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Stillinovic, Martina; Sarangdhar, Mayuresh Anant; Andina, Nicola; Tardivel, Aubry; Greub, Frédéric; Bombaci, Giuseppe; Ansermet, Camille; Zatti, Marco; Saha, Dipanjali; Xiong, Jieyu; Sagae, Takeru; Yokogawa, Mariko; Osawa, Masanori; Heller, Manfred; Keogh, Adrian; Keller, Irene; Angelillo-Scherrer, Anne; Allam, Ramanjaneyulu (2024). Ribonuclease inhibitor and angiogenin system regulates cell type-specific global translation. Science Advances, 10(22) American Association for the Advancement of Science 10.1126/sciadv.adl0320
Lambrecht, Rebekka; Rudolf, Franziska; Ückert, Anna-Katharina; Sladky, Valentina C; Phan, Truong San; Jansen, Jasmin; Naim, Samara; Kaufmann, Thomas; Keogh, Adrian; Kirschnek, Susanne; Mangerich, Aswin; Stengel, Florian; Leist, Marcel; Villunger, Andreas; Brunner, Thomas (2024). Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis. Cell death and differentiation, 31(1), pp. 119-131. Nature Publishing Group 10.1038/s41418-023-01245-7
Lett, Martin J; Mehta, Hema; Keogh, Adrian; Jaeger, Tina; Jacquet, Maxime; Powell, Kate; Meier, Marie-Anne; Fofana, Isabel; Melhem, Hassan; Vosbeck, Jürg; Cathomas, Gieri; Heigl, Andres; Heim, Markus H; Burri, Emanuel; Mertz, Kirsten D; Niess, Jan Hendrik; Kollmar, Otto; Zech, Christoph J; Ivanek, Robert; Duthaler, Urs; ... (2022). Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells. Gut, 71(12), pp. 2526-2538. BMJ Publishing Group 10.1136/gutjnl-2021-324478
Yarahmadov, Tural; Wang, Junhua; Sanches-Taltavull, Daniel; Rojas, Cristian A Alvarez; Brodie, Tess; Büchi, Isabel; Keogh, Adrian; Gottstein, Bruno; Stroka, Deborah; Beldi, Guido (2022). Primary Infection by E. multilocularis Induces Distinct Patterns of Cross Talk between Hepatic Natural Killer T Cells and Regulatory T Cells in Mice. Infection and immunity, 90(8), e0017422. American Society for Microbiology 10.1128/iai.00174-22
Sánchez-Taltavull, Daniel; Castelo-Székely, Violeta; Murugan, Shaira; Hamley, Jonathan I. D.; Rollenske, Tim; Ganal-Vonarburg, Stephanie C.; Büchi, Isabel; Keogh, Adrian; Li, Hai; Salm, Lilian; Spari, Daniel; Yilmaz, Bahtiyar; Zimmermann, Jakob; Gerfin, Michael; Roldan, Edgar; Beldi, Guido (2021). Regular testing of asymptomatic healthcare workers identifies cost-efficient SARS-CoV-2 preventive measures. PLoS ONE, 16(11), e0258700. Public Library of Science 10.1371/journal.pone.0258700
Wang, Zhong-Yi; Keogh, Adrian; Waldt, Annick; Cuttat, Rachel; Neri, Marilisa; Zhu, Shanshan; Schuierer, Sven; Ruchti, Alexandra; Crochemore, Christophe; Knehr, Judith; Bastien, Julie; Ksiazek, Iwona; Sánchez-Taltavull, Daniel; Ge, Hui; Wu, Jing; Roma, Guglielmo; Helliwell, Stephen B; Stroka, Deborah; Nigsch, Florian (2021). Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis. Scientific reports, 11(1), p. 19396. Springer Nature 10.1038/s41598-021-98806-y
Baier, Felix Alexander; Sánchez-Taltavull, Daniel; Yarahmadov, Tural; Castellà, Cristina Gómez; Jebbawi, Fadi; Keogh, Adrian; Tombolini, Riccardo; Odriozola, Adolfo; Castro Dias, Mariana; Deutsch, Urban; Furuse, Mikio; Engelhardt, Britta; Zuber, Benoît; Odermatt, Alex; Candinas, Daniel; Keogh-Stroka, Deborah M. (2021). Loss of claudin-3 impairs hepatic metabolism, biliary barrier function and cell proliferation in the murine liver. Cellular and molecular gastroenterology and hepatology, 12(2), pp. 745-767. Elsevier 10.1016/j.jcmgh.2021.04.003
