Plattet, Philippe

Leborgne, Nathan GF; Devisme, Christelle; Kozarac, Nedim; Berenguer Veiga, Inês; Ebert, Nadine; Godel, Aurélie; Grau Roma, Llorenç; Scherer, Melanie; Plattet, Philippe; Thiel, Volker; Zimmer, Gert; Taddeo, Adriano; Benarafa, Charaf (2024). Neutrophil proteases are protective against SARS-CoV-2 by degrading the spike protein and dampening virus-mediated inflammation. JCI insight, 9(7) JCI Insight 10.1172/jci.insight.174133

Gradauskaite, Vaiva; Inglebert, Marine; Doench, John; Scherer, Melanie; Dettwiler, Martina; Wyss, Marianne; Shrestha, Neeta; Rottenberg, Sven; Plattet, Philippe (2023). LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus. mBio, 14(1), e0311422. American Society for Microbiology 10.1128/mbio.03114-22

Kalbermatter, David; Jeckelmann, Jean-Marc; Wyss, Marianne; Shrestha, Neeta; Pliatsika, Dimanthi; Riedl, Rainer; Lemmin, Thomas; Plattet, Philippe; Fotiadis, Dimitrios (2023). Structure and supramolecular organization of the canine distemper virus attachment glycoprotein. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 120(6), e2208866120. National Academy of Sciences NAS 10.1073/pnas.2208866120

Gradauskaite, Vaiva; Khosravi, Mojtaba; Plattet, Philippe (2022). Selective SLAM/CD150 Receptor-Detargeting of Canine Distemper Virus. Virus research, 318, p. 198841. Elsevier 10.1016/j.virusres.2022.198841

Taddeo, Adriano; Berenguer Veiga, Inês; Devisme, Christelle; Boss, Renate; Plattet, Philippe; Weigang, Sebastian; Kochs, Georg; Thiel, Volker; Benarafa, Charaf; Zimmer, Gert (2022). Optimized intramuscular immunization with VSV-vectored spike protein triggers a superior immune response to SARS-CoV-2. NPJ vaccines, 7(1), p. 82. Springer Nature 10.1038/s41541-022-00508-7

Wyss, Marianne; Gradauskaite, Vaiva; Ebert, Nadine; Thiel, Volker; Zurbriggen, Andreas; Plattet, Philippe (2022). Efficient Recovery of Attenuated Canine Distemper Virus from cDNA. Virus research, 316, p. 198796. Elsevier 10.1016/j.virusres.2022.198796

Walter, Justin D; Scherer, Melanie; Hutter, Cedric A J; Garaeva, Alisa A; Zimmermann, Iwan; Wyss, Marianne; Rheinberger, Jan; Ruedin, Yelena; Earp, Jennifer C; Egloff, Pascal; Sorgenfrei, Michèle; Hürlimann, Lea M; Gonda, Imre; Meier, Gianmarco; Remm, Sille; Thavarasah, Sujani; van Geest, Geert; Bruggmann, Rémy; Zimmer, Gert; Slotboom, Dirk J; ... (2022). Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance. EMBO reports, 23(4), e54199. EMBO press 10.15252/embr.202154199

Kratzel, Annika; Kelly, Jenna N; V'kovski, Philip; Portmann, Jasmine; Brüggemann, Yannick; Todt, Daniel; Ebert, Nadine; Shrestha, Neeta; Plattet, Philippe; Staab-Weijnitz, Claudia A; von Brunn, Albrecht; Steinmann, Eike; Dijkman, Ronald; Zimmer, Gert; Pfaender, Stephanie; Thiel, Volker (2021). A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets. PLoS biology, 19(12), e3001490. Public Library of Science 10.1371/journal.pbio.3001490

Shrestha, Neeta; Gall, Flavio Max; Mathieu, Cyrille; Hierweger, Melanie Michaela; Brügger, Melanie; Alves, Marco P.; Vesin, Jonathan; Banfi, Damiano; Kalbermatter, David; Horvat, Branka; Chambon, Marc; Turcatti, Gerardo; Fotiadis, Dimitrios; Riedl, Rainer; Plattet, Philippe (2021). Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier. mBio, 12(6), e0262121. American Society for Microbiology 10.1128/mBio.02621-21

