Grad, Sibylle

Gewiess, Jan; Eglauf, Janick; Soubrier, Astrid; Grad, Sibylle; Alini, Mauro; Peroglio, Marianna; Ma, Junxuan (2023). The influence of intervertebral disc overloading on nociceptor calcium flickering. JOR Spine, 6(3), e1267. Wiley 10.1002/jsp2.1267

Ma, Junxuan; Häne, Surya; Eglauf, Janick; Pfannkuche, Judith; Soubrier, Astrid; Li, Zhen; Peroglio, Marianna; Hoppe, Sven; Benneker, Lorin; Lang, Gernot; Wangler, Sebastian; Alini, Mauro; Creemers, Laura B; Grad, Sibylle; Häckel, Sonja (2023). Celecoxib alleviates nociceptor sensitization mediated by interleukin-1beta-primed annulus fibrosus cells. European spine journal, 32(6), pp. 2048-2058. Springer 10.1007/s00586-023-07672-x

Basatvat, Shaghayegh; Bach, Frances C; Barcellona, Marcos N; Binch, Abbie L; Buckley, Conor T; Bueno, Brian; Chahine, Nadeen O; Chee, Ana; Creemers, Laura B; Dudli, Stefan; Fearing, Bailey; Ferguson, Stephen J; Gansau, Jennifer; Gantenbein, Benjamin; Gawri, Rahul; Glaeser, Juliane D; Grad, Sibylle; Guerrero, Julien; Haglund, Lisbet; Hernandez, Paula A; ... (2023). Harmonization and standardization of nucleus pulposus cell extraction and culture methods. JOR Spine, 6(1), e1238. Wiley 10.1002/jsp2.1238

Zuncheddu, Daniele; Della Bella, Elena; Petta, Dalila; Bärtschi, Cecilia; Häckel, Sonja; Deml, Moritz C; Stoddart, Martin J; Grad, Sibylle; Basoli, Valentina (2022). Effect of glucose depletion and fructose administration during chondrogenic commitment in human bone marrow-derived stem cells. Stem cell research & therapy, 13(1), p. 533. BioMed Central 10.1186/s13287-022-03214-2

Schol, Jordy; Sakai, Daisuke; Warita, Takayuki; Nukaga, Tadashi; Sako, Kosuke; Wangler, Sebastian; Tamagawa, Shota; Zeiter, Stephan; Alini, Mauro; Grad, Sibylle (2022). Homing of vertebral-delivered mesenchymal stromal cells for degenerative intervertebral discs repair - an in vivo proof-of-concept study. JOR Spine, 6(1), e1228. Wiley 10.1002/jsp2.1228

Saravi, Babak; Li, Zhen; Basoli, Valentina; Grad, Sibylle; Häckel, Sonja; Albers, Christoph E; Alini, Mauro; Schmal, Hagen; Obid, Peter; Lang, Gernot (2022). In Vitro Characterization of a Tissue Renin-Angiotensin System in Human Nucleus Pulposus Cells. Cells, 11(21) MDPI 10.3390/cells11213418

Du, Jie; Guo, Wei; Häckel, Sonja; Hoppe, Sven; Garcia, João P.; Alini, Mauro; Tryfonidou, Marianna A.; Creemers, Laura B.; Grad, Sibylle; Li, Zhen (2022). The function of CD146 in human annulus fibrosus cells and mechanism of the regulation by TGF‐β. Journal of orthopaedic research, 40(7), pp. 1661-1671. Wiley 10.1002/jor.25190

Constant, Caroline; Hom, Warren W; Nehrbass, Dirk; Carmel, Eric-Norman; Albers, Christoph E; Deml, Moritz C; Gehweiler, Dominic; Lee, Yunsoo; Hecht, Andrew; Grad, Sibylle; Iatridis, James C; Zeiter, Stephan (2022). Comparison and optimization of sheep in vivo intervertebral disc injury model. JOR Spine, 5(2), e1198. Wiley 10.1002/jsp2.1198

Sturm, Lisa; Schwemberger, Bettina; Menzel, Ursula; Häckel, Sonja; Albers, Christoph E.; Plank, Christian; Rip, Jaap; Alini, Mauro; Traweger, Andreas; Grad, Sibylle; Basoli, Valentina (2021). In Vitro Evaluation of a Nanoparticle-Based mRNA Delivery System for Cells in the Joint. Biomedicines, 9(7) MDPI 10.3390/biomedicines9070794

