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Schön, Jacob; Barut, G Tuba; Trüeb, Bettina Salome; Halwe, Nico Joel; Berenguer Veiga, Inês; Kratzel, Annika; Ulrich, Lorenz; Kelly, Jenna N; Brügger, Melanie; Wylezich, Claudia; Taddeo, Adriano; Aguiar Moreira, Etori; Túrós, Demeter; Grau-Roma, Llorenç; Ahrens, Ann Kathrin; Schlottau, Kore; Britzke, Tobias; Breithaupt, Angele; Corleis, Björn; Kochmann, Jana; ... (2024). A safe, effective and adaptable live-attenuated SARS-CoV-2 vaccine to reduce disease and transmission using one-to-stop genome modifications. Nature microbiology, 9(8), pp. 2099-2112. Springer Nature 10.1038/s41564-024-01755-1
Leborgne, Nathan GF; Devisme, Christelle; Kozarac, Nedim; Berenguer Veiga, Inês; Ebert, Nadine; Godel, Aurélie; Grau Roma, Llorenç; Scherer, Melanie; Plattet, Philippe; Thiel, Volker; Zimmer, Gert; Taddeo, Adriano; Benarafa, Charaf (2024). Neutrophil proteases are protective against SARS-CoV-2 by degrading the spike protein and dampening virus-mediated inflammation. JCI insight, 9(7) JCI Insight 10.1172/jci.insight.174133
Schmied, Kimberly; Ehmann, Rosina; Kristen-Burmann, Claudia; Ebert, Nadine; Barut, Güliz Tuba; Almeida, Lea; Kelly, Jenna N; Thomann, Lisa; Stalder, Hanspeter; Lang, Reto; Tekes, Gergely; Thiel, Volker (2024). An RNA replicon system to investigate promising inhibitors of feline coronavirus. Journal of virology, 98(2), e0121623. American Society for Microbiology 10.1128/jvi.01216-23
Kristen-Burmann, Claudia; Rogger, Peter; Berenguer Veiga, Inês; Riebesehl, Stefanie; Rappe, Julie; Ebert, Nadine; Sautter, Carmen A; Kelly, Jenna N; Stalder, Hanspeter; Ehmann, Rosina; Huber, Michael; Posthaus, Horst; Ruggli, Nicolas; Thiel, Volker; Tekes, Gergely (2023). Reverse Genetic Assessment of the Roles Played by the Spike Protein and ORF3 in Porcine Epidemic Diarrhea Virus Pathogenicity. Journal of virology, 97(7), e0196422. American Society for Microbiology 10.1128/jvi.01964-22
Jochmans, Dirk; Liu, Cheng; Donckers, Kim; Stoycheva, Antitsa; Boland, Sandro; Stevens, Sarah K; De Vita, Chloe; Vanmechelen, Bert; Maes, Piet; Trüeb, Bettina; Ebert, Nadine; Thiel, Volker; De Jonghe, Steven; Vangeel, Laura; Bardiot, Dorothée; Jekle, Andreas; Blatt, Lawrence M; Beigelman, Leonid; Symons, Julian A; Raboisson, Pierre; ... (2023). The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir. mBio, 14(1), e0281522. American Society for Microbiology 10.1128/mbio.02815-22
Beer, Julius; Crotta, Stefania; Breithaupt, Angele; Ohnemus, Annette; Becker, Jan; Sachs, Benedikt; Kern, Lisa; Llorian, Miriam; Ebert, Nadine; Labroussaa, Fabien; Nhu Thao, Tran Thi; Trueeb, Bettina Salome; Jores, Joerg; Thiel, Volker; Beer, Martin; Fuchs, Jonas; Kochs, Georg; Wack, Andreas; Schwemmle, Martin and Schnepf, Daniel (2022). Impaired immune response drives age-dependent severity of COVID-19. The Journal of experimental medicine, 219(12) Rockefeller Univ. Press 10.1084/jem.20220621
Barut, G Tuba; Halwe, Nico Joel; Taddeo, Adriano; Kelly, Jenna N; Schön, Jacob; Ebert, Nadine; Ulrich, Lorenz; Devisme, Christelle; Steiner, Silvio; Trüeb, Bettina Salome; Hoffmann, Bernd; Berenguer Veiga, Inês; Leborgne, Nathan Georges François; Aguiar Moreira, Etori; Breithaupt, Angele; Wylezich, Claudia; Höper, Dirk; Wernike, Kerstin; Godel, Aurélie; Thomann, Lisa; ... (2022). The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype. Nature Communications, 13(1), p. 5929. Springer Nature 10.1038/s41467-022-33632-y
