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Müller, Joachim; Boubaker, Ghalia; Müller, Norbert; Uldry, Anne-Christine; Braga-Lagache, Sophie; Heller, Manfred; Hemphill, Andrew (2024). Investigating Antiprotozoal Chemotherapies with Novel Proteomic Tools-Chances and Limitations: A Critical Review. International journal of molecular sciences, 25(13) MDPI 10.3390/ijms25136903
Ajiboye, Jubilee; Uldry, Anne-Christine; Heller, Manfred; Naguleswaran, Arunasalam; Fan, Erkang; Van Voorhis, Wesley C; Hemphill, Andrew; Müller, Joachim (2024). Molecular Targets of the 5-Amido-Carboxamide Bumped Kinase Inhibitor BKI-1748 in Cryptosporidium parvum and HCT-8 Host Cells. International journal of molecular sciences, 25(5) MDPI 10.3390/ijms25052707
Müller, Joachim; Hemphill, Andrew (2024). In vitro screening technologies for the discovery and development of novel drugs against Toxoplasma gondii. Expert opinion on drug discovery, 19(1), pp. 97-109. Taylor & Francis 10.1080/17460441.2023.2276349
Imhof, Dennis; Hänggeli, Kai Pascal Alexander; Ferreira de Sousa, Maria Cristina; Vigneswaran, Anitha; Hofmann, Larissa; Amdouni, Yosra; Boubaker, Ghalia; Müller, Joachim; Hemphill, Andrew (2024). Working towards the development of vaccines and chemotherapeutics against neosporosis—With all of its ups and downs—Looking ahead. Advances in Parasitology, 124, pp. 91-154. Elsevier 10.1016/bs.apar.2024.01.001
Schlange, Carling; Müller, Joachim; Imhof, Dennis; Hänggeli, Kai Pascal Alexander; Boubaker, Ghalia; Ortega-Mora, Luis-Miguel; Wong, Ho Ning; Haynes, Richard K; Van Voorhis, Wesley C; Hemphill, Andrew (2023). Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice. Experimental parasitology, 255(108655), p. 108655. Elsevier 10.1016/j.exppara.2023.108655
Hänggeli, Kai Pascal Alexander; Hemphill, Andrew; Müller, Norbert; Heller, Manfred; Uldry, Anne-Christine; Braga-Lagache, Sophie; Müller, Joachim; Boubaker, Ghalia (2023). Comparative Proteomic Analysis of Toxoplasma gondii RH Wild-Type and Four SRS29B (SAG1) Knock-Out Clones Reveals Significant Differences between Individual Strains. International journal of molecular sciences, 24(13) MDPI 10.3390/ijms241310454
Hemphill, Andrew; Müller, Joachim (2023). Toxoplasma gondii infection: Novel emerging therapeutic targets. Expert opinion on therapeutic targets, 27(4-5), pp. 293-304. Taylor & Francis 10.1080/14728222.2023.2217353
Müller, Joachim; Schlange, Carling; Heller, Manfred; Uldry, Anne-Christine; Braga-Lagache, Sophie; Haynes, Richard K; Hemphill, Andrew (2023). Proteomic characterization of Toxoplasma gondii ME49 derived strains resistant to the artemisinin derivatives artemiside and artemisone implies potential mode of action independent of ROS formation. International journal for parasitology. Drugs and drug resistance, 21, pp. 1-12. Elsevier 10.1016/j.ijpddr.2022.11.005
Memedovski, Roman; Preza, Matías; Müller, Joachim; Kämpfer, Tobias Emmanuel; Rufener, Reto; de Souza, Marcus Vinicius Nora; da Silva, Emerson Teixeira; de Andrade, Gabriel Fernandes; Braga, Sophie; Uldry, Anne-Christine; Buchs, Natasha; Heller, Manfred; Lundström-Stadelmann, Britta (2023). Investigation of the mechanism of action of mefloquine and derivatives against the parasite Echinococcus multilocularis. International journal for parasitology. Drugs and drug resistance, 21, pp. 114-124. Elsevier 10.1016/j.ijpddr.2023.03.002
Müller, Joachim; Preza, Matías; Kaethner, Marc; Rufener, Reto; Braga, Sophie; Uldry, Anne-Christine; Heller, Manfred; Lundström-Stadelmann, Britta (2023). Targeted and non-targeted proteomics to characterize the parasite proteins of Echinococcus multilocularis metacestodes. Frontiers in cellular and infection microbiology, 13, p. 1170763. Frontiers 10.3389/fcimb.2023.1170763
Müller, Joachim; Boubaker, Ghalia; Imhof, Dennis; Hänggeli, Kai; Haudenschild, Noé; Uldry, Anne-Christine; Braga-Lagache, Sophie; Heller, Manfred; Ortega-Mora, Luis-Miguel; Hemphill, Andrew (2022). Differential Affinity Chromatography Coupled to Mass Spectrometry: A Suitable Tool to Identify Common Binding Proteins of a Broad-Range Antimicrobial Peptide Derived from Leucinostatin. Biomedicines, 10(11) MDPI 10.3390/biomedicines10112675