Melin, Nicolas; Sánchez-Taltavull, Daniel; Fahrner, René; Keogh, Adrian; Dosch, Michel; Büchi, Isabel; Zimmer, Yitzhak; Medová, Michaela; Beldi, Guido; Aebersold, Daniel M.; Candinas, Daniel; Stroka, Deborah (2021). Synergistic effect of the TLR5 agonist CBLB502 and its downstream effector IL-22 against liver injury. Cell death & disease, 12(4), p. 366. Nature Publishing Group 10.1038/s41419-021-03654-3
Sánchez-Taltavull, Daniel; Perkins, Theodore J; Dommann, Noelle; Melin, Nicolas; Keogh, Adrian; Candinas, Daniel; Stroka, Deborah; Beldi, Guido (2020). Bayesian correlation is a robust gene similarity measure for single-cell RNA-seq data. NAR genomics and bioinformatics, 2(1) Oxford University Press 10.1093/nargab/lqaa002
Gavini, Jacopo; Dommann, Noëlle; Jakob, Manuel O.; Keogh, Adrian; Bouchez, Laure C; Karkampouna, Sofia; Kruithof-de Julio, Marianna; Medova, Michaela; Zimmer, Yitzhak; Schläfli, Anna M; Tschan, Mario P.; Candinas, Daniel; Stroka, Deborah; Banz, Vanessa (2019). Verteporfin-induced lysosomal compartment dysregulation potentiates the effect of sorafenib in hepatocellular carcinoma. Cell death & disease, 10(10), p. 749. Springer Nature 10.1038/s41419-019-1989-z
Melhem, Hassan; Kallol, Sampada; Huang, Xiao; Lüthi, Michael; Ontsouka, Edgar; Keogh, Adrian; Stroka, Deborah; Thormann, Wolfgang; Schneider, Henning; Albrecht, Christiane (2019). Placental secretion of apolipoprotein A1 and E: the anti-atherogenic impact of the placenta. Scientific Reports, 9(1), p. 6225. Nature Publishing Group 10.1038/s41598-019-42522-1
Melin, Nicolas; Fahrner, René; Keogh, Adrian; Medova, Michaela; Zimmer, Yitzhak; Aebersold, Daniel; Candinas, Daniel; Beldi, Guido; Keogh-Stroka, Deborah M. (2018). Direct and indirect hepatoprotective mechanism of CBLB502 a TLR5 agonist. Journal of hepatology, 68, S140-S141. Elsevier 10.1016/S0168-8278(18)30497-5
Keogh, Adrian; Şenkardeş, Sevil; Idle, Jeffrey; Küçükgüzel, Ş Güniz; Beyoglu, Diren (2017). A Novel Anti-Hepatitis C Virus and Antiproliferative Agent Alters Metabolic Networks in HepG2 and Hep3B Cells. Metabolites, 7(2) MDPI 10.3390/metabo7020023
Loforese, Giulio; Malinka, Thomas; Keogh, Adrian; Baier, Felix; Simillion, Cedric André Marie; Montani, Matteo; Halazonetis, Thanos D; Candinas, Daniel; Keogh-Stroka, Deborah M. (2017). Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2. EMBO molecular medicine, 9(1), pp. 46-60. EMBO Press 10.15252/emmm.201506089
Lugli, Natalia; Kamileri, Irene; Keogh, Adrian; Malinka, Thomas; Sarris, Michalis E; Talianidis, Iannis; Schaad, Olivier; Candinas, Daniel; Halazonetis, Thanos D; Keogh-Stroka, Deborah M. (2016). R-spondin 1 and noggin facilitate expansion of resident stem cells from non-damaged gallbladders. EMBO reports, 17(5), pp. 769-779. Nature Publishing Group 10.15252/embr.201642169
Kudira, Ramesh; Malinka, Thomas; Kohler, Andreas; Dosch, Michel; Gomez de Agüero Tamargo, Maria de la Mercedes; Melin, Nicolas; Haegele, S; Starlinger, P; Maharjan, Niran; Saxena, Smita; Keogh, Adrian; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (2016). P2X1 regulated IL-22 secretion by innate lymphoid cells is required for efficient liver regeneration. Hepatology, 63(6), pp. 2004-2017. Wiley Interscience 10.1002/hep.28492
Wang, Min; Keogh, Adrian; Treves, Susan; Idle, Jeffrey; Beyoglu, Diren (2016). The metabolomic profile of gamma-irradiated human hepatoma and muscle cells reveals metabolic changes consistent with the Warburg effect. PeerJ, 4, e1624. PeerJ, Ltd 10.7717/peerj.1624
Laemmle, Alexander; Gallagher, Renata C; Keogh, Adrian; Stricker, Tamar; Gautschi, Matthias; Nuoffer, Jean-Marc; Baumgartner, Matthias R; Häberle, Johannes (2016). Frequency and Pathophysiology of Acute Liver Failure in Ornithine Transcarbamylase Deficiency (OTCD). PLoS ONE, 11(4), e0153358. Public Library of Science 10.1371/journal.pone.0153358