Gast, Matthieu; Kadzioch, Nicole P.; Milius, Doreen; Origgi, Francesco; Plattet, Philippe (2021). Oligomerization and Cell Egress Controlled by Two Microdomains of Canine Distemper Virus Matrix Protein. mSphere, 6(2) American Society for Microbiology 10.1128/mSphere.01024-20

Shrestha, Neeta; Gall, Flavio M; Vesin, Jonathan; Chambon, Marc; Turcatti, Gerardo; Fotiadis, Dimitrios; Riedl, Rainer; Plattet, Philippe (2021). Antiviral Screen against Canine Distemper Virus-Induced Membrane Fusion Activity. Viruses, 13(1) MDPI 10.3390/v13010128

Pownall, William Robert; Imhof, Dennis; Fernandez Trigo, Nerea; Ganal-Vonarburg, Stephanie C.; Plattet, Philippe; Monney, Camille; Forterre, Franck; Hemphill, Andrew; Oevermann, Anna (2021). Safety of a Novel Listeria monocytogenes-Based Vaccine Vector Expressing NcSAG1 (Neospora caninum Surface Antigen 1). Frontiers in cellular and infection microbiology, 11(675219), p. 675219. Frontiers 10.3389/fcimb.2021.675219

Kadzioch, Nicole P.; Gast, Matthieu; Origgi, Francesco; Plattet, Philippe (2020). Clustered Lysine Residues of the Canine Distemper Virus Matrix Protein Regulate Membrane Association and Budding Activity. Journal of virology, 95(1) American Society for Microbiology 10.1128/JVI.01269-20

Kalbermatter, David; Shrestha, Neeta; Gall, Flavio M.; Wyss, Marianne; Riedl, Rainer; Plattet, Philippe; Fotiadis, Dimitrios (2020). Cryo-EM structure of the prefusion state of canine distemper virus fusion protein ectodomain. Journal of structural biology: X, 4, p. 100021. Elsevier 10.1016/j.yjsbx.2020.100021

Lemmin, Thomas; Kalbermatter, David; Harder, Daniel; Plattet, Philippe; Fotiadis, Dimitrios (2020). Structures and dynamics of the novel S1/S2 protease cleavage site loop of the SARS-CoV-2 spike glycoprotein. Journal of structural biology: X, 4, p. 100038. Elsevier 10.1016/j.yjsbx.2020.100038

Kalbermatter, David; Shrestha, Neeta; Ebert, Nadine; Herren, Michael; Moll, Pascal Dominique; Plemper, Richard K; Altmann, Karl-Heinz; Langedijk, Johannes P; Gall, Flavio; Lindenmann, Urs; Riedl, Rainer; Fotiadis, Dimitrios José; Plattet, Philippe (2019). Primary resistance mechanism of the canine distemper virus fusion protein against a small-molecule membrane fusion inhibitor. Virus research, 259, pp. 28-37. Elsevier 10.1016/j.virusres.2018.10.003

Herren, Michael; Shrestha, Neeta; Wyss, Marianne; Zurbriggen, Andreas; Plattet, Philippe (2018). Regulatory Role of the Morbillivirus Attachment Protein Head-to-Stalk Linker Module in Membrane Fusion Triggering. Journal of virology, 92(18) American Society for Microbiology 10.1128/JVI.00679-18

Bringolf, Fanny Anne; Herren, Michael; Wyss, Marianne; Vidondo, Beatriz; Langedijk, Johannes P; Zurbriggen, Andreas; Plattet, Philippe (2017). Dimerization Efficiency of Canine Distemper Virus Matrix Protein Regulates Membrane-Budding Activity. Journal of virology, 91(16), pp. 1-20. American Society for Microbiology 10.1128/JVI.00521-17

Murgiano, Leonardo; Shirokova, Vera; Welle, Monika Maria; Jagannathan, Vidhya; Plattet, Philippe; Oevermann, Anna; Pienkowska-Schelling, Aldona; Gallo, Daniele; Gentile, Arcangelo; Mikkola, Marja L; Drögemüller, Cord (2016). Correction: Hairless Streaks in Cattle Implicate TSR2 in Early Hair Follicle Formation. PLoS genetics, 12(5), e1005688. Public Library of Science 10.1371/journal.pgen.1005688