Russo, Fabrizio; Ambrosio, Luca; Peroglio, Marianna; Guo, Wei; Wangler, Sebastian; Gewiess, Jan; Grad, Sibylle; Alini, Mauro; Papalia, Rocco; Vadalà, Gianluca; Denaro, Vincenzo (2021). A Hyaluronan and Platelet-Rich Plasma Hydrogel for Mesenchymal Stem Cell Delivery in the Intervertebral Disc: An Organ Culture Study. International journal of molecular sciences, 22(6) MDPI 10.3390/ijms22062963

Wangler, Sebastian; Kamali, Amir; Wapp, Christina; Wuertz-Kozak, Karin; Häckel, Sonja; Fortes, Claudia; Benneker, Lorin M.; Haglund, Lisbet; Richards, R. Geoff; Alini, Mauro; Peroglio, Marianna; Grad, Sibylle (2021). Uncovering the secretome of mesenchymal stromal cells exposed to healthy, traumatic, and degenerative intervertebral discs: a proteomic analysis. Stem cell research & therapy, 12(1), p. 11. BioMed Central 10.1186/s13287-020-02062-2

Croft, Andreas S.; Illien-Jünger, Svenja; Grad, Sibylle; Guerrero, Julien; Wangler, Sebastian; Gantenbein, Benjamin (2021). The Application of Mesenchymal Stromal Cells and Their Homing Capabilities to Regenerate the Intervertebral Disc. International journal of molecular sciences, 22(7) MDPI 10.3390/ijms22073519

Saravi, Babak; Li, Zhen; Pfannkuche, Judith; Wystrach, Laura; Häckel, Sonja; Albers, Christoph E; Grad, Sibylle; Alini, Mauro; Richards, Robert Geoffrey; Lang, Corinna; Südkamp, Norbert; Schmal, Hagen; Lang, Gernot (2021). Angiotensin II Type 1 Receptor Antagonist Losartan Inhibits TNF-α-Induced Inflammation and Degeneration Processes in Human Nucleus Pulposus Cells. Applied Sciences, 11(1), p. 417. MDPI 10.3390/app11010417

Du, Jie; Pfannkuche, Judith-J; Lang, Gernot; Häckel, Sonja; Creemers, Laura B; Alini, Mauro; Grad, Sibylle; Li, Zhen (2020). Proinflammatory intervertebral disc cell and organ culture models induced by tumor necrosis factor alpha. JOR Spine, 3(3), e1104. Wiley 10.1002/jsp2.1104

Long, Rose G; Ferguson, Stephen J; Benneker, Lorin M.; Sakai, Daisuke; Li, Zhen; Pandit, Abhay; Grijpma, Dirk W; Eglin, David; Zeiter, Stephan; Schmid, Tanja; Eberli, Ursula; Nehrbass, Dirk; Di Pauli von Treuheim, Theodor; Alini, Mauro; Iatridis, James C; Grad, Sibylle (2020). Morphological and biomechanical effects of annulus fibrosus injury and repair in an ovine cervical model. JOR Spine, 3(1), e1074. Wiley 10.1002/jsp2.1074

Wangler, Sebastian; Peroglio, Marianna; Menzel, Ursula; Benneker, Lorin M.; Haglund, Lisbet; Sakai, Daisuke; Alini, Mauro; Grad, Sibylle (2019). Mesenchymal Stem Cell Homing Into Intervertebral Discs Enhances the Tie2-positive Progenitor Cell Population, Prevents Cell Death, and Induces a Proliferative Response. Spine, 44(23), pp. 1613-1622. Lippincott Williams & Wilkins 10.1097/BRS.0000000000003150

Häckel, Sonja; Zolfaghar, Mona; Du, Jie; Hoppe, Sven; Benneker, Lorin M.; Garstka, Nathalie; Peroglio, Marianna; Alini, Mauro; Grad, Sibylle; Yayon, Avner; Li, Zhen (2019). Fibrin-Hyaluronic Acid Hydrogel (RegenoGel) with Fibroblast Growth Factor-18 for In Vitro 3D Culture of Human and Bovine Nucleus Pulposus Cells. International journal of molecular sciences, 20(20) MDPI 10.3390/ijms20205036

Frauchiger, Daniela A; Tekari, Adel; May, Rahel Deborah; Džafo, Emina; Chan, Samantha Cw; Stoyanov, Jivko; Bertolo, Alessandro; Zhang, Xingshuo; Guerrero, Julien; Sakai, Daisuke; Schol, Jordy; Grad, Sibylle; Tryfonidou, Marianna A; Benneker, Lorin M.; Gantenbein, Benjamin (2019). FACS is more potent to fish IVD progenitor cells than magnetic and bead-based methods. Tissue engineering. Part C, Methods, 25(10), pp. 571-580. Mary Ann Liebert 10.1089/ten.TEC.2018.0375