Piguet, Anne-Christine; Medova, Michaela; Keogh, Adrian; Glück, Astrid Andreina; Aebersold, Daniel; Dufour, Jean-François; Dufour, Jean-François; Zimmer, Yitzhak (2015). Impact of MET targeting on tumor-associated angiogenesis and growth of MET mutations-driven models of liver cancer. Genes & cancer, 6(7-8), pp. 317-327. Impact Journals
Keogh-Stroka, Deborah M.; Keogh, Adrian; Vu, Dung; Fort, Alfredo; Stoffel, Michael Hubert; Kühni, Kathrin; Furer, Cynthia; Banz Wüthrich, Vanessa; Demarmels Biasiutti, Franziska; Lämmle, Bernhard; Candinas, Daniel; Neerman-Arbez, Marguerite (2014). In vitro rescue of FGA deletion by lentiviral transduction of an afibrinogenemic patient's hepatocytes. Journal of thrombosis and haemostasis, 12(11), pp. 1874-1879. Wiley-Blackwell 10.1111/jth.12714
Fahrner, René; Trochsler, Markus; Corazza, Nadia; Graubardt, Nadine; Keogh, Adrian; Candinas, Daniel; Brunner, Thomas; Keogh-Stroka, Deborah M.; Beldi, Guido (2014). Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand on NK Cells Protects From Hepatic Ischemia-Reperfusion Injury. Transplantation, 97(11), pp. 1102-1109. Lippincott Williams & Wilkins 10.1097/TP.0000000000000101
Medová, Michaela; Pochon, Benoît; Streit, Bruno; Blank-Liss, Wieslawa; Francica, Paola; Stroka, Deborah; Keogh, Adrian; Aebersold, Daniel M.; Blaukat, Andree; Bladt, Friedhelm; Zimmer, Yitzhak (2013). The novel ATP-competitive inhibitor of the MET hepatocyte growth factor receptor EMD1214063 displays inhibitory activity against selected MET-mutated variants. Molecular cancer therapeutics, 12(11), pp. 2415-2424. American Association for Cancer Research AACR 10.1158/1535-7163.MCT-13-0151
Portmann, Simone; Fahrner, René; Lechleiter, Antje; Keogh, Adrian; Overney, Sarah; Lämmle, Alexander; Mikami, Kei; Montani, Matteo; Tschan, Mario; Candinas, Daniel; Keogh-Stroka, Deborah M. (2013). Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo. Molecular cancer therapeutics, 12(4), pp. 499-508. American Association for Cancer Research AACR 10.1158/1535-7163.MCT-12-0700
Graubardt, Nadine; Fahrner, René; Trochsler, Markus; Keogh, Adrian; Breu, Karin; Furer, Cynthia; Keogh-Stroka, Deborah M.; Robson, Simon C.; Slack, Emma; Candinas, Daniel; Beldi, Guido (2013). Promotion of liver regeneration by natural killer cells in a murine model is dependent on extracellular adenosine triphosphate phosphohydrolysis. Hepatology, 57(5), pp. 1969-1979. Wiley Interscience 10.1002/hep.26008
Laemmle, Alexander; Lechleiter, Antje; Roh, Vincent; Schwarz, Christa; Portmann, Simone; Furer, Cynthia; Keogh, Adrian; Tschan, Mario P; Candinas, Daniel; Vorburger, Stephan A; Stroka, Deborah (2012). Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions. PLoS ONE, 7(3), e33433. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0033433
Badmann, Anastasia; Langsch, Stephanie; Keogh, Adrian; Brunner, Thomas; Kaufmann, Thomas; Corazza, Nadia (2012). TRAIL enhances paracetamol-induced liver sinusoidal endothelial cell death in a Bim- and Bid-dependent manner. Cell death & disease, 3(12), e447. London: Nature Publishing Group 10.1038/cddis.2012.185
Banz, Vanessa M; Medová, Michaela; Keogh, Adrian; Furer, Cynthia; Zimmer, Yitzhak; Candinas, Daniel; Stroka, Deborah (2009). Hsp90 transcriptionally and post-translationally regulates the expression of NDRG1 and maintains the stability of its modifying kinase GSK3beta. Biochimica et biophysica acta - molecular cell research, 1793(10), pp. 1597-603. New York, N.Y.: Elsevier 10.1016/j.bbamcr.2009.08.002
