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Manaila, Roxana-Cristiana; Huwiler, Andrea (2024). [Polypharmacy in acute and chronic kidney diseases]. Innere Medizin, 65(1), pp. 22-28. Springer 10.1007/s00108-023-01634-7
Huwiler, Andrea (2023). Topical Collection: New Insights on Sphingolipids in Health and Disease. International journal of molecular sciences, 24(11) MDPI 10.3390/ijms24119528
Huwiler, Andrea; Beck, Karl-Friedrich; Pfeilschifter, Josef (2023). Cross-Regulation of the Cellular Redox System, Oxygen, and Sphingolipid Signalling. Metabolites, 13(3) MDPI 10.3390/metabo13030426
Imeri, Faik; Stepanovska Tanturovska, Bisera; Manaila, Roxana; Pavenstädt, Hermann; Pfeilschifter, Josef; Huwiler, Andrea (2023). Loss of S1P Lyase Expression in Human Podocytes Causes a Reduction in Nephrin Expression That Involves PKCδ Activation. International journal of molecular sciences, 24(4) MDPI 10.3390/ijms24043267
Stepanovska Tanturovska, Bisera; Manaila, Roxana; Fabbro, Doriano; Huwiler, Andrea (2023). Lipids as Targets for Renal Cell Carcinoma Therapy. International journal of molecular sciences, 24(4) MDPI 10.3390/ijms24043272
Beyoğlu, Diren; Schwalm, Stephanie; Semmo, Nasser; Huwiler, Andrea; Idle, Jeffrey R (2023). Hepatitis C Virus Infection Upregulates Plasma Phosphosphingolipids and Endocannabinoids and Downregulates Lysophosphoinositols. International journal of molecular sciences, 24(2) MDPI 10.3390/ijms24021407
Hafizi, Redona; Imeri, Faik; Stepanovska Tanturovska, Bisera; Manaila, Roxana; Schwalm, Stephanie; Trautmann, Sandra; Wenger, Roland H; Pfeilschifter, Josef; Huwiler, Andrea (2022). Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells. International journal of molecular sciences, 23(11) MDPI 10.3390/ijms23115882
Theodoropoulou, Maria A; Psarra, Anastasia; Erhardt, Martin; Nikolaou, Aikaterini; Gerogiannopoulou, Anna-Dimitra D; Hadjipavlou-Litina, Dimitra; Hayashi, Daiki; Dennis, Edward A; Huwiler, Andrea; Kokotos, George (2022). N-Acylated and N-Alkylated 2-Aminobenzothiazoles Are Novel Agents That Suppress the Generation of Prostaglandin E2. Biomolecules, 12(2) MDPI 10.3390/biom12020267
Hafizi, Redona; Imeri, Faik; Wenger, Roland H.; Huwiler, Andrea (2021). S1P Stimulates Erythropoietin Production in Mouse Renal Interstitial Fibroblasts by S1P1 and S1P3 Receptor Activation and HIF-2α Stabilization. International journal of molecular sciences, 22(17) MDPI 10.3390/ijms22179467
Stepanovska Tanturovska, Bisera; Zivkovic, Aleksandra; Imeri, Faik; Homann, Thomas; Kleuser, Burkhard; Stark, Holger; Huwiler, Andrea (2021). ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P1 Agonist and Functional Antagonist Potency In Vitro and In Vivo. Molecules, 26(17) MDPI 10.3390/molecules26175134
Huwiler, Andrea; Pfeilschifter, Josef (2021). Recuperation of Vascular Homeostasis. Circulation research, 129(2), pp. 237-239. American Heart Association 10.1161/CIRCRESAHA.121.319558
Imeri, Faik; Stepanovska Tanturovska, Bisera; Schwalm, Stephanie; Saha, Sarbari; Zeng-Brouwers, Jinyang; Pavenstädt, Herrmann; Pfeilschifter, Josef; Schaefer, Liliana; Huwiler, Andrea (2021). Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice. Matrix biology, 98, pp. 32-48. Elsevier 10.1016/j.matbio.2021.05.003
