Seebeck, Thomas

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Kuhn-Nentwig, Lucia; Fedorova, Irina M; Lüscher, Benjamin P; Kopp, Lukas; Trachsel, Christian; Schaller, Johann; Vu Nguyen, Xuan Lan; Seebeck, Thomas; Streitberger, Kathrin; Nentwig, Wolfgang; Sigel, Erwin; Magazanik, Lev G (2012). A venom-derived neurotoxin, CsTx-1, from the spider Cupiennius salei exhibits cytolytic activities. Journal of biological chemistry, 287(30), pp. 25640-25649. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M112.339051

de Koning, H.; Gould, M.; Sterk, G.J.; Tenor, H.; Kunz, S.; Luginbuehl, E.; Seebeck, T. (2012). Pharmacological Validation of Trypanosoma brucei Phosphodiesterases as Novel Drug Targets. Journal of infectious diseases, 206(2), pp. 229-237. Cary, N.C.: Oxford University Press 10.1093/infdis/jir857

Wang, H.; Kunz, S.; Chen, G.; Seebeck, T.; Wan, Y.; Robinson, H.; Martinelli, S.; Ke, H. (2012). Biological and Structural Characterization of Trypanosoma cruzi Phosphodiesterase C and Implications for Design of Parasite Selective Inhibitors. Journal of biological chemistry, 287(15), pp. 11788-11797. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M111.326777

Orrling, KM; Jansen, C; Vu, XL; Balmer, V; Bregy, P; Shanmugham, A; England, P; Bailey, D; Cos, P; Maes, L; Adams, E; van den Bogaart, E; Chatelain, E; Ioset, JR; van de Stolpe, A; Zorg, S; Veerman, J; Seebeck, T; Sterk, GJ; de Esch, IJ; ... (2012). Catechol pyrazolinones as trypanocidals: fragment-based design, synthesis, and pharmacological evaluation of nanomolar inhibitors of trypanosomal phosphodiesterase B1. Journal of medicinal chemistry, 55(20), pp. 8645-8756. Easton, Pa.: American Chemical Society 10.1021/jm301059b


Kuhn-Nentwig, Lucia; Willems, Jean; Seebeck, Thomas; Shalaby, Tarek; Kaiser, Marcel; Nentwig, Wolfgang (2011). Cupiennin 1a exhibits a remarkably broad, non-stereospecific cytolytic activity on bacteria, protozoan parasites, insects, and human cancer cells. Amino acids, 40(1), pp. 69-76. Wien: Springer Vienna 10.1007/s00726-009-0471-0


Cristodero, Marina; Seebeck, Thomas; Schneider, André (2010). Mitochondrial translation is essential in bloodstream forms of Trypanosoma brucei. Molecular microbiology, 78(3), pp. 757-769. Oxford: Blackwell Science 10.1111/j.1365-2958.2010.07368.x

Luginbuehl, Edith; Ryter, Damaris; Schranz-Zumkehr, Judith; Oberholzer, Michael; Kunz, Stefan; Seebeck, Thomas (2010). The N-terminus of phosphodiesterase TbrPDEB of Trypanosoma brucei contains the signal for integration into the flagellar skeleton. Eukaryotic cell, 9(10), pp. 1466-1475. Washington, D.C.: American Society for Microbiology ASM 10.1128/EC.00112-10


Seebeck, Thomas; Maeser, Pascal (2009). Drug Resistance in African Trypanosomiasis. In: Mayers, Douglas L. (ed.) Antimicrobial Drug Resistance. Infectious Disease: Vol. 2 (pp. 589-604). New York: Humana Press 10.1007/978-1-59745-180-2_42

Kunz, Stefan; Luginbühl, Edith; Seebeck, Thomas (2009). Gene Conversion Transfers the GAF-A Domain of Phosphodiesterase TbrPDEB1 to One Allele of TbrPDEB2 of Trypanosoma brucei. PLoS neglected tropical diseases, 3(6), e455. San Francisco, Calif.: Public Library of Science 10.1371/journal.pntd.0000455

Kunz, S.; Minca, M.; Luginbuehl, E.; Bregy, P.; Seebeck, T. (2009). Cyclic nucleotide signalling in the kinetoplastids. In: Bradshaw, Ralph A. (ed.) The Handbook of Cell Signaling (pp. 1543-1547). Fribourg: Academic Press

Seebeck, J.; Kiri, V.A. (2009). Some Practical Processes for Streamlining Post-Marketing Product Surveillance: A Synergistic Approach. Drug Safety, 32(10), p. 889.


