Keogh-Stroka, Deborah M.

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2017

Loforese, Giulio; Malinka, Thomas; Keogh, Adrian; Baier, Felix; Simillion, Cedric André Marie; Montani, Matteo; Halazonetis, Thanos D; Candinas, Daniel; Keogh-Stroka, Deborah M. (2017). Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2. EMBO molecular medicine, 9(1), pp. 46-60. EMBO Press 10.15252/emmm.201506089

2016

Francica, Paola; Nisa Hernandez, Lluis; Aebersold, Daniel; Langer, Rupert; Bladt, Friedhelm; Blaukat, Andree; Keogh-Stroka, Deborah M.; Martínez, María Rodríguez; Zimmer, Yitzhak; Medova, Michaela (2016). Depletion of FOXM1 via MET Targeting Underlies Establishment of a DNA Damage-Induced Senescence Program in Gastric Cancer. Clinical cancer research, 22(21), pp. 5322-5336. Association for Cancer Research 10.1158/1078-0432.CCR-15-2987

Lugli, Natalia; Kamileri, Irene; Keogh, Adrian; Malinka, Thomas; Sarris, Michalis E; Talianidis, Iannis; Schaad, Olivier; Candinas, Daniel; Halazonetis, Thanos D; Keogh-Stroka, Deborah M. (2016). R-spondin 1 and noggin facilitate expansion of resident stem cells from non-damaged gallbladders. EMBO reports, 17(5), pp. 769-779. Nature Publishing Group 10.15252/embr.201642169

Kudira, Ramesh; Malinka, Thomas; Kohler, Andreas; Dosch, Michel; Gomez de Agüero Tamargo, Maria de la Mercedes; Melin, Nicolas; Haegele, S; Starlinger, P; Maharjan, Niran; Saxena, Smita; Keogh, Adrian; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (2016). P2X1 regulated IL-22 secretion by innate lymphoid cells is required for efficient liver regeneration. Hepatology, 63(6), pp. 2004-2017. Wiley Interscience 10.1002/hep.28492

Kudira, Ramesh; Malinka, Thomas; Kohler, Andreas; Dosch, Michel; Gomez de Agüero Tamargo, Maria de la Mercedes; Melin, Nicolas; Haegele, S; Starlinger, P; Maharjan, Niran; Saxena, Smita; Keogh, Adrian; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (2016). P2X1 regulated IL-22 secretion by innate lymphoid cells is required for efficient liver regeneration (Unpublished). In: Keystone Symposium. Vancouver. 29.01.2016.

2015

Studer, Peter; da Silva, C G; Revuelta Cervantes, J M; Mele, A; Csizmadia, E; Siracuse, J J; Damrauer, S M; Peterson, C R; Candinas, Daniel; Keogh-Stroka, Deborah M.; Ma, A; Bhasin, M; Ferran, C (2015). Significant lethality following liver resection in A20 heterozygous knockout mice uncovers a key role for A20 in liver regeneration. Cell death and differentiation, 22(12), pp. 2068-2077. Nature Publishing Group 10.1038/cdd.2015.52

Leiser, Dominic; Medova, Michaela; Mikami, Kei; Nisa Hernandez, Lluis; Keogh-Stroka, Deborah M.; Blaukat, Andree; Bladt, Friedhelm; Aebersold, Daniel; Zimmer, Yitzhak (2015). KRAS and HRAS mutations confer resistance to MET targeting in preclinical models of MET-expressing tumor cells. Molecular oncology, 9(7), pp. 1434-1446. Elsevier 10.1016/j.molonc.2015.04.001

2014

Keogh-Stroka, Deborah M.; Keogh, Adrian; Vu, Dung; Fort, Alfredo; Stoffel, Michael Hubert; Kühni, Kathrin; Furer, Cynthia; Banz Wüthrich, Vanessa; Demarmels Biasiutti, Franziska; Lämmle, Bernhard; Candinas, Daniel; Neerman-Arbez, Marguerite (2014). In vitro rescue of FGA deletion by lentiviral transduction of an afibrinogenemic patient's hepatocytes. Journal of thrombosis and haemostasis, 12(11), pp. 1874-1879. Blackwell 10.1111/jth.12714

Malinka, Thomas; Keogh, Adrian; Kudira, Ramesh; Moghadamrad, Sheida; McCoy, Kathleen; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (September 2014). Liver regeneration is not impacted in the absence of intestinal microbiota (Unpublished). In: Schweizerische Gesellschaft für Gastroenterologie (SGG) - Schweizerische Gesellschaft für Viszeralchirurgie (SGVC) Annual Congress. Interlaken. 11.-12.9.2014.