Gultom, Mitra; Kratzel, Annika; Portmann, Jasmine; Stalder, Hanspeter; Chanfon Bätzner, Astrid; Gantenbein, Hans; Gurtner, Corinne; Ebert, Nadine; Gad, Hans Henrik; Hartmann, Rune; Posthaus, Horst; Zanolari, Patrik; Pfaender, Stephanie; Thiel, Volker Earl; Dijkman, Ronald (2022). Establishment of well-differentiated camelid airway cultures to study Middle East respiratory syndrome coronavirus. Scientific reports, 12(1), p. 10340. Springer Nature 10.1038/s41598-022-13777-y
Wyss, Marianne; Gradauskaite, Vaiva; Ebert, Nadine; Thiel, Volker; Zurbriggen, Andreas; Plattet, Philippe (2022). Efficient Recovery of Attenuated Canine Distemper Virus from cDNA. Virus research, 316, p. 198796. Elsevier 10.1016/j.virusres.2022.198796
Pan, Ruangang; Kindler, Eveline; Cao, Liu; Zhou, Yu; Zhang, Zhen; Liu, Qianyun; Ebert, Nadine; Züst, Roland; Sun, Ying; Gorbalenya, Alexander E.; Perlman, Stanley; Thiel, Volker; Chen, Yu; Guo, Deyin; Britton, Paul; Schultz-Cherry, Stacey (2022). N7-Methylation of the Coronavirus RNA Cap Is Required for Maximal Virulence by Preventing Innate Immune Recognition. mBio, 13(1), e0366221. American Society for Microbiology 10.1128/mbio.03662-21
Barut, Tuba; Halwe, Nico Joel; Taddeo, Adriano; Kelly, Jenna N.; Schön, Jacob; Ebert, Nadine; Ulrich, Lorenz; Devisme, Christelle; Steiner, Silvio; Trüeb, Bettina Salome; Hoffmann, Bernd; Berenguer Veiga, Inês; Leborgne, Nathan Georges François; Aguiar Moreira, Etori; Breithaupt, Angele; Wylezich, Claudia; Höper, Dirk; Wernike, Kerstin; Godel, Aurélie; Thomann, Lisa; ... (2022). The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA. 1 phenotype (bioRxiv). Cold Spring Harbor Laboratory
Ulrich, Lorenz; Halwe, Nico Joel; Taddeo, Adriano; Ebert, Nadine; Schön, Jacob; Devisme, Christelle; Trüeb, Bettina Salome; Hoffmann, Bernd; Wider, Manon; Fan, Xiaoyu; Bekliz, Meriem; Essaidi-Laziosi, Manel; Schmidt, Marie Luisa; Niemeyer, Daniela; Corman, Victor Max; Kraft, Anna; Godel, Aurélie; Laloli, Laura; Kelly, Jenna N; Calderon, Brenda M; ... (2022). Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta. Nature, 602(7896), pp. 307-313. Springer Nature 10.1038/s41586-021-04342-0
Kratzel, Annika; Kelly, Jenna N; V'kovski, Philip; Portmann, Jasmine; Brüggemann, Yannick; Todt, Daniel; Ebert, Nadine; Shrestha, Neeta; Plattet, Philippe; Staab-Weijnitz, Claudia A; von Brunn, Albrecht; Steinmann, Eike; Dijkman, Ronald; Zimmer, Gert; Pfaender, Stephanie; Thiel, Volker (2021). A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets. PLoS biology, 19(12), e3001490. Public Library of Science 10.1371/journal.pbio.3001490
Trimpert, Jakob; Adler, Julia M; Eschke, Kathrin; Abdelgawad, Azza; Firsching, Theresa C; Ebert, Nadine; Tran, Thi Nhu Thao; Gruber, Achim D; Thiel, Volker; Osterrieder, Nikolaus; Kunec, Dusan (2021). Live attenuated virus vaccine protects against SARS-CoV-2 variants of concern B.1.1.7 (Alpha) and B.1.351 (Beta). Science Advances, 7(49), eabk0172. American Association for the Advancement of Science 10.1126/sciadv.abk0172
