Oehler-Jänne, Christoph; Arnold, Lucia; Stearns, Duncan; Eberhart, Charles G; Arcaro, Alexandre; Pruschy, Martin; Grotzer, Michael A (2009). RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells. BMC cancer, 9, p. 10. London: BioMed Central 10.1186/1471-2407-9-10
