Pfeilschifter, Josef

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Journal Article

Schwalm, Stephanie; Erhardt, Martin; Römer, Isolde; Pfeilschifter, Josef; Zangemeister-Wittke, Uwe; Huwiler, Andrea (2020). Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt. International journal of molecular sciences, 21(4) Molecular Diversity Preservation International MDPI 10.3390/ijms21041396

Stepanovska, Bisera; Lange, Antonia I; Schwalm, Stephanie; Pfeilschifter, Josef; Coldewey, Sina M; Huwiler, Andrea (2020). Downregulation of S1P Lyase Improves Barrier Function in Human Cerebral Microvascular Endothelial Cells Following an Inflammatory Challenge. International journal of molecular sciences, 21(4) Molecular Diversity Preservation International MDPI 10.3390/ijms21041240

Huwiler, Andrea; Pfeilschifter, Josef (2018). Sphingolipid signaling in renal fibrosis. Matrix biology, 68-69, pp. 230-247. Elsevier 10.1016/j.matbio.2018.01.006

Blanchard, Olivier; Stepanovska, Bisera; Starck, Manuel Thierry; Erhardt, Martin; Römer, Isolde; Meyer Zu Heringdorf, Dagmar; Pfeilschifter, Josef; Zangemeister-Wittke, Uwe; Huwiler, Andrea (2018). Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells. International journal of molecular sciences, 19(5) Molecular Diversity Preservation International MDPI 10.3390/ijms19051498

Eresch, Jeanette; Stumpf, Martin; Koch, Alexander; Vutukuri, Rajkumar; Ferreirós, Nerea; Schreiber, Yannick; Schröder, Katrin; Devraj, Kavi; Popp, Rüdiger; Huwiler, Andrea; Hattenbach, Lars-Olof; Pfeilschifter, Josef; Pfeilschifter, Waltraud (2018). Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy. Investigative ophthalmology & visual science, 59(2), pp. 653-661. Association for Research in Vision and Ophthalmology 10.1167/iovs.17-22544

Beyer, Sandra; Schwalm, Stephanie; Pfeilschifter, Josef; Huwiler, Andrea (2018). Renal Mesangial Cells Isolated from Sphingosine Kinase 2 Transgenic Mice Show Reduced Proliferation and are More Sensitive to Stress-Induced Apoptosis. Cellular physiology and biochemistry, 47(6), pp. 2522-2533. Karger 10.1159/000491625

Schwalm, Stephanie; Beyer, Sandra; Frey, Helena; Haceni, Riad; Grammatikos, Georgios; Thomas, Dominique; Geisslinger, Gerd; Schaefer, Liliana; Huwiler, Andrea; Pfeilschifter, Josef (2017). Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction. American journal of pathology, 187(11), pp. 2413-2429. Elsevier 10.1016/j.ajpath.2017.06.017

Hsieh, Louise Tzung-Harn; Nastase, Madalina-Viviana; Roedig, Heiko; Zeng-Brouwers, Jinyang; Poluzzi, Chiara; Schwalm, Stephanie; Fork, Christian; Tredup, Claudia; Brandes, Ralf P; Wygrecka, Malgorzata; Huwiler, Andrea; Pfeilschifter, Josef; Schaefer, Liliana (2017). Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants. International journal of molecular sciences, 18(3) Molecular Diversity Preservation International MDPI 10.3390/ijms18030595

Filipenko, Iuliia; Schwalm, Stephanie; Reali, Luca; Pfeilschifter, Josef; Fabbro, Doriano; Huwiler, Andrea; Zangemeister-Wittke, Uwe (2016). Upregulation of the S1P3 receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE2 and EP2/EP4 activation. Biochimica et biophysica acta (BBA) - molecular and cell biology of lipids, 1861(11), pp. 1840-1851. Elsevier 10.1016/j.bbalip.2016.09.005

Imeri, Faik; Schwalm, Stephanie; Lyck, Ruth; Zivkovic, Aleksandra; Stark, Holger; Engelhardt, Britta; Pfeilschifter, Josef; Huwiler, Andrea (2016). Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments. Neuropharmacology, 105, pp. 341-350. Elsevier 10.1016/j.neuropharm.2016.01.031

Coldewey, Sina M; Benetti, Elisa; Collino, Massimo; Pfeilschifter, Josef; Sponholz, Christoph; Bauer, Michael; Huwiler, Andrea; Thiemermann, Christoph (2016). Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis. Scientific Reports, 6, p. 27594. Nature Publishing Group 10.1038/srep27594