Piguet, Anne-Christine; Semela, David; Keogh, Adrian; Wilkens, Ludwig; Stroka, Deborah; Stoupis, Christoforos; St-Pierre, Marie V; Dufour, Jean-François (2008). Inhibition of mTOR in combination with doxorubicin in an experimental model of hepatocellular carcinoma. Journal of hepatology, 49(1), pp. 78-87. Amsterdam: Elsevier 10.1016/j.jhep.2008.03.024
Quarta, Mattia; Stroka, Deborah; Keogh, Adrian; Sidler, Daniel; Avital, Itzhak; Gloor, Beat; Muraca, Maurizio; Candinas, Daniel; Inderbitzin, Daniel (2008). Multiparameter flow cytometry characterization of MHC class I negative mouse bone marrow cells. Medical science monitor, 14(12), BR286-93. Warszawa: Medical Science International
Inderbitzin, Daniel; Beldi, Guido; Sidler, Daniel; Studer, Peter; Keogh, Adrian; Bisch-Knaden, Sonja; Weimann, Rosy; Kappeler, Andreas; Gloor, Beat; Candinas, Daniel (2007). Granulocyte colony-stimulating factor supports liver regeneration in a small-for-size liver remnant mouse model. Journal of gastrointestinal surgery, 11(3), pp. 280-5. New York, N.Y.: Springer-Verlag 10.1007/s11605-007-0096-0
Plock, Jan; Frese, Steffen; Keogh, Adrian; Bisch-Knaden, Sonja; Ayuni, Erick; Corazza, Nadia; Weikert, Christian; Jakob, Stephan; Erni, Dominique; Dufour, Jean-François; Brunner, Thomas; Candinas, Daniel; Stroka, Deborah (2007). Activation of non-ischemic, hypoxia-inducible signalling pathways up-regulate cytoprotective genes in the murine liver. Journal of hepatology, 47(4), pp. 538-45. Amsterdam: Elsevier 10.1016/j.jhep.2007.04.016
Sibold, Sonja; Roh, Vincent; Keogh, Adrian; Studer, Peter; Tiffon, Céline; Angst, Eliane; Vorburger, Stephan A; Weimann, Rosemarie; Candinas, Daniel; Stroka, Deborah (2007). Hypoxia increases cytoplasmic expression of NDRG1, but is insufficient for its membrane localization in human hepatocellular carcinoma. FEBS letters, 581(5), pp. 989-94. Amsterdam: Elsevier 10.1016/j.febslet.2007.01.080
Peyer, Anne-Kathrin; Jung, Diana; Beer, Markus; Gnerre, Carmela; Keogh, Adrian; Stroka, Deborah; Zavolan, Mihaela; Meyer, Urs-A (2007). Regulation of human liver delta-aminolevulinic acid synthase by bile acids. Hepatology, 46(6), pp. 1960-70. Hoboken, N.J.: Wiley Interscience 10.1002/hep.21879
Inderbitzin, Daniel; Studer, Peter; Sidler, Daniel; Beldi, Guido; Djonov, Valentin; Keogh, Adrian; Candinas, Daniel (2006). Regenerative capacity of individual liver lobes in the microsurgical mouse model. Microsurgery, 26(6), pp. 465-9. New York, N.Y.: Wiley-Liss 10.1002/micr.20271
Bonvin, Marianne; Achermann, François; Greeve, Isabell; Stroka, Deborah; Keogh, Adrian; Inderbitzin, Daniel; Candinas, Daniel; Sommer, Peter; Wain-Hobson, Simon; Vartanian, Jean-Pierre; Greeve, Jobst (2006). Interferon-inducible expression of APOBEC3 editing enzymes in human hepatocytes and inhibition of hepatitis B virus replication. Hepatology, 43(6), pp. 1364-74. Hoboken, N.J.: Wiley Interscience 10.1002/hep.21187
Corazza, Nadia; Jakob, Sabine; Schaer, Corinne; Frese, Steffen; Keogh, Adrian; Stroka, Deborah; Kassahn, Daniela; Torgler, Ralph; Mueller, Christoph; Schneider, Pascal; Brunner, Thomas (2006). TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality. Journal of clinical investigation, 116(9), pp. 2493-9. Ann Arbor, Mich.: American Society for Clinical Investigation 10.1172/JCI27726
Inderbitzin, Daniel; Avital, Itzhak; Keogh, Adrian; Beldi, Guido; Quarta, Mattia; Gloor, Beat; Candinas, Daniel (2005). Interleukin-3 induces hepatocyte-specific metabolic activity in bone marrow-derived liver stem cells. Journal of gastrointestinal surgery, 9(1), pp. 69-74. Springer-Verlag 10.1016/j.gassur.2004.10.013
