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Zhang, Ting; Ambrodji, Alisa; Huang, Huixing; Bouchonville, Kelly J; Etheridge, Amy S; Schmidt, Remington E; Bembenek, Brianna M; Temesgen, Zoey B; Wang, Zhiquan; Innocenti, Federico; Stroka, Deborah; Diasio, Robert B; Largiadèr, Carlo R; Offer, Steven M (2024). Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD). eLife, 13 eLife Sciences Publications 10.7554/eLife.94075
Deng, Haibin; Ge, Huixiang; Dubey, Christelle; Losmanova, Tereza; Medova, Michaela; Konstantinidou, Georgia; Mutlu, Seyran Mathilde; Birrer, Fabienne Esther; Brodie, Tess Melinda; Stroka, Deborah; Wang, Wenxiang; Peng, Ren-Wang; Dorn, Patrick; Marti, Thomas Michael (2023). An optimized protocol for the generation and monitoring of conditional orthotopic lung cancer in the KP mouse model using an adeno-associated virus vector compatible with biosafety level 1. Cancer immunology, immunotherapy : CII, 72(12), pp. 4457-4470. Springer 10.1007/s00262-023-03542-z
Esposito, Roberta; Lanzos, Andrés; Uroda, Tina; Ramnarayanan, Sunandini; Büchi, Isabel; Polidori, Taisia; Guillen-Ramirez, Hugo; Mihaljevic, Ante; Merlin, Bernard Mefi; Mela, Lia; Zoni, Eugenio; Hovhannisyan, Lusine; McCluggage, Finn; Medo, Matúš; Basile, Giulia; Meise, Dominik F; Zwyssig, Sandra; Wenger, Corina; Schwarz, Kyriakos; Vancura, Adrienne; ... (2023). Author Correction: Tumour mutations in long noncoding RNAs enhance cell fitness. Nature communications, 14(1), p. 5463. Nature Publishing Group 10.1038/s41467-023-41288-5
Magyar, Christian Tibor Josef; Vashist, Yogesh K; Stroka, Deborah; Kim-Fuchs, Corina; Berger, Martin D; Banz, Vanessa M (2023). Heat shock protein 90 (HSP90) inhibitors in gastrointestinal cancer: where do we currently stand?-A systematic review. Journal of cancer research and clinical oncology, 149(10), pp. 8039-8050. Springer 10.1007/s00432-023-04689-z
Esposito, Roberta; Lanzós, Andrés; Uroda, Tina; Ramnarayanan, Sunandini; Büchi, Isabel; Polidori, Taisia; Guillen-Ramirez, Hugo; Mihaljevic, Ante; Merlin, Bernard Mefi; Lia, Mela; Zoni, Eugenio; Hovhannisyan, Lusine; McCluggage, Finn; Medo, Matúš; Basile, Giulia; Meise, Dominik F; Zwyssig, Sandra; Wenger, Corina; Schwarz, Kyriakos; Vancura, Adrienne; ... (2023). Tumour mutations in long noncoding RNAs enhance cell fitness. Nature communications, 14(1), p. 3342. Nature Publishing Group 10.1038/s41467-023-39160-7
Ontsouka, Edgar; Schroeder, Mariana; Ok, Linda; Vaillancourt, Cathy; Stroka, Deborah; Albrecht, Christiane (2023). The Placenta-A New Source of Bile Acids during Healthy Pregnancy? First Results of a Gene Expression Study in Humans and Mice. International journal of molecular sciences, 24(11) MDPI 10.3390/ijms24119511
Jakob, Manuel O; Spari, Daniel; Sánchez Taltavull, Daniel; Salm, Lilian; Yilmaz, Bahtiyar; Doucet Ladevèze, Rémi; Mooser, Catherine; Pereyra, David; Ouyang, Ye; Schmidt, Theresa; Mattiola, Irene; Starlinger, Patrick; Stroka, Deborah; Tschan, Franziska; Candinas, Daniel; Gasteiger, Georg; Klose, Christoph S N; Diefenbach, Andreas; Gomez de Agüero, Mercedes and Beldi, Guido (2023). ILC3s restrict the dissemination of intestinal bacteria to safeguard liver regeneration after surgery. Cell reports, 42(3), p. 112269. Cell Press 10.1016/j.celrep.2023.112269