Plattet, Philippe; Alves, Lisa; Herren, Michael; Aguilar, Hector C (2016). Measles Virus Fusion Protein: Structure, Function and Inhibition. Viruses, 8(4), p. 112. MDPI 10.3390/v8040112

Khosravi, Mojtaba; Bringolf, Fanny Anne; Röthlisberger, Silvan; Bieringer, Maria; Schneider-Schaulies, Jürgen; Zurbriggen, Andreas; Origgi, Francesco; Plattet, Philippe (2016). Canine Distemper Virus Fusion Activation: Critical Role of Residue E123 of CD150/SLAM. Journal of virology, 90(3), pp. 1622-1637. American Society for Microbiology 10.1128/JVI.02405-15

Duart Garcia, Carolina; Plattet, Philippe; Bruggmann, Rémy; Simillion, Cedric André Marie; Irene, Keller; Göran, Andersson; Braunschweig, Martin (2016). Evidence for two protein coding transcripts at the Igf2as locus. Gene Reports, 4, pp. 60-66. Elsevier 10.1016/j.genrep.2016.04.003

Dorotea, Tiziano; Grünberg, Walter; Murgiano, Leonardo; Plattet, Philippe; Drögemüller, Cord; Mascarello, Francesco; Sacchetto, Roberta (2015). Fast-twitch skeletal muscle fiber adaptation to SERCA1 deficiency in a Dutch Improved Red and White calf pseudomyotonia case. Neuromuscular disorders, 25(11), pp. 888-897. Elsevier 10.1016/j.nmd.2015.08.010

Murgiano, Leonardo; Shirokova, Vera; Welle, Monika Maria; Jagannathan, Vidhya; Plattet, Philippe; Oevermann, Anna; Pienkowska-Schelling, Aldona; Gallo, Daniele; Gentile, Arcangelo; Mikkola, Marja; Drögemüller, Cord (2015). Hairless Streaks in Cattle Implicate TSR2 in Early Hair Follicle Formation. PLoS genetics, 11(7), e1005427. Public Library of Science 10.1371/journal.pgen.1005427

Ader-Ebert, Nadine; Khosravi, Mojtaba; Herren, Michael; Avila Sanchez, Mislay; Alves, Lisa; Bringolf, Fanny Anne; Örvell, Claes; Langedijk, Johannes P; Zurbriggen, Andreas; Plemper, Richard K; Plattet, Philippe (2015). Sequential conformational changes in the morbillivirus attachment protein initiate the membrane fusion process. PLoS pathogens, 11(5), e1004880. Public Library of Science 10.1371/journal.ppat.1004880

Cardoso Alves, Lisa Alexandra; Khosravi, Mojtaba; Avila Sanchez, Mislay; Ader-Ebert, Nadine; Bringolf, Fanny Anne; Zurbriggen, Andreas; Vandevelde, Marc; Plattet, Philippe (2015). SLAM- and nectin-4-independent noncytolytic spread of canine distemper virus in astrocytes. Journal of virology, 89(10), pp. 5724-5733. American Society for Microbiology 10.1128/JVI.00004-15

Avila Sanchez, Mislay; Khosravi, Mojtaba; Alves, Lisa; Ader-Ebert, Nadine; Bringolf, Fanny Anne; Zurbriggen, Andreas; Plemper, Richard K; Plattet, Philippe (2015). Canine distemper virus envelope protein interactions modulated by hydrophobic residues in the fusion protein globular head. Journal of virology, 89(2), pp. 1445-1451. American Society for Microbiology 10.1128/JVI.01828-14

Frischknecht, Mirjam; Jagannathan, Vidhya; Plattet, Philippe; Neuditschko, Markus; Signer-Hasler, Heidi; Bachmann, Iris; Pacholewska, Alicja Elzbieta; Drögemüller, Cord; Dietschi, Elisabeth; Flury, Christine; Rieder, Stefan; Leeb, Tosso (2015). A Non-Synonymous HMGA2 Variant Decreases Height in Shetland Ponies and Other Small Horses. PLoS ONE, 10(10), e0140749. Public Library of Science 10.1371/journal.pone.0140749

