Clemetson, Kenneth John

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2015

van Geffen, Johanna P; Kleinegris, Marie-Claire; Verdoold, Remco; Baaten, Constance C F M J; Cosemans, Judith M E M; Ten Cate, Hugo; Roest, Mark; de Laat, Bas; Clemetson, Kenneth John; Heemskerk, Johan W M (2015). Normal platelet activation profile in patients with peripheral arterial disease on aspirin. Thrombosis research, 135(3), pp. 513-520. Elsevier 10.1016/j.thromres.2014.12.029

Clemetson, Kenneth John (2015). Platelet receptors and patient responses: The contributions of Professor Stan Heptinstall to platelet research. Platelets, 26(5), pp. 382-385. Informa Healthcare 10.3109/09537104.2015.1042449

2014

Navdaev, Alexey; Subramanian, Hariharan; Petunin, Alexey; Clemetson, Kenneth John; Gambaryan, Stepan; Walter, Ulrich (2014). Echicetin coated polystyrene beads: a novel tool to investigate GPIb-specific platelet activation and aggregation. PLoS ONE, 9(4), e93569. Public Library of Science 10.1371/journal.pone.0093569

de Witt, Susanne M; Swieringa, Frauke; Cavill, Rachel; Lamers, Moniek M E; van Kruchten, Roger; Mastenbroek, Tom; Baaten, Constance; Coort, Susan; Pugh, Nicholas; Schulz, Ansgar; Scharrer, Inge; Jurk, Kerstin; Zieger, Barbara; Clemetson, Kenneth John; Farndale, Richard W; Heemskerk, Johan W M; Cosemans, Judith M E M (2014). Identification of platelet function defects by multi-parameter assessment of thrombus formation. Nature communications, 5, p. 4257. Nature Publishing Group 10.1038/ncomms5257

2013

Kappelmayer, J.; Beke Debreceni, I.; Vida, A.; Antal-Szalmás, P.; Clemetson, Kenneth J.; Nagy Jr, B. (2013). Distinct effects of Re- and S-forms of LPS on modulating platelet activation. Journal of thrombosis and haemostasis, 11(4), pp. 775-778. Blackwell 10.1111/jth.12151

2008

Clemetson, Kenneth J; Clemetson, Jeannine M (2008). Platelet GPIb complex as a target for anti-thrombotic drug development. Thrombosis and haemostasis, 99(3), pp. 473-9. Stuttgart: Schattauer 10.1160/TH07-12-0718

Li, Rui; Zhu, Shaowen; Wu, Jianbo; Wang, Wanyu; Lu, Qiumin; Clemetson, Kenneth J (2008). L-amino acid oxidase from Naja atra venom activates and binds to human platelets. Acta biochimica et biophysica Sinica - ABBS, 40(1), pp. 19-26. Shanghai: Inst. of Biochemistry and Cell Biology 10.1111/j.1745-7270.2008.00372.x

Hooley, Elizabeth; Papagrigoriou, Evangelos; Navdaev, Alexei; Pandey, Amit V; Clemetson, Jeannine M; Clemetson, Kenneth J; Emsley, Jonas (2008). The crystal structure of the platelet activator aggretin reveals a novel (alphabeta)2 dimeric structure. Biochemistry, 47(30), pp. 7831-7. Washington, D.C.: American Chemical Society 10.1021/bi800528t

2007

Clemetson, Kenneth John; Clemetson, Jeannine (2007). Platelet Receptors. In: Michelson, Alan D (ed.) Platelets, Second Edition (pp. 117-144). Fribourg: Elsevier

Clemetson, Kenneth J (2007). A short history of platelet glycoprotein Ib complex. Thrombosis and haemostasis, 98(1), pp. 63-8. Stuttgart: Schattauer 10.1160/TH07-05-0327

Thiele, Thomas; Steil, Leif; Gebhard, Simon; Scharf, Christian; Hammer, Elke; Brigulla, Matthias; Lubenow, Norbert; Clemetson, Kenneth J; Völker, Uwe; Greinacher, Andreas (2007). Profiling of alterations in platelet proteins during storage of platelet concentrates. Transfusion, 47(7), pp. 1221-33. Malden, Mass.: Wiley-Blackwell 10.1111/j.1537-2995.2007.01255.x