Zheng, Yang; Müller, Joachim; Kunz, Stefan; Siderius, Marco; Maes, Louis; Caljon, Guy; Müller, Norbert; Hemphill, Andrew; Sterk, Geert Jan; Leurs, Rob (2022). 3-nitroimidazo[1,2-b]pyridazine as a novel scaffold for antiparasitics with sub-nanomolar anti-Giardia lamblia activity. International journal for parasitology. Drugs and drug resistance, 19, pp. 47-55. Elsevier 10.1016/j.ijpddr.2022.05.004
Müller, Joachim; Anghel, Nicoleta; Imhof, Dennis; Hänggeli, Kai; Uldry, Anne-Christine; Braga-Lagache, Sophie; Heller, Manfred; Ojo, Kayode K; Ortega-Mora, Luis-Miguel; Van Voorhis, Wesley C; Hemphill, Andrew (2022). Common Molecular Targets of a Quinolone Based Bumped Kinase Inhibitor in Neospora caninum and Danio rerio. International journal of molecular sciences, 23(4) MDPI 10.3390/ijms23042381
Hänggeli, Kai Pascal Alexander; Hemphill, Andrew; Müller, Norbert; Schimanski, Bernd; Olias, Philipp; Müller, Joachim; Boubaker, Ghalia (2022). Single- and duplex TaqMan-quantitative PCR for determining the copy numbers of integrated selection markers during site-specific mutagenesis in Toxoplasma gondii by CRISPR-Cas9. PLoS ONE, 17(9), e0271011. Public Library of Science 10.1371/journal.pone.0271011
Neff, Dominik; Padberg Sgier, Barbara-Christina; Dietze, Hannah; Müller, Joachim; Früh, Martin (2022). Unusually Aggressive Presentation of Malignant Peritoneal Mesothelioma: Two Case Reports. Case reports in oncology, 15(3), pp. 1001-1008. Karger 10.1159/000526974
Anghel, Nicoleta; Müller, Joachim; Serricchio, Mauro; Jelk, Jennifer; Bütikofer, Peter; Boubaker, Ghalia; Imhof, Dennis; Ramseier, Jessica; Desiatkina, Oksana; Paunescu, Emilia; Braga, Sophie Marie-Pierre; Heller, Manfred; Furrer, Julien; Hemphill, Andrew (2021). Cellular and Molecular Targets of Nucleotide-Tagged Trithiolato-Bridged Arene Ruthenium Complexes in the Protozoan Parasites Toxoplasma gondii and Trypanosoma brucei. International journal of molecular sciences, 22(19) MDPI 10.3390/ijms221910787
Müller, Joachim; Heller, Manfred; Uldry, Anne-Christine; Braga, Sophie; Müller, Norbert (2021). Nitroreductase Activites in Giardia lamblia: ORF 17150 Encodes a Quinone Reductase with Nitroreductase Activity. Pathogens, 10(2), p. 129. MDPI AG 10.3390/pathogens10020129
Van Voorhis, Wesley C; Hulverson, Matthew A; Choi, Ryan; Huang, Wenlin; Arnold, Samuel L M; Schaefer, Deborah A; Betzer, Dana P; Vidadala, Rama S R; Lee, Sangun; Whitman, Grant R; Barrett, Lynn K; Maly, Dustin J; Riggs, Michael W; Fan, Erkang; Kennedy, Thomas J; Tzipori, Saul; Doggett, J Stone; Winzer, Pablo; Anghel, Nicoleta; Imhof, Dennis; ... (2021). One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases. Veterinary parasitology, 289, p. 109336. Elsevier 10.1016/j.vetpar.2020.109336
Anghel, Nicoleta; Winzer, Pablo A.; Imhof, Dennis; Müller, Joachim; Langa, Javier; Rieder, Jessica; Barrett, Lynn K.; Vidadala, Rama Subba Rao; Huang, Wenlin; Choi, Ryan; Hulverson, Mathew A.; Whitman, Grant R.; Arnold, Samuel L.; Van Voorhis, Wesley C.; Ojo, Kayode K.; Maly, Dustin J.; Fan, Erkang; Hemphill, Andrew (2020). Comparative assessment of the effects of bumped kinase inhibitorson early zebrafish embryo development and pregnancy in mice. International journal of antimicrobial agents, 56(3), p. 106099. Elsevier 10.1016/j.ijantimicag.2020.106099
Müller, Joachim; Braga, Sophie; Uldry, Anne-Christine; Heller, Manfred; Müller, Norbert (2020). Comparative proteomics of three Giardia lamblia strains: investigation of antigenic variation in the post-genomic era. Parasitology, 147(9), pp. 1008-1018. Cambridge University Press 10.1017/S0031182020000657
Winzer, Pablo; Müller, Joachim; Imhof, Dennis; Ritler, Dominic; Uldry, Anne-Christine; Braga-Lagache, Sophie; Heller, Manfred; Ojo, Kayode K; Van Voorhis, Wesley C; Ortega-Mora, Luis-Miguel; Hemphill, Andrew (2020). Neospora caninum: Differential Proteome of Multinucleated Complexes Induced by the Bumped Kinase Inhibitor BKI-1294. Microorganisms, 8(6) MDPI 10.3390/microorganisms8060801