Kudira, Ramesh; Malinka, Thomas; Gomez de Agüero Tamargo, Maria de la Mercedes; Keogh, Adrian; Furer, Cynthia; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (September 2014). Secretion of IL-22 is modulated by CD39 and is required for liver regeneration post partial hepatectomy. In: Schweizerische Gesellschaft für Gastroenterologie (SGG) - Schweizerische Gesellschaft für Viszeralchirurgie (SGVC) Annual Congress. Interlaken. 11.-12.9.2014.

Malinka, Thomas; Keogh, Adrian; Kudira, Ramesh; Moghadamrad, Sheida; McCoy, Kathleen; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (September 2014). Travel Award: Liver regeneration is not impacted in the absence of intestinal microbiota (Unpublished). In: Schweizerische Gesellschaft für Gastroenterologie (SGG) - Schweizerische Gesellschaft für Viszeralchirurgie (SGVC) Annual Congress. Interlaken. 11.-12.9.2014.

Kudira, Ramesh; Malinka, Thomas; Gomez de Agüero Tamargo, Maria de la Mercedes; Keogh, Adrian; Furer, Cynthia; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (September 2014). Travel Award: Secretion of IL-22 is modulated by CD39 and is required for liver regeneration post partial hepatectomy (Unpublished). In: Schweizerische Gesellschaft für Gastroenterologie (SGG) - Schweizerische Gesellschaft für Viszeralchirurgie (SGVC) Annual Congress. Interlaken. 11.-12.09.2014.

Fahrner, René; Trochsler, Markus; Corazza, Nadia; Graubardt, Nadine; Keogh, Adrian; Candinas, Daniel; Brunner, Thomas; Keogh-Stroka, Deborah M.; Beldi, Guido (2014). Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand on NK Cells Protects From Hepatic Ischemia-Reperfusion Injury. Transplantation, 97(11), pp. 1102-1109. Lippincott Williams & Wilkins 10.1097/TP.0000000000000101

Balmer, Maria Luisa; Slack, Emma; De Gottardi, Andrea; Lawson, Melissa; Hapfelmeier, Siegfried Hektor; Miele, Luca; Grieco, Antonio; Van Vlierberghe, Hans; Fahrner, René; Patuto, Nicola; Bernsmeier, Christine; Ronchi, Francesca; Wyss, Madeleine; Keogh-Stroka, Deborah M.; Dickgreber, Nina; Heim, Markus H; McCoy, Kathy D; Macpherson, Andrew (2014). The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiota. Science translational medicine, 6(237), 237ra66. American Association for the Advancement of Science 10.1126/scitranslmed.3008618

Fahrner, René; Patsenker, Eleanora; De Gottardi, Andrea; Stickel, Felix; Montani, Matteo; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (2014). Elevated liver regeneration in response to pharmacological reduction of elevated portal venous pressure by terlipressin after partial hepatectomy. Transplantation, 97(9), pp. 892-900. Lippincott Williams & Wilkins 10.1097/TP.0000000000000045

Malinka, Thomas; Keogh, Adrian; Kudira, Ramesh; Moghadamrad, Sheida; McCoy, Kathleen; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (May 2014). Liver regeneration is not impacted in the absence of intestinal microbiota. (Unpublished). In: Annual meeting of the Swiss Surgical Society. Bern. 21.-23.05.2014.