Clemetson, Kenneth J (2007). American Society of Hematology--48th Annual Meeting and Exposition. Updates on therapies. 9-12 December 2006 Orlando, FL, USA. IDrugs, 10(2), pp. 90-2. London: Thomson Scientific

Clemetson, Kenneth J; Lu, Qiumin; Clemetson, Jeannine M (2007). Snake venom proteins affecting platelets and their applications to anti-thrombotic research. Current pharmaceutical design, 13(28), pp. 2887-92. Hilversum: Bentham Science Publishers 10.2174/138161207782023702

Clemetson, Kenneth J; Clemetson, Jeannine M (2007). Collagen receptors as potential targets for novel anti-platelet agents. Current pharmaceutical design, 13(26), pp. 2673-83. Hilversum: Bentham Science Publishers 10.2174/138161207781662894

2006

Clemetson, Kenneth John; Lu, Qiumin; Clemetson, Jeannine (2006). Snake C-type lectin-like proteins and platelet receptors. Pathophysiology of Haemostasis and Thrombosis, 34(4-5), pp. 150-155. Karger 10.1159/000092414

2005

Solum, NO; Clemetson, KJ (2005). The discovery and characterization of platelet GPIb. Journal of thrombosis and haemostasis, 3(6), pp. 1125-32. Oxford: Blackwell 10.1111/j.1538-7836.2005.01072.x

Alberio, L; Clemetson, KJ (2005). [Platelet inhibition and activation. Mechanisms and clinical implications.]. Herz, 30(3), pp. 176-80. München: Springer-Medizin-Verlag 10.1007/s00059-005-2681-x

Bettex-Galland, M; Clemetson, KJ (2005). First isolation of actomyosin from a non-muscle cell: first isolated platelet protein. Journal of thrombosis and haemostasis, 3(5), pp. 834-9. Oxford: Blackwell 10.1111/j.1538-7836.2005.01261.x

Stephens, G; Yan, Y; Jandrot-Perrus, M; Villeval, JL; Clemetson, KJ; Phillips, DR (2005). Platelet activation induces metalloproteinase-dependent GP VI cleavage to down-regulate platelet reactivity to collagen. Blood, 105(1), pp. 186-91. Washington, D.C.: American Society of Hematology 10.1182/blood-2004-07-2842

Liang, HP; Morel-Kopp, MC; Clemetson, JM; Clemetson, KJ; Kekomaki, R; Kroll, H; Michaelides, K; Tuddenham, EG; Vanhoorelbeke, K; Ward, CM (2005). A common ancestral glycoprotein (GP) 9 1828A>G (Asn45Ser) gene mutation occurring in European families from Australia and Northern Europe with Bernard-Soulier Syndrome (BSS). Thrombosis and haemostasis, 94(3), pp. 599-605. Stuttgart: Schattauer 10.1160/TH05-03-0165

Lu, Q; Clemetson, JM; Clemetson, KJ (2005). Translocation of GPIb and Fc receptor gamma-chain to cytoskeleton in mucetin-activated platelets. Journal of thrombosis and haemostasis, 3(9), pp. 2065-76. Oxford: Blackwell 10.1111/j.1538-7836.2005.01481.x

Lu, Q; Clemetson, JM; Clemetson, KJ (2005). Snake venoms and hemostasis. Journal of thrombosis and haemostasis, 3(8), pp. 1791-9. Oxford: Blackwell 10.1111/j.1538-7836.2005.01358.x

Lu, Q; Navdaev, A; Clemetson, JM; Clemetson, KJ (2005). Snake venom C-type lectins interacting with platelet receptors. Structure-function relationships and effects on haemostasis. Toxicon, 45(8), pp. 1089-98. Oxford: Elsevier 10.1016/j.toxicon.2005.02.022

2004

Alberio, LJ; Clemetson, KJ (2004). All platelets are not equal: COAT platelets. Current hematology reports, 3(5), pp. 338-43. Philadelphia, Pa.: Current Science