Lin, Yan; Ong, Yih Ching; Keller, Sarah; Karges, Johannes; Bouchene, Rafika; Manoury, Eric; Blacque, Olivier; Müller, Joachim; Anghel, Nicoleta; Hemphill, Andrew; Häberli, Cécile; Taki, Aya C; Gasser, Robin B; Cariou, Kevin; Keiser, Jennifer; Gasser, Gilles (2020). Synthesis, characterization and antiparasitic activity of organometallic derivatives of the anthelmintic drug albendazole. Dalton transactions, 49(20), pp. 6616-6626. Royal Society of Chemistry 10.1039/d0dt01107j
Winzer, Pablo Arnold; Anghel, Nicoleta; Imhof, Dennis; Balmer, Vreni; Ortega-Mora, Luis-Miguel; Ojo, Kayode K; Van Voorhis, Wesley C; Müller, Joachim; Hemphill, Andrew (2020). Neospora caninum: Structure and Fate of Multinucleated Complexes Induced by the Bumped Kinase Inhibitor BKI-1294. Pathogens, 9(5) MDPI AG 10.3390/pathogens9050382
Müller, Joachim; Winzer, Pablo A.; Samby, Kirandeep; Hemphill, Andrew (2020). In Vitro Activities of MMV Malaria Box Compounds against the Apicomplexan Parasite Neospora caninum, the Causative Agent of Neosporosis in Animals. Molecules, 25(6) MDPI 10.3390/molecules25061460
Müller, Joachim; Vermathen, Martina; Leitsch, David; Vermathen, Peter; Müller, Norbert (2020). Metabolomic Profiling of Wildtype and Transgenic Giardia lamblia Strains by 1H HR-MAS NMR Spectroscopy. Metabolites, 10(2) MDPI 10.3390/metabo10020053
Heller, Manfred; Braga, Sophie; Müller, Norbert; Müller, Joachim (2020). Transfection With Plasmid Causing Stable Expression of a Foreign Gene Affects General Proteome Pattern in Giardia lamblia Trophozoites. Frontiers in cellular and infection microbiology, 10 Frontiers 10.3389/fcimb.2020.602756
Winzer, Pablo; Imhof, Dennis; Anghel, Nicoleta; Ritler, Dominic; Müller, Joachim; Boubaker, Ghalia; Aguado-Martinez, Adriana; Ortega-Mora, Luis-Miguel; Ojo, Kayode K; VanVoorhis, Wesley C; Hemphill, Andrew (2020). The Impact of BKI-1294 Therapy in Mice Infected With the Apicomplexan Parasite Neospora caninum and Re-infected During Pregnancy. Frontiers in veterinary science, 7, p. 587570. Frontiers Media 10.3389/fvets.2020.587570
Eberhard, Naja; Balmer, Vreni; Müller, Joachim; Müller, Norbert; Winter, Rolf; Pou, Soviti; Nilsen, Aaron; Riscoe, Mike; Francisco, Samuel; Leitao, Alexandre; Doggett, J Stone; Hemphill, Andrew (2020). Activities of Endochin-Like Quinolones Against in vitro Cultured Besnoitia besnoiti Tachyzoites. Frontiers in veterinary science, 7, p. 96. Frontiers Media 10.3389/fvets.2020.00096
Hemphill, Andrew; Müller, Norbert; Müller, Joachim (2019). Comparative Pathobiology of the Intestinal Protozoan Parasites Giardia lamblia, Entamoeba histolytica, and Cryptosporidium parvum. Pathogens, 8(3) MDPI AG 10.3390/pathogens8030116
Müller, Joachim; Braga, Sophie; Heller, Manfred; Müller, Norbert (2019). Resistance formation to nitro drugs in Giardia lamblia: No common markers identified by comparative proteomics. International journal for parasitology. Drugs and drug resistance, 9, pp. 112-119. Elsevier 10.1016/j.ijpddr.2019.03.002
Silva Pinto Basto, Afonso; Anghel, Nicoleta; Rubbiani, Riccardo; Müller, Joachim; Stibal, David; Giannini, Federico; Süss-Fink, Georg; Balmer, Vreni; Gasser, Gilles; Furrer, Julien; Hemphill, Andrew (2019). Targeting of the mitochondrion by dinuclear thiolato-bridged arene ruthenium complexes in cancer cells and in the apicomplexan parasite Neospora caninum. Metallomics, 11(2), pp. 462-474. Royal Society of Chemistry 10.1039/C8MT00307F
Sánchez-Sánchez, Roberto; Ferre, Ignacio; Regidor-Cerrillo, Javier; Gutiérrez-Expósito, Daniel; Ferrer, Luis Miguel; Arteche-Villasol, Noive; Moreno-Gonzalo, Javier; Müller, Joachim; Aguado Martinez, Adriana; Pérez, Valentín; Hemphill, Andrew; Ortega-Mora, Luis Miguel; Benavides, Julio (2019). Virulence in Mice of a Toxoplasma gondii Type II Isolate Does Not Correlate With the Outcome of Experimental Infection in Pregnant Sheep. Frontiers in cellular and infection microbiology, 8(436), p. 436. Frontiers 10.3389/fcimb.2018.00436
Müller, Joachim; Manser, Vera; Hemphill, Andrew (2019). In vitro treatment of Besnoitia besnoiti with the naphto-quinone buparvaquone results in marked inhibition of tachyzoite proliferation, mitochondrial alterations and rapid adaptation of tachyzoites to increased drug concentrations. Parasitology, 146(1), pp. 112-120. Cambridge University Press 10.1017/S0031182018000975
