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Taelman, Vincent; Radojewski, Piotr; Marincek, Nicolas; Ben-Shlomo, Anat; Grotzky, Andrea; Olariu, Cristina I; Perren, Aurel; Stettler, Christoph; Krause, Thomas Michael; Meier, Lorenz; Cescato, Renzo; Walter, Martin A. (2016). Upregulation of Key Molecules for Targeted Imaging and Therapy. Journal of nuclear medicine, 57(11), pp. 1805-1810. Society of Nuclear Medicine 10.2967/jnumed.115.165092
Mansi, Rosalba; Abiraj, Keelara; Wang, Xuejuan; Tamma, Maria Luisa; Gourni, Eleni; Cescato, Renzo; Berndt, Sandra; Reubi, Jean Claude; Maecke, Helmut R (2015). Evaluation of three different families of bombesin receptor radioantagonists for targeted imaging and therapy of gastrin releasing peptide receptor (GRP-R) positive tumors. Journal of medicinal chemistry, 58(2), pp. 682-691. American Chemical Society 10.1021/jm5012066
Maina, Theodosia; Cescato, Renzo; Waser, Beatrice; Tatsi, Aikaterini; Kaloudi, Aikaterini; Krenning, Eric P; de Jong, Marion; Nock, Berthold A; Reubi, Jean-Claude (2014). [111In-DOTA]LTT-SS28, a first pansomatostatin radioligand for in vivo targeting of somatostatin receptor-positive tumors. Journal of medicinal chemistry, 57(15), pp. 6564-6571. American Chemical Society 10.1021/jm500581d
Tatsi, Aikaterini; Maina, Theodosia; Cescato, Renzo; Waser, Beatrice; Krenning, Eric P; de Jong, Marion; Cordopatis, Paul; Reubi, Jean-Claude; Nock, Berthold A (2014). [DOTA]Somatostatin-14 analogs and their (111)In-radioligands: effects of decreasing ring-size on sst1-5 profile, stability and tumor targeting. European journal of medicinal chemistry, 73, pp. 30-37. Elsevier Masson SAS 10.1016/j.ejmech.2013.12.003
Waser, Beatrice; Cescato, Renzo; Liu, Qisheng; Kao, Yachu J; Körner, Meike; Christ, Emanuel; Schonbrunn, Agnes; Reubi, Jean-Claude (2012). Phosphorylation of sst2 receptors in neuroendocrine tumors after octreotide treatment of patients. American journal of pathology, 180(5), pp. 1942-9. New York, N.Y.: Elsevier 10.1016/j.ajpath.2012.01.041
Nock, Berthold A; Cescato, Renzo; Ketani, Eleni; Waser, Beatrice; Reubi, Jean-Claude; Maina, Theodosia (2012). [(99m)Tc]Demomedin C, a radioligand based on human gastrin releasing peptide(18-27): synthesis and preclinical evaluation in gastrin releasing peptide receptor-expressing models. Journal of medicinal chemistry, 55(19), pp. 8364-74. Easton, Pa.: American Chemical Society 10.1021/jm300741f
Fani, Melpomeni; Braun, Friederike; Waser, Beatrice; Beetschen, Karin; Cescato, Renzo; Erchegyi, Judit; Rivier, Jean E; Weber, Wolfgang A; Maecke, Helmut R; Reubi, Jean-Claude (2012). Unexpected sensitivity of sst2 antagonists to N-terminal radiometal modifications. Journal of nuclear medicine, 53(9), pp. 1481-9. New York, N.Y.: Society of Nuclear Medicine 10.2967/jnumed.112.102764
Tatsi, Aikaterini; Maina, Theodosia; Cescato, Renzo; Waser, Beatrice; Krenning, Eric P; de Jong, Marion; Cordopatis, Paul; Reubi, Jean-Claude; Nock, Berthold A (2012). [111In-DOTA]Somatostatin-14 analogs as potential pansomatostatin-like radiotracers - first results of a preclinical study. EJNMMI research, 2(1), p. 25. Berlin: Springer 10.1186/2191-219X-2-25
