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Rozman, Sasa; Yousefi, Shida; Oberson, Kevin; Kaufmann, Thomas; Benarafa, Charaf; Simon, Hans-Uwe (2015). The generation of neutrophils in the bone marrow is controlled by autophagy. Cell death and differentiation, 22(3), pp. 445-456. Nature Publishing Group 10.1038/cdd.2014.169
Schön, Jacob; Barut, G Tuba; Trüeb, Bettina Salome; Halwe, Nico Joel; Berenguer Veiga, Inês; Kratzel, Annika; Ulrich, Lorenz; Kelly, Jenna N; Brügger, Melanie; Wylezich, Claudia; Taddeo, Adriano; Aguiar Moreira, Etori; Túrós, Demeter; Grau-Roma, Llorenç; Ahrens, Ann Kathrin; Schlottau, Kore; Britzke, Tobias; Breithaupt, Angele; Corleis, Björn; Kochmann, Jana; ... (2024). A safe, effective and adaptable live-attenuated SARS-CoV-2 vaccine to reduce disease and transmission using one-to-stop genome modifications. Nature microbiology, 9(8), pp. 2099-2112. Springer Nature 10.1038/s41564-024-01755-1
Leborgne, Nathan GF; Devisme, Christelle; Kozarac, Nedim; Berenguer Veiga, Inês; Ebert, Nadine; Godel, Aurélie; Grau Roma, Llorenç; Scherer, Melanie; Plattet, Philippe; Thiel, Volker; Zimmer, Gert; Taddeo, Adriano; Benarafa, Charaf (2024). Neutrophil proteases are protective against SARS-CoV-2 by degrading the spike protein and dampening virus-mediated inflammation. JCI insight, 9(7) JCI Insight 10.1172/jci.insight.174133
Wang, Lihua; Ganges, Llilianne; Dixon, Linda K; Bu, Zhigao; Zhao, Dongming; Truong, Quang Lam; Richt, Juergen A; Jin, Meilin; Netherton, Christopher L; Benarafa, Charaf; Summerfield, Artur; Weng, Changjiang; Peng, Guiqing; Reis, Ana L; Han, Jun; Penrith, Mary-Louise; Mo, Yupeng; Su, Zhipeng; Vu Hoang, Dang; Pogranichniy, Roman M; ... (2024). 2023 International African Swine Fever Workshop: Critical Issues That Need to Be Addressed for ASF Control. Viruses, 16(1) MDPI 10.3390/v16010004
Brigger, Daniel; Guntern, Pascal; Jonsdottir, Hulda R; Pennington, Luke F; Weber, Benjamin; Taddeo, Adriano; Zimmer, Gert; Leborgne, Nathan G F; Benarafa, Charaf; Jardetzky, Theodore S; Eggel, Alexander (2023). Sex-specific differences in immune response to SARS-CoV-2 vaccination vanish with age. Allergy, 78(6), pp. 1683-1686. Wiley 10.1111/all.15652
Stojkov, Darko; Claus, Meike J; Kozlowski, Evelyne; Oberson, Kevin; Schaeren, Olivier P; Benarafa, Charaf; Yousefi, Shida; Simon, Hans-Uwe (2023). NET formation is independent of gasdermin D and pyroptotic cell death. Science signaling, 16(769), eabm0517. American Association for the Advancement of Science 10.1126/scisignal.abm0517
Barut, G Tuba; Halwe, Nico Joel; Taddeo, Adriano; Kelly, Jenna N; Schön, Jacob; Ebert, Nadine; Ulrich, Lorenz; Devisme, Christelle; Steiner, Silvio; Trüeb, Bettina Salome; Hoffmann, Bernd; Berenguer Veiga, Inês; Leborgne, Nathan Georges François; Aguiar Moreira, Etori; Breithaupt, Angele; Wylezich, Claudia; Höper, Dirk; Wernike, Kerstin; Godel, Aurélie; Thomann, Lisa; ... (2022). The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype. Nature Communications, 13(1), p. 5929. Springer Nature 10.1038/s41467-022-33632-y
Radulovic, Emilia; Mehinagic, Kemal; Wüthrich, Tsering; Hilty, Markus; Posthaus, Horst; Summerfield, Artur; Ruggli, Nicolas; Benarafa, Charaf (2022). The baseline immunological and hygienic status of pigs impact disease severity of African swine fever. PLoS pathogens, 18(8), e1010522. Public Library of Science 10.1371/journal.ppat.1010522
Taddeo, Adriano; Berenguer Veiga, Inês; Devisme, Christelle; Boss, Renate; Plattet, Philippe; Weigang, Sebastian; Kochs, Georg; Thiel, Volker; Benarafa, Charaf; Zimmer, Gert (2022). Optimized intramuscular immunization with VSV-vectored spike protein triggers a superior immune response to SARS-CoV-2. NPJ vaccines, 7(1), p. 82. Springer Nature 10.1038/s41541-022-00508-7