Birrer, Fabienne; Brodie, Tess; Stroka, Deborah (2023). OMIP-088: Twenty-target imaging mass cytometry panel for major cell populations in mouse formalin fixed paraffin embedded liver. Cytometry Part A, 103(3), pp. 189-192. Wiley 10.1002/cyto.a.24714
Lett, Martin J; Mehta, Hema; Keogh, Adrian; Jaeger, Tina; Jacquet, Maxime; Powell, Kate; Meier, Marie-Anne; Fofana, Isabel; Melhem, Hassan; Vosbeck, Jürg; Cathomas, Gieri; Heigl, Andres; Heim, Markus H; Burri, Emanuel; Mertz, Kirsten D; Niess, Jan Hendrik; Kollmar, Otto; Zech, Christoph J; Ivanek, Robert; Duthaler, Urs; ... (2022). Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells. Gut, 71(12), pp. 2526-2538. BMJ Publishing Group 10.1136/gutjnl-2021-324478
Bührer, Elias D; Amrein, Michael A; Forster, Stefan; Isringhausen, Stephan; Schürch, Christian M; Bhate, Salil S; Brodie, Tess; Zindel, Joel; Stroka, Deborah; Al Sayed, Mohamad; Nombela-Arrieta, César; Radpour, Ramin; Riether, Carsten; Ochsenbein, Adrian F (2022). Splenic red pulp macrophages provide a niche for CML stem cells and induce therapy resistance. Leukemia, 36(11), pp. 2634-2646. Springer Nature 10.1038/s41375-022-01682-2
Bayer, Julia; Stroka, Deborah; Kubes, Paul; Candinas, Daniel; Zindel, Joel (2022). Combination of Sterile Injury and Microbial Contamination to Model Post-surgical Peritoneal Adhesions in Mice. Bio-protocol, 12(16) 10.21769/BioProtoc.4491
Yarahmadov, Tural; Wang, Junhua; Sanches-Taltavull, Daniel; Rojas, Cristian A Alvarez; Brodie, Tess; Büchi, Isabel; Keogh, Adrian; Gottstein, Bruno; Stroka, Deborah; Beldi, Guido (2022). Primary Infection by E. multilocularis Induces Distinct Patterns of Cross Talk between Hepatic Natural Killer T Cells and Regulatory T Cells in Mice. Infection and immunity, 90(8), e0017422. American Society for Microbiology 10.1128/iai.00174-22
Dommann, Noëlle; Gavini, Jacopo; Sánchez-Taltavull, Daniel; Baier, Felix Alexander; Birrer, Fabienne; Loforese, Giulio; Candinas, Daniel; Stroka, Deborah (2022). LIM protein Ajuba promotes liver cell proliferation through its involvement in DNA replication and DNA damage control. FEBS letters, 596(14), pp. 1746-1764. FEBS Press 10.1002/1873-3468.14371
Melin, Nicolas; Yarahmadov, Tural; Sanchez-Taltavull, Daniel; Birrer, Fabienne E; Brodie, Tess M; Petit, Benoît; Felser, Andrea; Nuoffer, Jean-Marc; Montani, Matteo; Vozenin, Marie-Catherine; Herrmann, Evelyn; Candinas, Daniel; Aebersold, Daniel M; Stroka, Deborah (2022). A new mouse model of radiation-induced liver disease reveals mitochondrial dysfunction as an underlying fibrotic stimulus. JHEP reports, 4(7), p. 100508. Elsevier 10.1016/j.jhepr.2022.100508
Zindel, Joel; Mittner, Jonas; Bayer, Julia; April-Monn, Simon L.; Kohler, Andreas; Nusse, Ysbrand; Dosch, Michel; Büchi, Isabel; Sanchez-Taltavull, Daniel; Dawson, Heather; Gomez de Agüero, Mercedes; Asahina, Kinji; Kubes, Paul; Macpherson, Andrew J.; Stroka, Deborah; Candinas, Daniel (2021). Intraperitoneal microbial contamination drives post-surgical peritoneal adhesions by mesothelial EGFR-signaling. Nature Communications, 12(1), p. 7316. Springer Nature 10.1038/s41467-021-27612-x
