A fundamental evaluation of the electrical properties and function of cardiac transverse tubules

Vermij, S.H.; Abriel, H.; Kucera, J.P. (2019). A fundamental evaluation of the electrical properties and function of cardiac transverse tubules (In Press). Biochimica et biophysica acta - molecular cell research Elsevier 10.1016/j.bbamcr.2019.06.016

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This work discusses active and passive electrical properties of transverse (T-)tubules in ventricular cardiomyocytes to understand the physiological roles of T-tubules. T-tubules are invaginations of the lateral membrane that provide a large surface for calcium-handling proteins to facilitate sarcomere shortening. Higher heart rates correlate with higher T-tubular densities in mammalian ventricular cardiomyocytes. We assess ion dynamics in T-tubules and the effects of sodium current in T-tubules on the extracellular potential, which leads to a partial reduction of the sodium current in deep segments of a T-tubule. We moreover reflect on the impact of T-tubules on macroscopic conduction velocity, integrating fundamental principles of action potential propagation and conduction. We also theoretically assess how the conduction velocity is affected by different T-tubular sodium current densities. Lastly, we critically assess literature on ion channel expression to determine whether action potentials can be initiated in T-tubules.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Vermij, Sarah Helena; Abriel, Hugues and Kucera, J.P.

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0167-4889

Publisher:

Elsevier

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Sarah Helena Vermij

Date Deposited:

12 Aug 2019 15:10

Last Modified:

21 Nov 2019 08:07

Publisher DOI:

10.1016/j.bbamcr.2019.06.016

PubMed ID:

31269418

BORIS DOI:

10.7892/boris.131820

URI:

https://boris.unibe.ch/id/eprint/131820

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