Barut, Tuba; Halwe, Nico Joel; Taddeo, Adriano; Kelly, Jenna N.; Schön, Jacob; Ebert, Nadine; Ulrich, Lorenz; Devisme, Christelle; Steiner, Silvio; Trüeb, Bettina Salome; Hoffmann, Bernd; Berenguer Veiga, Inês; Leborgne, Nathan Georges François; Aguiar Moreira, Etori; Breithaupt, Angele; Wylezich, Claudia; Höper, Dirk; Wernike, Kerstin; Godel, Aurélie; Thomann, Lisa; ... (2022). The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA. 1 phenotype (bioRxiv). Cold Spring Harbor Laboratory
Ulrich, Lorenz; Halwe, Nico Joel; Taddeo, Adriano; Ebert, Nadine; Schön, Jacob; Devisme, Christelle; Trüeb, Bettina Salome; Hoffmann, Bernd; Wider, Manon; Fan, Xiaoyu; Bekliz, Meriem; Essaidi-Laziosi, Manel; Schmidt, Marie Luisa; Niemeyer, Daniela; Corman, Victor Max; Kraft, Anna; Godel, Aurélie; Laloli, Laura; Kelly, Jenna N; Calderon, Brenda M; ... (2022). Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta. Nature, 602(7896), pp. 307-313. Springer Nature 10.1038/s41586-021-04342-0
Germic, Nina; Hosseini, Aref; Stojkov, Darko; Oberson, Kevin; Claus, Meike; Benarafa, Charaf; Calzavarini, Sara; Angelillo-Scherrer, Anne; Arnold, Isabelle C; Müller, Anne; Riether, Carsten; Yousefi, Shida; Simon, Hans-Uwe (2021). ATG5 promotes eosinopoiesis, but inhibits eosinophil effector functions. Blood, 137(21), pp. 2958-2969. American Society of Hematology 10.1182/blood.2020010208
Démoulins, Thomas; Brügger, Melanie; Zumkehr, Beatrice; Oliveira Esteves, Blandina I; Mehinagic, Kemal; Fahmi, Amal; Borcard, Loïc; Taddeo, Adriano; Jandrasits, Damian; Posthaus, Horst; Benarafa, Charaf; Ruggli, Nicolas; Alves, Marco P (2021). The specific features of the developing T cell compartment of the neonatal lung are a determinant of respiratory syncytial virus immunopathogenesis. PLoS pathogens, 17(4), e1009529. Public Library of Science 10.1371/journal.ppat.1009529
Zhou, Bin; Tran, Thi Nhu Thao; Hoffmann, Donata; Taddeo, Adriano; Ebert, Nadine; Labroussaa, Fabien; Pohlmann, Anne; King, Jacqueline; Steiner, Silvio; Kelly, Jenna N.; Portmann, Jasmine; Halwe, Nico Joel; Ulrich, Lorenz; Trüeb, Bettina Salome; Fan, Xiaoyu; Hoffmann, Bernd; Wang, Li; Thomann, Lisa; Lin, Xudong; Stalder, Hanspeter; ... (2021). SARS-CoV-2 spike D614G change enhances replication and transmission. Nature, 592(7852), pp. 122-127. Springer Nature 10.1038/s41586-021-03361-1
Burgener, Sabrina Sofia; Brügger, Melanie; Leborgne, Nathan Georges François; Sollberger, Sophia; Basilico, Paola; Kaufmann, Thomas; Bird, Phillip Ian; Benarafa, Charaf (2021). Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells. Frontiers in cell and developmental biology, 9, p. 630166. Frontiers 10.3389/fcell.2021.630166
Hilty, Markus; Wüthrich, Tsering M.; Godel, Aurélie; Adelfio, Roberto; Aebi, Susanne; Burgener, Sabrina S.; Illgen-Wilcke, Brunhilde; Benarafa, Charaf (2020). Chronic cigarette smoke exposure and pneumococcal infection induce oropharyngeal microbiota dysbiosis and contribute to long-lasting lung damage in mice. Microbial genomics, 6(12) Microbiology Society 10.1099/mgen.0.000485
Leborgne, Nathan G. F.; Taddeo, Adriano; Freigang, Stefan; Benarafa, Charaf (2020). Serpinb1a Is Dispensable for the Development and Cytokine Response of Invariant Natural Killer T Cell Subsets. Frontiers in immunology, 11, p. 562587. Frontiers Research Foundation 10.3389/fimmu.2020.562587
