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Duthaler, Urs; Bachmann, Fabio; Suenderhauf, Claudia; Grandinetti, Tanja; Pfefferkorn, Florian; Haschke, Manuel; Hruz, Petr; Bouitbir, Jamal; Krähenbühl, Stephan (2022). Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently. Clinical pharmacokinetics, 61(7), pp. 1039-1055. Springer 10.1007/s40262-022-01119-0
Kummer, Mirjam; Müller, Thomas; Exadaktylos, Aristomenis K; Krähenbühl, Stephan; Liakoni, Evangelia (2021). Characteristics of Presentations to the Emergency Department Following Attempted Suicide with Drugs. International journal of environmental research and public health, 18(19) MDPI 10.3390/ijerph181910232
Mueller, Alexandra M; Liakoni, Evangelia; Schneider, Cornelia; Burkard, Theresa; Jick, Susan S; Krähenbühl, Stephan; Meier, Christoph R; Spoendlin, Julia (2021). The Risk of Muscular Events Among New Users of Hydrophilic and Lipophilic Statins: an Observational Cohort Study. Journal of general internal medicine, 36(9), pp. 2639-2647. Springer 10.1007/s11606-021-06651-6
Bachmann, Fabio; Duthaler, Urs; Meyer Zu Schwabedissen, Henriette E; Puchkov, Maxim; Huwyler, Jörg; Haschke, Manuel; Krähenbühl, Stephan (2021). Metamizole is a moderate cytochrome P450 inducer via the constitutive androstane receptor and a weak inhibitor of CYP1A2. Clinical pharmacology and therapeutics, 109(6), pp. 1505-1516. Wiley 10.1002/cpt.2141
Vischer, Annina S; Kuster, Gabriela M; Twerenbold, Raphael; Pfister, Otmar; Zhou, Qian; Villiger, Andrea; Poglitsch, Marko; Krähenbühl, Stephan; Mayr, Michael; Osswald, Stefan; Haschke, Manuel; Burkard, Thilo (2021). Influence of Antihypertensive Treatment on RAAS Peptides in Newly Diagnosed Hypertensive Patients. Cells, 10(3) MDPI 10.3390/cells10030534
Scholz, Irene; Liakoni, Evangelia; Hammann, Felix; Grafinger, Katharina Elisabeth; Duthaler, Urs; Nagler, Michael; Krähenbühl, Stephan; Haschke, Manuel (2021). Effects of Hypericum perforatum (St John's wort) on the pharmacokinetics and pharmacodynamics of rivaroxaban in humans. British journal of clinical pharmacology, 87(3), pp. 1466-1474. Wiley-Blackwell 10.1111/bcp.14553
Duthaler, Urs; Weber, Michael; Hofer, Lorenz; Chaccour, Carlos; Maia, Marta; Müller, Pie; Krähenbühl, Stephan; Hammann, Felix (2021). The pharmacokinetics and drug-drug interactions of ivermectin in Aedes aegypti mosquitoes. PLoS pathogens, 17(3), e1009382. Public Library of Science 10.1371/journal.ppat.1009382
Banholzer, Sarah; Dunkelmann, Lea; Haschke, Manuel; Derungs, Adrian; Exadaktylos, Aristomenis; Krähenbühl, Stephan; Liakoni, Evangelia (2021). Retrospective analysis of adverse drug reactions leading to short-term emergency hospital readmission. Swiss medical weekly, 151, w20400. EMH Media 10.4414/smw.2021.20400
Blaser, Lea S; Duthaler, Urs; Bouitbir, Jamal; Leuppi-Taegtmeyer, Anne B; Liakoni, Evangelia; Dolf, Reto; Mayr, Michael; Drewe, Jürgen; Krähenbühl, Stephan; Haschke, Manuel (2021). Comparative Effects of Metamizole (Dipyrone) and Naproxen on Renal Function and Prostacyclin Synthesis in Salt-Depleted Healthy Subjects - A Randomized Controlled Parallel Group Study. Frontiers in Pharmacology, 12(620635), p. 620635. Frontiers 10.3389/fphar.2021.620635
Cismaru, Anca Liliana; Rudin, Deborah; Ibañez, Luisa; Liakoni, Evangelia; Bonadies, Nicolas; Kreutz, Reinhold; Carvajal, Alfonso; Lucena, Maria Isabel; Martin, Javier; Sancho Ponce, Esther; Molokhia, Mariam; Eriksson, Niclas; EuDAC, Collaborators; Krähenbühl, Stephan; Largiadèr, Carlo R.; Haschke, Manuel Martin; Hallberg, Pär; Wadelius, Mia; Amstutz, Ursula (2020). Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations. Genes, 11(11) MDPI 10.3390/genes11111275