Ritler, Dominic; Rufener, Reto; Li, Jia V.; Kämpfer, Urs; Müller, Joachim; Bühr, Claudia; Schürch, Stefan; Lundström Stadelmann, Britta (2019). In vitro metabolomic footprint of the Echinococcus multilocularis metacestode. Scientific reports, 9(1), p. 19438. Springer Nature 10.1038/s41598-019-56073-y
Müller, Joachim; Müller, Norbert (2019). Nitroreductases of bacterial origin in Giardia lamblia : Potential role in detoxification of xenobiotics. MicrobiologyOpen, 8(10), pp. 1-9. Wiley 10.1002/mbo3.904
Anghel, Nicoleta; Balmer, Vreni; Müller, Joachim; Winzer, Pablo Arnold; Aguado Martinez, Adriana; Roozbehani, Mona; Pou, Sovitj; Nilsen, Aaron; Riscoe, Michael; Doggett, J Stone; Hemphill, Andrew (2018). Endochin-Like Quinolones Exhibit Promising Efficacy Against Neospora Caninum in vitro and in Experimentally Infected Pregnant Mice. Frontiers in veterinary science, 5, p. 285. Frontiers Media 10.3389/fvets.2018.00285
Vermathen, Martina; Müller, Joachim; Furrer, Julien; Müller, Norbert; Vermathen, Peter (2018). 1H HR-MAS NMR spectroscopy to study the metabolome of the protozoan parasite Giardia lamblia. Talanta, 188, pp. 429-441. Elsevier 10.1016/j.talanta.2018.06.006
De Amorim Cardoso, Rita Isabel; Wang, Junhua; Müller, Joachim; Rupp, Sebastian Dominic Alexander; Leitão, Alexandre; Hemphill, Andrew (2018). Modulation of cis- and trans- Golgi and the Rab9A-GTPase during infection by Besnoitia besnoiti, Toxoplasma gondii and Neospora caninum. Experimental parasitology, 187, pp. 75-85. Elsevier 10.1016/j.exppara.2018.02.008
Rajan, Gunesh; Tavora-Vieira, Dayse; Baumgartner, Wolf-Dieter; Godey, Benoit; Müller, Joachim; O'Driscoll, Martin; Skarzynski, Henryk; Skarzynski, Piotr; Usami, Shin-Ichi; Adunka, Oliver; Agrawal, Sumit; Bruce, Iain; De Bodt, Marc; Caversaccio, Marco; Pilsbury, Harold; Gavilán, Javier; Hagen, Rudolf; Hagr, Abdulrahman; Kameswaran, Mohan; Karltorp, Eva; ... (2018). Hearing preservation cochlear implantation in children: The HEARRING Group consensus and practice guide. Cochlear implants international, 19(1), pp. 1-13. Taylor & Francis 10.1080/14670100.2017.1379933
Rufener, Reto; Ritler, Dominic; Zielinski, Jana; Dick, Luca; da Silva, Emerson Teixeira; da Silva Araujo, Adriele; Joekel, Deborah Elisabeth; Czock, David; Göpfert, Christine; Moraes, Adriana Marques; de Souza, Marcus Vinicius Nora; Müller, Joachim; Mevissen, Meike; Hemphill, Andrew; Lundström-Stadelmann, Britta (2018). Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis. International journal for parasitology. Drugs and drug resistance, 8(2), pp. 331-340. Elsevier 10.1016/j.ijpddr.2018.06.004
Müller, Joachim; Hemphill, Andrew; Müller, Norbert (2018). Physiological aspects of nitro drug resistance in Giardia lamblia. International journal for parasitology. Drugs and drug resistance, 8(2), pp. 271-277. Elsevier 10.1016/j.ijpddr.2018.04.008
Harmse, Rozanne; Wong, Ho Ning; Smit, Frans J; Müller, Joachim; Hemphill, Andrew; N'Da, David D; Haynes, Richard K (2017). Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Neospora caninum and Comparative Cytotoxicities. ChemMedChem, 12(24), pp. 2094-2098. Wiley-VCH 10.1002/cmdc.201700600
Hulverson, Matthew A; Choi, Ryan; Arnold, Samuel L M; Schaefer, Deborah A; Hemphill, Andrew; McCloskey, Molly C; Betzer, Dana P; Müller, Joachim; Vidadala, Rama S R; Whitman, Grant R; Rivas, Kasey L; Barrett, Lynn K; Hackman, Robert C; Love, Melissa S; McNamara, Case W; Shaughnessy, Thomas K; Kondratiuk, Alison; Kurnick, Matthew; Banfor, Patricia N; Lynch, James J; ... (2017). Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis. International journal for parasitology, 47(12), pp. 753-763. Elsevier 10.1016/j.ijpara.2017.08.006
Müller, Joachim; Aguado Martinez, Adriana; Laleu, Benoît; Balmer, Vreni; Ritler, Dominic; Hemphill, Andrew (2017). In vitro screening of the open source Pathogen Box identifies novel compounds with profound activities against Neospora caninum. International journal for parasitology, 47(12), pp. 801-809. Elsevier 10.1016/j.ijpara.2017.06.002
