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Wojnacki, José; Quassollo, Gonzalo; Bordenave, Martín D; Unsain, Nicolás; Martínez, Gaby F; Szalai, Alan M; Pertz, Olivier; Gundersen, Gregg G; Bartolini, Francesca; Stefani, Fernando D; Cáceres, Alfredo; Bisbal, Mariano (2024). Dual spatio-temporal regulation of axon growth and microtubule dynamics by RhoA signaling pathways. Journal of cell science, 137(14) Company of Biologists 10.1242/jcs.261970
Gagliardi, Paolo Armando; Pertz, Olivier (2024). The mitogen-activated protein kinase network, wired to dynamically function at multiple scales. Current opinion in cell biology, 88, p. 102368. Elsevier 10.1016/j.ceb.2024.102368
Dobrzynski, Maciej; Grädel, Benjamin; Gagliardi, Paolo Armando; Pertz, Olivier (2024). Quantification of collective signalling in time-lapse microscopy images. Methods in microscopy, 1(1), pp. 19-30. de Gruyter 10.1515/mim-2024-0003
Pulfer, Alain; Pizzagalli, Diego Ulisse; Gagliardi, Paolo Armando; Hinderling, Lucien; Lopez, Paul; Zayats, Romaniya; Carrillo-Barberà, Pau; Antonello, Paola; Palomino-Segura, Miguel; Grädel, Benjamin; Nicolai, Mariaclaudia; Giusti, Alessandro; Thelen, Marcus; Gambardella, Luca Maria; Murooka, Thomas T; Pertz, Olivier; Krause, Rolf; Gonzalez, Santiago Fernandez (2024). Transformer-based spatial-temporal detection of apoptotic cell death in live-cell imaging. eLife, 12 eLife Sciences Publications 10.7554/eLife.90502
Gagliardi, Paolo Armando; Grädel, Benjamin; Jacques, Marc-Antoine; Hinderling, Lucien; Ender, Pascal; Cohen, Andrew R; Kastberger, Gerald; Pertz, Olivier; Dobrzynski, Maciej (2023). Automatic detection of spatio-temporal signaling patterns in cell collectives. The Journal of cell biology, 222(10) Rockefeller Institute Press 10.1083/jcb.202207048
Nałęcz-Jawecki, Paweł; Gagliardi, Paolo Armando; Kochańczyk, Marek; Dessauges, Coralie; Pertz, Olivier; Lipniacki, Tomasz (2023). The MAPK/ERK channel capacity exceeds 6 bit/hour. PLoS computational biology, 19(5), e1011155. Public Library of Science 10.1371/journal.pcbi.1011155
Hell, Tanja; Dobrzyński, Maciej; Gröflin, Fabian; Reinhardt, Jakob K; Dürr, Lara; Pertz, Olivier; Hamburger, Matthias; Garo, Eliane (2022). Flavonoids from Ericameria nauseosa inhibiting PI3K/AKT pathway in human melanoma cells. Biomedicine & pharmacotherapy, 156(113754), p. 113754. Elsevier 10.1016/j.biopha.2022.113754
Dürr, Lara; Reinhardt, Jakob K; Dobrzyński, Maciej; Hell, Tanja; Smieško, Martin; Pertz, Olivier; Hamburger, Matthias; Garo, Eliane (2022). A Dimerosesquiterpene and Sesquiterpene Lactones from Artemisia argyi Inhibiting Oncogenic PI3K/AKT Signaling in Melanoma Cells. Journal of natural products, 85(11), pp. 2557-2569. American Chemical Society 10.1021/acs.jnatprod.2c00471
Ender, Pascal; Gagliardi, Paolo Armando; Dobrzyński, Maciej; Frismantiene, Agne; Dessauges, Coralie; Höhener, Thomas; Jacques, Marc-Antoine; Cohen, Andrew R; Pertz, Olivier (2022). Spatiotemporal control of ERK pulse frequency coordinates fate decisions during mammary acinar morphogenesis. Developmental cell, 57(18), 2153-2167.e6. Elsevier 10.1016/j.devcel.2022.08.008