Ricardo-Lax, Inna; Luna, Joseph M; Tran, Thi Nhu Thao; Le Pen, Jérémie; Yu, Yingpu; Hoffmann, H-Heinrich; Schneider, William M; Razooky, Brandon S; Fernandez-Martinez, Javier; Schmidt, Fabian; Weisblum, Yiska; Trüeb, Bettina Salome; Berenguer Veiga, Inês; Schmied, Kimberly; Ebert, Nadine; Michailidis, Eleftherios; Peace, Avery; Sánchez-Rivera, Francisco J; Lowe, Scott W; Rout, Michael P; ... (2021). Replication and single-cycle delivery of SARS-CoV-2 replicons. Science, 374(6571), pp. 1099-1106. American Association for the Advancement of Science 10.1126/science.abj8430
Trimpert, Jakob; Dietert, Kristina; Firsching, Theresa C; Ebert, Nadine; Tran, Thi Nhu Thao; Vladimirova, Daria; Kaufer, Susanne; Labroussaa, Fabien; Abdelgawad, Azza; Conradie, Andelé; Höfler, Thomas; Adler, Julia M; Bertzbach, Luca D; Jores, Jörg; Gruber, Achim D; Thiel, Volker; Osterrieder, Nikolaus; Kunec, Dusan (2021). Development of safe and highly protective live-attenuated SARS-CoV-2 vaccine candidates by genome recoding. Cell reports, 36(5), p. 109493. Cell Press 10.1016/j.celrep.2021.109493
Gultom, Mitra; Licheri, Matthias; Laloli, Laura; Wider, Manon; Strässle, Marina; V'kovski, Philip; Steiner, Silvio; Kratzel, Annika; Tran, Thi Nhu Thao; Probst, Lukas; Stalder, Hanspeter; Portmann, Jasmine; Holwerda, Melle; Ebert, Nadine; Stokar-Regenscheit, Nadine; Gurtner, Corinne; Zanolari, Patrik; Posthaus, Horst; Schuller, Simone; Vicente-Santos, Amanda; ... (2021). Susceptibility of Well-Differentiated Airway Epithelial Cell Cultures from Domestic and Wild Animals to Severe Acute Respiratory Syndrome Coronavirus 2. Emerging infectious diseases, 27(7), pp. 1811-1820. Centers for Disease Control and Prevention 10.3201/eid2707.204660
Strässle, Marina; Laloli, Laura; Gultom, Mitra; V'kovski, Philip; Stoffel, Michael H.; Crespo Pomar, Silvia; Chanfon Bätzner, Astrid; Ebert, Nadine; Labroussaa, Fabien; Dijkman, Ronald; Jores, Joerg; Thiel, Volker (2021). Establishment of caprine airway epithelial cells grown in an air-liquid interface system to study caprine respiratory viruses and bacteria. Veterinary microbiology, 257, p. 109067. Elsevier 10.1016/j.vetmic.2021.109067
V'kovski, Philip; Gultom, Mitra; Kelly, Jenna N.; Steiner, Silvio; Russeil, Julie; Mangeat, Bastien; Cora, Elisa; Pezoldt, Joern; Holwerda, Melle; Kratzel, Annika; Laloli, Laura; Wider, Manon; Portmann, Jasmine; Tran, Thao; Ebert, Nadine; Stalder, Hanspeter; Hartmann, Rune; Gardeux, Vincent; Alpern, Daniel; Deplancke, Bart; ... (2021). Disparate temperature-dependent virus-host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium. PLoS biology, 19(3), e3001158. Public Library of Science 10.1371/journal.pbio.3001158
Zhou, Bin; Tran, Thi Nhu Thao; Hoffmann, Donata; Taddeo, Adriano; Ebert, Nadine; Labroussaa, Fabien; Pohlmann, Anne; King, Jacqueline; Steiner, Silvio; Kelly, Jenna N.; Portmann, Jasmine; Halwe, Nico Joel; Ulrich, Lorenz; Trüeb, Bettina Salome; Fan, Xiaoyu; Hoffmann, Bernd; Wang, Li; Thomann, Lisa; Lin, Xudong; Stalder, Hanspeter; ... (2021). SARS-CoV-2 spike D614G change enhances replication and transmission. Nature, 592(7852), pp. 122-127. Springer Nature 10.1038/s41586-021-03361-1