Müller, Joachim; Aguado Martinez, Adriana; Ortega-Mora, Luis-Miguel; Moreno-Gonzalo, Javier; Ferre, Ignacio; Hulverson, Matthew A; Choi, Ryan; McCloskey, Molly C; Barrett, Lynn K; Maly, Dustin J; Ojo, Kayode K; Van Voorhis, Wes; Hemphill, Andrew (2017). Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis. Journal of antimicrobial chemotherapy, 72(8), pp. 2334-2341. Oxford University Press 10.1093/jac/dkx134
Glatzer, Markus; Rittmeyer, Achim; Müller, Joachim; Opitz, Isabelle; Papachristofilou, Alexandros; Psallidas, Ioannis; Früh, Martin; Born, Diana; Putora, Paul Martin (2017). Treatment of limited disease small cell lung cancer: the multidisciplinary team. European respiratory journal, 50(2) European Respiratory Society 10.1183/13993003.00422-2017
Silva Pinto Basto, Afonso; Müller, Joachim; Rubbiani, Riccardo; Stibal, David; Giannini, Federico; Süss-Fink, Georg; Balmer, Vreni; Hemphill, Andrew; Gasser, Gilles; Furrer, Julien (2017). Characterization of the Activities of Dinuclear Thiolato-Bridged Arene Ruthenium Complexes against Toxoplasma gondii. Antimicrobial agents and chemotherapy, 61(9), e01031-17. American Society for Microbiology 10.1128/AAC.01031-17
Müller, Joachim; Aguado Martinez, Adriana; Balmer, Vreni; Maly, Dustin J; Fan, Erkang; Ortega-Mora, Luis-Miguel; Ojo, Kayode K; Van Voorhis, Wesley C; Hemphill, Andrew (2017). Two novel calcium-dependent kinase 1-inhibitors interfere with vertical transmission in mice infected with Neospora caninum tachyzoites. Antimicrobial agents and chemotherapy, 61(4) American Society for Microbiology 10.1128/AAC.02324-16
Serra, Fabienne Heirangi; Müller, Joachim; Gray, John; Lüthi, Ramona; Dudas, Sandor; Czub, Stefanie; Seuberlich, Torsten (2017). PrP-C1 fragment in cattle brains reveals features of the transmissible spongiform encephalopathy associated PrP(sc). Brain research, 1659, pp. 19-28. Elsevier 10.1016/j.brainres.2017.01.015
Leitsch, David; Müller, Joachim; Müller, Norbert (2016). Evaluation of Giardia lamblia thioredoxin reductase as drug activating enzyme and as drug target. International journal for parasitology. Drugs and drug resistance, 6(3), pp. 148-153. Elsevier 10.1016/j.ijpddr.2016.07.003
van de Heyning, Paul; Arauz, Santiago L; Atlas, Marcus; Baumgartner, Wolf-Dieter; Caversaccio, Marco; Chester-Browne, Ronel; Estienne, Patricia; Gavilan, Javier; Godey, Benoit; Gstöttner, Wolfgang; Han, Demin; Hagen, Rudolph; Kompis, Martin; Kuzovkov, Vlad; Lassaletta, Luis; Lefevre, Franc; Li, Yongxin; Müller, Joachim; Parnes, Lorne; Kleine Punte, Andrea; ... (2016). Electrically evoked compound action potentials are different depending on the site of cochlear stimulation. Cochlear implants international, 17(6), pp. 251-262. Taylor & Francis 10.1080/14670100.2016.1240427
Müller, Joachim; Hemphill, Andrew (2016). Drug target identification in protozoan parasites. Expert opinion on drug discovery, 11(8), pp. 815-824. Taylor & Francis 10.1080/17460441.2016.1195945
Van Voorhis, Wesley C; Adams, John H; Adelfio, Roberto; Ahyong, Vida; Akabas, Myles H; Alano, Pietro; Alday, Aintzane; Alemán Resto, Yesmalie; Alsibaee, Aishah; Alzualde, Ainhoa; Andrews, Katherine T; Avery, Simon V; Avery, Vicky M; Ayong, Lawrence; Baker, Mark; Baker, Stephen; Ben Mamoun, Choukri; Bhatia, Sangeeta; Bickle, Quentin; Bounaadja, Lotfi; ... (2016). Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS pathogens, 12(7), e1005763. Public Library of Science 10.1371/journal.ppat.1005763
Hostettler, Isabel; Müller, Joachim; Hemphill, Andrew (2016). In Vitro Screening of the Open-Source Medicines for Malaria Venture Malaria Box Reveals Novel Compounds with Profound Activities against Theileria annulata Schizonts. Antimicrobial agents and chemotherapy, 60(6), pp. 3301-3308. American Society for Microbiology 10.1128/AAC.02801-15
Aguado Martinez, Adriana; Silva Pinto Basto, Afonso; Müller, Joachim; Balmer, Vreni; Manser, Vera; Leitão, Alexandre; Hemphill, Andrew (2016). N-terminal fusion of a toll-like receptor 2-ligand to a Neospora caninum chimeric antigen efficiently modifies the properties of the specific immune response. Parasitology, 143(5), pp. 606-616. Cambridge University Press 10.1017/S0031182016000056