Höhener, Thomas Christoph; Landolt, Alex Erich; Dessauges, Coralie; Hinderling, Lucien; Gagliardi, Paolo Armando; Pertz, Olivier (2022). LITOS: a versatile LED illumination tool for optogenetic stimulation. Scientific reports, 12(1), p. 13139. Springer Nature 10.1038/s41598-022-17312-x
Hell, Tanja; Rutz, Adriano; Dürr, Lara; Dobrzyński, Maciej; Reinhardt, Jakob K; Lehner, Timo; Keller, Morris; John, Anika; Gupta, Mahabir; Pertz, Olivier; Hamburger, Matthias; Wolfender, Jean-Luc; Garo, Eliane (2022). Combining Activity Profiling with Advanced Annotation to Accelerate the Discovery of Natural Products Targeting Oncogenic Signaling in Melanoma. Journal of natural products, 85(6), pp. 1540-1554. American Chemical Society 10.1021/acs.jnatprod.2c00146
Dessauges, Coralie; Mikelson, Jan; Dobrzyński, Maciej; Jacques, Marc-Antoine; Frismantiene, Agne; Gagliardi, Paolo Armando; Khammash, Mustafa; Pertz, Olivier (2022). Optogenetic actuator - ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics. Molecular systems biology, 18(6), e10670. EMBO Press 10.15252/msb.202110670
Dürr, Lara; Hell, Tanja; Dobrzyński, Maciej; Mattei, Alberto; John, Anika; Augsburger, Nathanja; Bradanini, Gloria; Reinhardt, Jakob K; Rossberg, Florian; Drobnjakovic, Milos; Gupta, Mahabir P; Hamburger, Matthias; Pertz, Olivier; Garo, Eliane (2022). High-Content Screening Pipeline for Natural Products Targeting Oncogenic Signaling in Melanoma. Journal of natural products, 85(4), pp. 1006-1017. American Chemical Society 10.1021/acs.jnatprod.1c01154
Dobrzyński, Maciej; Jacques, Marc-Antoine; Pertz, Olivier (2022). Mining of Single-Cell Signaling Time-Series for Dynamic Phenotypes with Clustering. Methods in molecular biology, 2488, pp. 183-206. Springer 10.1007/978-1-0716-2277-3_13
Loewith, Robbie; Roux, Aurélien; Pertz, Olivier (2021). Chemical-Biology-derived in vivo Sensors: Past, Present, and Future. CHIMIA, 75(12), pp. 1017-1021. Schweizerische Chemische Gesellschaft 10.2533/chimia.2021.1017
Gagliardi, Paolo Armando; Dobrzyński, Maciej; Jacques, Marc-Antoine; Dessauges, Coralie; Ender, Pascal; Blum, Yannick; Hughes, Robert M; Cohen, Andrew R; Pertz, Olivier (2021). Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival. Developmental cell, 56(12), 1712-1726.e6. Elsevier 10.1016/j.devcel.2021.05.007
Jacques, Marc-Antoine; Dobrzyński, Maciej; Gagliardi, Paolo Armando; Sznitman, Raphael; Pertz, Olivier (2021). CODEX, a neural network approach to explore signaling dynamics landscapes. Molecular systems biology, 17(4), e10026. EMBO Press 10.15252/msb.202010026
Müller, Paul M; Rademacher, Juliane; Bagshaw, Richard D; Wortmann, Celina; Barth, Carolin; van Unen, Jakobus; Alp, Keziban M; Giudice, Girolamo; Eccles, Rebecca L; Heinrich, Louise E; Pascual-Vargas, Patricia; Sanchez-Castro, Marta; Brandenburg, Lennart; Mbamalu, Geraldine; Tucholska, Monika; Spatt, Lisa; Czajkowski, Maciej T; Welke, Robert-William; Zhang, Sunqu; Nguyen, Vivian; ... (2020). Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. Nature cell biology, 22(4), pp. 498-511. Springer Nature 10.1038/s41556-020-0488-x