Imeri, Faik; Stepanovska Tanturovska, Bisera; Zivkovic, Aleksandra; Enzmann, Gaby; Schwalm, Stephanie; Pfeilschifter, Josef; Homann, Thomas; Kleuser, Burkhard; Engelhardt, Britta; Stark, Holger; Huwiler, Andrea (2021). Novel compounds with dual S1P receptor agonist and histamine H3 receptor antagonist activities act protective in a mouse model of multiple sclerosis. Neuropharmacology, 186, p. 108464. Elsevier 10.1016/j.neuropharm.2021.108464
Schwalm, Stephanie; Beyer, Sandra; Hafizi, Redona; Trautmann, Sandra; Geisslinger, Gerd; Adams, David R; Pyne, Susan; Pyne, Nigel; Schaefer, Liliana; Huwiler, Andrea; Pfeilschifter, Josef (2021). Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis. Cellular signalling, 79(109881), p. 109881. Elsevier 10.1016/j.cellsig.2020.109881
Psarra, Anastasia; Theodoropoulou, Maria A; Erhardt, Martin; Mertiri, Marina; Mantzourani, Christiana; Vasilakaki, Sofia; Magrioti, Victoria; Huwiler, Andrea; Kokotos, George (2021). α-Ketoheterocycles Able to Inhibit the Generation of Prostaglandin E2 (PGE2) in Rat Mesangial Cells. Biomolecules, 11(2) MDPI 10.3390/biom11020275
Dennhardt, Sophie; Finke, Karl R; Huwiler, Andrea; Coldewey, Sina M (2020). Corrigendum to "Sphingosine-1-phosphate promotes barrier-stabilizing effects in human microvascular endothelial cells via AMPK-dependent mechanisms" [Biochim. Biophys. Acta Mol. Basis Dis. 2019 Apr 1;1865(4):774-781]. Biochimica et biophysica acta - molecular basis of disease, 1866(10), p. 165892. Elsevier 10.1016/j.bbadis.2020.165892
Stepanovska, Bisera; Zivkovic, Aleksandra; Enzmann, Gaby; Tietz, Silvia; Homann, Thomas; Kleuser, Burkhard; Engelhardt, Britta; Stark, Holger; Huwiler, Andrea (2020). Morpholino Analogues of Fingolimod as Novel and Selective S1P1 Ligands with In Vivo Efficacy in a Mouse Model of Experimental Antigen-Induced Encephalomyelitis. International journal of molecular sciences, 21(18), pp. 1-17. MDPI 10.3390/ijms21186463
Stepanovska, Bisera; Huwiler, Andrea (2020). Targeting the S1P receptor signaling pathways as a promising approach for treatment of autoimmune and inflammatory diseases. Pharmacological research, 154, p. 104170. Elsevier 10.1016/j.phrs.2019.02.009
Schwalm, Stephanie; Erhardt, Martin; Römer, Isolde; Pfeilschifter, Josef; Zangemeister-Wittke, Uwe; Huwiler, Andrea (2020). Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt. International journal of molecular sciences, 21(4) MDPI 10.3390/ijms21041396
Stepanovska, Bisera; Lange, Antonia I; Schwalm, Stephanie; Pfeilschifter, Josef; Coldewey, Sina M; Huwiler, Andrea (2020). Downregulation of S1P Lyase Improves Barrier Function in Human Cerebral Microvascular Endothelial Cells Following an Inflammatory Challenge. International journal of molecular sciences, 21(4) MDPI 10.3390/ijms21041240
Dennhardt, Sophie; Finke, Karl R; Huwiler, Andrea; Coldewey, Sina M (2019). Sphingosine-1-phosphate promotes barrier-stabilizing effects in human microvascular endothelial cells via AMPK-dependent mechanisms. Biochimica et biophysica acta - molecular basis of disease, 1865(4), pp. 774-781. Elsevier 10.1016/j.bbadis.2018.12.022
Evangelopoulos, Maria Eleftheria; Miclea, Andrei; Schrewe, Lisa; Briner, Myriam; Salmen, Anke; Engelhardt, Britta; Huwiler, Andrea; Chan, Andrew; Hoepner, Robert (2018). Frequency and clinical characteristics of Multiple Sclerosis rebounds after withdrawal of Fingolimod. CNS neuroscience & therapeutics, 24(10), pp. 984-986. Wiley 10.1111/cns.12992