Ohayon, Delphine; De Chiara, Alessia; Dang, Pham My-Chan; Thieblemont, Nathalie; Chatfield, Simon; Marzaioli, Viviana; Burgener, Sabrina Sofia; Mocek, Julie; Candalh, Céline; Pintard, Coralie; Tacnet-Delorme, Pascale; Renault, Gilles; Lagoutte, Isabelle; Favier, Maryline; Walker, Francine; Hurtado-Nedelec, Margarita; Desplancq, Dominique; Weiss, Etienne; Benarafa, Charaf; Housset, Dominique; ... (2019). Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils. Journal of experimental medicine, 216(11), pp. 2669-2687. Rockefeller University Press 10.1084/jem.20180371
Burgener, Sabrina Sofia; Leborgne, Nathan Georges François; Snipas, Scott J; Salvesen, Guy S; Bird, Phillip Ian; Benarafa, Charaf (2019). Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation. Cell reports, 27(12), 3646-3656.e5. Cell Press 10.1016/j.celrep.2019.05.065
Yousefi, Shida; Stojkov, Darko; Germic, Nina; Simon, Dagmar; Wang, Xiaoliang; Benarafa, Charaf; Simon, Hans-Uwe (2019). Untangling "NETosis" from NETs. European journal of immunology, 49(2), pp. 221-227. Wiley-VCH 10.1002/eji.201747053
Delaval, Mathilde; Egli, Daniel; Schüpfer, Patrick; Benarafa, Charaf; Geiser, Marianne; Burtscher, Heinz (2019). Novel instrument to generate representative e-cigarette vapors for physicochemical particle characterization and in-vitro toxicity. Journal of aerosol science, 129, pp. 40-52. Elsevier 10.1016/j.jaerosci.2018.11.011
Amini, Poorya; Stojkov, Darko; Felser, Andrea; Jackson, Christopher B; Courage, Carolina; Schaller, André; Gelman, Laurent; Soriano, Maria Eugenia; Nuoffer, Jean-Marc; Scorrano, Luca; Benarafa, Charaf; Yousefi, Shida; Simon, Hans-Uwe (2018). Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production. Nature communications, 9(1), p. 2958. Nature Publishing Group 10.1038/s41467-018-05387-y
Martin, Katherine R; Pederzoli-Ribeil, Magali; Pacreau, Emeline; Burgener, Sabrina S; Dahdah, Albert; Candalh, Céline; Lauret, Evelyne; Foretz, Marc; Mouthon, Luc; Lucas, Bruno; Thieblemont, Nathalie; Benarafa, Charaf; Launay, Pierre; Witko-Sarsat, Véronique (2017). Transgenic Mice Expressing Human Proteinase 3 Exhibit Sustained Neutrophil-Associated Peritonitis. Journal of immunology, 199(11), pp. 3914-3924. American Association of Immunologists 10.4049/jimmunol.1601522
Benarafa, Charaf; Simon, Hans-Uwe (2017). Role of granule proteases in the life and death of neutrophils. Biochemical and biophysical research communications, 482(3), pp. 473-481. Academic Press 10.1016/j.bbrc.2016.11.086
Stoeckle, Christina; Geering, Barbara; Yousefi, Shida; Rožman, Saša; Andina, Nicola; Benarafa, Charaf; Simon, Hans-Uwe (2016). RhoH is a negative regulator of eosinophilopoiesis. Cell death and differentiation, 23(12), pp. 1961-1972. Nature Publishing Group 10.1038/cdd.2016.73
Giese, Madleen; Turiello, Nadine; Molenda, Nicole; Palesch, David; Meid, Annika; Schroeder, Roman; Basilico, Paola; Benarafa, Charaf; Halatsch, Marc-Eric; Zimecki, Michal; Westhoff, Mike-Andrew; Wirtz, Christian Rainer; Burster, Timo (2016). Exogenous cathepsin G upregulates cell surface MHC class I molecules on immune and glioblastoma cells. OncoTarget, 7(46), pp. 74602-74611. Impact Journals LLC 10.18632/oncotarget.12980
Ataca, Dalya; Caikovski, Marian; Piersigilli, Alessandra; Moulin, Alexandre; Benarafa, Charaf; Earp, Sarah E; Guri, Yakir; Kostic, Corinne; Arsenijvic, Yvan; Soininen, Raija; Apte, Suneel S; Brisken, Cathrin (2016). Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development. Biology open BiO, 5(11), pp. 1585-1594. Company of Biologists 10.1242/bio.019711
Georgiev, Hristo; Ravens, Inga; Benarafa, Charaf; Förster, Reinhold; Bernhardt, Günter (2016). Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets. Nature communications, 7, p. 13116. Nature Publishing Group 10.1038/ncomms13116