Blum, Yannick; Mikelson, Jan; Dobrzynski, Maciej; Ryu, Hyunryul; Jacques, Marc-Antoine; Jeon, Noo Li; Khammash, Mustafa; Pertz, Olivier (2019). Temporal perturbation of ERK dynamics reveals network architecture of FGF2/MAPK signaling. Molecular systems biology, 15(11), e8947. EMBO Press 10.15252/msb.20198947
Gagliardi, Paolo Armando; Pertz, Olivier (2019). Developmental Erk Signaling Illuminated. Developmental cell, 48(3), pp. 289-290. Elsevier 10.1016/j.devcel.2019.01.022
Bagonis, Maria; Fusco, Ludovico; Pertz, Olivier; Danuser, Gaudenz (2019). Automated profiling of growth cone heterogeneity defines relations between morphology and motility. Journal of cell biology, 218(1), pp. 350-379. Rockefeller Institute Press 10.1083/jcb.201711023
Ryu, H; Chung, M; Pertz, Olivier; Jeon, NL (2018). Integrated Platform for Monitoring Single-cell MAPK Kinetics in Computer-controlled Temporal Stimulations. Scientific Reports, 8(1), p. 11126. Nature Publishing Group 10.1038/s41598-018-28873-1
Song, Jiyoung; Ryu, Hyunryul; Chung, Minhwan; Kim, Youngtaek; Blum, Yannick; Lee, Sung Sik; Pertz, Olivier; Jeon, Noo Li (2018). Microfluidic platform for single cell analysis under dynamic spatial and temporal stimulation. Biosensors & bioelectronics, 104, pp. 58-64. Elsevier 10.1016/j.bios.2017.12.038
Kempf, Anissa; Boda, Enrica; Kwok, Jessica C F; Fritz, Rafael; Grande, Valentina; Kaelin, Andrea M; Ristic, Zorica; Schmandke, Andre; Schmandke, Antonio; Tews, Bjoern; Fawcett, James W; Pertz, Olivier; Buffo, Annalisa; Schwab, Martin E (2017). Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction. Developmental cell, 43(1), 24-34.e5. Cell Press 10.1016/j.devcel.2017.08.014
Dessauges, Coralie; Pertz, Olivier (2017). Developmental ERK Signaling Goes Digital. Developmental cell, 42(5), pp. 443-444. Cell Press 10.1016/j.devcel.2017.08.023
Nölke, Thilo; Schwan, Carsten; Lehmann, Friederike; Østevold, Kristine; Pertz, Olivier; Aktories, Klaus (2016). Septins guide microtubule protrusions induced by actin-depolymerizing toxins like Clostridium difficile transferase (CDT). Proceedings of the National Academy of Sciences of the United States of America - PNAS, 113(28), pp. 7870-7875. National Academy of Sciences NAS 10.1073/pnas.1522717113
Fusco, Ludovico; Lefort, Riwal; Smith, Kevin; Benmansour, Fethallah; Gonzalez, German; Barillari, Caterina; Rinn, Bernd; Fleuret, Francois; Fua, Pascal; Pertz, Olivier (2016). Computer vision profiling of neurite outgrowth dynamics reveals spatiotemporal modularity of Rho GTPase signaling. Journal of cell biology, 212(1), pp. 91-111. Rockefeller Institute Press 10.1083/jcb.201506018
Martin, Katrin; Reimann, Andreas; Fritz, Rafael D; Ryu, Hyunryul; Jeon, Noo Li; Pertz, Olivier (2016). Spatio-temporal co-ordination of RhoA, Rac1 and Cdc42 activation during prototypical edge protrusion and retraction dynamics. Scientific Reports, 6, p. 21901. Nature Publishing Group 10.1038/srep21901
Fritz, Rafael Dominik; Pertz, Olivier (2016). The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns. F1000Research, 5(749) F1000 Research Ltd 10.12688/f1000research.7370.1
Ryu, Hyunryul; Chung, Minhwan; Dobrzyński, Maciej; Fey, Dirk; Blum, Yannick; Lee, Sung Sik; Peter, Matthias; Kholodenko, Boris N; Jeon, Noo Li; Pertz, Olivier (2015). Frequency modulation of ERK activation dynamics rewires cell fate. Molecular systems biology, 11(11), p. 838. EMBO Press 10.15252/msb.20156458