Duthaler, Urs; Leisegang, Rory; Karlsson, Mats O; Krähenbühl, Stephan; Hammann, Felix (2020). The effect of food on the pharmacokinetics of oral ivermectin. The journal of antimicrobial chemotherapy, 75(2), pp. 438-440. Oxford University Press 10.1093/jac/dkz466
Suenderhauf, Claudia; Berger, Benjamin; Puchkov, Maxim; Schmid, Yasmin; Müller, Sabine; Huwyler, Jörg; Haschke, Manuel; Krähenbühl, Stephan; Duthaler, Urs (2020). Pharmacokinetics and phenotyping properties of the Basel phenotyping cocktail combination capsule in healthy male adults. British journal of clinical pharmacology, 86(2), pp. 352-361. Wiley-Blackwell 10.1111/bcp.14157
Bachmann, Fabio; Blaser, Lea; Haschke, Manuel Martin; Krähenbühl, Stephan; Duthaler, Urs (2020). Development and validation of an LC-MS/MS method for the bioanalysis of the major metamizole metabolites in human plasma. Bioanalysis, 12(3), pp. 175-189. Future Science 10.4155/bio-2019-0251
Rudin, Deborah; Spoendlin, Julia; Cismaru, Anca L.; Liakoni, Evangelia; Bonadies, Nicolas; Amstutz, Ursula; Meier, Christoph R; Krähenbühl, Stephan; Haschke, Manuel (2019). Metamizole-associated neutropenia: Comparison of patients with neutropenia and metamizole-tolerant patients. European journal of internal medicine, 68, pp. 36-43. Elsevier 10.1016/j.ejim.2019.07.029
Duthaler, Urs; Suenderhauf, Claudia; Gaugler, Stefan; Vetter, Beatrice; Krähenbühl, Stephan; Hammann, Felix (2019). Development and validation of an LC-MS/MS method for the analysis of ivermectin in plasma, whole blood, and dried blood spots using a fully automatic extraction system. Journal of pharmaceutical and biomedical analysis, 172, pp. 18-25. Elsevier 10.1016/j.jpba.2019.04.007
Rudin, Deborah; Lanzilotto, Angelo; Bachmann, Fabio; Housecroft, Catherine E; Constable, Edwin C; Drewe, Jürgen; Haschke, Manuel Martin; Krähenbühl, Stephan (2019). Non-immunological toxicological mechanisms of metamizole-associated neutropenia in HL60 cells. Biochemical pharmacology, 163, pp. 345-356. Elsevier 10.1016/j.bcp.2019.01.011
Leuppi-Taegtmeyer, Anne; Duthaler, Urs; Hammann, Felix; Schmid, Yasmin; Dickenmann, Michael; Amico, Patricia; Jehle, Andreas W; Kalbermatter, Stefan; Lenherr, Christoph; Meyer Zu Schwabedissen, Henriette E; Haschke, Manuel Martin; Liechti, Matthias E; Krähenbühl, Stephan (2019). Pharmacokinetics of oxycodone/naloxone and its metabolites in patients with end-stage renal disease during and between haemodialysis sessions. Nephrology, dialysis, transplantation, 34(4), pp. 692-702. Oxford University Press 10.1093/ndt/gfy285
Hoemme, Alexander; Barth, Holger; Haschke, Manuel Martin; Krähenbühl, Stephan; Strasser, Florian; Lehner, Claudia; von Kameke, Alexander; Wälti, Thomas; Thürlimann, Beat; Früh, Martin; Driessen, Christoph; Joerger, Markus (2019). Prognostic impact of polypharmacy and drug interactions in patients with advanced cancer. Cancer chemotherapy and pharmacology, 83(4), pp. 763-774. Springer 10.1007/s00280-019-03783-9
Duthaler, Urs; Berger, Benjamin; Erb, Stefan; Battegay, Manuel; Letang, Emili; Gaugler, Stefan; Natamatungiro, Alex; Mnzava, Dorcas; Donzelli, Massimiliano; Krähenbühl, Stephan; Haschke, Manuel Martin (2018). Using dried blood spots to facilitate therapeutic drug monitoring of antiretroviral drugs in resource-poor regions. The journal of antimicrobial chemotherapy, 73(10), pp. 2729-2737. Oxford University Press 10.1093/jac/dky254
