Tschan, Mario

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Langsch, Stephanie; Baumgartner, Ulrich; Haemmig, Stefan; Schlup, Cornelia; Schäfer, Stephan; Berezowska, Sabina Anna; Rieger, Gregor; Dorn, Patrick; Tschan, Mario; Vassella, Erik (2016). miR-29b Mediates NF-κB Signaling in KRAS-Induced Non-Small Cell Lung Cancers. Cancer research, 76(14), pp. 4160-4169. American Association for Cancer Research AACR 10.1158/0008-5472.CAN-15-2580

Adams, Olivia Joan; Dislich, Bastian; Berezowska, Sabina Anna; Schläfli, Anna M; Seiler, Christian A.; Kröll, Dino; Tschan, Mario; Langer, Rupert (2016). Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas. OncoTarget, 7(26), pp. 39241-39255. Impact Journals LLC 10.18632/oncotarget.9649

Schläfli, Anna M; Adams, Olivia Joan; Galván Hernández, José Alberto; Gugger, Mathias; Savic Prince, Spasenija; Bubendorf, Lukas; Schmid, Ralph; Becker, Karl-Friedrich; Tschan, Mario; Langer, Rupert; Berezowska, Sabina Anna (2016). Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer. OncoTarget, 7(26), pp. 39544-39555. Impact Journals LLC 10.18632/oncotarget.9647

Rothschild, Sacha; Gautschi, Oliver; Batliner, Jasmin; Gugger, Mathias; Fey, Martin; Tschan, Mario (2016). MicroRNA-106a targets autophagy and enhances sensitivity of lung cancer cells to Src inhibitors. (In Press). Lung cancer Elsevier 10.1016/j.lungcan.2016.06.004

Weber, Martin R; Zuka, Masahiko; Lorger, Mihaela; Tschan, Mario; Torbett, Bruce E; Zijlstra, Andries; Quigley, James P; Staflin, Karin; Eliceiri, Brian P; Krueger, Joseph S; Marchese, Patrizia; Ruggeri, Zaverio M; Felding, Brunhilde H (2016). Activated tumor cell integrin αvβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream. Thrombosis research, 140(Suppl1), S27-36. Elsevier 10.1016/S0049-3848(16)30095-0

Berezowska, Sabina Anna; Schläfli, A M; Adams, O; Galván Hernández, José Alberto; Bubendorf, L; Prince, S Savic; Schmid, Ralph; Gugger, M; Tschan, Mario; Langer, Rupert (2016). 25P Autophagy in early stage NSCLC - prognostic significance of the autophagy markers p62 and LC3B. Journal of thoracic oncology, 11(4Suppl), S66-S66. Elsevier 10.1016/S1556-0864(16)30139-3

Wampfler, Julian; Federzoni, Elena; Torbett, Bruce E; Fey, Martin; Tschan, Mario (2016). The RNA binding proteins RBM38 and DND1 are repressed in AML and have a novel function in APL differentiation. Leukemia research, 41, pp. 96-102. Elsevier 10.1016/j.leukres.2015.12.006

Simon, Hans-Uwe; Tschan, Mario P. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1), pp. 1-222. Landes Bioscience 10.1080/15548627.2015.1100356


Mikami, K.; Medova, Michaela; Nisa Hernandez, Lluis; Francica, Paola; Glück, Astrid Andreina; Tschan, M.; Blaukat, A.; Bladt, F.; Aebersold, Daniel; Zimmer, Yitzhak (2015). Impact of p53 Status on Radiosensitization of Tumor Cells by MET Inhibition-Associated Checkpoint Abrogation. Molecular cancer research, 13(12), pp. 1544-1553. American Association for Cancer Research AACR 10.1158/1541-7786.MCR-15-0022