Kim-Fuchs, Corina; Winterhalder, Sebastian; Winter, Annja; Malinka, Thomas; Born, Diana; Schäfer, Stephan; Keogh-Stroka, Deborah M.; Gloor, Beat; Candinas, Daniel; Angst, Eliane (2014). The Silencing of N-myc Downstream-Regulated Gene-1 in an Orthotopic Pancreatic Cancer Model Leads to More Aggressive Tumor Growth and Metastases. Digestive surgery, 31(2), pp. 135-142. Karger 10.1159/000363065

Edelmann, Simone; Fahrner, René; Malinka, Thomas; Song, Bryan H.; Keogh-Stroka, Deborah M.; Mermod, Nicolas (2014). Nuclear Factor I-C acts as a regulator of hepatocyte proliferation at the onset of liver regeneration. Liver international, 35(4), pp. 1185-1194. Blackwell Munksgaard 10.1111/liv.12697

2013

Medová, Michaela; Pochon, Benoît; Streit, Bruno; Blank-Liss, Wieslawa; Francica, Paola; Stroka, Deborah; Keogh, Adrian; Aebersold, Daniel M.; Blaukat, Andree; Bladt, Friedhelm; Zimmer, Yitzhak (2013). The novel ATP-competitive inhibitor of the MET hepatocyte growth factor receptor EMD1214063 displays inhibitory activity against selected MET-mutated variants. Molecular cancer therapeutics, 12(11), pp. 2415-2424. American Association for Cancer Research AACR 10.1158/1535-7163.MCT-13-0151

Portmann, Simone; Fahrner, René; Lechleiter, Antje; Keogh, Adrian; Overney, Sarah; Lämmle, Alexander; Mikami, Kei; Montani, Matteo; Tschan, Mario; Candinas, Daniel; Keogh-Stroka, Deborah M. (2013). Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo. Molecular cancer therapeutics, 12(4), pp. 499-508. American Association for Cancer Research AACR 10.1158/1535-7163.MCT-12-0700

Kudira, Ramesh; Breu, Karin; Keogh, Adrian; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (March 2013). Extracellular nucleotides modulate the secretion of IL-22 by hepatic innate lymphoid cells. In: World immune regulation meeting Davos. Davos. 13.-16.3.2013.

Graubardt, Nadine; Fahrner, René; Trochsler, Markus; Keogh, Adrian; Breu, Karin; Furer, Cynthia; Keogh-Stroka, Deborah M.; Robson, Simon C.; Slack, Emma; Candinas, Daniel; Beldi, Guido (2013). Promotion of liver regeneration by natural killer cells in a murine model is dependent on extracellular adenosine triphosphate phosphohydrolysis. Hepatology, 57(5), pp. 1969-1979. Wiley Interscience 10.1002/hep.26008

2012

Laemmle, Alexander; Lechleiter, Antje; Roh, Vincent; Schwarz, Christa; Portmann, Simone; Furer, Cynthia; Keogh, Adrian; Tschan, Mario P; Candinas, Daniel; Vorburger, Stephan A; Stroka, Deborah (2012). Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions. PLoS ONE, 7(3), e33433. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0033433

Graubardt, N; Fahrner, R; Keogh, A; Stroka, D; Candinas, D; Beldi, G (2012). Promotion of liver regeneration by NK cells in mice is dependent upon extracellular ATP phosphohydrolysis. In: Jahreskongress SGC Davos.

2011

Angst, Eliane; Dawson, David W; Stroka, Deborah; Gloor, Beat; Park, Jenny; Candinas, Daniel; Reber, Howard A; Hines, O Joe; Eibl, Guido (2011). N-myc downstream regulated gene-1 expression correlates with reduced pancreatic cancer growth and increased apoptosis in vitro and in vivo. Surgery, 149(5), pp. 614-24. New York, N.Y.: Elsevier 10.1016/j.surg.2010.11.002

Studer, P; da Silva, C; Csizmadia, E; Mennicke, M; Inderbitzin, D; Stroka, D; Candinas, D; Ferran, C (2011). Partial liver resection reveals a distinct phenotype in A20 heterozygote mice. In: 98. Jahreskongress der Schweizerischen Gesellschaft für Chirurgie. Genf, Switzerland. 25.-27.5.2011.