Huwiler, Andrea; Pfeilschifter, Josef (2018). Sphingolipid signaling in renal fibrosis. Matrix biology, 68-69, pp. 230-247. Elsevier 10.1016/j.matbio.2018.01.006
Blanchard, Olivier; Stepanovska, Bisera; Starck, Manuel Thierry; Erhardt, Martin; Römer, Isolde; Meyer Zu Heringdorf, Dagmar; Pfeilschifter, Josef; Zangemeister-Wittke, Uwe; Huwiler, Andrea (2018). Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells. International journal of molecular sciences, 19(5) MDPI 10.3390/ijms19051498
Huwiler, Andrea; Zangemeister-Wittke, Uwe (2018). The sphingosine 1-phosphate receptor modulator fingolimod as a therapeutic agent: recent findings and new perspectives. Pharmacology & therapeutics, 185, pp. 34-49. Elsevier 10.1016/j.pharmthera.2017.11.001
Eresch, Jeanette; Stumpf, Martin; Koch, Alexander; Vutukuri, Rajkumar; Ferreirós, Nerea; Schreiber, Yannick; Schröder, Katrin; Devraj, Kavi; Popp, Rüdiger; Huwiler, Andrea; Hattenbach, Lars-Olof; Pfeilschifter, Josef; Pfeilschifter, Waltraud (2018). Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy. Investigative ophthalmology & visual science, 59(2), pp. 653-661. Association for Research in Vision and Ophthalmology 10.1167/iovs.17-22544
Vasilakaki, Sofia; Pastukhov, Oleksandr; Mavromoustakos, Thomas; Huwiler, Andrea; Kokotos, George (2018). Small Peptides Able to Suppress Prostaglandin E₂ Generation in Renal Mesangial Cells. Molecules, 23(1) MDPI 10.3390/molecules23010158
Beyer, Sandra; Schwalm, Stephanie; Pfeilschifter, Josef; Huwiler, Andrea (2018). Renal Mesangial Cells Isolated from Sphingosine Kinase 2 Transgenic Mice Show Reduced Proliferation and are More Sensitive to Stress-Induced Apoptosis. Cellular physiology and biochemistry, 47(6), pp. 2522-2533. Karger 10.1159/000491625
Schwalm, Stephanie; Beyer, Sandra; Frey, Helena; Haceni, Riad; Grammatikos, Georgios; Thomas, Dominique; Geisslinger, Gerd; Schaefer, Liliana; Huwiler, Andrea; Pfeilschifter, Josef (2017). Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction. American journal of pathology, 187(11), pp. 2413-2429. Elsevier 10.1016/j.ajpath.2017.06.017
Hsieh, Louise Tzung-Harn; Nastase, Madalina-Viviana; Roedig, Heiko; Zeng-Brouwers, Jinyang; Poluzzi, Chiara; Schwalm, Stephanie; Fork, Christian; Tredup, Claudia; Brandes, Ralf P; Wygrecka, Malgorzata; Huwiler, Andrea; Pfeilschifter, Josef; Schaefer, Liliana (2017). Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants. International journal of molecular sciences, 18(3) MDPI 10.3390/ijms18030595
McCracken, A N; McMonigle, R J; Tessier, J; Fransson, R; Perryman, M S; Chen, B; Keebaugh, A; Selwan, E; Barr, S A; Kim, S M; Roy, S G; Liu, G; Fallegger, D; Sernissi, L; Brandt, C; Moitessier, N; Snider, A J; Clare, S; Müschen, M; Huwiler, Andrea; ... (2017). Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation. Leukemia, 31(3), pp. 669-677. Nature Publishing Group 10.1038/leu.2016.244
Filipenko, Iuliia; Schwalm, Stephanie; Reali, Luca; Pfeilschifter, Josef; Fabbro, Doriano; Huwiler, Andrea; Zangemeister-Wittke, Uwe (2016). Upregulation of the S1P3 receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE2 and EP2/EP4 activation. Biochimica et biophysica acta (BBA) - molecular and cell biology of lipids, 1861(11), pp. 1840-1851. Elsevier 10.1016/j.bbalip.2016.09.005