Tschan, Mario P.; Federzoni, Elena A.; Haimovici, Aladin; Britschgi, Christian; Moser, Bettina A.; Jin, Jing; Reddy, Venkateshwar A.; Sheeter, Dennis A.; Fischer, Kimberlee M.; Sun, Peiqing; Torbett, Bruce E. (2015). Human DMTF1β antagonizes DMTF1α regulation of the p14(ARF) tumor suppressor and promotes cellular proliferation. Biochimica et biophysica acta, 1849(9), pp. 1198-1208. Elsevier 10.1016/j.bbagrm.2015.07.009

Wampfler, Julian; Federzoni, Elena; Torbett, Bruce E; Fey, Martin; Tschan, Mario (2015). Low DICER1 expression is associated with attenuated neutrophil differentiation and autophagy of NB4 APL cells. Journal of leukocyte biology, 98(3), pp. 357-363. Society for Leukocyte Biology 10.1189/jlb.1AB0514-258R

Orfali, Nina; O'Donovan, Tracey R; Nyhan, Michelle J; Britschgi, Adrian; Tschan, Mario; Cahill, Mary R; Mongan, Nigel P; Gudas, Lorraine J; McKenna, Sharon L (2015). Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation. Experimental hematology, 43(9), 781-793.e2. Elsevier 10.1016/j.exphem.2015.04.012

Delgado Tascón, Julia; Adrian, Jonas; Kopp, Kathrin; Scholz, Philipp; Tschan, Mario; Kuespert, Katharina; Hauck, Christof R (2015). The granulocyte orphan receptor CEACAM4 is able to trigger phagocytosis of bacteria. Journal of leukocyte biology, 97(3), pp. 521-531. Society for Leukocyte Biology 10.1189/jlb.2AB0813-449RR

Galván Hernández, José Alberto; Helbling, Melina; Kölzer, Viktor; Tschan, Mario; Berger, Martin Dave; Hädrich, Marion; Schnüriger, Beat; Karamitopoulou, Evanthia; Dawson, Heather; Inderbitzin, Daniel; Lugli, Alessandro; Zlobec, Inti (2015). TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer. OncoTarget, 6(2), pp. 874-885. Impact Journals LLC 10.18632/oncotarget.2716

Federzoni, Elena; Gloor, Severin; Jin, Jing; Krauer, Deborah; Fey, Martin; Torbett, Bruce E; Tschan, Mario (2015). Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells. Leukemia Research Reports, 4(1), pp. 32-35. Elsevier 10.1016/j.lrr.2015.04.002

Brockmann, Anette; Bluwstein, A; Kögel, A; May, S; Marx, A; Tschan, Mario; Brunner, Thomas (2015). Thiazolides promote apoptosis in colorectal tumor cells via MAP kinase-induced Bim and Puma activation. Cell death & disease, 6, e1778. Nature Publishing Group 10.1038/cddis.2015.137

Schläfli, Anna; Berezowska, Sabina Anna; Adams, Olivia Joan; Langer, Rupert; Tschan, Mario (2015). Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry. European journal of histochemistry, 59(2), p. 2481. Luigi Ponzio 10.4081/ejh.2015.2481

Brigger, D.; Schläfli, A. M.; Garattini, E.; Tschan, M. P. (2015). Activation of RARα induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity. Cell death & disease, 6, e1861. Nature Publishing Group 10.1038/cddis.2015.236

Geering, Barbara; Zokouri, Zina; Hürlemann, Samuel; Gerrits, Bertran; Ausländer, David; Britschgi, Adrian; Tschan, Mario; Simon, Hans-Uwe; Fussenegger, Martin (2015). Identification of Novel Death-Associated Protein Kinase 2 Interaction Partners by Proteomic Screening Coupled with Bimolecular Fluorescence Complementation. Molecular and cellular biology, 36(1), pp. 132-143. American Society for Microbiology 10.1128/MCB.00515-15


Trocoli, A; Bensadoun, P; Richard, E; Labrunie, G; Merhi, F; Schläfli, Anna; Brigger, Daniel; Souquere, S; Pierron, G; Pasquet, J-M; Soubeyran, P; Reiffers, J; Ségal-Bendirdjian, E; Tschan, Mario; Djavaheri-Mergny, M (2014). p62/SQSTM1 upregulation constitutes a survival mechanism that occurs during granulocytic differentiation of acute myeloid leukemia cells. Cell death and differentiation, 21(12), pp. 1852-1861. Nature Publishing Group 10.1038/cdd.2014.102