Pfaender, Stephanie; Mar, Katrina B; Michailidis, Eleftherios; Kratzel, Annika; Boys, Ian N; V'kovski, Philip; Fan, Wenchun; Kelly, Jenna N.; Hirt, Dagny; Ebert, Nadine; Stalder, Hanspeter; Kleine-Weber, Hannah; Hoffmann, Markus; Heinrich Hoffmann, H; Saeed, Mohsan; Dijkman, Ronald; Steinmann, Eike; Wight-Carter, Mary; McDougal, Matthew B; Hanners, Natasha W; ... (2020). LY6E impairs coronavirus fusion and confers immune control of viral disease. Nature microbiology, 5(11), pp. 1330-1339. Springer Nature 10.1038/s41564-020-0769-y
Kratzel, Annika; Todt, Daniel; V'kovski, Philip; Steiner, Silvio; Gultom, Mitra; Tran, Thi Nhu Thao; Ebert, Nadine; Holwerda, Melle; Steinmann, Jörg; Niemeyer, Daniela; Dijkman, Ronald; Kampf, Günter; Drosten, Christian; Steinmann, Eike; Thiel, Volker; Pfaender, Stephanie (2020). Inactivation of Severe Acute Respiratory Syndrome Coronavirus 2 by WHO-Recommended Hand Rub Formulations and Alcohols. Emerging infectious diseases, 26(7), pp. 1592-1595. Centers for Disease Control and Prevention 10.3201/eid2607.200915
Tran, Thi Nhu Thao; Labroussaa, Fabien; Ebert, Nadine; V'kovski, Philip; Stalder, Hanspeter; Portmann, Jasmine; Kelly, Jenna; Steiner, Silvio; Holwerda, Melle; Kratzel, Annika; Gultom, Mitra; Schmied, Kimberly; Laloli, Laura; Hüsser, Linda; Wider, Manon; Pfaender, Stephanie; Hirt, Dagny; Cippà, Valentina; Crespo-Pomar, Silvia; Schröder, Simon; ... (2020). Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform. Nature, 582(7813), pp. 561-565. Springer Nature 10.1038/s41586-020-2294-9
Tran, Thi Nhu Thao; Labroussaa, Fabien; Ebert, Nadine; Jores, Jörg; Thiel, Volker (2020). In-Yeast Assembly of Coronavirus Infectious cDNA Clones Using a Synthetic Genomics Pipeline. Methods in molecular biology, 2203, pp. 167-184. Springer 10.1007/978-1-0716-0900-2_13
V'kovski, Philip; Gerber, Markus; Kelly, Jenna Nicole; Pfänder, Stephanie; Ebert, Nadine; Braga Lagache, Sophie; Simillion, Cedric; Portmann, Jasmine; Stalder, Hanspeter; Gaschen, Véronique; Bruggmann, Rémy; Stoffel, Michael Hubert; Heller, Manfred; Dijkman, Ronald; Thiel, Volker Earl (2019). Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling. eLife, 8 eLife Sciences Publications 10.7554/eLife.42037
Kalbermatter, David; Shrestha, Neeta; Ebert, Nadine; Herren, Michael; Moll, Pascal Dominique; Plemper, Richard K; Altmann, Karl-Heinz; Langedijk, Johannes P; Gall, Flavio; Lindenmann, Urs; Riedl, Rainer; Fotiadis, Dimitrios José; Plattet, Philippe (2019). Primary resistance mechanism of the canine distemper virus fusion protein against a small-molecule membrane fusion inhibitor. Virus research, 259, pp. 28-37. Elsevier 10.1016/j.virusres.2018.10.003
Garcia Nicolas, Obdulio; V'kovski, Philip; Vielle, Nathalie J.; Ebert, Nadine; Züst, R; Portmann, Jasmine; Stalder, Hanspeter; Gaschen, Véronique; Vieyres, G; Stoffel, Michael; Schweizer, Matthias; Summerfield, Artur; Engler, O; Pietschmann, T; Todt, D; Alves, Marco; Thiel, Volker; Pfänder, Stephanie (2018). The small compound inhibitor K22 displays broad antiviral activity against different members of the family Flaviviridae and offers potential as pan-viral inhibitor. Antimicrobial agents and chemotherapy, 62(11) American Society for Microbiology 10.1128/AAC.01206-18