Hemphill, Andrew; Aguado Martinez, Adriana; Müller, Joachim (2016). Approaches for the vaccination and treatment of Neospora caninum infections in mice and ruminant models. Parasitology, 143(3), pp. 245-259. Cambridge University Press 10.1017/S0031182015001596
Müller, Joachim; Aguado Martinez, Adriana; Manser, Vera; Wong, Ho Ning; Haynes, Richard K; Hemphill, Andrew (2016). Repurposing of antiparasitic drugs: the hydroxy-naphthoquinone buparvaquone inhibits vertical transmission in the pregnant neosporosis mouse model. Veterinary research, 47, p. 32. BioMed Central 10.1186/s13567-016-0317-1
Küster, Tatiana; Lundström-Stadelmann, Britta; Rufener, Reto; Risch, Corina; Müller, Joachim; Hemphill, Andrew (2015). Oral treatments of Echinococcus multilocularis-infected mice with the antimalarial drug mefloquine that potentially interacts with parasite ferritin and cystatin. International journal of antimicrobial agents, 46(5), pp. 546-551. Elsevier 10.1016/j.ijantimicag.2015.07.016
Winzer, Pablo Arnold; Müller, Joachim; Aguado Martinez, Adriana; Rahman, Mahbubur; Balmer, Vreni; Manser, Vera; Ortega-Mora, Luis Miguel; Ojo, Kayode K; Fan, Erkang; Maly, Dustin J; Van Voorhis, Wesley C; Hemphill, Andrew (2015). In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum. Antimicrobial agents and chemotherapy, 59(10), pp. 6361-6374. American Society for Microbiology 10.1128/AAC.01236-15
Müller, Joachim; Rout, Samuel; Leitsch, David; Vaithilingam, Jathana; Hehl, Adrian; Müller, Norbert (2015). Comparative characterisation of two nitroreductases from Giardia lamblia as potential activators of nitro compounds. International journal for parasitology. Drugs and drug resistance, 5(2), pp. 37-43. Elsevier 10.1016/j.ijpddr.2015.03.001
Arranz Solis, David; Aguado Martinez, Adriana; Müller, Joachim; Regidor-Cerrillo, Javier; Ortega-Mora, Luis Miguel; Hemphill, Andrew (2015). Dose-dependent effects of experimental infection with the virulent Neospora caninum Nc-Spain7 isolate in a pregnant mouse model. Veterinary parasitology, 211(3-4), pp. 133-140. Elsevier 10.1016/j.vetpar.2015.05.021
Müller, Joachim; Balmer, Vreni; Winzer, Pablo Arnold; Rahman, Mahbubur; Manser, Vera; Haynes, Richard K; Hemphill, Andrew (2015). In vitro effects of new artemisinin derivatives in Neospora caninum-infected human fibroblasts. International journal of antimicrobial agents, 46(1), pp. 88-93. Elsevier 10.1016/j.ijantimicag.2015.02.020
Müller, Joachim; Aguado Martinez, Adriana; Manser, Vera; Balmer, Vreni; Winzer, Pablo Arnold; Ritler, Dominic; Hostettler, Isabel; Arranz Solis, David; Ortega-Mora, Luis; Hemphill, Andrew (2015). Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice. International journal for parasitology. Drugs and drug resistance, 5(1), pp. 16-25. Elsevier 10.1016/j.ijpddr.2015.02.001
Hostettler, Isabel; Müller, Joachim; Stephens, Chad E; Haynes, Richard; Hemphill, Andrew (2014). A quantitative reverse-transcriptase PCR assay for the assessment of drug activities against intracellular Theileria annulata schizonts. International journal for parasitology. Drugs and drug resistance, 4(3), pp. 201-209. Elsevier 10.1016/j.ijpddr.2014.09.003
Lundström-Stadelmann, Britta; Aeschbacher, Denise; Huber, Cristina; Spiliotis, Markus; Müller, Joachim; Hemphill, Andrew (2014). Profound activity of the anti-cancer drug bortezomib against Echinococcus multilocularis metacestodes identifies the proteasome as a novel drug target for cestodes. PLoS neglected tropical diseases, 8(12), e3352. Public Library of Science 10.1371/journal.pntd.0003352
Hemphill, Andrew; Lundström-Stadelmann, Britta; Rufener, Reto; Spiliotis, Markus; Boubaker, Ghalia; Müller, Joachim; Müller, Norbert; Gorgas, Daniela; Gottstein, Bruno (2014). Treatment of echinococcosis: albendazole and mebendazole - what else? Parasite, 21, p. 70. Princeps Editions 10.1051/parasite/2014073
Müller, Joachim; Vaithilingam, Jathana; Rosner, Judah Lee; Müller, Norbert (2014). Escherichia coli are susceptible to thiazolides if the tolc efflux system is inhibited. Journal of Developing Drugs, 3(2), p. 1000124. OMICS Group 10.4172/2329-6631.1000124