Wang, Zhong-Yi; Keogh, Adrian; Waldt, Annick; Cuttat, Rachel; Neri, Marilisa; Zhu, Shanshan; Schuierer, Sven; Ruchti, Alexandra; Crochemore, Christophe; Knehr, Judith; Bastien, Julie; Ksiazek, Iwona; Sánchez-Taltavull, Daniel; Ge, Hui; Wu, Jing; Roma, Guglielmo; Helliwell, Stephen B; Stroka, Deborah; Nigsch, Florian (2021). Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis. Scientific reports, 11(1), p. 19396. Springer Nature 10.1038/s41598-021-98806-y
Zwicky, Simone N.; Stroka, Deborah; Zindel, Joel (2021). Sterile Injury Repair and Adhesion Formation at Serosal Surfaces. Frontiers in immunology, 12, p. 684967. Frontiers Research Foundation 10.3389/fimmu.2021.684967
Melin, Nicolas; Sánchez-Taltavull, Daniel; Fahrner, René; Keogh, Adrian; Dosch, Michel; Büchi, Isabel; Zimmer, Yitzhak; Medová, Michaela; Beldi, Guido; Aebersold, Daniel M.; Candinas, Daniel; Stroka, Deborah (2021). Synergistic effect of the TLR5 agonist CBLB502 and its downstream effector IL-22 against liver injury. Cell death & disease, 12(4), p. 366. Nature Publishing Group 10.1038/s41419-021-03654-3
Dommann, Noëlle; Sánchez Taltavull, Daniel; Eggs, Linda; Birrer, Fabienne Esther; Brodie, Tess; Salm, Lilian; Baier, Felix Alexander; Medova, Michaela; Humbert, Magali; Tschan, Mario; Beldi, Guido; Candinas, Daniel; Stroka, Deborah (2020). The LIM Protein Ajuba Augments Tumor Metastasis in Colon Cancer. Cancers, 12(7) MDPI AG 10.3390/cancers12071913
Sánchez-Taltavull, Daniel; Perkins, Theodore J; Dommann, Noelle; Melin, Nicolas; Keogh, Adrian; Candinas, Daniel; Stroka, Deborah; Beldi, Guido (2020). Bayesian correlation is a robust gene similarity measure for single-cell RNA-seq data. NAR genomics and bioinformatics, 2(1) Oxford University Press 10.1093/nargab/lqaa002
Gavini, Jacopo; Dommann, Noëlle; Jakob, Manuel O.; Keogh, Adrian; Bouchez, Laure C; Karkampouna, Sofia; Kruithof-de Julio, Marianna; Medova, Michaela; Zimmer, Yitzhak; Schläfli, Anna M; Tschan, Mario P.; Candinas, Daniel; Stroka, Deborah; Banz, Vanessa (2019). Verteporfin-induced lysosomal compartment dysregulation potentiates the effect of sorafenib in hepatocellular carcinoma. Cell death & disease, 10(10), p. 749. Springer Nature 10.1038/s41419-019-1989-z
Castro Dias, Mariana; Coisne, Caroline; Lazarevic, Ivana; Baden, Pascale; Hata, Masaki; Iwamoto, Noriko; Ferreira Francisco, David Miguel; Vanlandewijck, Michael; He, Liqun; Baier, Felix A.; Stroka, Deborah; Bruggmann, Rémy; Lyck, Ruth; Enzmann, Gaby; Deutsch, Urban; Betsholtz, Christer; Furuse, Mikio; Tsukita, Shoichiro; Engelhardt, Britta (2019). Publisher Correction: Claudin-3-deficient C57BL/6J mice display intact brain barriers. Scientific reports, 9(1), p. 10702. Springer Nature 10.1038/s41598-019-43511-0
Melhem, Hassan; Kallol, Sampada; Huang, Xiao; Lüthi, Michael; Ontsouka, Edgar; Keogh, Adrian; Stroka, Deborah; Thormann, Wolfgang; Schneider, Henning; Albrecht, Christiane (2019). Placental secretion of apolipoprotein A1 and E: the anti-atherogenic impact of the placenta. Scientific Reports, 9(1), p. 6225. Nature Publishing Group 10.1038/s41598-019-42522-1
Dosch, Michel; Zindel, Joël; Jebbawi, Fadi; Melin, Nicolas; Sanchez-Taltavull, Daniel; Stroka, Deborah; Candinas, Daniel; Beldi, Guido (2019). Connexin-43-dependent ATP release mediates macrophage activation during sepsis. eLife, 8 10.7554/eLife.42670