Bachmann, Fabio; Duthaler, Urs; Rudin, Deborah; Krähenbühl, Stephan; Haschke, Manuel Martin (2018). N-demethylation of N-methyl-4-aminoantipyrine, the main metabolite of metamizole. European journal of pharmaceutical sciences, 120, pp. 172-180. Elsevier 10.1016/j.ejps.2018.05.003
Müller, Sabine; Nussbaumer, Susanne; Plitzko, Gabriel; Ludwig, Roger; Weinmann, Wolfgang; Krähenbühl, Stephan; Liakoni, Evangelia (2018). Recreational use of carfentanil - a case report with laboratory confirmation. Clinical toxicology, 56(2), pp. 151-152. Taylor & Francis 10.1080/15563650.2017.1355464
Berger, Benjamin; Bachmann, Fabio; Duthaler, Urs; Krähenbühl, Stephan; Haschke, Manuel Martin (2018). Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug. Frontiers in Pharmacology, 9(774), p. 774. Frontiers 10.3389/fphar.2018.00774
Liakoni, Evangelia; Gartwyl, Fabienne; Ricklin, Meret; Exadaktylos, Aristomenis; Krähenbühl, Stephan (2018). Psychoactive substances and violent offences: A retrospective analysis of presentations to an urban emergency department in Switzerland. PLoS ONE, 13(3), e0195234. Public Library of Science 10.1371/journal.pone.0195234
Parra-Guillen, Zinnia P; Berger, Peter B; Haschke, Manuel Martin; Donzelli, Massimiliano; Winogradova, Daria; Pfister, Bogumila; Früh, Martin; Gillessen, Silke; Krähenbühl, Stephan; Kloft, Charlotte; Joerger, Markus (2017). Role of Cytochrome P450 3A4 and 1A2 Phenotyping in Patients with Advanced Non-small-Cell Lung Cancer Receiving Erlotinib Treatment. Basic & clinical pharmacology & toxicology, 121(4), pp. 309-315. Wiley-Blackwell 10.1111/bcpt.12801
Blaser, Lea; Hassna, Hala; Hofmann, Sarah; Holbro, Andreas; Haschke, Manuel Martin; Rätz Bravo, Alexandra; Zeller, Andreas; Krähenbühl, Stephan; Taegtmeyer, Anne (2017). Leucopenia associated with metamizole: a case-control study. Swiss medical weekly, 147, w14438. EMH Schweizerischer Ärzteverlag 10.4414/smw.2017.14438
Liakoni, Evangelia; Rätz Bravo, Alexandra E; Krähenbühl, Stephan (2015). Hepatotoxicity of New Oral Anticoagulants (NOACs). Drug safety, 38(8), pp. 711-720. Springer 10.1007/s40264-015-0317-5
Liakoni, Evangelia; Rätz Bravo, Alexandra E; Terracciano, Luigi; Heim, Markus; Krähenbühl, Stephan (2014). Symptomatic hepatocellular liver injury with hyperbilirubinemia in two patients treated with rivaroxaban. JAMA Internal Medicine, 174(10), pp. 1683-1686. American Medical Association 10.1001/jamainternmed.2014.3912
Nezic, Lana; Derungs, Adrian; Bruggisser, Marcel; Tschudin-Sutter, Sarah; Krähenbühl, Stephan; Haschke, Manuel (2014). Therapeutic drug monitoring of once daily aminoglycoside dosing: comparison of two methods and investigation of the optimal blood sampling strategy. European journal of clinical pharmacology, 70(7), pp. 829-837. Springer 10.1007/s00228-014-1680-3
Wuillemin, Natascha Andrea; Terracciano, Luigi; Beltraminelli, Helmut; Schlapbach, Christoph; Fontana, Stefano; Krähenbühl, Stephan; Pichler, Werner Joseph; Yerly, Daniel (2014). T cells infiltrate the liver and kill hepatocytes in HLA-B(∗)57:01-associated floxacillin-induced liver injury. American journal of pathology, 184(6), pp. 1677-1682. Elsevier 10.1016/j.ajpath.2014.02.018
Donzelli, Massimiliano; Derungs, Adrian; Serratore, Maria-Giovanna; Noppen, Christoph; Nezic, Lana; Krähenbühl, Stephan; Haschke, Manuel (2014). The basel cocktail for simultaneous phenotyping of human cytochrome P450 isoforms in plasma, saliva and dried blood spots. Clinical pharmacokinetics, 53(3), pp. 271-282. Springer 10.1007/s40262-013-0115-0