Clemetson, KJ; Clemetson, JM (2004). Platelet receptor signalling. Hematology journal, 3(5), S159-63. Basingstoke, UK: Nature Publishing Group 10.1038/sj.thj.6200444

Lu, Qiumin; Navdaev, Alexei; Clemetson, Jeannine; Clemetson, Kenneth John (2004). GPIb is involved in platelet aggregation induced by mucetin, a snake C-type lectin protein from Chinese habu (Trimeresurus mucrosquamatus) venom. Thrombosis and haemostasis, 91(6), pp. 1168-1176. Stuttgart: Schattauer 10.1160/TH03-12-0747

2003

Lee, WH; Du, XY; Lu, QM; Clemetson, KJ; Zhang, Y (2003). Stejnulxin, a novel snake C-type lectin-like protein from Trimeresurus stejnegeri venom is a potent platelet agonist acting specifically via GPVI. Thrombosis and haemostasis, 90(4), pp. 662-71. Stuttgart: Schattauer 10.1160/TH03-05-0269

Chavakis, T; Santoso, S; Clemetson, KJ; Sachs, UJ; Isordia-Salas, I; Pixley, RA; Nawroth, PP; Colman, RW; Preissner, KT (2003). High molecular weight kininogen regulates platelet-leukocyte interactions by bridging Mac-1 and glycoprotein Ib. Journal of biological chemistry, 46(278), pp. 45375-81. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M304344200

Jurk, K; Clemetson, KJ; de Groot, PG; Brodde, MF; Steiner, M; Savion, N; Varon, D; Sixma, JJ; Van Aken, H; Kehrel, BE (2003). Thrombospondin-1 mediates platelet adhesion at high shear via glycoprotein Ib (GPIb): an alternative/backup mechanism to von Willebrand factor. FASEB journal, 11(17), pp. 1490-2. Bethesda, Md.: Federation of American Societies for Experimental Biology 10.1096/fj.02-0830fje

Clemetson, KJ (2003). Platelet receptors and their role in diseases. Clinical chemistry and laboratory medicine, 3(41), pp. 253-60. Berlin: De Gruyter 10.1515/CCLM.2003.039

2002

Alberio, L; Friese, P; Clemetson, KJ; Dale, GL (2002). Collagen response and glycoprotein VI function decline progressively as canine platelets age in vivo. Thrombosis and haemostasis, 88(3), pp. 510-6. Stuttgart: Schattauer

Navdaev, A; Clemetson, KJ (2002). Glycoprotein Ib cross-linking/ligation on echicetin-coated surfaces or echicetin-IgMkappa in stirred suspension activates platelets by cytoskeleton modulated calcium release. Journal of biological chemistry, 48(277), pp. 45928-34. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M206129200

Du, XY; Clemetson, KJ (2002). Snake venom L-amino acid oxidases. Toxicon, 40(6), pp. 659-65. Oxford: Elsevier 10.1016/S0041-0101(02)00102-2

Du, Xiao-Yan; Magnenat, E; Wells, TN; Clemetson, KJ (2002). Alboluxin, a snake C-type lectin from Trimeresurus albolabris venom is a potent platelet agonist acting via GPIb and GPVI. Thrombosis and haemostasis, 87(4), pp. 692-8. Stuttgart: Schattauer

Dale, GL; Friese, P; Batar, P; Hamilton, SF; Reed, GL; Jackson, KW; Clemetson, KJ; Alberio, L (2002). Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface. Nature, 6868(415), pp. 175-9. London: Macmillan Journals Ltd. 10.1038/415175a

Du, XY; Clemetson, JM; Navdaev, A; Magnenat, EM; Wells, TN; Clemetson, KJ (2002). Ophioluxin, a convulxin-like C-type lectin from Ophiophagus hannah (King cobra) is a powerful platelet activator via glycoprotein VI. Journal of biological chemistry, 38(277), pp. 35124-32. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M204372200

Uff, S; Clemetson, JM; Harrison, T; Clemetson, KJ; Emsley, J (2002). Crystal structure of the platelet glycoprotein Ib(alpha) N-terminal domain reveals an unmasking mechanism for receptor activation. Journal of biological chemistry, 38(277), pp. 35657-63. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M205271200

