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Aeschlimann, Leonore; Kehl, Alexandra; Guscetti, Franco; Posthaus, Caroline; Aupperle-Lellbach, Heike; Rottenberg, Sven; De Brot, Simone (2024). Effective detection of BRAFV595E mutation in canine urothelial and prostate carcinomas using immunohistochemistry. (In Press). Veterinary and comparative oncology Wiley 10.1111/vco.12978
Akhoundova, Dilara; Francica, Paola; Rottenberg, Sven; Rubin, Mark A (2024). DNA Damage Response and Mismatch Repair Gene Defects in Advanced and Metastatic Prostate Cancer. Advances in anatomic pathology, 31(2), pp. 61-69. Lippincott Williams & Wilkins 10.1097/PAP.0000000000000422
Andronikou, Christina; Burdova, Kamila; Dibitetto, Diego; Lieftink, Cor; Malzer, Elke; Kuiken, Hendrik J; Gogola, Ewa; Ray Chaudhuri, Arnab; Beijersbergen, Roderick L; Hanzlikova, Hana; Jonkers, Jos; Rottenberg, Sven (2024). PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair. The EMBO journal, 43(6), pp. 1015-1042. EMBO Press 10.1038/s44318-024-00043-2
Decollogny, Morgane; Rottenberg, Sven (2024). Persisting cancer cells are different from bacterial persisters. (In Press). Trends in cancer Elsevier 10.1016/j.trecan.2024.02.002
Dibitetto, Diego; Rottenberg, Sven (2024). DNA repair, gap suppression, or fork protection: BRCA2 needs a break! Molecular cell, 84(3), pp. 409-410. Cell Press 10.1016/j.molcel.2023.12.026
Valdeolivas, Alberto; Amberg, Bettina; Giroud, Nicolas; Richardson, Marion; Gálvez, Eric J C; Badillo, Solveig; Julien-Laferrière, Alice; Túrós, Demeter; Voith von Voithenberg, Lena; Wells, Isabelle; Pesti, Benedek; Lo, Amy A; Yángüez, Emilio; Das Thakur, Meghna; Bscheider, Michael; Sultan, Marc; Kumpesa, Nadine; Jacobsen, Björn; Bergauer, Tobias; Saez-Rodriguez, Julio; ... (2024). Profiling the heterogeneity of colorectal cancer consensus molecular subtypes using spatial transcriptomics. NPJ precision oncology, 8(1), p. 10. Springer Nature 10.1038/s41698-023-00488-4
Jankovic, Jana; Tièche, Eve; Dettwiler, Martina; Hahn, Kerstin; Scheemaeker, Stephanie; Kessler, Martin; Daminet, Sylvie; Rottenberg, Sven; Campos, Miguel (2023). Canine follicular cell and medullary thyroid carcinomas: Immunohistochemical characterization. (In Press). Veterinary pathology(3009858231217245), p. 3009858231217245. Sage 10.1177/03009858231217245
Küchler, Leonore; Posthaus, Caroline; Jäger, Kathrin; Guscetti, Franco; van der Weyden, Louise; von Bomhard, Wolf; Schmidt, Jarno M; Farra, Dima; Aupperle-Lellbach, Heike; Kehl, Alexandra; Rottenberg, Sven; de Brot, Simone (2023). Artificial Intelligence to Predict the BRAF V595E Mutation in Canine Urinary Bladder Urothelial Carcinomas. Animals, 13(15) MDPI 10.3390/ani13152404
Zelceski, Anabel; Francica, Paola; Lingg, Lea; Mutlu, Merve; Stok, Colin; Liptay, Martin; Alexander, John; Baxter, Joseph S; Brough, Rachel; Gulati, Aditi; Haider, Syed; Raghunandan, Maya; Song, Feifei; Sridhar, Sandhya; Forment, Josep V; O'Connor, Mark J; Davies, Barry R; van Vugt, Marcel A T M; Krastev, Dragomir B; Pettitt, Stephen J; ... (2023). MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells. Cell reports, 42(5), p. 112484. Cell Press 10.1016/j.celrep.2023.112484
Bhin, Jinhyuk; Paes Dias, Mariana; Gogola, Ewa; Rolfs, Frank; Piersma, Sander R; de Bruijn, Roebi; de Ruiter, Julian R; van den Broek, Bram; Duarte, Alexandra A; Sol, Wendy; van der Heijden, Ingrid; Andronikou, Christina; Kaiponen, Taina S; Bakker, Lara; Lieftink, Cor; Morris, Ben; Beijersbergen, Roderick L; van de Ven, Marieke; Jimenez, Connie R; Wessels, Lodewyk F A; ... (2023). Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors. Cell reports, 42(5), p. 112538. Cell Press 10.1016/j.celrep.2023.112538