Imeri, Faik; Blanchard, Olivier; Jenni, Aurelio Leandro; Schwalm, Stephanie; Wünsche, Christin; Zivkovic, Aleksandra; Stark, Holger; Pfeilschifter, Josef; Huwiler, Andrea (2015). FTY720 and two novel butterfly derivatives exert a general anti-inflammatory potential by reducing immune cell adhesion to endothelial cells through activation of S1P3 and phosphoinositide 3-kinase. Naunyn-Schmiedeberg's archives of pharmacology, 388(12), pp. 1283-1292. Springer 10.1007/s00210-015-1159-5

Schwalm, Stephanie; Maneva Timcheva, Tankica; Filipenko, Iuliia; Ebadi, Mahsa; Hofmann, Lotte P; Zangemeister-Wittke, Uwe; Pfeilschifter, Josef; Huwiler, Andrea (2015). Sphingosine kinase 2 deficiency increases proliferation and migration of renal mouse mesangial cells and fibroblasts. Biological chemistry, 396(6-7), pp. 813-825. De Gruyter 10.1515/hsz-2014-0289

Wünsche, Christin; Koch, Alexander; Goldschmeding, Roel; Schwalm, Stephanie; Meyer Zu Heringdorf, Dagmar; Huwiler, Andrea; Pfeilschifter, Josef (2015). Transforming growth factor β2 (TGF-β2)-induced connective tissue growth factor (CTGF) expression requires sphingosine 1-phosphate receptor 5 (S1P5) in human mesangial cells. Biochimica et biophysica acta (BBA) - molecular and cell biology of lipids, 1851(5), pp. 519-526. Elsevier 10.1016/j.bbalip.2015.01.003

Koch, Alexander; Jäger, Manuel; Völzke, Anja; Grammatikos, Georgios; Zu Heringdorf, Dagmar Meyer; Huwiler, Andrea; Pfeilschifter, Josef (2015). Downregulation of sphingosine 1-phosphate (S1P) receptor 1 by dexamethasone inhibits S1P-induced mesangial cell migration. Biological chemistry, 396(6-7), pp. 803-812. De Gruyter 10.1515/hsz-2014-0288

Pastukhov, Oleksandr; Schalm, Stephanie; Zangemeister-Wittke, Uwe; Fabbro, Doriano; Bornancin, Frederic; Japtok, Lukasz; Kleuser, Burkhrad; Pfeilschifter, Josef; Huwiler, Andrea (2014). The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death. British journal of pharmacology, 171(24), pp. 5829-5844. Wiley-Blackwell 10.1111/bph.12886

Imeri, Faik; Fallegger, Daniel; Zivkovic, Aleksandra; Schwalm, Stephanie; Enzmann, Gaby; Blankenbach, Kira; Meyer zu Heringdorf, Dagmar; Homann, Thomas; Kleuser, Burkhard; Pfeilschifter, Josef; Engelhardt, Britta; Stark, Holger; Huwiler, Andrea (2014). Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice. Neuropharmacology, 85, pp. 314-327. Elsevier 10.1016/j.neuropharm.2014.05.012

Schwalm, Stephanie; Pfeilschifter, Josef; Huwiler, Andrea (2014). Targeting the sphingosine kinase/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases. Basic Clinical Pharmacology and Toxicology, 1(114), pp. 44-49. Wiley 10.1111/bcpt.12103

Völzke, Anja; Koch, Alexander; Meyer zu Heringdorf, Dagmar; Huwiler, Andrea; Pfeilschifter, Josef (2014). Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells. Biochimica and biophysica acta - molecular and cell biology of lipids, 1841(1), pp. 11-21. Elsevier 10.1016/j.bbalip.2013.09.009

Pastukhov, Oleksandr; Schalm, Stephanie; Römer, Isolde; Pfeilschifter, Josef; Huwiler, Andrea; Zangemeister-Wittke, Uwe (2014). Ceramide kinase contributes to proliferation but not to prostaglandin E2 formation in renal mesangial cells and fibroblasts. Cellular physiology and biochemistry, 34(1), pp. 119-133. Karger 10.1159/000362989

Koch, Alexander; Völzke, Anja; Puff, Bianca; Blankenbach, Kira; Meyer zu Heringdorf, Dagmar; Huwiler, Andrea; Pfeilschifter, Josef (2013). PARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces S1P-induced [Ca(2+)]i increases in renal mesangial cells. Biochimica and biophysica acta - molecular and cell biology of lipids, 1831(11), pp. 1634-1643. Elsevier 10.1016/j.bbalip.2013.07.011