Ojo, Kayode K; Reid, Molly C; Kallur Siddaramaiah, Latha; Müller, Joachim; Winzer, Pablo Arnold; Zhang, Zhongsheng; Keyloun, Katelyn R; Vidadala, Rama Subba Rao; Merritt, Ethan A; Hol, Wim G J; Maly, Dustin J; Fan, Erkang; Van Voorhis, Wesley C; Hemphill, Andrew (2014). Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy. PLoS ONE, 9(3), e92929. Public Library of Science 10.1371/journal.pone.0092929
Hemphill, Andrew; Debache, Karim; Monney, Thierry; Schorer, Michelle; Gouinaud, Christophe; Alaeddine, Ferial; Müller, Norbert; Müller, Joachim (2013). Proteins mediating the Neospora caninum-host cell interaction as targets for vaccination. Frontiers in Bioscience (Elite Edition), 5(1), pp. 23-36. Frontiers in Bioscience
Müller, Joachim; Schildknecht, Patricia; Müller, Norbert (2013). Metabolism of nitro drugs metronidazole and nitazoxanide in Giardia lamblia: characterization of a novel nitroreductase (GlNR2). Journal of antimicrobial chemotherapy, 68(8), pp. 1781-1789. Oxford University Press 10.1093/jac/dkt106
Hemphill, Andrew; Müller, Norbert; Müller, Joachim (2013). Thiazolides, a Novel Class of Anti-Infective Drugs, Effective Against Viruses, Bacteria, Intracellular and Extracellular Protozoan Parasites and Proliferating Mammalian Cells. Anti-infective agents in medicinal chemistry, 11(1), pp. 22-30. Bentham Science 10.2174/22113626130103
Reinmann, Karin; Müller, Norbert; Kuhnert, Peter; Campero, Carlos M.; Leitsch, David; Hess, M; Henning, K; Fort, M; Müller, Joachim; Gottstein, Bruno; Frey, Caroline (2012). Tritrichomonas foetus isolates from cats and cattle show minor genetic differences in unrelated loci ITS-2 and EF-1alpha. Veterinary parasitology, 185(2-4), pp. 138-44. Amsterdam: Elsevier 10.1016/j.vetpar.2011.09.032
Manneck, Theresia; Keiser, Jennifer; Müller, Joachim (2012). Mefloquine interferes with glycolysis in schistosomula of Schistosoma mansoni via inhibition of enolase. Parasitology, 139(4), pp. 497-505. Cambridge University Press 10.1017/S0031182011002204
Nillius, Dorothea; Müller, Joachim; Müller, Norbert (2011). Nitroreductase (GlNR1) increases susceptibility of Giardia lamblia and Escherichia coli to nitro drugs. Journal of antimicrobial chemotherapy, 66(5), pp. 1029-35. Oxford: Oxford University Press 10.1093/jac/dkr029
Gottstein, Bruno; Wittwer, Matthias; Schild, Marc; Merli, Michael; Leib, Stephen L.; Müller, Norbert; Müller, Joachim; Jaggi, Rolf (2010). Hepatic gene expression profile in mice perorally infected with Echinococcus multilocularis eggs. PLoS ONE, 5(4), e9779. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0009779
Debache, Karim; Alaeddine, Ferial; Guionaud, Christophe; Monney, Thierry; Müller, Joachim; Strohbusch, Maria; Leib, Stephen L.; Grandgirard, Denis; Hemphill, Andrew (2009). Vaccination with recombinant NcROP2 combined with recombinant NcMIC1 and NcMIC3 reduces cerebral infection and vertical transmission in mice experimentally infected with Neospora caninum tachyzoites. International journal for parasitology, 39(12), pp. 1373-1384. Kidlington, UK: Elsevier 10.1016/j.ijpara.2009.04.006
Schmuckli-Maurer, Jacqueline; Casanova, Carlo; Schmied, Stéfanie; Affentranger, Sarah; Parvanova, Iana; Kang'a, Simon; Nene, Vishvanath; Katzer, Frank; McKeever, Declan; Müller, Joachim; Bishop, Richard; Pain, Arnab; Dobbelaere, Dirk; Rodrigues, Mauricio Martins (2009). Expression Analysis of the Theileria parva Subtelomere-Encoded Variable Secreted Protein Gene Family. PLoS ONE, 4(3), e4839. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0004839
Müller, Joachim; Nillius, Dorothea; Hehl, A.; Hemphill, Andrew; Müller, Norbert (2009). Stable expression of Escherichia coli beta-glucuronidase A (GusA) in Giardia lamblia: application to high-throughput drug susceptibility testing. Journal of antimicrobial chemotherapy, 64(6), pp. 1187-1191. Oxford: Oxford University Press 10.1093/jac/dkp363