Haimovici, Aladin; Brigger, Daniel; Torbett, Bruce E; Fey, Martin; Tschan, Mario (2014). Induction of the autophagy-associated gene MAP1S via PU.1 supports APL differentiation. Leukemia research, 38(9), pp. 1041-1047. Elsevier 10.1016/j.leukres.2014.06.010

Helbling, Melina; Lukesch, Anne Carolin; Haimovici, Aladin; Karamitopoulou, Evanthia; Berger, Martin Dave; Hädrich, Marion; Mallaev, Makhmud; Schnüriger, Beat; Kölzer, Viktor; Dawson, Heather; Borner, Markus; Langer, Rupert; Rosenberg, Robert; Nitsche, Ulrich; Inderbitzin, Daniel; Lugli, Alessandro; Tschan, Mario; Zlobec, Inti (2014). Investigation of IL-23 (p19, p40) and IL-23R identifies nuclear expression of IL-23 p19 as a favorable prognostic factor in colorectal cancer: a retrospective multicenter study of 675 patients. OncoTarget, 5(13), pp. 4671-4682. Impact Journals LLC

Pfisterer, Simon G; Bakula, Daniela; Frickey, Tancred; Cezanne, Alice; Brigger, Daniel; Tschan, Mario; Robenek, Horst; Proikas-Cezanne, Tassula (2014). Lipid droplet and early autophagosomal membrane targeting of Atg2A and Atg14L in human tumor cells. Journal of lipid research, 55(7), pp. 1267-1278. American Society for Biochemistry and Molecular Biology ASBMB 10.1194/jlr.M046359

Stutz, Emanuel; Gautschi, Oliver; Fey, Martin F.; Gugger, Mathias; Tschan, Mario; Rothschild, Sacha I. (2014). Crizotinib inhibits migration and expression of ID1 in MET-positive lung cancer cells: implications for MET targeting in oncology. Future oncology, 10(2), pp. 211-217. Future Medicine Ltd. 10.2217/fon.13.179

Humbert, Magali; Federzoni, Elena; Britschgi, Adrian; Schläfli, Anna; Valk, PJ; Kaufmann, Thomas; Haferlach, T.; Behre, G.; Simon, Hans-Uwe; Torbett, BE; Fey, Martin; Tschan, Mario (2014). The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL. Journal of leukocyte biology, 95(1), pp. 83-93. Society for Leukocyte Biology 10.1189/jlb.1112608

Federzoni, Elena; Humbert, Magali; Torbett, Bruce E; Behre, Gerhard; Fey, Martin; Tschan, Mario (2014). CEBPA-dependent HK3 and KLF5 expression in primary AML and during AML differentiation. Scientific Reports, 4, p. 4261. Nature Publishing Group 10.1038/srep04261

Brigger, Daniel; Proikas-Cezanne, T; Tschan, Mario (2014). WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells. Cell death & disease, 5(e1315), e1315. Nature Publishing Group 10.1038/cddis.2014.261

Haemmig, Stefan; Baumgartner, Ulrich; Glück, Astrid; Zbinden, Samuel; Tschan, Mario; Kappeler, Andreas; Mariani, L; Vajtai, Istvan; Vassella, Erik (2014). miR-125b controls apoptosis and temozolomide resistance by targeting TNFAIP3 and NKIRAS2 in glioblastomas. Cell death & disease, 5(e1279), e1279. Nature Publishing Group 10.1038/cddis.2014.245


Portmann, Simone; Fahrner, René; Lechleiter, Antje; Keogh, Adrian; Overney, Sarah; Lämmle, Alexander; Mikami, Kei; Montani, Matteo; Tschan, Mario; Candinas, Daniel; Keogh-Stroka, Deborah M. (2013). Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo. Molecular cancer therapeutics, 12(4), pp. 499-508. American Association for Cancer Research AACR 10.1158/1535-7163.MCT-12-0700