Schwlam, Stephanie; Pfeilschifter, Josef; Huwiler, Andrea (2013). Sphingosine-1-phosphate: a Janus-faced mediator of fibrotic diseases. Biochimica and biophysica acta - molecular and cell biology of lipids, 1831(1), pp. 239-250. Elsevier 10.1016/j.bbalip.2012.07.022

Ter Braak, Michael; Claas, Ralf Frederik; Hegen, Bianca; Labocha, Sandra; Ferreirós, Nerea; Pfeilschifter, Josef; Huwiler, Andrea; van Echten-Deckert, Gerhild; Meyer Zu Heringdorf, Dagmar (2011). Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator. Biochemical pharmacology, 81(5), pp. 617-25. New York, N.Y.: Elsevier 10.1016/j.bcp.2010.12.002

Pfeilschifter, Waltraud; Czech-Zechmeister, Bo?ena; Sujak, Marian; Mirceska, Ana; Koch, Alexander; Rami, Abdelhaq; Steinmetz, Helmuth; Foerch, Christian; Huwiler, Andrea; Pfeilschifter, Josef (2011). Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia. Biochemical and biophysical research communications, 413(2), pp. 212-7. Orlando, Fla.: Academic Press 10.1016/j.bbrc.2011.08.070

Huwiler, Andrea; Kotelevets, Nataliya; Xin, Cuiyan; Pastukhov, Oleksandr; Pfeilschifter, Josef; Zangemeister-Wittke, Uwe (2011). Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage. British journal of pharmacology, 162(2), pp. 532-43. Oxford: Wiley-Blackwell 10.1111/j.1476-5381.2010.01053.x

Schwalm, Stephanie; Pfeilschifter, Josef; Huwiler, Andrea (2010). Sphingosine kinase 1 is critically involved in nitric oxide-mediated human endothelial cell migration and tube formation. British journal of pharmacology, 160(7), pp. 1641-51. Oxford: Wiley-Blackwell 10.1111/j.1476-5381.2010.00818.x

Puneet, Padmam; Yap, Celestial T; Wong, Lingkai; Lam, Yulin; Koh, Dow Rhoon; Moochhala, Shabbir; Pfeilschifter, Josef; Huwiler, Andrea; Melendez, Alirio J (2010). SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis. Science, 328(5983), pp. 1290-4. Washington, D.C.: American Association for the Advancement of Science 10.1126/science.1188635

Ren, Shuyu; Xin, Cuiyan; Pfeilschifter, Josef; Huwiler, Andrea (2010). A novel mode of action of the putative sphingosine kinase inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation. Cellular physiology and biochemistry, 26(1), pp. 97-104. Basel: Karger 10.1159/000315110

Förster, Ankathrin; Emmler, Tanja; Schwalm, Stephanie; Ebadi, Mahsa; Heringdorf, Dagmar Meyer Zu; Nieuwenhuis, Barbara; Kleuser, Burkhardt; Huwiler, Andrea; Pfeilschifter, Josef (2010). Glucocorticoids protect renal mesangial cells from apoptosis by increasing cellular sphingosine-1-phosphate. Kidney international, 77(10), pp. 870-9. New York, N.Y.: Nature Publishing Group 10.1038/ki.2010.62

Czech, Bozena; Pfeilschifter, Waltraud; Mazaheri-Omrani, Niloufar; Strobel, Marc André; Kahles, Timo; Neumann-Haefelin, Tobias; Rami, Abdelhaq; Huwiler, Andrea; Pfeilschifter, Josef (2009). The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia. Biochemical and biophysical research communications, 389(2), pp. 251-6. Orlando, Fla.: Academic Press 10.1016/j.bbrc.2009.08.142

Ren, Shuyu; Babelova, Andrea; Moreth, Kristin; Xin, Cuiyan; Eberhardt, Wolfgang; Doller, Anke; Pavenstädt, Hermann; Schaefer, Liliana; Pfeilschifter, Josef; Huwiler, Andrea (2009). Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression. Kidney international, 76(8), pp. 857-67. New York, N.Y.: Nature Publishing Group 10.1038/ki.2009.297

Huwiler, Andrea; Pfeilschifter, Josef (2009). Lipids as targets for novel anti-inflammatory therapies. Pharmacology & therapeutics, 124(1), pp. 96-112. Amsterdam: Elsevier 10.1016/j.pharmthera.2009.06.008

Pushparaj, Peter N; Manikandan, Jayapal; Tay, Hwee Kee; H'ng, Shiau Chen; Kumar, Srinivasan D; Pfeilschifter, Josef; Huwiler, Andrea; Melendez, Alirio J (2009). Sphingosine kinase 1 is pivotal for Fc epsilon RI-mediated mast cell signaling and functional responses in vitro and in vivo. Journal of immunology, 183(1), pp. 221-7. Bethesda, Md.: American Association of Immunologists 10.4049/jimmunol.0803430