Spicher, Martin; Naguleswaran, Arunasalam; Ortega-Mora, Luis M; Müller, Joachim; Gottstein, Bruno; Hemphill, Andrew (2008). In vitro and in vivo effects of 2-methoxyestradiol, either alone or combined with albendazole, against Echinococcus metacestodes. Experimental parasitology, 119(4), pp. 475-482. Elsevier 10.1016/j.exppara.2008.02.012
Müller, Joachim; Naguleswaran, Arunasalam; Müller, Norbert; Hemphill, Andrew (2008). Neospora caninum: functional inhibition of protein disulfide isomerase by the broad-spectrum anti-parasitic drug nitazoxanide and other thiazolides. Experimental parasitology, 118(1), pp. 80-8. Amsterdam: Elsevier 10.1016/j.exppara.2007.06.008
Müller, Joachim; Sidler, Daniel; Nachbur, Ueli; Wastling, Jonathan; Brunner, Thomas; Hemphill, Andrew (2008). Thiazolides inhibit growth and induce glutathione-S-transferase Pi (GSTP1)-dependent cell death in human colon cancer cells. International journal of cancer, 123(8), pp. 1797-806. Malden, Mass.: Wiley-Blackwell 10.1002/ijc.23755
Kompis, Martin; Bertram, Matthias; Senn, Pascal; Müller, Joachim; Pelizzone, Marco; Häusler, Rudolf (2008). A two-microphone noise reduction system for cochlear implant users with nearby microphones. Part II: Performance Evaluation. EURASIP journal on advances in signal processing, 2008(1), p. 451273. New York, N.Y.: Hindawi Pub. Corp. 10.1155/2008/451273
Müller, Joachim; Ley, Serej; Felger, Ingrid; Hemphill, Andrew; Müller, Norbert (2008). Identification of differentially expressed genes in a Giardia lamblia WB C6 clone resistant to nitazoxanide and metronidazole. Journal of antimicrobial chemotherapy, 62(1), pp. 72-82. Oxford University Press 10.1093/jac/dkn142
Sterk, Maaike; Müller, Joachim; Hemphill, Andrew; Müller, Norbert (2007). Characterization of a Giardia lamblia WB C6 clone resistant to the isoflavone formononetin. Microbiology, 153(Pt 12), pp. 4150-8. Reading, UK: Society for General Microbiology 10.1099/mic.0.2007/010041-0
Hemphill, Andrew; Spicher, Martin; Lundström-Stadelmann, Britta; Müller, Joachim; Naguleswaran, Arunasalam; Gottstein, Bruno; Walker, M (2007). Innovative chemotherapeutical treatment options for alveolar and cystic echinococcosis. Parasitology, 134(Pt 12), pp. 1657-70. London: Cambridge University Press 10.1017/S0031182007003198
Müller, Joachim; Sterk, Maaike; Hemphill, Andrew; Müller, Norbert (2007). Characterization of Giardia lamblia WB C6 clones resistant to nitazoxanide and to metronidazole. Journal of antimicrobial chemotherapy, 60(2), pp. 280-7. Oxford: Oxford University Press 10.1093/jac/dkm205
Esposito, Marco; Moores, Shelley; Naguleswaran, Arunasalam; Müller, Joachim; Hemphill, Andrew (2007). Induction of tachyzoite egress from cells infected with the protozoan Neospora caninum by nitro- and bromo-thiazolides, a class of broad-spectrum anti-parasitic drugs. International journal for parasitology, 37(10), pp. 1143-52. Kidlington, UK: Elsevier 10.1016/j.ijpara.2007.03.007
Müller, Joachim; Wastling, Jonathan; Sanderson, Sanya; Müller, Norbert; Hemphill, Andrew (2007). A novel Giardia lamblia nitroreductase, GlNR1, interacts with nitazoxanide and other thiazolides. Antimicrobial agents and chemotherapy, 51(6), pp. 1979-86. Washington, D.C.: American Society for Microbiology 10.1128/AAC.01548-06
Brockmeier, Steffi Johanna; Grasmeder, Mary; Passow, Susanna; Mawmann, Deborah; Vischer, Mattheus; Jappel, Alexandra; Baumgartner, Wolfgang; Stark, Thomas; Müller, Joachim; Brill, S; Steffens, Thomas; Strutz, Jürgen; Kiefer, Jan; Baumann, Uwe; Arnold, Wolfgang (2007). Comparison of musical activities of cochlear implant users with different speech-coding strategies. Ear and hearing, 28(2 Suppl), 49S-51S. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/AUD.0b013e3180315468
Müller, Joachim; Rühle, Géraldine; Müller, Norbert; Rossignol, Jean-François; Hemphill, Andrew (2006). In vitro effects of thiazolides on Giardia lamblia WB clone C6 cultured axenically and in coculture with Caco2 cells. Antimicrobial agents and chemotherapy, 50(1), pp. 162-70. Washington, D.C.: American Society for Microbiology 10.1128/AAC.50.1.162-170.2006
Müller, Norbert; Müller, Joachim (2016). Giardia. In: Walochnik, Julia; Duchêne, Michael (eds.) Molecular Parasitology (pp. 93-114). Wien: Springer Verlag 10.1007/978-3-7091-1416-2_4