Felser, Andrea; Blum, Kim; Lindinger, Peter W; Bouitbir, Jamal; Krähenbühl, Stephan (2013). Mechanisms of hepatocellular toxicity associated with dronedarone--a comparison to amiodarone. Toxicological sciences, 131(2), pp. 480-90. Oxford: Oxford University Press 10.1093/toxsci/kfs298
Morand, Réjane; Donzelli, Massimiliano; Haschke, Manuel; Krähenbühl, Stephan (2013). Quantification of plasma carnitine and acylcarnitines by high-performance liquid chromatography-tandem mass spectrometry using online solid-phase extraction. Analytical and bioanalytical chemistry, 405(27), pp. 8829-8836. Heidelberg: Springer 10.1007/s00216-013-7309-z
Hirzel, Estelle; Lindinger, Peter W; Maseneni, Swarna; Giese, Maria; Rhein, Véronique Virginie; Eckert, Anne; Hoch, Matthias; Krähenbühl, Stephan; Eberle, Alex N (2013). Differential modulation of ROS signals and other mitochondrial parameters by the antioxidants MitoQ, resveratrol and curcumin in human adipocytes. Journal of receptor and signal transduction research, 33(5), pp. 304-312. New York, N.Y.: Marcel Dekker
Zahno, Anja; Bouitbir, Jamal; Maseneni, Swarna; Lindinger, Peter W; Brecht, Karin; Krähenbühl, Stephan (2013). Hepatocellular toxicity of clopidogrel: Mechanisms and risk factors. Free radical biology & medicine, 65, pp. 208-216. San Diego, Calif.: Elsevier
Krähenbühl, Stephan (2013). [In Process Citation]. Therapeutische Umschau, 70(5), pp. 284-8. Bern: Huber
Wuillemin, Natascha; Adam, Jacqueline; Fontana, Stefano; Krähenbühl, Stephan; Pichler, Werner J; Yerly, Daniel (2013). HLA haplotype determines hapten or p-i T cell reactivity to flucloxacillin. Journal of immunology, 190(10), pp. 4956-64. Bethesda, Md.: American Association of Immunologists 10.4049/jimmunol.1202949
Franz, Carmen C; Hildbrand, Carole; Born, Christa; Egger, Sabin; Rätz Bravo, Alexandra E; Krähenbühl, Stephan (2013). Dose adjustment in patients with liver cirrhosis: impact on adverse drug reactions and hospitalizations. European journal of clinical pharmacology, 69(8), pp. 1565-73. Berlin: Springer 10.1007/s00228-013-1502-z
Maseneni, Swarna; Donzelli, Massimiliano; Brecht, Karin; Krähenbühl, Stephan (2013). Toxicity of thienopyridines on human neutrophil granulocytes and lymphocytes. Toxicology, 308, pp. 11-19. Amsterdam: Elsevier 10.1016/j.tox.2013.03.002
Giger-Pabst, Urs; Lange, Jochen; Maurer, Christoph; Bucher, Carine; Schreiber, Vital; Schlumpf, Rolf; Kocher, Thomas; Schweizer, Walter; Krähenbühl, Stephan; Krähenbühl, Lukas (2013). Short-term preoperative supplementation of an immunoenriched diet does not improve clinical outcome in well-nourished patients undergoing abdominal cancer surgery. Nutrition, 29(5), pp. 724-9. New York, N.Y.: Elsevier 10.1016/j.nut.2012.10.007
Caduff Good, Angela; Nobel, Daniel; Krähenbühl, Stephan; Geisen, Christof; Henz, Samuel (2013). Randomised trial of a clinical dosing algorithm to start anticoagulation with phenprocoumon. Swiss medical weekly, 143, w13709. Muttenz: EMH Schweizerischer Ärzteverlag 10.4414/smw.2013.13709
Pham, Thi Thanh Thuy; See, Hong Heng; Morand, Réjane; Krähenbühl, Stephan; Hauser, Peter C (2012). Determination of free and total valproic acid in human plasma by capillary electrophoresis with contactless conductivity detection. Journal of chromatography. B - analytical technologies in the biomedical and life sciences, 907, pp. 74-78. New York, N.Y.: Elsevier 10.1016/j.jchromb.2012.08.037
Detampel, Pascal; Beck, Mareike; Krähenbühl, Stephan; Huwyler, Jörg (2012). Drug interaction potential of resveratrol. Drug metabolism reviews, 44(3), pp. 253-65. New York, N.Y.: Informa Healthcare 10.3109/03602532.2012.700715