Mansi, Rosalba; Wang, Xuejuan; Forrer, Flavio; Waser, Beatrice; Cescato, Renzo; Graham, Keith; Borkowski, Sandra; Reubi, Jean-Claude; Maecke, Helmut R (2011). Development of a potent DOTA-conjugated bombesin antagonist for targeting GRPr-positive tumours. European journal of nuclear medicine and molecular imaging, 38(1), pp. 97-107. Berlin: Springer 10.1007/s00259-010-1596-9
Chatenet, David; Cescato, Renzo; Waser, Beatrice; Erchegyi, Judit; Rivier, Jean E; Reubi, Jean-Claude (2011). Novel dimeric DOTA-coupled peptidic Y1-receptor antagonists for targeting of neuropeptide Y receptor-expressing cancers. European journal of nuclear medicine and molecular imaging, 1(1), p. 21. Berlin: Springer 10.1186/2191-219X-1-21
Abiraj, Keelara; Mansi, Rosalba; Tamma, Maria-Luisa; Fani, Melpomeni; Forrer, Flavio; Nicolas, Guillaume; Cescato, Renzo; Reubi, Jean-Claude; Maecke, Helmut R (2011). Bombesin antagonist-based radioligands for translational nuclear imaging of gastrin-releasing peptide receptor-positive tumors. Journal of nuclear medicine, 52(12), pp. 1970-8. New York, N.Y.: Society of Nuclear Medicine 10.2967/jnumed.111.094375
Cescato, Renzo; Waser, Beatrice; Fani, Melpomeni; Reubi, Jean-Claude (2011). Evaluation of 177Lu-DOTA-sst2 antagonist versus 177Lu-DOTA-sst2 agonist binding in human cancers in vitro. Journal of nuclear medicine, 52(12), pp. 1886-90. New York, N.Y.: Society of Nuclear Medicine 10.2967/jnumed.111.095778
Erchegyi, Judit; Cescato, Renzo; Waser, Beatrice; Rivier, Jean E; Reubi, Jean-Claude (2011). N-imidazolebenzyl-histidine substitution in somatostatin and in its octapeptide analogue modulates receptor selectivity and function. Journal of medicinal chemistry, 54(17), pp. 5981-7. Easton, Pa.: American Chemical Society 10.1021/jm200307v
Fani, Melpomeni; Del Pozzo, Luigi; Abiraj, Keelara; Mansi, Rosalba; Tamma, Maria Luisa; Cescato, Renzo; Waser, Beatrice; Weber, Wolfgang A; Reubi, Jean-Claude; Maecke, Helmut R (2011). PET of somatostatin receptor-positive tumors using 64Cu- and 68Ga-somatostatin antagonists: the chelate makes the difference. Journal of nuclear medicine, 52(7), pp. 1110-8. New York, N.Y.: Society of Nuclear Medicine 10.2967/jnumed.111.087999
Seebach, Dieter; Lukaszuk, Aneta; Patora-Komisarska, Krystyna; Podwysocka, Dominika; Gardiner, James; Ebert, Marc-Olivier; Reubi, Jean-Claude; Cescato, Renzo; Waser, Beatrice; Gmeiner, Peter; Hübner, Harald; Rougeot, Catherine (2011). On the terminal homologation of physiologically active peptides as a means of increasing stability in human serum--neurotensin, opiorphin, B27-KK10 epitope, NPY. Chemistry & Biodiversity, 8(5), pp. 711-39. Zürich: Verlag Helvetica Chimica Acta 10.1002/cbdv.201100093
Reubi, Jean-Claude; Waser, Beatrice; Cescato, Renzo; Gloor, Beat; Stettler, Christoph; Christ, Emanuel (2010). Internalized somatostatin receptor subtype 2 in neuroendocrine tumors of octreotide-treated patients. Journal of clinical endocrinology and metabolism, 95(5), pp. 2343-50. Chevy Chase, Md.: Endocrine Society 10.1210/jc.2009-2487
Fani, Melpomeni; Mueller, Andreas; Tamma, Maria-Luisa; Nicolas, Guillaume; Rink, Hans R; Cescato, Renzo; Reubi, Jean-Claude; Maecke, Helmut R (2010). Radiolabeled bicyclic somatostatin-based analogs: a novel class of potential radiotracers for SPECT/PET of neuroendocrine tumors. Journal of nuclear medicine, 51(11), pp. 1771-9. New York, N.Y.: Society of Nuclear Medicine 10.2967/jnumed.110.076695