Fritz, Rafael Dominik; Menshykau, Denis; Martin, Katrin; Reimann, Andreas; Pontelli, Valeria; Pertz, Olivier (2015). SrGAP2-Dependent Integration of Membrane Geometry and Slit-Robo-Repulsive Cues Regulates Fibroblast Contact Inhibition of Locomotion. Developmental cell, 35(1), pp. 78-92. Cell Press 10.1016/j.devcel.2015.09.002
Moretti, Francesca; Rolando, Chiara; Winker, Moritz; Ivanek, Robert; Rodriguez, Javier; Von Kriegsheim, Alex; Taylor, Verdon; Bustin, Michael; Pertz, Olivier (2015). Growth Cone Localization of the mRNA Encoding the Chromatin Regulator HMGN5 Modulates Neurite Outgrowth. Molecular and cellular biology, 35(11), pp. 2035-2050. American Society for Microbiology 10.1128/MCB.00133-15
Martin, Katrin; Vilela, Marco; Jeon, Noo Li; Danuser, Gaudenz; Pertz, Olivier (2014). A growth factor-induced, spatially organizing cytoskeletal module enables rapid and persistent fibroblast migration. Developmental cell, 30(6), pp. 701-716. Cell Press 10.1016/j.devcel.2014.07.022
Fengos, Georgios; Schmidt, Alexander; Martin, Katrin; Fluri, Erika; Aebersold, Ruedi; Iber, Dagmar; Pertz, Olivier (2014). Spatial proteomic and phospho-proteomic organization in three prototypical cell migration modes. Proteome Science, 12, p. 23. BioMed Central 10.1186/1477-5956-12-23
Fritz, Rafael D; Letzelter, Michel; Reimann, Andreas; Martin, Katrin; Fusco, Ludovico; Ritsma, Laila; Ponsioen, Bas; Fluri, Erika; Schulte-Merker, Stefan; van Rheenen, Jacco; Pertz, Olivier (2013). A versatile toolkit to produce sensitive FRET biosensors to visualize signaling in time and space. Science signaling, 6(285), rs12. American Association for the Advancement of Science 10.1126/scisignal.2004135
Feltrin, Daniel; Fusco, Ludovico; Witte, Harald; Moretti, Francesca; Martin, Katrin; Letzelter, Michel; Fluri, Erika; Scheiffele, Peter; Pertz, Olivier (2012). Growth cone MKK7 mRNA targeting regulates MAP1b-dependent microtubule bundling to control neurite elongation. PLoS biology, 10(12), e1001439. Public Library of Science 10.1371/journal.pbio.1001439
Pertz, Olivier (2010). Spatio-temporal Rho GTPase signaling - where are we now? Journal of cell science, 123(Pt 11), pp. 1841-1850. Company of Biologists Limited 10.1242/jcs.064345
Jang, Kyung-Jin; Kim, Min Sung; Feltrin, Daniel; Jeon, Noo Li; Suh, Kahp-Yang; Pertz, Olivier (2010). Two distinct filopodia populations at the growth cone allow to sense nanotopographical extracellular matrix cues to guide neurite outgrowth. PLoS ONE, 5(12), e15966. Public Library of Science 10.1371/journal.pone.0015966
Blum, Yannick; Fritz, Rafael D; Ryu, Hyunryul; Pertz, Olivier (2017). Measuring ERK Activity Dynamics in Single Living Cells Using FRET Biosensors. In: Jimenez, Gerardo (ed.) ERK signaling. Methods in molecular biology: Vol. 1487 (pp. 203-221). Springer 10.1007/978-1-4939-6424-6_15
Mattei, Alberto (2021). Exploring Signaling Mechanisms regulating genetic and non-genetic Drug Resistance in Melanoma (Unpublished). (Dissertation, Institute of Cell Biology, Faculty of Science)