2010

Piguet, Anne-Christine; Stroka, Deborah; Zimmermann, Arthur; Dufour, Jean-François (2010). Hypoxia aggravates non-alcoholic steatohepatitis in mice lacking hepatocellular PTEN. Clinical science, 118(6), pp. 401-10. London: Portland 10.1042/CS20090313

Tschan, Mario P; Shan, Deborah; Laedrach, Judith; Eyholzer, Marianne; Leibundgut, Elisabeth Oppliger; Baerlocher, Gabriela M; Tobler, Andreas; Stroka, Deborah; Fey, Martin F (2010). NDRG1/2 expression is inhibited in primary acute myeloid leukemia. Leukemia research, 34(3), pp. 393-8. Amsterdam: Elsevier 10.1016/j.leukres.2009.08.037

Patsenker, E; Wilkens, L; Banz, V; Osterreicher, C H; Weimann, R; Eisele, S; Keogh, A; Stroka, D; Zimmermann, A; Stickel, F (2010). The alphavbeta6 integrin is a highly specific immunohistochemical marker for cholangiocarcinoma. Journal of hepatology, 52(3), pp. 362-9. Amsterdam: Elsevier 10.1016/j.jhep.2009.12.006

TROCHSLER, M; FAHRNER, R; GRAUBARDT, N; KEOGH, A; CORAZZA, N; STROKA, D; CANDINAS, D; BELDI, G (2010). TRAIL expression on NK cells attenuates hepatic ischemia-reperfusion injury in mice. In: Best Poster Prize.

2009

Wampfler, Julian; Tschan, Mario P; Shan, Deborah; Laemmle, Alexander; Leibundgut, Elisabeth O; Baerlocher, Gabriela M; Stroka, Deborah; Fey, Martin F; Britschgi, Christian (2009). SIRT1 is downregulated during neutrophil differentiation of acute promyelocytic leukaemia cells. British journal of haematology, 146(3), pp. 337-41. Oxford: Wiley-Blackwell 10.1111/j.1365-2141.2009.07749.x

Banz, Vanessa M; Medová, Michaela; Keogh, Adrian; Furer, Cynthia; Zimmer, Yitzhak; Candinas, Daniel; Stroka, Deborah (2009). Hsp90 transcriptionally and post-translationally regulates the expression of NDRG1 and maintains the stability of its modifying kinase GSK3beta. Biochimica et biophysica acta - molecular cell research, 1793(10), pp. 1597-603. New York, N.Y.: Elsevier 10.1016/j.bbamcr.2009.08.002

Wagner, Markus; Roh, Vincent; Strehlen, Michael; Laemmle, Alexander; Stroka, Deborah; Egger, Bernhard; Trochsler, Markus; Hunt, Kelly K; Candinas, Daniel; Vorburger, Stephan A (2009). Effective treatment of advanced colorectal cancer by rapamycin and 5-FU/oxaliplatin monitored by TIMP-1. Journal of gastrointestinal surgery, 13(10), pp. 1781-90. New York, N.Y.: Springer 10.1007/s11605-009-0948-x

2008

Monastyrskaya, Katia; Tschumi, Fabian; Babiychuk, Eduard B; Stroka, Deborah; Draeger, Annette (2008). Annexins sense changes in intracellular pH during hypoxia. Biochemical journal, 409(1), pp. 65-75. London: Portland Press 10.1042/BJ20071116

Roh, V; Laemmle, A; Von Holzen, U; Stroka, D; Dufour, Jean-François; Hunt, K K; Candinas, D; Vorburger, S A (2008). Dual induction of PKR with E2F-1 and IFN-alpha to enhance gene therapy against hepatocellular carcinoma. Cancer gene therapy, 15(10), pp. 636-44. New York, N.Y.: Nature Publishing Group 10.1038/cgt.2008.34

Piguet, Anne-Christine; Semela, David; Keogh, Adrian; Wilkens, Ludwig; Stroka, Deborah; Stoupis, Christoforos; St-Pierre, Marie V; Dufour, Jean-François (2008). Inhibition of mTOR in combination with doxorubicin in an experimental model of hepatocellular carcinoma. Journal of hepatology, 49(1), pp. 78-87. Amsterdam: Elsevier 10.1016/j.jhep.2008.03.024