Waser, Beatrice; Cescato, Renzo; Tamma, Maria-Luisa; Maecke, Helmut R; Reubi, Jean-Claude (2010). Absence of somatostatin SST(2) receptor internalization in vivo after intravenous SOM230 application in the AR42J animal tumor model. European journal of pharmacology, 644(1-3), pp. 257-62. Amsterdam: Elsevier 10.1016/j.ejphar.2010.07.005
Reubi, Jean Claude; Erchegyi, Judit; Cescato, Renzo; Waser, Beatrice; Rivier, Jean E (2010). Switch from antagonist to agonist after addition of a DOTA chelator to a somatostatin analog. European journal of nuclear medicine and molecular imaging, 37(8), pp. 1551-8. Berlin: Springer-Verlag 10.1007/s00259-010-1445-x
Abiraj, Keelara; Mansi, Rosalba; Tamma, Maria-Luisa; Forrer, Flavio; Cescato, Renzo; Reubi, Jean-Claude; Akyel, Kayhan G; Maecke, Helmut R (2010). Tetraamine-derived bifunctional chelators for technetium-99m labelling: synthesis, bioconjugation and evaluation as targeted SPECT imaging probes for GRP-receptor-positive tumours. Chemistry - a European journal, 16(7), pp. 2115-24. Weinheim: Wiley-VCH 10.1002/chem.200902011
Cescato, Renzo; Loesch, Kimberly A; Waser, Beatrice; Mäcke, Helmut R; Rivier, Jean E; Reubi, Jean-Claude; Schonbrunn, Agnes (2010). Agonist-biased signaling at the sst2A receptor: the multi-somatostatin analogs KE108 and SOM230 activate and antagonize distinct signaling pathways. Molecular endocrinology, 24(1), pp. 240-9. Bethesda, Md.: Endocrine Society 10.1210/me.2009-0321
Mansi, Rosalba; Wang, Xuejuan; Forrer, Flavio; Kneifel, Stefan; Tamma, Maria-Luisa; Waser, Beatrice; Cescato, Renzo; Reubi, Jean-Claude; Maecke, Helmut R (2009). Evaluation of a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-conjugated bombesin-based radioantagonist for the labeling with single-photon emission computed tomography, positron emission tomography, and therapeutic radionuclides. Clinical cancer research, 15(16), pp. 5240-9. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-08-3145
Waser, Bea; Tamma, Maria-Luisa; Cescato, Renzo; Maecke, Helmut R; Reubi, Jean-Claude (2009). Highly efficient in vivo agonist-induced internalization of sst2 receptors in somatostatin target tissues. Journal of nuclear medicine, 50(6), pp. 936-41. New York, N.Y.: Society of Nuclear Medicine 10.2967/jnumed.108.061457
Erchegyi, Judit; Cescato, Renzo; Grace, Christy Rani R; Waser, Beatrice; Piccand, Véronique; Hoyer, Daniel; Riek, Roland; Rivier, Jean E; Reubi, Jean-Claude (2009). Novel, potent, and radio-iodinatable somatostatin receptor 1 (sst1) selective analogues. Journal of medicinal chemistry, 52(9), pp. 2733-46. Easton, Pa.: American Chemical Society 10.1021/jm801314f
Feytens, Debby; De Vlaeminck, Magali; Cescato, Renzo; Tourwé, Dirk; Reubi, Jean-Claude (2009). Highly potent 4-amino-indolo[2,3-c]azepin-3-one-containing somatostatin mimetics with a range of sst receptor selectivities. Journal of medicinal chemistry, 52(1), pp. 95-104. Easton, Pa.: American Chemical Society 10.1021/jm801205x
Erchegyi, Judit; Grace, Christy Rani R; Samant, Manoj; Cescato, Renzo; Piccand, Veronique; Riek, Roland; Reubi, Jean Claude; Rivier, Jean E (2008). Ring size of somatostatin analogues (ODT-8) modulates receptor selectivity and binding affinity. Journal of medicinal chemistry, 51(9), pp. 2668-75. Easton, Pa.: American Chemical Society 10.1021/jm701444y
