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Augustynek, Bartlomiej; Gyimesi, Gergely; Dernic, Jan; Sallinger, Matthias; Albano, Giuseppe; Klesse, Gabriel J.; Kandasamy, Palanivel; Grabmayr, Herwig; Frischauf, Irene; Fuster, Daniel G.; Peinelt, Christine; Hediger, Matthias A.; Bhardwaj, Rajesh (2021). Dissecting gating mechanisms of Orai calcium channel paralogs using constitutively active Orai mutants that mimic STIM1-gated state (In Press) (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2021.10.26.465861
Kappel, Sven; Melek, Korollus; Ross-Kaschitza, Daniela; Hauert, Barbara; Gerber, Christian E.; Lochner, Martin; Peinelt, Christine (2024). CBA (4-chloro-2-(2-chlorophenoxy)acetamido) benzoic acid) inhibits TMEM206 mediated currents and TMEM206 does not contribute to acid-induced cell death in colorectal cancer cells. Frontiers in Pharmacology, 15 Frontiers 10.3389/fphar.2024.1369513
Tscherrig, Dominic; Bhardwaj, Rajesh; Biner, Daniel; Dernič, Jan; Ross-Kaschitza, Daniela; Peinelt, Christine; Hediger, Matthias A; Lochner, Martin (2024). Development of chemical tools based on GSK-7975A to study store-operated calcium entry in cells. Cell calcium, 117, p. 102834. Elsevier 10.1016/j.ceca.2023.102834
Papapostolou, Irida; Bochen, Florian; Peinelt, Christine; Maldifassi, Maria Constanza (2023). A Simple and Fast Method for the Formation and Downstream Processing of Cancer-Cell-Derived 3D Spheroids: An Example Using Nicotine-Treated A549 Lung Cancer 3D Spheres. Methods and protocols, 6(5) MDPI AG 10.3390/mps6050094
Papapostolou, Irida; Ross, Daniela; Bochen, Florian; Peinelt, Christine; Maldifassi, Maria Constanza (2023). Contribution of the α5 nAChR Subunit and α5SNP to Nicotine-Induced Proliferation and Migration of Human Cancer Cells. Cells, 12(15) MDPI 10.3390/cells12152000
Preti, Barbara; Rougier, Jean-Sébastien; Papapostolou, Irida; Bochen, Florian; Gerber, Christian E; Abriel, Hugues; Lochner, Martin; Peinelt, Christine (2022). Targeting Ion Channel TRPM4. CHIMIA, 76(12), pp. 1039-1044. Schweizerische Chemische Gesellschaft 10.2533/chimia.2022.1039
Kappel, Sven; Peinelt, Christine (2022). Targeting CRAC channels in inflammatory bowel disease. EMBO molecular medicine, 14(9), e16489. EMBO Press 10.15252/emmm.202216489
Augustynek, Bartlomiej; Gyimesi, Gergely; Dernič, Jan; Sallinger, Matthias; Albano, Giuseppe; Klesse, Gabriel J; Kandasamy, Palanivel; Grabmayr, Herwig; Frischauf, Irene; Fuster, Daniel G; Peinelt, Christine; Hediger, Matthias A; Bhardwaj, Rajesh (2022). Discovery of novel gating checkpoints in the Orai1 calcium channel by systematic analysis of constitutively active mutants of its paralogs and orthologs. Cell calcium, 105, p. 102616. Elsevier 10.1016/j.ceca.2022.102616
Kappel, Sven; Ross, Daniela; Hauert, Barbara; Rother, Karen; Peinelt, Christine (2022). p53 alters intracellular Ca2+ signaling through regulation of TRPM4. Cell calcium, 104(102591), p. 102591. Elsevier 10.1016/j.ceca.2022.102591
Stokłosa, Paulina; Kappel, Sven; Peinelt, Christine (2022). A Novel Role of the TRPM4 Ion Channel in Exocytosis. Cells, 11(11) MDPI 10.3390/cells11111793
Stoklosa, Paulina; Borgström, Anna; Hauert, Barbara; Baur, Roland; Peinelt, Christine (2021). Investigation of Novel Small Molecular TRPM4 Inhibitors in Colorectal Cancer Cells. Cancers, 13(21) MDPI AG 10.3390/cancers13215400
Borgström, Anna; Hauert, Barbara; Kappel, Sven; Zoni, Eugenio; Kiener, Mirjam; Stokłosa, Paulina; Baur, Roland; Spahn, Martin; Kruithof-de Julio, Marianna; Peinelt, Christine (2021). Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions. Journal of molecular biology, 433(17), p. 166665. Elsevier 10.1016/j.jmb.2020.09.024
Borgström, Anna; Peinelt, Christine; Stoklosa, Paulina (2021). TRPM4 in Cancer-A New Potential Drug Target. Biomolecules, 11(2) MDPI 10.3390/biom11020229