2001

Boehlen, F; Clemetson, KJ (2001). Platelet chemokines and their receptors: what is their relevance to platelet storage and transfusion practice? Transfusion medicine, 11(6), pp. 403-17. Oxford: Blackwell Scientific Publications 10.1046/j.1365-3148.2001.00340.x

Clemetson, KJ (2001). Platelet receptors for adhesion and activation. Variability as a factor in susceptibility to cardiovascular diseases. Italian heart journal, 2(11), pp. 816-8. Roma: Centro Editoriale Pubblicitario Italiano CEPI

Clemetson, KJ (2001). Platelet glycoproteins and their role in diseases. Transfusion clinique et biologique, 8(3), pp. 155-62. Paris: Elsevier Masson SAS 10.1016/S1246-7820(01)00184-7

Du, XY; Navdaev, A; Clemetson, JM; Magnenat, E; Wells, TN; Clemetson, KJ (2001). Bilinexin, a snake C-type lectin from Agkistrodon bilineatus venom agglutinates platelets via GPIb and alpha2beta1. Thrombosis and haemostasis, 86(5), pp. 1277-83. Stuttgart: Schattauer

Furihata, K; Clemetson, KJ; Deguchi, H; Kunicki, TJ (2001). Variation in human platelet glycoprotein VI content modulates glycoprotein VI-specific prothrombinase activity. Arteriosclerosis, thrombosis, and vascular biology, 21(11), pp. 1857-63. Philadelphia, Pa.: Lippincott Williams & Wilkins 10.1161/hq1001.096643

Clemetson, KJ; Clemetson, JM (2001). Platelet collagen receptors. Thrombosis and haemostasis, 86(1), pp. 189-97. Stuttgart: Schattauer

Navdaev, A; Dörmann, D; Clemetson, JM; Clemetson, KJ (2001). Echicetin, a GPIb-binding snake C-type lectin from Echis carinatus, also contains a binding site for IgMkappa responsible for platelet agglutination in plasma and inducing signal transduction. Blood, 97(8), pp. 2333-41. Washington, D.C.: American Society of Hematology 10.1182/blood.V97.8.2333

Navdaev, A; Clemetson, JM; Polgar, J; Kehrel, BE; Glauner, M; Magnenat, E; Wells, TN; Clemetson, KJ (2001). Aggretin, a heterodimeric C-type lectin from Calloselasma rhodostoma (malayan pit viper), stimulates platelets by binding to alpha 2beta 1 integrin and glycoprotein Ib, activating Syk and phospholipase Cgamma 2, but does not involve the glycoprotein VI/Fc receptor gamma chain collagen receptor. Journal of biological chemistry, 24(276), pp. 20882-9. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M101585200

Dörmann, D; Clemetson, JM; Navdaev, A; Kehrel, BE; Clemetson, KJ (2001). Alboaggregin A activates platelets by a mechanism involving glycoprotein VI as well as glycoprotein Ib. Blood, 97(4), pp. 929-36. Washington, D.C.: American Society of Hematology 10.1182/blood.V97.4.929

2000

Clemetson, KJ (2000). Vascular biology--XIth International Meeting. 5-9 September 2000, Geneva, Switzerland. IDrugs, 3(11), pp. 1307-11. London: Thomson Scientific

Dörmann, D; Clemetson, KJ; Kehrel, BE (2000). The GPIb thrombin-binding site is essential for thrombin-induced platelet procoagulant activity. Blood, 96(7), pp. 2469-78. Washington, D.C.: American Society of Hematology

Alberio, L; Safa, O; Clemetson, KJ; Esmon, CT; Dale, GL (2000). Surface expression and functional characterization of alpha-granule factor V in human platelets: effects of ionophore A23187, thrombin, collagen, and convulxin. Blood, 95(5), pp. 1694-702. Washington, D.C.: American Society of Hematology

Clemetson, KJ; Clemetson, JM; Proudfoot, AE; Power, CA; Baggiolini, M; Wells, TN (2000). Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets. Blood, 96(13), pp. 4046-54. Washington, D.C.: American Society of Hematology