Vasilakaki, Sofia; Barbayianni, Efrosini; Magrioti, Victoria; Pastukhov, Oleksandr; Constantinou-Kokotou, Violetta; Huwiler, Andrea; Kokotos, George (2016). Inhibitors of secreted phospholipase A2 suppress the release of PGE2 in renal mesangial cells. Bioorganic & medicinal chemistry, 24(13), pp. 3029-3034. Elsevier 10.1016/j.bmc.2016.05.017
Imeri, Faik; Schwalm, Stephanie; Lyck, Ruth; Zivkovic, Aleksandra; Stark, Holger; Engelhardt, Britta; Pfeilschifter, Josef; Huwiler, Andrea (2016). Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments. Neuropharmacology, 105, pp. 341-350. Elsevier 10.1016/j.neuropharm.2016.01.031
Chen, Bin; Roy, Saurabh G; McMonigle, Ryan J; Keebaugh, Andrew; McCracken, Alison N; Selwan, Elizabeth; Fransson, Rebecca; Fallegger, Daniel; Huwiler, Andrea; Kleinman, Michael T; Edinger, Aimee L; Hanessian, Stephen (2016). Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo. ACS Chemical Biology, 11(2), pp. 409-414. American Chemical Society 10.1021/acschembio.5b00761
Coldewey, Sina M; Benetti, Elisa; Collino, Massimo; Pfeilschifter, Josef; Sponholz, Christoph; Bauer, Michael; Huwiler, Andrea; Thiemermann, Christoph (2016). Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis. Scientific Reports, 6, p. 27594. Nature Publishing Group 10.1038/srep27594
Imeri, Faik; Blanchard, Olivier; Jenni, Aurelio Leandro; Schwalm, Stephanie; Wünsche, Christin; Zivkovic, Aleksandra; Stark, Holger; Pfeilschifter, Josef; Huwiler, Andrea (2015). FTY720 and two novel butterfly derivatives exert a general anti-inflammatory potential by reducing immune cell adhesion to endothelial cells through activation of S1P3 and phosphoinositide 3-kinase. Naunyn-Schmiedeberg's archives of pharmacology, 388(12), pp. 1283-1292. Springer 10.1007/s00210-015-1159-5
Urtz, Nicole; Gaertner, Florian; von Bruehl, Marie-Luise; Chandraratne, Sue; Rahimi, Faridun; Zhang, Lingli; Orban, Mathias; Barocke, Verena; Beil, Johannes; Schubert, Irene; Lorenz, Michael; Legate, Kyle R; Huwiler, Andrea; Pfeilschifter, Josef M; Beerli, Christian; Ledieu, David; Persohn, Elke; Billich, Andreas; Baumruker, Thomas; Mederos y Schnitzler, Michael; ... (2015). Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo. Circulation research, 117(4), pp. 376-387. Lippincott Williams & Wilkins 10.1161/CIRCRESAHA.115.306901
Schwalm, Stephanie; Maneva Timcheva, Tankica; Filipenko, Iuliia; Ebadi, Mahsa; Hofmann, Lotte P; Zangemeister-Wittke, Uwe; Pfeilschifter, Josef; Huwiler, Andrea (2015). Sphingosine kinase 2 deficiency increases proliferation and migration of renal mouse mesangial cells and fibroblasts. Biological chemistry, 396(6-7), pp. 813-825. De Gruyter 10.1515/hsz-2014-0289
Schröder, Matthias; Arlt, Olga; Schmidt, Helmut; Huwiler, Andrea; Angioni, Carlo; Pfeilschifter, Josef M; Schwiebs, Anja; Radeke, Heinfried H (2015). Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application. Biological chemistry, 396(6-7), pp. 795-802. De Gruyter 10.1515/hsz-2014-0287