Humbert, Magali; Medova, Michaela; Aebersold, Daniel; Blaukat, Andree; Bladt, Friedhelm; Fey, Martin; Zimmer, Yitzhak; Tschan, Mario P. (2013). Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells. Biochemical and biophysical research communications, 431(2), pp. 264-269. Academic Press 10.1016/j.bbrc.2012.12.120

Federzoni, Elena A.; Humbert, Magali; Valk, Peter J. M.; Behre, Gerhard; Leibundgut, Elisabeth O.; Torbett, Bruce E; Fey, Martin F.; Tschan, Mario (2013). The actin-binding protein CORO1A is a novel PU.1 (SPI1)- and CEBPA-regulated gene with significantly lower expression in APL and CEBPA-mutated AML patients. British journal of haematology, 160(6), pp. 855-859. Oxford: Wiley-Blackwell 10.1111/bjh.12170

Wojtalla, Anna; Fischer, Barbara; Kotelevets, Nataliya; Mauri, Francesco A; Sobek, Jens; Rehrauer, Hubert; Wotzkow, Carlos; Tschan, Mario P; Seckl, Michael J; Zangemeister-Wittke, Uwe; Arcaro, Alexandre (2013). Targeting the phosphoinositide 3-kinase p110-α isoform impairs cell proliferation, survival, and tumor growth in small cell lung cancer. Clinical cancer research, 19(1), pp. 96-105. Philadelphia, Pa.: Association for Cancer Research 10.1158/1078-0432.CCR-12-1138

He, Zhaoyue; Liu, He; Agostini, M.; Yousefi, Shida; Perren, Aurel; Tschan, Mario; Mak, TW; Melino, G:; Simon, Hans-Uwe (2013). p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene. Cell death and differentiation, 20(10), pp. 1415-1424. Nature Publishing Group 10.1038/cdd.2013.104

Brigger, Daniel; Torbett, Bruce E.; Chen, Joy; Fey, Martin; Tschan, Mario (2013). Inhibition of GATE-16 attenuates ATRA-induced neutrophil differentiation of APL cells and interferes with autophagosome formation. Biochemical and biophysical research communications, 438(2), pp. 283-288. Academic Press 10.1016/j.bbrc.2013.07.056


Batliner, Jasmin; Buehrer, Emanuel; Federzoni, Elena A; Jenal, Mathias; Tobler, Andreas; Torbett, Bruce E; Fey, Martin F; Tschan, Mario P (2012). Transcriptional regulation of MIR29B by PU.1 (SPI1) and MYC during neutrophil differentiation of acute promyelocytic leukaemia cells. British journal of haematology, 157(2), pp. 270-4. Oxford: Wiley-Blackwell

Batliner, Jasmin; Buehrer, Emanuel; Fey, Martin F; Tschan, Mario P (2012). Inhibition of the miR-143/145 cluster attenuated neutrophil differentiation of APL cells. Leukemia research, 36(2), pp. 237-40. Amsterdam: Elsevier 10.1016/j.leukres.2011.10.006

Laemmle, Alexander; Lechleiter, Antje; Roh, Vincent; Schwarz, Christa; Portmann, Simone; Furer, Cynthia; Keogh, Adrian; Tschan, Mario P; Candinas, Daniel; Vorburger, Stephan A; Stroka, Deborah (2012). Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions. PLoS ONE, 7(3), e33433. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0033433

Rothschild, S I; Tschan, M P; Federzoni, E A; Jaggi, R; Fey, M F; Gugger, M; Gautschi, O (2012). MicroRNA-29b is involved in the Src-ID1 signaling pathway and is dysregulated in human lung adenocarcinoma. Oncogene, 31(38), pp. 4221-32. Basingstoke, UK: Nature Publishing Group 10.1038/onc.2011.578