Medová, Michaela; Pochon, Benoît; Streit, Bruno; Blank-Liss, Wieslawa; Francica, Paola; Stroka, Deborah; Keogh, Adrian; Aebersold, Daniel M.; Blaukat, Andree; Bladt, Friedhelm; Zimmer, Yitzhak (2013). The novel ATP-competitive inhibitor of the MET hepatocyte growth factor receptor EMD1214063 displays inhibitory activity against selected MET-mutated variants. Molecular cancer therapeutics, 12(11), pp. 2415-2424. American Association for Cancer Research AACR 10.1158/1535-7163.MCT-13-0151
Laemmle, Alexander; Lechleiter, Antje; Roh, Vincent; Schwarz, Christa; Portmann, Simone; Furer, Cynthia; Keogh, Adrian; Tschan, Mario P; Candinas, Daniel; Vorburger, Stephan A; Stroka, Deborah (2012). Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions. PLoS ONE, 7(3), e33433. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0033433
Angst, Eliane; Dawson, David W; Stroka, Deborah; Gloor, Beat; Park, Jenny; Candinas, Daniel; Reber, Howard A; Hines, O Joe; Eibl, Guido (2011). N-myc downstream regulated gene-1 expression correlates with reduced pancreatic cancer growth and increased apoptosis in vitro and in vivo. Surgery, 149(5), pp. 614-24. New York, N.Y.: Elsevier 10.1016/j.surg.2010.11.002
Piguet, Anne-Christine; Stroka, Deborah; Zimmermann, Arthur; Dufour, Jean-François (2010). Hypoxia aggravates non-alcoholic steatohepatitis in mice lacking hepatocellular PTEN. Clinical science, 118(6), pp. 401-10. London: Portland 10.1042/CS20090313
Tschan, Mario P; Shan, Deborah; Laedrach, Judith; Eyholzer, Marianne; Leibundgut, Elisabeth Oppliger; Baerlocher, Gabriela M; Tobler, Andreas; Stroka, Deborah; Fey, Martin F (2010). NDRG1/2 expression is inhibited in primary acute myeloid leukemia. Leukemia research, 34(3), pp. 393-8. Amsterdam: Elsevier 10.1016/j.leukres.2009.08.037
Wampfler, Julian; Tschan, Mario P; Shan, Deborah; Laemmle, Alexander; Leibundgut, Elisabeth O; Baerlocher, Gabriela M; Stroka, Deborah; Fey, Martin F; Britschgi, Christian (2009). SIRT1 is downregulated during neutrophil differentiation of acute promyelocytic leukaemia cells. British journal of haematology, 146(3), pp. 337-41. Oxford: Wiley-Blackwell 10.1111/j.1365-2141.2009.07749.x
Banz, Vanessa M; Medová, Michaela; Keogh, Adrian; Furer, Cynthia; Zimmer, Yitzhak; Candinas, Daniel; Stroka, Deborah (2009). Hsp90 transcriptionally and post-translationally regulates the expression of NDRG1 and maintains the stability of its modifying kinase GSK3beta. Biochimica et biophysica acta - molecular cell research, 1793(10), pp. 1597-603. New York, N.Y.: Elsevier 10.1016/j.bbamcr.2009.08.002
Wagner, Markus; Roh, Vincent; Strehlen, Michael; Laemmle, Alexander; Stroka, Deborah; Egger, Bernhard; Trochsler, Markus; Hunt, Kelly K; Candinas, Daniel; Vorburger, Stephan A (2009). Effective treatment of advanced colorectal cancer by rapamycin and 5-FU/oxaliplatin monitored by TIMP-1. Journal of gastrointestinal surgery, 13(10), pp. 1781-90. New York, N.Y.: Springer-Verlag 10.1007/s11605-009-0948-x
Monastyrskaya, Katia; Tschumi, Fabian; Babiychuk, Eduard B; Stroka, Deborah; Draeger, Annette (2008). Annexins sense changes in intracellular pH during hypoxia. Biochemical journal, 409(1), pp. 65-75. London: Portland Press 10.1042/BJ20071116