Schild, Achille; Bhardwaj, Rajesh; Wenger, Nicolas; Tscherrig, Dominic; Kandasamy, Palanivel; Dernič, Jan; Baur, Roland; Peinelt, Christine; Hediger, Matthias A.; Lochner, Martin (2020). Synthesis and Pharmacological Characterization of 2-Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells. International journal of molecular sciences, 21(16) MDPI 10.3390/ijms21165604
Stoklosa, Paulina; Probst, Daniel; Reymond, Jean-Louis; Peinelt, Christine (2020). The name tells the story: Two-pore channels. Cell calcium, 89, p. 102215. Elsevier 10.1016/j.ceca.2020.102215
Kappel, Sven; Kilch, Tatiana; Baur, Roland; Lochner, Martin; Peinelt, Christine (2020). The Number and Position of Orai3 Units within Heteromeric Store-Operated Ca2+ Channels Alter the Pharmacology of ICRAC. International journal of molecular sciences, 21(7) MDPI 10.3390/ijms21072458
Bhardwaj, Rajesh; Augustynek, Bartlomiej S.; Ercan-Herbst, Ebru; Kandasamy, Palanivel; Seedorf, Matthias; Peinelt, Christine; Hediger, Matthias A. (2020). Ca2+/Calmodulin Binding to STIM1 Hydrophobic Residues Facilitates Slow Ca2+-Dependent Inactivation of the Orai1 Channel. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 54(2), pp. 252-270. 10.33594/000000218
Stoklosa, Paulina; Borgström, Anna; Kappel, Sven; Peinelt, Christine (2020). TRP Channels in Digestive Tract Cancers. International journal of molecular sciences, 21(5) MDPI 10.3390/ijms21051877
Kappel, Sven; Stoklosa, Paulina; Hauert, Barbara; Ross-Kaschitza, Daniela; Borgström, Anna; Baur, Roland; Galván, José A.; Zlobec, Inti; Peinelt, Christine (2019). TRPM4 is highly expressed in human colorectal tumor buds and contributes to proliferation, cell cycle, and invasion of colorectal cancer cells. Molecular oncology, 13(11), pp. 2393-2405. FEBS Press 10.1002/1878-0261.12566
Kappel, Sven; Borgström, Anna; Stoklosa, Paulina; Dörr, Kathrin; Peinelt, Christine (2019). Store-operated calcium entry in disease: Beyond STIM/Orai expression levels. Seminars in cell & developmental biology, 94, pp. 66-73. Elsevier 10.1016/j.semcdb.2019.01.003
Borgström, A.; Kiener, M.; Kappel, S.; Hauert, B.; Delalande, C.; Zoni, E.; Reymond, J.; Thalmann, G. N.; Peinelt, C.; Kruithof-de Julio, M. (15 March 2019). Investigation of TRPM4 and store-operated calcium entry in prostate cancer cell systems and a primary prostate cancer stem cell model. European Urology Supplements, 18(1), e342-e342. Elsevier https://doi.org/10.1016/S1569-9056(19)30254-4
Borgström, A.; Kiener, M.; Kappel, S.; Hauert, B.; Delalande, C.; Zoni, E.; Reymond, J.-L.; Thalmann, G. N.; Peinelt, C.; Kruithof-de Julio, M. (2019). Investigation of TRPM4 and store-operated calcium entry in prostate cancer cell systems and a primary prostate cancer stem cell model. Der Urologe, 58(Suppl 1), S42-S42. Springer https://doi.org/10.1007/s00120-019-1018-y
Ozhathil, Lijo Cherian; Delalande, Clémence Marie Sandrine; Bianchi, Beatrice; Nemeth, Gabor; Kappel, Sven; Thomet, Urs; Ross, Daniela; Simonin, Céline; Rubin, Matthias; Gertsch, Jürg; Lochner, Martin; Peinelt, Christine; Reymond, Jean-Louis; Abriel, Hugues (2018). Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. British journal of pharmacology, 175(12), pp. 2504-2519. Wiley-Blackwell 10.1111/bph.14220
Kappel, Sven; dos Santos Marques, Ines Joao; Zoni, Eugenio; Stoklosa, Paulina Agnieszka; Peinelt, Christine; Mercader Huber, Nadia; Kruithof-de Julio, Marianna; Borgström, Anna (2017). Store-Operated Ca2+ Entry as a Prostate Cancer Biomarker — a Riddle with Perspectives. Current Molecular Biology Reports, 3(4), pp. 208-217. Springer 10.1007/s40610-017-0072-8