Dettwiler, Ramona; Schmitz, Andrea; Plattet, Philippe; Zielinski, Jana; Mevissen, Meike (2014). Heterologous expression of equine CYP3A94 and investigation of a tunable system to regulate co-expressed NADPH P450 oxidoreductase levels. PLoS ONE, 9(11), e113540. Public Library of Science 10.1371/journal.pone.0113540

Sattler, Ursula; Khosravi, Mojtaba; Avila Sanchez, Mislay; Pilo, Paola; Langedijk, Johannes P; Ader-Ebert, Nadine; Alves, Lisa Alexandra; Plattet, Philippe; Origgi, Francesco C (2014). Identification of amino acid substitutions with compensational effects in the attachment protein of canine distemper virus. Journal of virology, 88(14), pp. 8057-8064. American Society for Microbiology 10.1128/JVI.00454-14

Avila, Mislay; Alves, Lisa; Khosravi, Mojtaba; Ader-Ebert, Nadine; Origgi, Francesco; Schneider-Schaulies, J.; Zurbriggen, Andreas; Plemper, R. K.; Plattet, Philippe; Lyles, D. S. (2014). Molecular Determinants Defining the Triggering Range of Prefusion F Complexes of Canine Distemper Virus. Journal of virology, 88(5), pp. 2951-2966. American Society for Microbiology 10.1128/JVI.03123-13

Ader, Nadine; Brindley, Melinda; Avila, Mislay; Örvell, Claes; Horvat, Branka; Hiltensperger, Georg; Schneider-Schaulies, Jürgen; Vandevelde, Marc; Zurbriggen, Andreas; Plemper, Richard K.; Plattet, Philippe (2013). Mechanism for active membrane fusion triggering by morbillivirus attachment protein. Journal of virology, 87(1), pp. 314-326. American Society for Microbiology 10.1128/JVI.01826-12

Jagannathan, Vidhya; Bannoehr, Jeanette; Plattet, Philippe; Hauswirth, Regula; Drögemüller, Cord; Drögemüller, Michaela; Wiener, Dominique Judith; Doherr, Marcus; Owczarek-Lipska, Marta; Galichet, Arnaud; Welle, Monika Maria; Tengvall, Katarina; Bergvall, Kerstin; Lohi, Hannes; Rüfenacht, Silvia; Linek, Monika; Paradis, Manon; Müller, Eliane Jasmine; Roosje, Petra and Leeb, Tosso (2013). A mutation in the SUV39H2 gene in Labrador Retrievers with hereditary nasal parakeratosis (HNPK) provides insights into the epigenetics of keratinocyte differentiation. PLoS genetics, 9(10), e1003848. Public Library of Science 10.1371/journal.pgen.1003848

Bieringer, Maria; Han, Jung Woo; Kendl, Sabine; Khosravi, Mojtaba; Plattet, Philippe; Schneider-Schaulies, Jürgen (2013). Experimental adaptation of wild-type canine distemper virus (CDV) to the human entry receptor CD150. PLoS ONE, 8(3), e57488. Public Library of Science 10.1371/journal.pone.0057488

Plattet, Philippe; Plemper, Richard K. (2013). Envelope protein dynamics in paramyxovirus entry. mBio, 4(4) American Society for Microbiology 10.1128/mBio.00413-13

Ader, Nadine; Brindley, M. A.; Avila, Mislay; Origgi, Francesco; Langedijk, J. P.; Orvell, C.; Vandevelde, Marc; Zurbriggen, Andreas; Plemper, R. K.; Plattet, Philippe (2012). Structural rearrangements of the central region of the morbillivirus attachment protein stalk domain trigger F protein refolding for membrane fusion. Journal of biological chemistry, 287(20), pp. 16324-34. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M112.342493

Origgi, Francesco; Plattet, Philippe; Sattler, Ursula; Robert, N.; Casaubon, J.; Mavrot, Fabien; Pewsner, Mirjam Lea; Wu, Natacha; Giovannini, Samoa; Oevermann, Anna; Stoffel, Michael Hubert; Gaschen, Véronique; Segner, Helmut; Ryser-Degiorgis, Marie-Pierre (2012). Emergence of Canine Distemper Virus Strains With Modified Molecular Signature and Enhanced Neuronal Tropism Leading to High Mortality in Wild Carnivores. Veterinary pathology, 49(6), pp. 913-929. American College of Veterinary Pathologists 10.1177/0300985812436743