Inderbitzin, Daniel; Avital, Itzhak; Gloor, Beat; Keogh, Adrian; Candinas, Daniel (2005). Functional comparison of bone marrow-derived liver stem cells: Selection strategy for cell-based therapy. Journal of gastrointestinal surgery, 9(9), pp. 1340-1345. Springer-Verlag 10.1016/j.gassur.2005.06.010
Kudira, Ramesh; Malinka, Thomas; Kohler, Andreas; Dosch, Michel; Gomez de Agüero Tamargo, Maria de la Mercedes; Melin, Nicolas; Haegele, S; Starlinger, P; Maharjan, Niran; Saxena, Smita; Keogh, Adrian; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (2016). P2X1 regulated IL-22 secretion by innate lymphoid cells is required for efficient liver regeneration (Unpublished). In: Keystone Symposium. Vancouver. 29.01.2016.
Malinka, Thomas; Keogh, Adrian; Kudira, Ramesh; Moghadamrad, Sheida; McCoy, Kathleen; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (September 2014). Liver regeneration is not impacted in the absence of intestinal microbiota (Unpublished). In: Schweizerische Gesellschaft für Gastroenterologie (SGG) - Schweizerische Gesellschaft für Viszeralchirurgie (SGVC) Annual Congress. Interlaken. 11.-12.9.2014.
Kudira, Ramesh; Malinka, Thomas; Gomez de Agüero Tamargo, Maria de la Mercedes; Keogh, Adrian; Furer, Cynthia; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (September 2014). Secretion of IL-22 is modulated by CD39 and is required for liver regeneration post partial hepatectomy. In: Schweizerische Gesellschaft für Gastroenterologie (SGG) - Schweizerische Gesellschaft für Viszeralchirurgie (SGVC) Annual Congress. Interlaken. 11.-12.9.2014.
Malinka, Thomas; Keogh, Adrian; Kudira, Ramesh; Moghadamrad, Sheida; McCoy, Kathleen; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (September 2014). Travel Award: Liver regeneration is not impacted in the absence of intestinal microbiota (Unpublished). In: Schweizerische Gesellschaft für Gastroenterologie (SGG) - Schweizerische Gesellschaft für Viszeralchirurgie (SGVC) Annual Congress. Interlaken. 11.-12.9.2014.
Kudira, Ramesh; Malinka, Thomas; Gomez de Agüero Tamargo, Maria de la Mercedes; Keogh, Adrian; Furer, Cynthia; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (September 2014). Travel Award: Secretion of IL-22 is modulated by CD39 and is required for liver regeneration post partial hepatectomy (Unpublished). In: Schweizerische Gesellschaft für Gastroenterologie (SGG) - Schweizerische Gesellschaft für Viszeralchirurgie (SGVC) Annual Congress. Interlaken. 11.-12.09.2014.
Malinka, Thomas; Keogh, Adrian; Kudira, Ramesh; Moghadamrad, Sheida; McCoy, Kathleen; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (May 2014). Liver regeneration is not impacted in the absence of intestinal microbiota. (Unpublished). In: Annual meeting of the Swiss Surgical Society. Bern. 21.-23.05.2014.
Kudira, Ramesh; Breu, Karin; Keogh, Adrian; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (March 2013). Extracellular nucleotides modulate the secretion of IL-22 by hepatic innate lymphoid cells. In: World immune regulation meeting Davos. Davos. 13.-16.3.2013.
Keogh-Stroka, Deborah M.; Plock, Jan Alexander; Beldi, Guido; Frese, Steffen R.; Keogh, Adrian; Bisch-Knaden, Sonja Maria; Dufour, Jean-François; Brunner, Thomas; Candinas, Daniel (2006). Temporary hypoxic stress protects the liver from Fas-mediated apoptosis and ischemia reperfusion injury. In: 93. Jahreskongress der Schweizerischen Gesellschaft für Chirurgie. Lugano, Switzerland. 21.-23.6.2006.