Dörr, Kathrin; Kilch, Tatiana; Kappel, Sven; Alansary, Dalia; Schwär, Gertrud; Niemeyer, Barbara A; Peinelt, Christine (2016). Cell type-specific glycosylation of Orai1 modulates store-operated Ca2+ entry. Science signaling, 9(418), ra25. American Association for the Advancement of Science 10.1126/scisignal.aaa9913
Kilch, Tatiana; Kappel, Sven; Peinelt, Christine (2016). Regulation of Ca(2+) signaling in prostate cancer cells. Channels, 10(3), pp. 170-171. Taylor & Francis 10.1080/19336950.2015.1137176
Holzmann, Christian; Kappel, Sven; Kilch, Tatiana; Jochum, Marcus Martin; Urban, Sabine Katharina; Jung, Volker; Stöckle, Michael; Rother, Karen; Greiner, Markus; Peinelt, Christine (2015). Transient receptor potential melastatin 4 channel contributes to migration of androgen-insensitive prostate cancer cells. OncoTarget, 6(39), pp. 41783-41793. Impact Journals LLC 10.18632/oncotarget.6157
Holzmann, Christian; Kilch, Tatiana; Kappel, Sven; Dörr, Kathrin; Jung, Volker; Stöckle, Michael; Bogeski, Ivan; Peinelt, Christine (2015). Differential Redox Regulation of Ca²⁺ Signaling and Viability in Normal and Malignant Prostate Cells. Biophysical journal, 109(7), pp. 1410-1419. Biophysical Society 10.1016/j.bpj.2015.08.006
Beck, Andreas; Fleig, Andrea; Penner, Reinhold; Peinelt, Christine (2014). Regulation of endogenous and heterologous Ca²⁺ release-activated Ca²⁺ currents by pH. Cell calcium, 56(3), pp. 235-243. Elsevier 10.1016/j.ceca.2014.07.011
Alansary, Dalia; Kilch, Tatiana; Holzmann, Christian; Peinelt, Christine; Hoth, Markus; Lis, Annette (2014). Patch-clamp measurement of ICRAC and ORAI channel activity. Cold Spring Harbor protocols, 2014(6), pp. 602-607. Cold Spring Harbor Laboratory 10.1101/pdb.top066795
Alansary, Dalia; Kilch, Tatiana; Holzmann, Christian; Peinelt, Christine; Hoth, Markus; Lis, Annette (2014). The minimal requirements to use calcium imaging to analyze ICRAC. Cold Spring Harbor protocols, 2014(6), pp. 638-642. Cold Spring Harbor Laboratory 10.1101/pdb.prot073262
Alansary, Dalia; Kilch, Tatiana; Holzmann, Christian; Peinelt, Christine; Hoth, Markus; Lis, Annette (2014). Measuring endogenous ICRAC and ORAI currents with the patch-clamp technique. Cold Spring Harbor protocols, 2014(6), pp. 630-637. Cold Spring Harbor Laboratory 10.1101/pdb.prot073254
Holzmann, Christian; Kilch, Tatiana; Kappel, Sven; Armbrüster, Andrea; Jung, Volker; Stöckle, Michael; Bogeski, Ivan; Schwarz, Eva C; Peinelt, Christine (2013). ICRAC controls the rapid androgen response in human primary prostate epithelial cells and is altered in prostate cancer. OncoTarget, 4(11), pp. 2096-2107. Impact Journals LLC 10.18632/oncotarget.1483
Carreras-Sureda, Amado; Cantero-Recasens, Gerard; Rubio-Moscardo, Fanny; Kiefer, Kerstin; Peinelt, Christine; Niemeyer, Barbara A; Valverde, Miguel A; Vicente, Rubén (2013). ORMDL3 modulates store-operated calcium entry and lymphocyte activation. Human molecular genetics, 22(3), pp. 519-530. Oxford University Press 10.1093/hmg/dds450
Kilch, Tatiana; Alansary, Dalia; Peglow, Martin; Dörr, Kathrin; Rychkov, Grigori; Rieger, Heiko; Peinelt, Christine; Niemeyer, Barbara A (2013). Mutations of the Ca2+-sensing stromal interaction molecule STIM1 regulate Ca2+ influx by altered oligomerization of STIM1 and by destabilization of the Ca2+ channel Orai1. Journal of biological chemistry, 288(3), pp. 1653-1664. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M112.417246
Stanisz, Hedwig; Stark, Alexandra; Kilch, Tatiana; Schwarz, Eva C; Müller, Cornelia S L; Peinelt, Christine; Hoth, Markus; Niemeyer, Barbara A; Vogt, Thomas; Bogeski, Ivan (2012). ORAI1 Ca(2+) channels control endothelin-1-induced mitogenesis and melanogenesis in primary human melanocytes. Journal of Investigative Dermatology, 132(5), pp. 1443-1451. Nature Publishing 10.1038/jid.2011.478