Nieuwenhuis, Barbara; Lüth, Anja; Chun, Jerold; Huwiler, Andrea; Pfeilschifter, Josef; Schäfer-Korting, Monika; Kleuser, Burkhard (2009). Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P(3) in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone. International journal of molecular medicine, 87(6), pp. 645-57. Athens: Spandidos Publications 10.1007/s00109-009-0468-x

Hofmann, Lotte P; Ren, Shuyu; Schwalm, Stephanie; Pfeilschifter, Josef; Huwiler, Andrea (2008). Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner. Biological chemistry, 389(11), pp. 1399-407. Berlin: Walter de Gruyter 10.1515/BC.2008.160

Huwiler, Andrea; Pfeilschifter, Josef (2008). New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets. Biochemical pharmacology, 75(10), pp. 1893-900. New York, N.Y.: Elsevier 10.1016/j.bcp.2007.12.018

Schwalm, Stephanie; Döll, Frauke; Römer, Isolde; Bubnova, Svetlana; Pfeilschifter, Josef; Huwiler, Andrea (2008). Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells. Biochemical and biophysical research communications, 368(4), pp. 1020-5. Orlando, Fla.: Academic Press 10.1016/j.bbrc.2008.01.132

Doller, Anke; Akool, El-Sayed; Huwiler, Andrea; Müller, Roswitha; Radeke, Heinfried H; Pfeilschifter, Josef; Eberhardt, Wolfgang (2008). Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA. Molecular and cellular biology, 28(8), pp. 2608-25. Washington, D.C.: American Society for Microbiology 10.1128/MCB.01530-07

Döll, Frauke; Pfeilschifter, Josef; Huwiler, Andrea (2007). Prolactin upregulates sphingosine kinase-1 expression and activity in the human breast cancer cell line MCF7 and triggers enhanced proliferation and migration. Endocrine-related cancer, 14(2), pp. 325-35. Bristol: BioScientifica Ltd. 10.1677/ERC-06-0050

Xin, Cuiyan; Ren, Shuyu; Eberhardt, Wolfgang; Pfeilschifter, Josef; Huwiler, Andrea (2007). Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation. Journal of lipid research, 48(9), pp. 1985-96. Bethesda, Md.: American Society for Biochemistry and Molecular Biology ASBMB 10.1194/jlr.M700077-JLR200

Doller, Anke; Huwiler, Andrea; Müller, Roswitha; Radeke, Heinfried H; Pfeilschifter, Josef; Eberhardt, Wolfgang (2007). Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2. Molecular biology of the cell, 18(6), pp. 2137-48. Bethesda, Md.: American Society for Cell Biology 10.1091/mbc.E06-09-0850

Huwiler, Andrea; Pfeilschifter, Josef (2006). Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy. Current pharmaceutical design, 12(35), pp. 4625-35. Hilversum: Bentham Science Publishers 10.2174/138161206779010422

Huwiler, Andrea; Pfeilschifter, Josef (2006). Hypoxia and lipid signaling. Biological chemistry, 387(10-11), pp. 1321-8. Berlin: Walter de Gruyter 10.1515/BC.2006.165

Huwiler, Andrea; Döll, Frauke; Ren, Shuyu; Klawitter, Sabine; Greening, Anna; Römer, Isolde; Bubnova, Svetlana; Reinsberg, Luise; Pfeilschifter, Josef (2006). Histamine increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 by a PKC-alpha-dependent mechanism. Biochimica and biophysica acta - molecular and cell biology of lipids, 1761(3), pp. 367-376. Biochimica and biophysica acta - molecular and cell biology of lipids: Elsevier 10.1016/j.bbalip.2006.02.007

Xin, Cuiyan; Ren, Shuyu; Eberhardt, Wolfgang; Pfeilschifter, Josef; Huwiler, Andrea (2006). The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells. British journal of pharmacology, 147(2), pp. 164-74. Oxford: Wiley-Blackwell 10.1038/sj.bjp.0706452

Plesková, Miriam; Beck, Karl-Friedrich; Behrens, Meik Helmut; Huwiler, Andrea; Fichtlscherer, Birgit; Wingerter, Oliver; Brandes, Ralf P; Mülsch, Alexander; Pfeilschifter, Josef (2006). Nitric oxide down-regulates the expression of the catalytic NADPH oxidase subunit Nox1 in rat renal mesangial cells. FASEB journal, 20(1), pp. 139-41. Bethesda, Md.: Federation of American Societies for Experimental Biology 10.1096/fj.05-3791fje

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