Gantenbein, Benjamin; Frauchiger, Daniela A.; May, Rahel Deborah; Bakirci, Ezgi; Rohrer, Urs; Grad, Sibylle (2019). Developing Bioreactors to Host Joint-Derived Tissues That Require Mechanical Stimulation. In: Reference Module in Biomedical Sciences. Elsevier 10.1016/B978-0-12-801238-3.65611-8

Frauchiger, Daniela A; Tekari, Adel; May, Rahel; Dzafo, Emina; Chan, Samantha C.W.; Stoyanov, Jivko; Bertolo, Alessandro; Zhang, Xingshuo; Sakai, Daisuke; Schol, Jordy; Grad, Sibylle; Tryfonidou, Marianna; Benneker, Lorin M.; Gantenbein, Benjamin (2019). Different isolation methods for nucleus pulposus progenitor cells. In: 7th International Congress on Biotechnologies for Spinal Surgery (BioSpine7). Rom, Italy. 3-5 April 2019.

Tekari, Adel; Chan, Samantha C.W.; Sakai, Daisuke; Grad, Sibylle; Gantenbein, Benjamin (2019). Correction to: Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells. Stem cell research & therapy, 10(1) BioMed Central 10.1186/s13287-019-1150-z

Peroglio, Marianna; Douma, Luzia Simone; Caprez, Tansinee Stephanie; Janki, Milena; Benneker, Lorin Michael; Alini, Mauro; Grad, Sibylle (2017). Intervertebral disc response to stem cell treatment is conditioned by disc state and cell carrier: An ex vivo study. Journal of orthopaedic translation, 9, pp. 43-51. Elsevier 10.1016/j.jot.2017.03.003

Frauchiger, Daniela Angelika; Tekari, Adel; Benneker, Lorin Michael; Sakai, Daisuke; Grad, Sibylle; Stoyanov, Jivko; Bertolo, Alessandro; Gantenbein, Benjamin (2017). Nucleus pulposus progenitor cells isolation and injection into degenerative disc (Unpublished). In: AOSpine Masters Symposium-Novel and Emerging Technologies in Translational Medicine. 23 September 2017.

Frauchiger, Daniela Angelika; Tekari, Adel; Benneker, Lorin Michael; Sakai, Daisuke; Grad, Sibylle; Gantenbein, Benjamin (2017). Protocols for isolation of nucleus pulposus progenitor cells from bovine intervertebral disc (Unpublished). In: Proceedings of Biospine6. Berlin. 25-29 April.

Frauchiger, Daniela Angelika; Tekari, Adel; Benneker, Lorin Michael; Sakai, Daisuke; Grad, Sibylle; Stoyanov, Jivko; Bertolo, Alessandro; Gantenbein, Benjamin (2017). Fishing nucleus pulposus progenitor cells from bovine intervertebral discs using three different sorting methods (Unpublished). In: Proceedings of TERMIS-EU Chapter. Davos. 25 June 2017.

Tekari, Adel; Chan, Samantha C.W.; Sakai, Daisuke; Grad, Sibylle; Gantenbein, Benjamin (2016). Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells. Stem cell research & therapy, 7(1), p. 75. BioMed Central 10.1186/s13287-016-0337-9

Tekari, Adel; Chan, Samantha; Wuertz-Kozak, Karin; Sakai, Daisuke; Benneker, Lorin Michael; Grad, Sibylle; Gantenbein, Benjamin (4 November 2015). Bovine coccygeal intervertebral discs contain multipotent Tie2+ cells which can differentiate into osteogenic adipogenic and chondrogenic lineages. In: Day of Clinical Research 2015, Department of Clinical Research.

Tekari, Adel; Chan, Samantha; Wuertz, Karin; Sakai, Daisuke; Benneker, Lorin Michael; Grad, Sibylle; Gantenbein, Benjamin (9 June 2015). Nucleus pulposus of bovine coccygeal intervertebral disc contains progenitor cells capable of differentiating into osteocytes and adipocytes (Unpublished). In: Proceedings of the 42nd ISSLS Congress. 08.-12.06.2015.