Piguet, Anne-Christine; Semela, David; Keogh, Adrian; Wilkens, Ludwig; Stroka, Deborah; Stoupis, Christoforos; St-Pierre, Marie V; Dufour, Jean-François (2008). Inhibition of mTOR in combination with doxorubicin in an experimental model of hepatocellular carcinoma. Journal of hepatology, 49(1), pp. 78-87. Amsterdam: Elsevier 10.1016/j.jhep.2008.03.024
Quarta, Mattia; Stroka, Deborah; Keogh, Adrian; Sidler, Daniel; Avital, Itzhak; Gloor, Beat; Muraca, Maurizio; Candinas, Daniel; Inderbitzin, Daniel (2008). Multiparameter flow cytometry characterization of MHC class I negative mouse bone marrow cells. Medical science monitor, 14(12), BR286-93. Warszawa: Medical Science International
Plock, Jan; Frese, Steffen; Keogh, Adrian; Bisch-Knaden, Sonja; Ayuni, Erick; Corazza, Nadia; Weikert, Christian; Jakob, Stephan; Erni, Dominique; Dufour, Jean-François; Brunner, Thomas; Candinas, Daniel; Stroka, Deborah (2007). Activation of non-ischemic, hypoxia-inducible signalling pathways up-regulate cytoprotective genes in the murine liver. Journal of hepatology, 47(4), pp. 538-45. Amsterdam: Elsevier 10.1016/j.jhep.2007.04.016
Sibold, Sonja; Roh, Vincent; Keogh, Adrian; Studer, Peter; Tiffon, Céline; Angst, Eliane; Vorburger, Stephan A; Weimann, Rosemarie; Candinas, Daniel; Stroka, Deborah (2007). Hypoxia increases cytoplasmic expression of NDRG1, but is insufficient for its membrane localization in human hepatocellular carcinoma. FEBS letters, 581(5), pp. 989-94. Amsterdam: Elsevier 10.1016/j.febslet.2007.01.080
Peyer, Anne-Kathrin; Jung, Diana; Beer, Markus; Gnerre, Carmela; Keogh, Adrian; Stroka, Deborah; Zavolan, Mihaela; Meyer, Urs-A (2007). Regulation of human liver delta-aminolevulinic acid synthase by bile acids. Hepatology, 46(6), pp. 1960-70. Hoboken, N.J.: Wiley Interscience 10.1002/hep.21879
Bonvin, Marianne; Achermann, François; Greeve, Isabell; Stroka, Deborah; Keogh, Adrian; Inderbitzin, Daniel; Candinas, Daniel; Sommer, Peter; Wain-Hobson, Simon; Vartanian, Jean-Pierre; Greeve, Jobst (2006). Interferon-inducible expression of APOBEC3 editing enzymes in human hepatocytes and inhibition of hepatitis B virus replication. Hepatology, 43(6), pp. 1364-74. Hoboken, N.J.: Wiley Interscience 10.1002/hep.21187
Corazza, Nadia; Jakob, Sabine; Schaer, Corinne; Frese, Steffen; Keogh, Adrian; Stroka, Deborah; Kassahn, Daniela; Torgler, Ralph; Mueller, Christoph; Schneider, Pascal; Brunner, Thomas (2006). TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality. Journal of clinical investigation, 116(9), pp. 2493-9. Ann Arbor, Mich.: American Society for Clinical Investigation 10.1172/JCI27726
Jakob, Manuel O.; Sánchez-Taltavull, Daniel; Yilmaz, Bahtiyar; Malinka, Thomas; Mooser, Catherine; Spari, Daniel; Salm, Lilian A.; Freiburghaus, Katrin; Pereyra, David; Hapfelmeier, Siegfried; Masoodi, Mojgan; Starlinger, Patrick; Stroka, Deborah; Tschan, Franziska; Candinas, Daniel; Gomez de Agüero, Mercedes; Beldi, Guido (19 September 2019). Compartmentalization of intestinal bacteria by hepatic ILC3s prevents infections after surgery (bioRxiv). Cold Spring Harbor Laboratory 10.1101/773150
