Deciphering the Complete Deletion of the MgrB Locus in an Unusual Colistin-Resistant Klebsiella pneumoniae Colonizing the Gut of a Traveler Returning from India

Bernasconi, Odette Joëlle; Donà, Valentina; Do Couto Pires, Joao Pedro; Kuenzli, Esther; Christoph, Hatz; Luzzaro, Francesco; Perreten, Vincent; Endimiani, Andrea (2018). Deciphering the Complete Deletion of the MgrB Locus in an Unusual Colistin-Resistant Klebsiella pneumoniae Colonizing the Gut of a Traveler Returning from India. International journal of antimicrobial agents, 51(3), pp. 529-531. Elsevier 10.1016/j.ijantimicag.2017.09.014

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most colistin-resistant (Col-R) Klebsiella pneumoniae strains possess alterations of the two-component systems PhoP/Q and PmrA/B. These systems respond to environmental stimuli increasing the expression of the operon pmrHFIJKLM whose products are responsible for lipid A modifications leading to decreased affinity for polymyxins. This process is regulated by a negative feedback of the mgrB gene that encodes for a small protein repressing the PhoP/Q system. Thus, inactivation of mgrB leads to polymyxin resistance.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Bernasconi, Odette Joëlle; Donà, Valentina; Do Couto Pires, Joao Pedro; Perreten, Vincent and Endimiani, Andrea

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0924-8579

Publisher:

Elsevier

Funders:

[4] Swiss National Science Foundation

Projects:

[577] SNF project 153377 to Andrea Endimiani

Language:

English

Submitter:

Andrea Endimiani

Date Deposited:

21 Nov 2017 09:49

Last Modified:

10 Oct 2018 02:30

Publisher DOI:

10.1016/j.ijantimicag.2017.09.014

PubMed ID:

29024775

BORIS DOI:

10.7892/boris.105755

URI:

https://boris.unibe.ch/id/eprint/105755

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