1999

Ruan, J; Schmugge, M; Clemetson, KJ; Cazes, E; Combrie, R; Bourre, F; Nurden, AT (1999). Homozygous Cys542-->Arg substitution in GPIIIa in a Swiss patient with type I Glanzmann's thrombasthenia. British journal of haematology, 2(105), pp. 523-31. Oxford: Wiley-Blackwell 10.1111/j.1365-2141.1999.01376.x

Jandrot-Perrus, M; Clemetson, KJ; Guillin, MC; Bouton, MC (1999). Binding of heparin to platelet membrane glycoprotein Ib: functional effects. Thrombosis and haemostasis, 81(2), pp. 316-7. Stuttgart: Schattauer

Clemetson, KJ (1999). Primary haemostasis: sticky fingers cement the relationship. Current Biology, 3(9), R110-2. Cambridge, Mass.: Cell Press 10.1016/S0960-9822(99)80063-3

Clemetson, JM; Polgar, J; Magnenat, E; Wells, TN; Clemetson, KJ (1999). The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors. Journal of biological chemistry, 41(274), pp. 29019-24. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.274.41.29019

Clemetson, KJ (1999). Platelet collagen receptors: a new target for inhibition? Haemostasis, 29(1), pp. 16-26. Basel: Karger

1998

Polgár, J; Magnenat, E; Wells, TN; Clemetson, KJ (1998). Platelet glycoprotein Ia* is the processed form of multimerin--isolation and determination of N-terminal sequences of stored and released forms. Thrombosis and haemostasis, 80(4), pp. 645-8. Stuttgart: Schattauer

Schmitz, G; Rothe, G; Ruf, A; Barlage, S; Tschöpe, D; Clemetson, KJ; Goodall, AH; Michelson, AD; Nurden, AT; Shankey, TV (1998). European Working Group on Clinical Cell Analysis: Consensus protocol for the flow cytometric characterisation of platelet function. Thrombosis and haemostasis, 79(5), pp. 885-96. Stuttgart: Schattauer

Polgár, J; Eichler, P; Greinacher, A; Clemetson, KJ (1998). Adenosine diphosphate (ADP) and ADP receptor play a major role in platelet activation/aggregation induced by sera from heparin-induced thrombocytopenia patients. Blood, 91(2), pp. 549-54. Washington, D.C.: American Society of Hematology

Kehrel, B; Wierwille, S; Clemetson, KJ; Anders, O; Steiner, M; Knight, CG; Farndale, RW; Okuma, M; Barnes, MJ (1998). Glycoprotein VI is a major collagen receptor for platelet activation: it recognizes the platelet-activating quaternary structure of collagen, whereas CD36, glycoprotein IIb/IIIa, and von Willebrand factor do not. Blood, 91(2), pp. 491-9. Washington, D.C.: American Society of Hematology

Clemetson, KJ; Polgár, J; Clemetson, JM (1998). Snake venom C-type lectins as tools in platelet research. Platelets, 9(3-4), pp. 165-9. London: Informa Healthcare 10.1080/09537109876636

Clemetson, KJ; Clemetson, JM (1998). Integrins and cardiovascular disease. Cellular and molecular life sciences, 6(54), pp. 502-13. Basel: Springer 10.1007/s000180050179

1997

Polgár, J; Kramer, RM; Um, SL; Jakubowski, JA; Clemetson, KJ (1997). Human group II 14 kDa phospholipase A2 activates human platelets. Biochemical journal, 327(Pt 1), pp. 259-65. London: Portland Press

Clemetson, KJ (1997). Platelet GPIb-V-IX complex. Thrombosis and haemostasis, 78(1), pp. 266-70. Stuttgart: Schattauer

Polgár, J; Magnenat, EM; Peitsch, MC; Wells, TN; Saqi, MS; Clemetson, KJ (1997). Amino acid sequence of the alpha subunit and computer modelling of the alpha and beta subunits of echicetin from the venom of Echis carinatus (saw-scaled viper). Biochemical journal, 323(Pt 2), pp. 533-7. London: Portland Press

Polgár, J; Clemetson, JM; Kehrel, BE; Wiedemann, M; Magnenat, EM; Wells, TN; Clemetson, KJ (1997). Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor. Journal of biological chemistry, 21(272), pp. 13576-83. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.272.21.13576

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