Brindley, M. A.; Takeda, M.; Plattet, Philippe; Plemper, R. K. (2012). Triggering the measles virus membrane fusion machinery. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 109(44), E3018-E3027. National Academy of Sciences NAS 10.1073/pnas.1210925109

Brunner, Jean-Marc; Plattet, Philippe; Doucey, Marie-Agnès; Rosso, Lia; Curie, Thomas; Montagner, Alexandra; Wittek, Riccardo; Vandelvelde, Marc; Zurbriggen, Andreas; Hirling, Harald; Desvergne, Béatrice; Subbiah, Elankumaran (2012). Morbillivirus Glycoprotein Expression Induces ER Stress, Alters Ca2+ Homeostasis and Results in the Release of Vasostatin. PLoS ONE, 7(3), e32803. Public Library of Science 10.1371/journal.pone.0032803

Janda, Jozef; Plattet, Philippe; Torsteinsdottir, Sigurbjörg; Jonsdottir, Sigridur; Zurbriggen, Andreas; Marti, Eliane Isabelle (2012). Generation of equine TSLP-specific antibodies and their use for detection of TSLP produced by equine keratinocytes and leukocytes. Veterinary immunology and immunopathology, 147(3-4), pp. 180-186. Elsevier 10.1016/j.vetimm.2012.04.013

Owczarek-Lipska, Marta; Plattet, Philippe; Zipperle, Ljerka; Drögemüller, Cord; Posthaus, Horst; Dolf, Gaudenz; Braunschweig, Martin (2011). A nonsense mutation in the optic atrophy 3 gene (OPA3) causes dilated cardiomyopathy in Red Holstein cattle. Genomics, 97(1), pp. 51-7. San Diego, Calif.: Elsevier 10.1016/j.ygeno.2010.09.005

Langedijk, J.P.; Janda, Jozef; Origgi, Francesco; Orvell, C.; Vandevelde, Marc; Zurbriggen, Andreas; Plattet, Philippe (2011). Canine distemper virus infects canine keratinocytes and immune cells by using overlapping and distinct regions located on one side of the attachment protein. Journal of virology, 85(21), pp. 11242-54. Baltimore: American Society for Microbiology 10.1128/JVI.05340-11

Lauber, Beatrice; Marti, Eliane Isabelle; Plattet, Philippe; Urwyler, A.; Rai, M.F.; Schmidt, M.F.; Welle, Monika Maria; Zurbriggen, Andreas; Janda, Jozef (2010). Distinct reactivities of interleukin-4-specific antibodies with recombinant and native canine interleukin-4 in various assays. Veterinary immunology and immunopathology, 137(3-4), pp. 310-6. Amsterdam: Elsevier 10.1016/j.vetimm.2010.05.015

Röthlisberger, Anne; Wiener, Dominique Judith; Schweizer, Matthias; Peterhans, Ernst; Zurbriggen, Andreas; Plattet, Philippe (2010). Two domains of the V protein of virulent canine distemper virus selectively inhibit STAT1 and STAT2 nuclear import. Journal of virology, 84(13), pp. 6328-43. Baltimore: American Society for Microbiology 10.1128/JVI.01878-09

Wiener, Dominique Judith; Vandevelde, Marc; Zurbriggen, Andreas; Plattet, Philippe (2010). Investigation of a unique short open reading frame within the 3' untranslated region of the canine distemper virus matrix messenger RNA. Virus research, 153(2), pp. 234-43. Amsterdam: Elsevier 10.1016/j.virusres.2010.08.007

Wyss-Fluehmann, Gabriela; Zurbriggen, Andreas; Vandevelde, Marc; Plattet, Philippe (2010). Canine distemper virus persistence in demyelinating encephalitis by swift intracellular cell-to-cell spread in astrocytes is controlled by the viral attachment protein. Acta neuropathologica, 119(5), pp. 617-30. Berlin: Springer-Verlag 10.1007/s00401-010-0644-7