Wentzingera, Laurent; Bopp, Selina; Tenorc, Hermann; Klarc, Juergen; Brun, Reto; Beck, Hans Peter; Seebeck, Thomas (2008). Cyclic nucleotide-specific phosphodiesterases of Plasmodium falciparum: PfPDE , a non-essential cGMP-specific PDE that is an integral membrane protein. International journal for parasitology, 38(14), pp. 1625-1637. Kidlington, UK: Elsevier 10.1016/j.ijpara.2008.05.016

Goulda, Matthew K.; Vu, Xuan Lan; Seebeck, Thomas; de Koning, Harry P. (2008). Propidium iodide-based methods for monitoring drug action in the kinetoplastidae: Comparison with the Alamar Blue assay. Analytical biochemistry, 382(2), pp. 87-93. San Diego, Calif.: Elsevier 10.1016/j.ab.2008.07.036


Oberholzer, Michael; Marti, Gabriela; Baresic, Mario; Kunz, Stefan; Hemphill, Andrew; Seebeck, Thomas (2007). The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence. FASEB journal, 21(3), pp. 720-731. Bethesda, Md.: Federation of American Societies for Experimental Biology 10.1096/fj.06-6818com

Oberholzer, Michael; Bregy, Patrick; Marti, Gabriela; Minca, Mihaela; Peier, Mihaela; Seebeck, Thomas (2007). Trypanosomes and mammalian sperm: one of a kind? Trends in parasitology, 23(2), pp. 71-7. Oxford: Elsevier Current Trends 10.1016/

Wang, Huanchen; Yan, Zier; Geng, Jie; Kunz, Stefan; Seebeck, Thomas; Ke, Hengming (2007). Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors. Molecular microbiology, 66(4), pp. 1029-38. Oxford: Blackwell Science 10.1111/j.1365-2958.2007.05976.x


Alibu, Vincent; Richter, Christina; Voncken, Frank; Marti, Gabriela; Shahi, Sanjay; Kunz Rengli, Christina; Seebeck, Thomas; Brun, Reto; Clayton, Christine (2006). The role of Trypanosoma brucei MRPA in melarsoprol susceptibility. Molecular and biochemical parasitology, 146(1), pp. 38-44. Amsterdam: Elsevier 10.1016/j.molbiopara.2005.10.016

Johner, Andrea; Kunz, Stefan; Linder, Markus; Shakur, Yasmin; Seebeck, Thomas (2006). Cyclic nucleotide specific phosphodiesterases of Leishmania major. BMC microbiology, 6(25), [1-13]. London: BioMed Central 10.1186/1471-2180-6-25

Wedekind, Claus; Seebeck, Thomas; Bettens, Florence; Paepke, Alexander (2006). The intensity of human body odours and the MHC - should we expect a link ? Evolutionary psychology, 4, pp. 85-94. Cleckheaton: The Human Nature Review

Wentzinger, Laurent; Seebeck, Thomas (2006). Protozoal phosphodiesterases. In: Beavo, Joseph A.; Francis, Sharron H.; Houslay, Miles D. (eds.) Cyclic Nucleotide Phosphodiesterases in Health and Disease (pp. 277-300). Boca Raton: CRC Press


Imboden, M.; Müller, N.; Hemphill, A.; Mattioli, R.; Seebeck, T. (1995). Repetitive proteins from the flagellar cytoskeleton of African trypanosomes are diagnostically useful antigens. Parasitology, 110(3), pp. 249-258. Cambridge University Press 10.1017/S0031182000080835


Müller, N.; Imboden, M.; Detmer, E.; Mansfield, J. M.; Seebeck, T. (1993). Cytoskeleton-associated antigens from African trypanosomes are recognized by self-reactive antibodies of uninfected mice. Parasitology, 107(4), pp. 411-417. Cambridge University Press 10.1017/S0031182000067767


Müller, N.; Hemphill, A.; Imboden, M.; Duvallet, G.; Dwinger, R. H.; Seebeck, T. (1992). Identification and characterization of two repetitive non-variable antigens from African trypanosomes which are recognized early during infection. Parasitology, 104(1), pp. 111-120. Cambridge University Press 10.1017/S0031182000060856


Vogel, Monique; Müller, Norbert; Gottstein, Bruno; Flury, K; Eckert, J; Seebeck, Thomas (1990). Echinococcus multilocularis: characterization of a DNA probe. Acta tropica, 48(2), pp. 109-116. Elsevier 10.1016/0001-706X(90)90050-A

Gottstein, Bruno; Müller, Norbert; Cryz, S J; Vogel, Monique; Tanner, I; Seebeck, Thomas (1990). Humoral and cellular immune response in mice and dogs induced by a recombinant Echinococcus multilocularis antigen produced by a Salmonella typhimurium vaccine strain. Parasite immunology, 12(2), pp. 163-174. Blackwell Scientific Publications 10.1111/j.1365-3024.1990.tb00945.x


Müller, Norbert; Gottstein, Bruno; Vogel, Monique; Flury, Karin; Seebeck, Thomas (1989). Application of a recombinant Echinococcus multilocularis antigen in an enzyme-linked immunosorbent assay for immunodiagnosis of human alveolar echinococcosis. Molecular and biochemical parasitology, 36(2), pp. 151-159. Elsevier 10.1016/0166-6851(89)90187-4


Vogel, Monique; Gottstein, Bruno; Müller, Norbert; Seebeck, Thomas (1988). Production of a recombinant antigen of Echinococcus multilocularis with high immunodiagnostic sensitivity and specificity. Molecular and biochemical parasitology, 31(2), pp. 117-125. Elsevier 10.1016/0166-6851(88)90162-4

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