Scheemaeker, Stephanie; Inglebert, Marine; Daminet, Sylvie; Dettwiler, Martina; Letko, Anna; Drögemüller, Cord; Kessler, Martin; Ducatelle, Richard; Rottenberg, Sven; Campos, Miguel (2023). Organoids of patient-derived medullary thyroid carcinoma: the first milestone towards a new in vitro model in dogs. Veterinary and comparative oncology, 21(1), pp. 111-122. Wiley 10.1111/vco.12872
Gradauskaite, Vaiva; Inglebert, Marine; Doench, John; Scherer, Melanie; Dettwiler, Martina; Wyss, Marianne; Shrestha, Neeta; Rottenberg, Sven; Plattet, Philippe (2023). LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus. mBio, 14(1), e0311422. American Society for Microbiology 10.1128/mbio.03114-22
Monod, Anne; Koch, Christoph; Jindra, Christoph; Haspeslagh, Maarten; Howald, Denise; Wenker, Christian; Gerber, Vinzenz; Rottenberg, Sven; Hahn, Kerstin (2023). CRISPR/Cas9-Mediated Targeting of BPV-1-Transformed Primary Equine Sarcoid Fibroblasts. Viruses, 15(9), p. 1942. Molecular Diversity Preservation International MDPI 10.3390/v15091942
Inglebert, Marine; Dettwiler, Martina; Hahn, Kerstin; Letko, Anna; Drögemüller, Cord; Doench, John; Brown, Adam; Memari, Yasin; Davies, Helen R; Degasperi, Andrea; Nik-Zainal, Serena; Rottenberg, Sven (2022). A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer. Scientific Reports, 12(1), p. 18051. Nature Publishing Group 10.1038/s41598-022-21706-2
Dibitetto, Diego; Marshall, Shannon; Sanchi, Andrea; Liptay, Martin; Badar, Jumana; Lopes, Massimo; Rottenberg, Sven; Smolka, Marcus B (2022). DNA-PKcs promotes fork reversal and chemoresistance. Molecular cell, 82(20), 3932-3942.e6. Cell Press 10.1016/j.molcel.2022.08.028
Janowczyk, Andrew; Baumhoer, Daniel; Dirnhofer, Stefan; Grobholz, Rainer; Kipar, Anja; de Leval, Laurence; Merkler, Doron; Michielin, Olivier; Moch, Holger; Perren, Aurel; Rottenberg, Sven; Rubbia-Brandt, Laura; Rubin, Mark A; Sempoux, Christine; Tolnay, Markus; Zlobec, Inti; Koelzer, Viktor Hendrik (2022). Towards a national strategy for digital pathology in Switzerland. Virchows Archiv, 481(4), pp. 647-652. Springer 10.1007/s00428-022-03345-0
Zingg, Daniel; Bhin, Jinhyuk; Yemelyanenko, Julia; Kas, Sjors M; Rolfs, Frank; Lutz, Catrin; Lee, Jessica K; Klarenbeek, Sjoerd; Silverman, Ian M; Annunziato, Stefano; Chan, Chang S; Piersma, Sander R; Eijkman, Timo; Badoux, Madelon; Gogola, Ewa; Siteur, Bjørn; Sprengers, Justin; de Klein, Bim; de Goeij-de Haas, Richard R; Riedlinger, Gregory M; ... (2022). Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers. Nature, 609(7929), E13. Springer Nature 10.1038/s41586-022-05287-8
Zingg, Daniel; Bhin, Jinhyuk; Yemelyanenko, Julia; Kas, Sjors M; Rolfs, Frank; Lutz, Catrin; Lee, Jessica K; Klarenbeek, Sjoerd; Silverman, Ian M; Annunziato, Stefano; Chan, Chang S; Piersma, Sander R; Eijkman, Timo; Badoux, Madelon; Gogola, Ewa; Siteur, Bjørn; Sprengers, Justin; de Klein, Bim; de Goeij-de Haas, Richard R; Riedlinger, Gregory M; ... (2022). Truncated FGFR2 is a clinically actionable oncogene in multiple cancers. Nature, 608(7923), pp. 609-617. Springer Nature 10.1038/s41586-022-05066-5