Rothschild, Sacha I; Tschan, Mario P; Jaggi, Rolf; Fey, Martin F; Gugger, Mathias; Gautschi, Oliver (2012). MicroRNA-381 Represses ID1 and is Deregulated in Lung Adenocarcinoma. Journal of thoracic oncology, 7(7), pp. 1069-77. Hagerstown, Md.: Wolters Kluwer Health/Lippincott Williams & Wilkins 10.1097/JTO.0b013e31824fe976

Federzoni, Elena A; Valk, Peter J M; Torbett, Bruce E; Haferlach, Torsten; Löwenberg, Bob; Fey, Martin F; Tschan, Mario P (2012). PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells. Blood, 119(21), pp. 4963-70. Washington, D.C.: American Society of Hematology 10.1182/blood-2011-09-378117

Humbert, Magali; Mueller, Chantal; Fey, Martin F; Tschan, Mario P (2012). Inhibition of damage-regulated autophagy modulator-1 (DRAM-1) impairs neutrophil differentiation of NB4 APL cells. Leukemia research, 36(12), pp. 1552-6. Amsterdam: Elsevier 10.1016/j.leukres.2012.08.024

Yusuf, Dimas; Butland, Stefanie L; Swanson, Magdalena I; Bolotin, Eugene; Ticoll, Amy; Cheung, Warren A; Zhang, Xiao Yu Cindy; Dickman, Christopher T D; Fulton, Debra L; Lim, Jonathan S; Schnabl, Jake M; Ramos, Oscar H P; Vasseur-Cognet, Mireille; de Leeuw, Charles N; Simpson, Elizabeth M; Ryffel, Gerhart U; Lam, Eric W-F; Kist, Ralf; Wilson, Miranda S C; Marco-Ferreres, Raquel; ... (2012). The transcription factor encyclopedia. Genome biology, 13(3), R24. London: BioMed Central Ltd. 10.1186/gb-2012-13-3-r24


Rothschild, Sacha I; Kappeler, Andreas; Ratschiller, Daniel; Betticher, Daniel C; Tschan, Mario P; Gugger, Mathias; Gautschi, Oliver (2011). The stem cell gene "inhibitor of differentiation 1" (ID1) is frequently expressed in non-small cell lung cancer. Lung cancer, 71(3), pp. 306-11. Amsterdam: Elsevier 10.1016/j.lungcan.2010.06.018

Batliner, Jasmin; Mancarelli, Maria Michela; Jenal, Mathias; Reddy, Venkateshwar A; Fey, Martin F; Torbett, Bruce E; Tschan, Mario P (2011). CLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation. Molecular immunology, 48(4), pp. 714-9. Amsterdam: Elsevier 10.1016/j.molimm.2010.10.016

Humbert, Magali; Halter, Veronika; Shan, Deborah; Laedrach, Judith; Leibundgut, Elisabeth Oppliger; Baerlocher, Gabriela M; Tobler, Andreas; Fey, Martin F; Tschan, Mario P (2011). Deregulated expression of Kruppel-like factors in acute myeloid leukemia. Leukemia research, 35(7), pp. 909-13. Amsterdam: Elsevier 10.1016/j.leukres.2011.03.010


Tschan, Mario P; Shan, Deborah; Laedrach, Judith; Eyholzer, Marianne; Leibundgut, Elisabeth Oppliger; Baerlocher, Gabriela M; Tobler, Andreas; Stroka, Deborah; Fey, Martin F (2010). NDRG1/2 expression is inhibited in primary acute myeloid leukemia. Leukemia research, 34(3), pp. 393-8. Amsterdam: Elsevier 10.1016/j.leukres.2009.08.037

Jenal, M; Batliner, J; Reddy, V A; Haferlach, T; Tobler, A; Fey, M F; Torbett, B E; Tschan, M P (2010). The anti-apoptotic gene BCL2A1 is a novel transcriptional target of PU.1. Leukemia, 24(5), pp. 1073-6. Basingstoke: Nature Publishing Group 10.1038/leu.2010.26