Wünsche, Christin; Koch, Alexander; Goldschmeding, Roel; Schwalm, Stephanie; Meyer Zu Heringdorf, Dagmar; Huwiler, Andrea; Pfeilschifter, Josef (2015). Transforming growth factor β2 (TGF-β2)-induced connective tissue growth factor (CTGF) expression requires sphingosine 1-phosphate receptor 5 (S1P5) in human mesangial cells. Biochimica et biophysica acta (BBA) - molecular and cell biology of lipids, 1851(5), pp. 519-526. Elsevier 10.1016/j.bbalip.2015.01.003
Koch, Alexander; Jäger, Manuel; Völzke, Anja; Grammatikos, Georgios; Zu Heringdorf, Dagmar Meyer; Huwiler, Andrea; Pfeilschifter, Josef (2015). Downregulation of sphingosine 1-phosphate (S1P) receptor 1 by dexamethasone inhibits S1P-induced mesangial cell migration. Biological chemistry, 396(6-7), pp. 803-812. De Gruyter 10.1515/hsz-2014-0288
Pastukhov, Oleksandr; Schalm, Stephanie; Zangemeister-Wittke, Uwe; Fabbro, Doriano; Bornancin, Frederic; Japtok, Lukasz; Kleuser, Burkhrad; Pfeilschifter, Josef; Huwiler, Andrea (2014). The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death. British journal of pharmacology, 171(24), pp. 5829-5844. Wiley-Blackwell 10.1111/bph.12886
Imeri, Faik; Fallegger, Daniel; Zivkovic, Aleksandra; Schwalm, Stephanie; Enzmann, Gaby; Blankenbach, Kira; Meyer zu Heringdorf, Dagmar; Homann, Thomas; Kleuser, Burkhard; Pfeilschifter, Josef; Engelhardt, Britta; Stark, Holger; Huwiler, Andrea (2014). Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice. Neuropharmacology, 85, pp. 314-327. Elsevier 10.1016/j.neuropharm.2014.05.012
Thangaiyan, Rabi; Huwiler, Andrea; Zangemeister-Wittke, Uwe (2014). AMR-Me inhibits PI3K/Akt signaling in hormone-dependent MCF-7 breast cancer cells and inactivates NF-κB in hormone-independent MDA-MB-231 cells. Molecular carcinogenesis, 53(7), pp. 578-588. Wiley 10.1002/mc.22012
Imeri, Faik; Jashri, Ahmed; Bullazhi, Lulzime; Shabani, Agim; Mikhova, Bozhana; Dräger, Gerald; Popovski, Emil; Huwiler, Andrea (2014). Synthesis and cellular characterization of novel isoxazolo- and thiazolohydrazinylidene-chroman-2,4-diones on cancer and non-cancer cell growth and death. Bioorganic & medicinal chemistry, 22(9), pp. 2655-2660. Elsevier 10.1016/j.bmc.2014.03.026
Schwalm, Stephanie; Pfeilschifter, Josef; Huwiler, Andrea (2014). Targeting the sphingosine kinase/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases. Basic & clinical pharmacology & toxicology, 1(114), pp. 44-49. Wiley-Blackwell 10.1111/bcpt.12103
Völzke, Anja; Koch, Alexander; Meyer zu Heringdorf, Dagmar; Huwiler, Andrea; Pfeilschifter, Josef (2014). Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells. Biochimica and biophysica acta - molecular and cell biology of lipids, 1841(1), pp. 11-21. Elsevier 10.1016/j.bbalip.2013.09.009
Kondo, Shunya; Bottos, Alessia; Allegood, Jeremy C.; Masson, Regis; Maurer, Francisca G.; Genoud, Christel; Kaeser, Patrick; Huwiler, Andrea; Murakami, Masato; Spiegel, Sarah; Hynes, Nancy E. (2014). Memo has a novel role in S1P signaling and crucial for vascular development. PLoS ONE, 9(4), e94114. Public Library of Science 10.1371/journal.pone.0094114
Pastukhov, Oleksandr; Schalm, Stephanie; Römer, Isolde; Pfeilschifter, Josef; Huwiler, Andrea; Zangemeister-Wittke, Uwe (2014). Ceramide kinase contributes to proliferation but not to prostaglandin E2 formation in renal mesangial cells and fibroblasts. Cellular physiology and biochemistry, 34(1), pp. 119-133. Karger 10.1159/000362989