Paes Dias, Mariana; Rottenberg, Sven; Jonkers, Jos (2022). Functional genetic dropout screens and in vivo validation of candidate therapeutic targets using mouse mammary tumoroids. STAR protocols, 3(1), p. 101132. Elsevier 10.1016/j.xpro.2022.101132
Lingg, Lea; Rottenberg, Sven; Francica, Paola (2022). Meiotic genes and DNA double strand break repair in cancer. Frontiers in genetics, 13 Frontiers Media SA 10.3389/fgene.2022.831620
Widmer, Carmen A; Klebic, Ismar; Domanitskaya, Natalya; Decollogny, Morgane Francine; Howald, Denise; Siffert, Myriam; Essers, Paul; Nowicka, Zuzanna; Stokar-Regenscheit, Nadine; van de Ven, Marieke; de Korte-Grimmerink, Renske; Galván, José A; Pritchard, Colin E.J.; Huijbers, Ivo J; Fendler, Wojciech; Vens, Conchita; Rottenberg, Sven (2022). Loss of the volume-regulated anion channel components LRRC8A and LRRC8D limits platinum drug efficacy. Cancer research communications, 2(10), pp. 1266-1281. American Association for Cancer Research 10.1158/2767-9764.CRC-22-0208
Inglebert, Marine; Dettwiler, Martina; Hahn, Kerstin; Letko, Anna; Drögemüller, Cord; Doench, John; Brown, Adam; Memari, Yasin; Davies, Helen; Degasperi, Andrea; Nik-Zainal, Serena; Rottenberg, Sven (2022). A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2022.09.02.505845
Paes Dias, Mariana; Tripathi, Vivek; van der Heijden, Ingrid; Cong, Ke; Manolika, Eleni-Maria; Bhin, Jinhyuk; Gogola, Ewa; Galanos, Panagiotis; Annunziato, Stefano; Lieftink, Cor; Andújar-Sánchez, Miguel; Chakrabarty, Synjiban; Smith, Graeme C. M.; van de Ven, Marieke; Beijersbergen, Roderick; Bartkova, Jirina; Rottenberg, Sven; Cantor, Sharon; Bartek, Jiri; Chaudhuri, Arnab Ray; ... (2021). Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps. Molecular cell, 81(22), pp. 4692-4708. Cell Press 10.1016/j.molcel.2021.09.005
Jankovic, Jana; Dettwiler, Martina; González Fernández, Martin; Tièche, Eve; Hahn, Kerstin; April-Monn, Simon; Dettmer, Matthias S; Kessler, Martin; Rottenberg, Sven; Campos, Miguel (2021). Validation of Immunohistochemistry for Canine Proteins Involved in Thyroid Iodine Uptake and Their Expression in Canine Follicular Cell Thyroid Carcinomas (FTCs) and FTC-Derived Organoids. Veterinary pathology, 58(6), pp. 1172-1180. Sage 10.1177/03009858211018813
Andronikou, Christina; Rottenberg, Sven (2021). Studying PAR-Dependent Chromatin Remodeling to Tackle PARPi Resistance. Trends in molecular medicine, 27(7), pp. 630-642. Cell Press 10.1016/j.molmed.2021.04.010
Rottenberg, Sven; Disler, Carmen; Perego, Paola (2021). The rediscovery of platinum-based cancer therapy. Nature reviews - cancer, 21(1), pp. 37-50. Nature Publishing Group 10.1038/s41568-020-00308-y
Franica, Paola; Mutlu, Merve; Blomen, Vincent A.; Oliveira, Catarina; Nowicka, Zuzanna; Trenner, Anika; Gerhards, Nora M.; Bouwman, Peter; Stickel, Elmer; Hekkelman, Maarten L.; Lingg, Lea; Klebic, Ismar; van den Ven, Marieke; de Korte-Grimmerink, Renske; Howald, Denise; Jonkers, Jos; Sartori, Alessandro A.; Fendler, Wojciech; Chapman, J. Ross; Brummelkamp, Thijn; ... (2020). Functional radiogenetic profiling implicates ERCC6L2 in non-homologous end joining. Cell reports, 32(8), p. 108068. Cell Press 10.1016/j.celrep.2020.108068
Benvegnen, Jennifer; De Breuyn, Bettina; Gerber, Vinzenz; Rottenberg, Sven; Koch, Christoph (2020). Immunohistochemical analysis of programmed death-ligand 1 expression in equine sarcoids. Journal of equine veterinary science, 97, p. 103338. Elsevier 10.1016/j.jevs.2020.103338
