Deciphering the Complete Deletion of the MgrB Locus in an Unusual Colistin-Resistant Klebsiella pneumoniae Colonizing the Gut of a Traveler Returning from India

Bernasconi, Odette Joëlle; Donà, Valentina; Do Couto Pires, Joao Pedro; Kuenzli, Esther; Christoph, Hatz; Luzzaro, Francesco; Perreten, Vincent; Endimiani, Andrea (2018). Deciphering the Complete Deletion of the MgrB Locus in an Unusual Colistin-Resistant Klebsiella pneumoniae Colonizing the Gut of a Traveler Returning from India. International journal of antimicrobial agents, 51(3), pp. 529-531. Elsevier 10.1016/j.ijantimicag.2017.09.014

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most colistin-resistant (Col-R) Klebsiella pneumoniae strains possess alterations of the two-component systems PhoP/Q and PmrA/B. These systems respond to environmental stimuli increasing the expression of the operon pmrHFIJKLM whose products are responsible for lipid A modifications leading to decreased affinity for polymyxins. This process is regulated by a negative feedback of the mgrB gene that encodes for a small protein repressing the PhoP/Q system. Thus, inactivation of mgrB leads to polymyxin resistance.

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