Quarta, Mattia; Stroka, Deborah; Keogh, Adrian; Sidler, Daniel; Avital, Itzhak; Gloor, Beat; Muraca, Maurizio; Candinas, Daniel; Inderbitzin, Daniel (2008). Multiparameter flow cytometry characterization of MHC class I negative mouse bone marrow cells. Medical science monitor, 14(12), BR286-93. Warszawa: Medical Science International

2007

Plock, Jan; Frese, Steffen; Keogh, Adrian; Bisch-Knaden, Sonja; Ayuni, Erick; Corazza, Nadia; Weikert, Christian; Jakob, Stephan; Erni, Dominique; Dufour, Jean-François; Brunner, Thomas; Candinas, Daniel; Stroka, Deborah (2007). Activation of non-ischemic, hypoxia-inducible signalling pathways up-regulate cytoprotective genes in the murine liver. Journal of hepatology, 47(4), pp. 538-45. Amsterdam: Elsevier 10.1016/j.jhep.2007.04.016

Sibold, Sonja; Roh, Vincent; Keogh, Adrian; Studer, Peter; Tiffon, Céline; Angst, Eliane; Vorburger, Stephan A; Weimann, Rosemarie; Candinas, Daniel; Stroka, Deborah (2007). Hypoxia increases cytoplasmic expression of NDRG1, but is insufficient for its membrane localization in human hepatocellular carcinoma. FEBS letters, 581(5), pp. 989-94. Amsterdam: Elsevier 10.1016/j.febslet.2007.01.080

Inderbitzin, D; Quarta, M; Keogh, A; Sidler, D; Gloor, B; Stroka, D; Candinas, D (2007). Phenotypic characterization of the MHC-1 negative mouse bone marrow compartment: A potential source for adult liver committed stem cells. Gastroenterology(132), p. 889. Philadelphia, Pa.: Elsevier

Keogh, A; Gass, M; Candinas, D; Stroka, D (2007). Up-regulation of A20, an anti-apoptotic protein, is part of the protective response to hypoxic stress in the liver. Journal of hepatology, 46(46), S114. Amsterdam: Elsevier 10.1016/S0168-8278(07)61883-2

Peyer, Anne-Kathrin; Jung, Diana; Beer, Markus; Gnerre, Carmela; Keogh, Adrian; Stroka, Deborah; Zavolan, Mihaela; Meyer, Urs-A (2007). Regulation of human liver delta-aminolevulinic acid synthase by bile acids. Hepatology, 46(6), pp. 1960-70. Hoboken, N.J.: Wiley Interscience 10.1002/hep.21879

Keogh-Stroka, Deborah M.; Trochsler, M; Hlushchuk, R; Baum, O; Candinas, Daniel; Dufour, Jean-François; Djonov, V (2007). Sinusoidal duplication by intussusception is an early event in liver regeneration after partial hepatectomy. Journal of hepatology, 46(46), S146. Amsterdam: Elsevier 10.1016/S0168-8278(07)61974-6

Piguet, A; Ledermann, C; Zimmermann, A; Keogh-Stroka, Deborah M.; Dufour, Jean-François (2007). Hypoxia worsens non-alcoholic steatohepatitis. Journal of hepatology, 46(46), S10. Amsterdam: Elsevier 10.1016/S0168-8278(07)61616-X

2006

Keogh-Stroka, Deborah M.; Plock, Jan Alexander; Beldi, Guido; Frese, Steffen R.; Keogh, Adrian; Bisch-Knaden, Sonja Maria; Dufour, Jean-François; Brunner, Thomas; Candinas, Daniel (2006). Temporary hypoxic stress protects the liver from Fas-mediated apoptosis and ischemia reperfusion injury. In: 93. Jahreskongress der Schweizerischen Gesellschaft für Chirurgie. Lugano, Switzerland. 21.-23.6.2006.

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