Liptay, Martin; Barbosa, Joana S.; Rottenberg, Sven (2020). Replication Fork Remodeling and Therapy Escape in DNA Damage Response-Deficient Cancers. Frontiers in oncology, 10, p. 670. Frontiers Research Foundation 10.3389/fonc.2020.00670
Pantelidou, Constantia; Sonzogni, Olmo; de Oliveira Taveira, Mateus; Mehta, Anita K; Kothari, Aditi; Wang, Dan; Visal, Tanvi; Li, Michelle K; Pinto, Jocelin; Castrillon, Jessica A; Cheney, Emily M; Bouwman, Peter; Jonkers, Jos; Rottenberg, Sven; Guerriero, Jennifer L; Wulf, Gerburg M; Shapiro, Geoffrey I (2019). PARP inhibitor efficacy depends on CD8+ T cell recruitment via intratumoral STING pathway activation in BRCA-deficient models of triple-negative breast cancer. Cancer discovery, 9(6), pp. 722-737. American Association for Cancer Research 10.1158/2159-8290.CD-18-1218
Gerhards, Nora Merete; Blomen, Vincent A; Mutlu, Merve; Nieuwenhuis, Joppe; Howald, Denise; Guyader, Charlotte; Jonkers, Jos; Brummelkamp, Thijn R; Rottenberg, Sven (2018). Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents. Molecular oncology, 12(6), pp. 953-971. Elsevier 10.1002/1878-0261.12307
Duarte, Alexandra A; Gogola, Ewa; Sachs, Norman; Barazas, Marco; Annunziato, Stefano; R de Ruiter, Julian; Velds, Arno; Blatter, Sohvi Tuulikki; Houthuijzen, Julia M; van de Ven, Marieke; Clevers, Hans; Borst, Piet; Jonkers, Jos; Rottenberg, Sven (2018). BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance. Nature methods, 15(2), pp. 134-140. Nature Publishing Group 10.1038/nmeth.4535
Sachs, Norman; de Ligt, Joep; Kopper, Oded; Gogola, Ewa; Bounova, Gergana; Weeber, Fleur; Balgobind, Anjali Vanita; Wind, Karin; Gracanin, Ana; Begthel, Harry; Korving, Jeroen; van Boxtel, Ruben; Duarte, Alexandra Alves; Lelieveld, Daphne; van Hoeck, Arne; Ernst, Robert Frans; Blokzijl, Francis; Nijman, Isaac Johannes; Hoogstraat, Marlous; van de Ven, Marieke; ... (2018). A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. Cell, 172(1-2), pp. 373-386. Cell Press 10.1016/j.cell.2017.11.010
Pajic, Marina; Blatter, Sohvi Tuulikki; Guyader, Charlotte; Gonggrijp, Maaike; Kersbergen, Ariena; Küçükosmanoğlu, Aslι; Sol, Wendy; Drost, Rinske; Jonkers, Jos; Borst, Piet; Rottenberg, Sven (2017). Selected Alkylating Agents Can Overcome Drug Tolerance of G-like Tumor Cells and Eradicate BRCA1-Deficient Mammary Tumors in Mice. Clinical cancer research, 23(22), pp. 7020-7033. American Association for Cancer Research 10.1158/1078-0432.CCR-17-1279
Rondinelli, Beatrice; Gogola, Ewa; Yücel, Hatice; Duarte, Alexandra A; van de Ven, Marieke; van der Sluijs, Roxanne; Konstantinopoulos, Panagiotis A; Jonkers, Jos; Ceccaldi, Raphaël; Rottenberg, Sven; D'Andrea, Alan D (2017). EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation. Nature cell biology, 19(11), pp. 1371-1378. Nature Publishing Group 10.1038/ncb3626
Borst, Gerben R; Kumareswaran, Ramya; Yücel, Hatice; Telli, Seyda; Do, Trevor; McKee, Trevor; Zafarana, Gaetano; Jonkers, Jos; Verheij, Marcel; O'Connor, Mark J; Rottenberg, Sven; Bristow, Robert G (2017). Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model. OncoTarget, 8(50), pp. 87638-87646. Impact Journals LLC 10.18632/oncotarget.20936
Schoonen, Pepijn M; Talens, Francien; Stok, Colin; Gogola, Ewa; Heijink, Anne Margriet; Bouwman, Peter; Foijer, Floris; Tarsounas, Madalena; Blatter, Sohvi Tuulikki; Jonkers, Jos; Rottenberg, Sven; van Vugt, Marcel A T M (2017). Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells. Nature communications, 8(15981), p. 15981. Nature Publishing Group 10.1038/ncomms15981