Zipperle, Ljerka; Langedijk, J.P.; Orvell, C.; Vandevelde, Marc; Zurbriggen, Andreas; Plattet, Philippe (2010). Identification of key residues in virulent canine distemper virus hemagglutinin that control CD150/SLAM-binding activity. Journal of virology, 84(18), pp. 9618-24. Baltimore: American Society for Microbiology 10.1128/JVI.01077-10

Singethan, K.; Hiltensperger, G.; Kendl, S.; Wohlfahrt, J.; Plattet, P.; Holzgrabe, U.; Schneider-Schaulies, (2010). N-(3-Cyanophenyl)-2-phenylacetamide, an effective inhibitor of morbillivirus-induced membrane fusion with low cytotoxicity. Journal of general virology, 91(Pt 11), pp. 2762-72. Reading: Society for General Microbiology 10.1099/vir.0.025650-0

Plattet, Philippe; Langedijk, J.P.; Zipperle, Ljerka; Vandevelde, Marc; Orvell, C.; Zurbriggen, Andreas (2009). Conserved leucine residue in the head region of morbillivirus fusion protein regulates the large conformational change during fusion activity. Biochemistry, 48(38), pp. 9112-21. Washington, D.C.: American Chemical Society 10.1021/bi9008566

Rivals, Jean-Paul; Plattet, Philippe; Currat-Zweifel, Christine; Zurbriggen, Andreas; Wittek, Riccardo (2007). Adaptation of canine distemper virus to canine footpad keratinocytes modifies polymerase activity and fusogenicity through amino acid substitutions in the P/V/C and H proteins. Virology, 359(1), pp. 6-18. New York, N.Y.: Academic Press 10.1016/j.virol.2006.07.054

Wiener, Dominique; Plattet, Philippe; Cherpillod, Pascal; Zipperle, Ljerka; Doherr, Marcus G; Vandevelde, Marc; Zurbriggen, Andreas (2007). Synergistic inhibition in cell-cell fusion mediated by the matrix and nucleocapsid protein of canine distemper virus. Virus research, 129(2), pp. 145-54. Amsterdam: Elsevier 10.1016/j.virusres.2007.07.004

Brunner, Jean-Marc; Plattet, Philippe; Majcherczyk, Paul; Zurbriggen, Andreas; Wittek, Riccardo; Hirling, Harald (2007). Canine distemper virus infection of primary hippocampal cells induces increase in extracellular glutamate and neurodegeneration. Journal of neurochemistry, 103(3), pp. 1184-95. Oxford: Wiley-Blackwell 10.1111/j.1471-4159.2007.04819.x

Plattet, Philippe; Cherpillod, Pascal; Wiener, Dominique; Zipperle, Ljerka; Vandevelde, Marc; Wittek, Riccardo; Zurbriggen, Andreas (2007). Signal peptide and helical bundle domains of virulent canine distemper virus fusion protein restrict fusogenicity. Journal of virology, 81(20), pp. 11413-25. Baltimore: American Society for Microbiology 10.1128/JVI.01287-07

Wenzlow, N; Plattet, Philippe; Wittek, R; Zurbriggen, Andreas; Gröne, A (2007). Immunohistochemical demonstration of the putative canine distemper virus receptor CD150 in dogs with and without distemper. Veterinary pathology, 44(6), pp. 943-8. Middleton, Wis.: American College of Veterinary Pathologists 10.1354/vp.44-6-943

Plattet, Philippe; Strahle, Laura; le Mercier, Philippe; Hausmann, Stéphane; Garcin, Dominique; Kolakofsky, Daniel (2007). Sendai virus RNA polymerase scanning for mRNA start sites at gene junctions. Virology, 362(2), pp. 411-20. New York, N.Y.: Academic Press 10.1016/j.virol.2006.12.033

Plattet, Philippe; Rivals, Jean-Paul; Zuber, Benoît; Brunner, Jean-Marc; Zurbriggen, Andreas; Wittek, Riccardo (2005). The fusion protein of wild-type canine distemper virus is a major determinant of persistent infection. Virology, 337(2), pp. 312-326. Elsevier 10.1016/j.virol.2005.04.012