Burgener, Sabrina; Baumann, Mathias; Basilico, Paola; Remold-O'Donnell, Eileen; Touw, Ivo P; Benarafa, Charaf (2016). Myeloid conditional deletion and transgenic models reveal a threshold for the neutrophil survival factor Serpinb1. Biological chemistry, 397(9), pp. 897-905. De Gruyter 10.1515/hsz-2016-0132
Modregger, Peter; Cremona, Tiziana Patrizia; Benarafa, Charaf; Schittny, Johannes C; Olivo, Alessandro; Endrizzi, Marco (2016). Small angle x-ray scattering with edge-illumination. Scientific Reports, 6(30940), p. 30940. Nature Publishing Group 10.1038/srep30940
Carevic, M; Öz, H; Fuchs, K; Laval, J; Schroth, C; Frey, N; Hector, A; Bilich, T; Haug, M; Schmidt, A; Autenrieth, S E; Bucher, K; Beer-Hammer, S; Gaggar, A; Kneilling, M; Benarafa, Charaf; Gao, J L; Murphy, P M; Schwarz, S; Moepps, B; ... (2016). CXCR1 Regulates Pulmonary Anti-Pseudomonas Host Defense. Journal of innate immunity, 8(4), pp. 362-373. Karger 10.1159/000444125
Benarafa, Charaf; Wolf, Marlene (2015). CXCL14: the Swiss army knife chemokine. OncoTarget, 6(33), pp. 34065-34066. Oncotarget: Impact Journals LLC 10.18632/oncotarget.6040
Basilico, Paola; Cremona, Tiziana Patrizia; Oevermann, Anna; Piersigilli, Alessandra; Benarafa, Charaf (2015). Cigarette Smoke Exposure Increases Myeloid Cell Production and Lung Bacterial Clearance in Mice. American journal of respiratory cell and molecular biology, 54(3), pp. 424-435. American Lung Association 10.1165/rcmb.2015-0017OC
Dai, Chen; Basilico, Paola; Cremona, Tiziana Patrizia; Collins, Paul; Moser, Bernhard; Benarafa, Charaf; Wolf, Marlene (2015). CXCL14 Displays Antimicrobial Activity against Respiratory Tract Bacteria and Contributes to Clearance of Streptococcus pneumoniae Pulmonary Infection. Journal of immunology, 194(12), pp. 5980-5989. American Association of Immunologists 10.4049/jimmunol.1402634
Kruger, Philipp; Saffarzadeh, Mona; Weber, Alexander N R; Rieber, Nikolaus; Radsak, Markus; von Bernuth, Horst; Benarafa, Charaf; Roos, Dirk; Skokowa, Julia; Hartl, Dominik (2015). Neutrophils: Between host defence, immune modulation, and tissue injury. PLoS pathogens, 11(3), e1004651. Public Library of Science 10.1371/journal.ppat.1004651
Benarafa, Charaf (2015). Tumor-induced inflammation alters neutrophil phenotype and disease progression. Breast cancer research, 17(1), p. 135. BioMed Central Ltd. 10.1186/s13058-015-0644-6
Benarafa, Charaf (2015). Regulation of Neutrophil Serine Proteases by Intracellular Serpins. In: Geiger, Margarethe; Wahlmüller, Felix; Furtmüller, Margareta (eds.) The Serpin Family. Proteins with Multiple Functions in Health and Disease (pp. 59-76). Cham: Springer 10.1007/978-3-319-22711-5_5
Geering, Barbara; Stoeckle, Christina; Rozman, Sasa; Oberson, Kevin; Benarafa, Charaf; Simon, Hans-Uwe (2014). DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants. Journal of leukocyte biology, 95(2), pp. 293-303. Society for Leukocyte Biology 10.1189/jlb.0813462
Cremona, Tiziana P.; Tschanz, Stefan A.; von Garnier, Christophe; Benarafa, Charaf (2013). SerpinB1 deficiency is not associated with increased susceptibility to pulmonary emphysema in mice. American journal of physiology - lung cellular and molecular physiology, 305(12), L981-L989. American Physiological Society 10.1152/ajplung.00181.2013
Baumann, Mathias; Pham, Christine T. N.; Benarafa, Charaf (2013). SerpinB1 is critical for neutrophil survival through cell-autonomous inhibition of cathepsin G. Blood, 121(19), pp. 3900-3907. The American Society of Hematology 10.1182/blood-2012-09-455022
Fischer, Heinz; Scherz, Jennifer; Szabo, Sandra; Mildner, Michael; Benarafa, Charaf; Torriglia, Alicia; Tschachler, Erwin; Eckhart, Leopold (2011). DNase 2 is the main DNA-degrading enzyme of the stratum corneum. PLoS ONE, 6(3), e17581. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0017581