Lis, Annette; Zierler, Susanna; Peinelt, Christine; Fleig, Andrea; Penner, Reinhold (2010). A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating. Journal of general physiology, 136(6), pp. 673-686. Rockefeller University Press 10.1085/jgp.201010484
Bogeski, Ivan; Al-Ansary, Dalia; Qu, Bin; Niemeyer, Barbara A; Hoth, Markus; Peinelt, Christine (2010). Pharmacology of ORAI channels as a tool to understand their physiological functions. Expert review of clinical pharmacology, 3(3), pp. 291-303. Taylor & Francis 10.1586/ecp.10.23
Bogeski, Ivan; Kummerow, Carsten; Al-Ansary, Dalia; Schwarz, Eva C; Koehler, Richard; Kozai, Daisuke; Takahashi, Nobuaki; Peinelt, Christine; Griesemer, Desiree; Bozem, Monika; Mori, Yasuo; Hoth, Markus; Niemeyer, Barbara A (2010). Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling. Science signaling, 3(115), ra24. American Association for the Advancement of Science 10.1126/scisignal.2000672
Peinelt, Christine; Beck, Andreas; Monteilh-Zoller, Mahealani K; Penner, Reinhold; Fleig, Andrea (2009). IP(3) receptor subtype-dependent activation of store-operated calcium entry through I(CRAC). Cell calcium, 45(4), pp. 326-330. Elsevier 10.1016/j.ceca.2008.12.001
Peinelt, Christine; Lis, Annette; Beck, Andreas; Fleig, Andrea; Penner, Reinhold (2008). 2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels. Journal of physiology, 586(13), pp. 3061-3073. Wiley-Blackwell 10.1113/jphysiol.2008.151365
Parvez, Suhel; Beck, Andreas; Peinelt, Christine; Soboloff, Jonathan; Lis, Annette; Monteilh-Zoller, Mahealani; Gill, Donald L; Fleig, Andrea; Penner, Reinhold (2008). STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation. FASEB journal, 22(3), pp. 752-761. Federation of American Societies for Experimental Biology 10.1096/fj.07-9449com
Lis, Annette; Peinelt, Christine; Beck, Andreas; Parvez, Suhel; Monteilh-Zoller, Mahealani; Fleig, Andrea; Penner, Reinhold (2007). CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties. Current Biology, 17(9), pp. 794-800. Cell Press 10.1016/j.cub.2007.03.065
Vig, Monika; Beck, Andreas; Billingsley, James M; Lis, Annette; Parvez, Suhel; Peinelt, Christine; Koomoa, Dana L; Soboloff, Jonathan; Gill, Donald L; Fleig, Andrea; Kinet, Jean-Pierre; Penner, Reinhold (2006). CRACM1 multimers form the ion-selective pore of the CRAC channel. Current Biology, 16(20), pp. 2073-2079. Cell Press 10.1016/j.cub.2006.08.085
Peinelt, Christine; Vig, Monika; Koomoa, Dana L; Beck, Andreas; Nadler, Monica J S; Koblan-Huberson, Murielle; Lis, Annette; Fleig, Andrea; Penner, Reinhold; Kinet, Jean-Pierre (2006). Amplification of CRAC current by STIM1 and CRACM1 (Orai1). Nature cell biology, 8(7), pp. 771-773. Nature Publishing Group 10.1038/ncb1435
Vig, M; Peinelt, Christine; Beck, A; Koomoa, D L; Rabah, D; Koblan-Huberson, M; Kraft, S; Turner, H; Fleig, A; Penner, R; Kinet, J-P (2006). CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science, 312(5777), pp. 1220-1223. American Association for the Advancement of Science 10.1126/science.1127883
Peinelt, Christine; Apell, Hans-Jürgen (2005). Kinetics of Ca2+ binding to the SR Ca-ATPase in the E1 state. Biophysical journal, 89(4), pp. 2427-2433. Biophysical Society 10.1529/biophysj.105.068411
Peinelt, Christine; Apell, Hans-Jürgen (2004). Time-resolved charge movements in the sarcoplasmatic reticulum Ca-ATPase. Biophysical journal, 86(2), pp. 815-824. Biophysical Society 10.1016/S0006-3495(04)74157-0
Peinelt, Christine; Apell, Hans-Jürgen (2003). Time-resolved partial reactions of the SR Ca-ATPase investigated with a fluorescent styryl dye. Annals of the New York Academy of Sciences, 986, pp. 325-326. Blackwell
Peinelt, Christine; Apell, Hans-Jürgen (2002). Kinetics of the Ca(2+), H(+), and Mg(2+) interaction with the ion-binding sites of the SR Ca-ATPase. Biophysical journal, 82(1 Pt 1), pp. 170-181. Biophysical Society 10.1016/S0006-3495(02)75384-8