Tekari, Adel; Chan, Samantha; Frauchiger, Daniela Angelika; Wuertz, Karin; Sakai, Daisuke; Benneker, Lorin Michael; Grad, Sibylle; Gantenbein, Benjamin (9 June 2015). Nucleus pulposus contain progenitor-like cells able to differentiate into osteogenic and adipogenic lineages in vitro. European cells & materials eCM, 30(Suppl. 1), p. 66. University of Wales

Tekari, Adel; Chan, Samantha; Wuertz, Karin; Saikai, Daisuke; Benneker, Lorin Michael; Grad, Sibylle; Gantenbein, Benjamin (2015). Tie2+ cells of the bovine Nucleus Pulposus are Progenitor Cells capable of differentiating into Osteocytes and Adipocytes. Global Spine Journal, 5(1_suppl), s-0035-1554231-s-0035-1554231. Buenos Aires, Argentinia: Thieme 10.1055/s-0035-1554231

Gantenbein, Benjamin; Illien-Jünger, Svenja; Chan, Samantha Cw; Walser, Jochen; Haglund, Lisbet; Ferguson, Stephen J; Iatridis, James C; Grad, Sibylle (2015). Organ Culture Bioreactors - Platforms to Study Human Intervertebral Disc Degeneration and Regenerative Therapy. Current stem cell research & therapy, 10(4), pp. 339-352. Bentham Science Publishers 10.2174/1574888X10666150312102948

Tekari, Adel; Chan, Samantha; Wuertz, Karin; Sakai, Daisuke; Benneker, Lorin M.; Grad, Sibylle; Gantenbein, Benjamin (1 March 2015). Bovine coccygeal intervertebral discs contain multipotent Tie2+ cells which can differentiate into osteogenic and adipogenic lineages. European spine journal(22), pp. 650-651. Springer

Pirvu, Tatiana; Blanquer, Sebastien B G; Benneker, Lorin M; Grijpma, Dirk W; Richards, Robert G; Alini, Mauro; Eglin, David; Grad, Sibylle; Li, Zhen (2015). A combined biomaterial and cellular approach for annulus fibrosus rupture repair. Biomaterials, 42, pp. 11-19. Elsevier 10.1016/j.biomaterials.2014.11.049

Peroglio, Marianna; Eglin, David; Benneker, Lorin M.; Alini, Mauro; Grad, Sibylle (2013). Thermoreversible hyaluronan-based hydrogel supports in vitro and ex vivo disc-like differentiation of human mesenchymal stem cells. Spine Journal, 13(11), pp. 1627-1639. Elsevier 10.1016/j.spinee.2013.05.029

Vadalà, Gianluca; Russo, Fabrizio; Pattappa, Girish; Schiuma, Damiano; Peroglio, Marianna; Benneker, Lorin M.; Grad, Sibylle; Alini, Mauro; Denaro, Vincenzo (2013). The transpedicular approach as an alternative route for intervertebral disc regeneration. Spine, 38(6), E319-E324. Lippincott Williams & Wilkins 10.1097/BRS.0b013e318285bc4a

Guterl, Clare C.; See, Eugene Y.; Blanquer, Sebastien B. G.; Pandit, Abhay; Ferguson, Stephen J.; Benneker, Lorin M.; Grijpma, Dirk W.; Sakai, Daisuke; Eglin, David; Alini, Mauro; Iatridis, James C.; Grad, Sibylle (2013). Challenges and strategies in the repair of ruptured annulus fibrosus. European cells & materials eCM, 25, pp. 1-21. University of Wales

Illien-Jünger, Svenja; Pattappa, Girish; Peroglio, Marianna; Benneker, Lorin M; Stoddart, Martin J; Sakai, Daisuke; Mochida, Joji; Grad, Sibylle; Alini, Mauro (2012). Homing of mesenchymal stem cells in induced degenerative intervertebral discs in a whole organ culture system. Spine, 37(22), pp. 1865-73. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/BRS.0b013e3182544a8a

Gantenbein-Ritter, Benjamin; Guggisberg, Stefan; Chan, Samantha CW; Benneker, Lorin M; Grad, Sibylle (2012). Discogenic Pre-Conditioning of human Mesenchymal Stem Cells in synthetic MMP-Degradable Poly-Ethylene-Glycol (PEG) Hydrogels under Load and rhGDF-5. In: Orthopaedic Research Society. San Francisco.

Gantenbein-Ritter, Benjamin; Sprecher, Christoph M.; Chan, Samantha; Illien-Junger, Svenja; Grad, Sibylle (2011). Confocal imaging protocols for live/dead staining in three-dimensional carriers. Methods in molecular biology, 740, pp. 127-140. Totowa, N.J.: Humana Press 10.1007/978-1-61779-108-6_14

Wernike, Ellen; Li, Zhen; Alini, Mauro; Grad, Sibylle (2008). Effect of reduced oxygen tension and long-term mechanical stimulation on chondrocyte-polymer constructs. Cell and tissue research, 331(2), pp. 473-83. Heidelberg: Springer 10.1007/s00441-007-0500-9