Britschgi, Adrian; Simon, Hans-Uwe; Tobler, Andreas; Fey, Martin F; Tschan, Mario P (2010). Epigallocatechin-3-gallate induces cell death in acute myeloid leukaemia cells and supports all-trans retinoic acid-induced neutrophil differentiation via death-associated protein kinase 2. British journal of haematology, 149(1), pp. 55-64. Oxford: Wiley-Blackwell 10.1111/j.1365-2141.2009.08040.x

Tschan, M P; Simon, H-U (2010). The role of autophagy in anticancer therapy: promises and uncertainties. Journal of internal medicine, 268(5), pp. 410-8. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2796.2010.02266.x

Schneider-Jakob, S; Corazza, N; Badmann, A; Sidler, D; Stuber-Roos, R; Keogh, A; Frese, S; Tschan, M; Brunner, T (2010). Synergistic induction of cell death in liver tumor cells by TRAIL and chemotherapeutic drugs via the BH3-only proteins Bim and Bid. Cell death & disease, 1(e86), e86. London: Nature Publishing Group 10.1038/cddis.2010.66

Jenal, Mathias; Britschgi, Christian; Fey, Martin F; Tschan, Mario P (2010). Inactivation of the hypermethylated in cancer 1 tumour suppressor--not just a question of promoter hypermethylation? Swiss medical weekly, 140, w13106. Muttenz: EMH Schweizerischer Ärzteverlag 10.4414/smw.2011.13106


Wampfler, Julian; Tschan, Mario P; Shan, Deborah; Laemmle, Alexander; Leibundgut, Elisabeth O; Baerlocher, Gabriela M; Stroka, Deborah; Fey, Martin F; Britschgi, Christian (2009). SIRT1 is downregulated during neutrophil differentiation of acute promyelocytic leukaemia cells. British journal of haematology, 146(3), pp. 337-41. Oxford: Wiley-Blackwell 10.1111/j.1365-2141.2009.07749.x

Jenal, Mathias; Trinh, Emmanuelle; Britschgi, Christian; Britschgi, Adrian; Roh, Vincent; Vorburger, Stephan A; Tobler, Andreas; Leprince, Dominique; Fey, Martin F; Helin, Kristian; Tschan, Mario P (2009). The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1. Molecular cancer research, 7(6), pp. 916-22. Philadelphia, Pa.: American Association for Cancer Research AACR 10.1158/1541-7786.MCR-08-0359


Britschgi, Christian; Jenal, Mathias; Rizzi, Mattia; Mueller, Beatrice U; Torbett, Bruce E; Andres, Anne-Catherine; Tobler, Andreas; Fey, Martin F; Tschan, Mario P (2008). HIC1 tumour suppressor gene is suppressed in acute myeloid leukaemia and induced during granulocytic differentiation. British journal of haematology, 141(2), pp. 179-87. Oxford: Wiley-Blackwell 10.1111/j.1365-2141.2008.06992.x

Tschan, M P; Reddy, V A; Ress, A; Arvidsson, G; Fey, M F; Torbett, B E (2008). PU.1 binding to the p53 family of tumor suppressors impairs their transcriptional activity. Oncogene, 27(24), pp. 3489-93. Basingstoke, UK: Nature Publishing Group 10.1038/sj.onc.1211004


Tschan, M P; Gullberg, U; Shan, D; Torbett, B E; Fey, M F; Tobler, A (2007). The hDMP1 tumor suppressor is a new WT1 target in myeloid leukemias. Leukemia, 22(5), pp. 1087-1090. Basingstoke: Nature Publishing Group 10.1038/sj.leu.2405018


Peters, Uwe R; Hasse, Urs; Oppliger Leibundgut, Elisabeth; Tschan, Mario; Ong, S Tiong; Rassool, Feyruz V; Borisch, Bettina; Tobler, Andreas; Fey, Martin (1999). Aberrant FHIT mRNA transcripts are present in malignant and normal haematopoiesis, but absence of FHIT protein is restricted to leukaemia. Oncogene, 18(1), pp. 79-85. Nature Publishing Group 10.1038/sj.onc.1202256

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