Bhabak, Krishna P.; Kleuser, Burkhard; Huwiler, Andrea; Arenz, Christoph (2013). Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues. Bioorganic & medicinal chemistry, 21(4), pp. 874-882. Elsevier 10.1016/j.bmc.2012.12.014
Koch, Alexander; Völzke, Anja; Puff, Bianca; Blankenbach, Kira; Meyer zu Heringdorf, Dagmar; Huwiler, Andrea; Pfeilschifter, Josef (2013). PARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces S1P-induced [Ca(2+)]i increases in renal mesangial cells. Biochimica and biophysica acta - molecular and cell biology of lipids, 1831(11), pp. 1634-1643. Elsevier 10.1016/j.bbalip.2013.07.011
Albinet, V.; Bats, M-L; Huwiler, Andrea; Rochaix, P.; Chevreau, C.; Ségui, B.; Levande, T.; Andrieu-Abadie, N. (2013). Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells. Oncogene, 33(26), pp. 3364-3373. Nature Publishing Group 10.1038/onc.2013.303
Schwlam, Stephanie; Pfeilschifter, Josef; Huwiler, Andrea (2013). Sphingosine-1-phosphate: a Janus-faced mediator of fibrotic diseases. Biochimica and biophysica acta - molecular and cell biology of lipids, 1831(1), pp. 239-250. Elsevier 10.1016/j.bbalip.2012.07.022
Koch, Alexander; Pfeilschrifter, Josef; Huwiler, Andrea (2013). Sphingosine 1-phosphate in renal diseases. Cellular physiology and biochemistry, 31(6), pp. 745-760. Karger 10.1159/000350093
Kotelevets, Nataliya; Fabbro, Doriano; Huwiler, Andrea; Zangemeister-Wittke, Uwe (2012). Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis. PLoS ONE, 7(6), e39209. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0039209
Huwiler, Andrea; Bourquin, Florence; Kotelevets, Nataliya; Pastukhov, Oleksandr; Capitani, Guido; Grütter, Markus G; Zangemeister-Wittke, Uwe (2011). A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders. PLoS ONE, 6(8), e22436. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0022436
Ren, Shuyu; Xin, Cuiyan; Pfeilschifter, Josef; Huwiler, Andrea (2010). A novel mode of action of the putative sphingosine kinase inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation. Cellular physiology and biochemistry, 26(1), pp. 97-104. Basel: Karger 10.1159/000315110
Hofmann, Lotte P; Ren, Shuyu; Schwalm, Stephanie; Pfeilschifter, Josef; Huwiler, Andrea (2008). Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner. Biological chemistry, 389(11), pp. 1399-407. Berlin: Walter de Gruyter 10.1515/BC.2008.160
Zangemeister-Wittke, Uwe; Huwiler, Andrea (2006). Antisense targeting of Mcl-1 has therapeutic potential in gastric cancer. Cancer biology & therapy, 5(10), pp. 1355-1356. Georgetown, Tex.: Landes Bioscience 10.4161/cbt.5.10.3488
Huwiler, Andrea; Pfeilschifter, Josef (2006). Hypoxia and lipid signaling. Biological chemistry, 387(10-11), pp. 1321-1328. Berlin: Walter de Gruyter 10.1515/BC.2006.165
Huwiler, Andrea; Döll, Frauke; Ren, Shuyu; Klawitter, Sabine; Greening, Anna; Römer, Isolde; Bubnova, Svetlana; Reinsberg, Luise; Pfeilschifter, Josef (2006). Histamine increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 by a PKC-alpha-dependent mechanism. Biochimica and biophysica acta - molecular and cell biology of lipids, 1761(3), pp. 367-376. Biochimica and biophysica acta - molecular and cell biology of lipids: Elsevier 10.1016/j.bbalip.2006.02.007