V'kovski, Philip; Gerber, M; Kelly, Jenna Nicole; Pfänder, Stephanie; Ebert, Nadine; Braga, Sophie Marie-Pierre; Simillion, Cedric André Marie; Portmann, Jasmine; Stalder, Hanspeter; Gaschen, Véronique; Bruggmann, Rémy; Stoffel, Michael Hubert; Heller, Manfred; Dijkman, Ronald; Thiel, Volker Earl (14 September 2018). Determination of host cell proteins constituting the molecular microenvironment of coronavirus replicase complexes by proximity-labeling (bioRxiv). Cold Spring Harbor Laboratory 10.1101/417907
Pfänder, Stephanie; Vielle, Nathalie Jane; Ebert, Nadine; Steinmann, E; Alves, Marco; Thiel, Volker Earl (2017). Inactivation of Zika virus in human breast milk by prolonged storage or pasteurization. Virus research, 228, pp. 58-60. Elsevier 10.1016/j.virusres.2016.11.025
Ader-Ebert, Nadine; Khosravi, Mojtaba; Herren, Michael; Avila Sanchez, Mislay; Alves, Lisa; Bringolf, Fanny Anne; Örvell, Claes; Langedijk, Johannes P; Zurbriggen, Andreas; Plemper, Richard K; Plattet, Philippe (2015). Sequential conformational changes in the morbillivirus attachment protein initiate the membrane fusion process. PLoS pathogens, 11(5), e1004880. Public Library of Science 10.1371/journal.ppat.1004880
Cardoso Alves, Lisa Alexandra; Khosravi, Mojtaba; Avila Sanchez, Mislay; Ader-Ebert, Nadine; Bringolf, Fanny Anne; Zurbriggen, Andreas; Vandevelde, Marc; Plattet, Philippe (2015). SLAM- and nectin-4-independent noncytolytic spread of canine distemper virus in astrocytes. Journal of virology, 89(10), pp. 5724-5733. American Society for Microbiology 10.1128/JVI.00004-15
Sattler, Ursula; Khosravi, Mojtaba; Avila Sanchez, Mislay; Pilo, Paola; Langedijk, Johannes P; Ader-Ebert, Nadine; Alves, Lisa Alexandra; Plattet, Philippe; Origgi, Francesco C (2014). Identification of amino acid substitutions with compensational effects in the attachment protein of canine distemper virus. Journal of virology, 88(14), pp. 8057-8064. American Society for Microbiology 10.1128/JVI.00454-14
Avila, Mislay; Alves, Lisa; Khosravi, Mojtaba; Ader-Ebert, Nadine; Origgi, Francesco; Schneider-Schaulies, J.; Zurbriggen, Andreas; Plemper, R. K.; Plattet, Philippe; Lyles, D. S. (2014). Molecular Determinants Defining the Triggering Range of Prefusion F Complexes of Canine Distemper Virus. Journal of virology, 88(5), pp. 2951-2966. American Society for Microbiology 10.1128/JVI.03123-13
Ader, Nadine; Brindley, Melinda; Avila, Mislay; Örvell, Claes; Horvat, Branka; Hiltensperger, Georg; Schneider-Schaulies, Jürgen; Vandevelde, Marc; Zurbriggen, Andreas; Plemper, Richard K.; Plattet, Philippe (2013). Mechanism for active membrane fusion triggering by morbillivirus attachment protein. Journal of virology, 87(1), pp. 314-326. American Society for Microbiology 10.1128/JVI.01826-12
Ader, Nadine; Brindley, M. A.; Avila, Mislay; Origgi, Francesco; Langedijk, J. P.; Orvell, C.; Vandevelde, Marc; Zurbriggen, Andreas; Plemper, R. K.; Plattet, Philippe (2012). Structural rearrangements of the central region of the morbillivirus attachment protein stalk domain trigger F protein refolding for membrane fusion. Journal of biological chemistry, 287(20), pp. 16324-34. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M112.342493