Grace, Christy Rani R; Erchegyi, Judit; Samant, Manoj; Cescato, Renzo; Piccand, Veronique; Riek, Roland; Reubi, Jean Claude; Rivier, Jean E (2008). Ring size in octreotide amide modulates differently agonist versus antagonist binding affinity and selectivity. Journal of medicinal chemistry, 51(9), pp. 2676-81. Easton, Pa.: American Chemical Society 10.1021/jm701445q
Ginj, Mihaela; Zhang, Hanwen; Eisenwiener, Klaus-Peter; Wild, Damian; Schulz, Stefan; Rink, Hans; Cescato, Renzo; Reubi, Jean Claude; Maecke, Helmut R (2008). New pansomatostatin ligands and their chelated versions: affinity profile, agonist activity, internalization, and tumor targeting. Clinical cancer research, 14(7), pp. 2019-27. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-07-1687
Cescato, Renzo; Maina, Theodosia; Nock, Berthold; Nikolopoulou, Anastasia; Charalambidis, David; Piccand, Véronique; Reubi, Jean Claude (2008). Bombesin receptor antagonists may be preferable to agonists for tumor targeting. Journal of nuclear medicine, 49(2), pp. 318-26. New York, N.Y.: Society of Nuclear Medicine 10.2967/jnumed.107.045054
Gugger, Mathias; White, Richard; Song, Susan; Waser, Bea; Cescato, Renzo; Rivière, Pierre; Reubi, Jean Claude (2008). GPR87 is an overexpressed G-protein coupled receptor in squamous cell carcinoma of the lung. Disease markers, 24(1), pp. 41-50. Amsterdam: IOS Press 10.1155/2008/857474
Cescato, Renzo; Erchegyi, Judith; Waser, Beatrice; Piccand, Véronique; Maecke, Helmut R; Rivier, Jean E; Reubi, Jean Claude (2008). Design and in vitro characterization of highly sst2-selective somatostatin antagonists suitable for radiotargeting. Journal of medicinal chemistry, 51(13), pp. 4030-7. Easton, Pa.: American Chemical Society 10.1021/jm701618q
Feytens, Debby; Cescato, Renzo; Reubi, Jean Claude; Tourwé, Dirk (2007). New sst4/5-selective somatostatin peptidomimetics based on a constrained tryptophan scaffold. Journal of medicinal chemistry, 50(14), pp. 3397-401. Easton, Pa.: American Chemical Society 10.1021/jm070246f
Cescato, Renzo; Schulz, Stefan; Waser, Beatrice; Eltschinger, Véronique; Rivier, Jean E; Wester, Hans-Jürgen; Culler, Michael; Ginj, Mihaela; Liu, Qisheng; Schonbrunn, Agnes; Reubi, Jean Claude (2006). Internalization of sst2, sst3, and sst5 receptors: effects of somatostatin agonists and antagonists. Journal of nuclear medicine, 47(3), pp. 502-11. New York, N.Y.: Society of Nuclear Medicine
Ginj, Mihaela; Zhang, Hanwen; Waser, Beatrice; Cescato, Renzo; Wild, Damian; Wang, Xuejuan; Erchegyi, Judit; Rivier, Jean; Mäcke, Helmut R; Reubi, Jean Claude (2006). Radiolabeled somatostatin receptor antagonists are preferable to agonists for in vivo peptide receptor targeting of tumors. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 103(44), pp. 16436-41. Washington, D.C.: National Academy of Sciences NAS 10.1073/pnas.0607761103
Chatenet, D; Cescato, R; Waser, B; Rivier, J; Reubi, JC (2011). Synthesis and characterization of DOTA-coupled dimeric Y1 receptors antagonists for breast cancer targeting. In: Lebl, M (ed.) Proceeding of the 22nd American Peptide Symposium. American Peptide Society