Morand, Réjane; Todesco, Liliane; Donzelli, Massimiliano; Fischer-Barnicol, David; Mullen, Peter J; Krähenbühl, Stephan (2012). Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans. Therapeutic drug monitoring, 34(4), pp. 406-14. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/FTD.0b013e3182608e2f
Henkel, Verena; Casaulta, Flurina; Seemüller, Florian; Krähenbühl, Stephan; Obermeier, Michael; Hüsler, Jürg; Möller, Hans-Jürgen (2012). Study design features affecting outcome in antidepressant trials. Journal of Affective Disorders, 141(2-3), pp. 160-7. Amsterdam: Elsevier 10.1016/j.jad.2012.03.021
Maseneni, Swarna; Donzelli, Massimiliano; Taegtmeyer, Anne Barbara; Brecht, Karin; Krähenbühl, Stephan (2012). Toxicity of clopidogrel and ticlopidine on human myeloid progenitor cells: importance of metabolites. Toxicology, 299(2-3), pp. 139-45. Amsterdam: Elsevier 10.1016/j.tox.2012.05.017
Hysek, Cédric M; Simmler, Linda D; Nicola, Valentina G; Vischer, Nerina; Donzelli, Massimiliano; Krähenbühl, Stephan; Grouzmann, Eric; Huwyler, Jörg; Hoener, Marius C; Liechti, Matthias E (2012). Duloxetine inhibits effects of MDMA ("ecstasy") in vitro and in humans in a randomized placebo-controlled laboratory study. PLoS ONE, 7(5), e36476. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0036476
See, Hong Heng; Schmidt-Marzinkowski, Julia; Pormsila, Worapan; Morand, Réjane; Krähenbühl, Stephan; Hauser, Peter C (2012). Determination of creatine and phosphocreatine in muscle biopsy samples by capillary electrophoresis with contactless conductivity detection. Analytica Chimica Acta, 727, pp. 78-82. Amsterdam: Elsevier 10.1016/j.aca.2012.03.055
Franz, Carmen C; Egger, Sabin; Born, Christa; Rätz Bravo, Alexandra E; Krähenbühl, Stephan (2012). Potential drug-drug interactions and adverse drug reactions in patients with liver cirrhosis. European journal of clinical pharmacology, 68(2), pp. 179-88. Berlin: Springer 10.1007/s00228-011-1105-5
Joerger, Markus; Ferreri, Andrés J M; Krähenbühl, Stephan; Schellens, Jan H M; Cerny, Thomas; Zucca, Emanuele; Huitema, Alwin D R (2012). Dosing algorithm to target a predefined AUC in patients with primary central nervous system lymphoma receiving high dose methotrexate. British journal of clinical pharmacology, 73(2), pp. 240-7. Oxford: Wiley-Blackwell 10.1111/j.1365-2125.2011.04084.x
Knapp, Andrea Caroline; Todesco, Liliane; Beier, Konstantin; Terracciano, Luigi; Sägesser, Hans; Reichen, Jürg; Krähenbühl, Stephan (2008). Toxicity of valproic acid in mice with decreased plasma and tissue carnitine stores. Journal of pharmacology and experimental therapeutics, 324(2), pp. 568-75. Bethesda, Md.: American Society for Pharmacology and Experimental Therapeutics 10.1124/jpet.107.131185
Ramelli, Gian Paolo; Gallati, Sabina; Weis, Joachim; Krähenbühl, Stephan; Burgunder, Jean-Marc (2006). Point mutation tRNA(Ser(UCN)) in a child with hearing loss and myoclonus epilepsy. Journal of child neurology, 21(3), pp. 253-5. Hamilton, Ontario: Decker 10.2310/7010.2006.00047
Stettler, Christoph; Allemann, Sabin; Jüni, Peter; Cull, Carole A; Holman, Rury R; Egger, Matthias; Krähenbühl, Stephan; Diem, Peter (2006). Glycemic control and macrovascular disease in types 1 and 2 diabetes mellitus: Meta-analysis of randomized trials. American Heart Journal, 152(1), pp. 27-38. St. Louis, Mo.: Elsevier 10.1016/j.ahj.2005.09.015
Roten, Laurent; Schoenenberger, Ronald A; Krähenbühl, Stephan; Schlienger, Raymond G (2004). Rhabdomyolysis in association with simvastatin and amiodarone. The Annals of pharmacotherapy, 38(6), pp. 978-981. Sage 10.1345/aph.1D498
