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Smith, Joseph T; Tylec, Brianna; Naguleswaran, Arunasalam; Roditi, Isabel; Read, Laurie K (2023). Developmental dynamics of mitochondrial mRNA abundance and editing reveal roles for temperature and the differentiation-repressive kinase RDK1 in cytochrome oxidase subunit II mRNA editing. mBio, 14(5), e0185423. American Society for Microbiology 10.1128/mbio.01854-23
Pozzi, Berta; Naguleswaran, Arunasalam; Florini, Francesca; Rezaei, Zahra; Roditi, Isabel (2023). The RNA export factor TbMex67 connects transcription and RNA export in Trypanosoma brucei and sets boundaries for RNA polymerase I. Nucleic acids research, 51(10), pp. 5177-5192. Oxford University Press 10.1093/nar/gkad251
Shaw, Sebastian; Roditi, Isabel (2023). The sweet and sour sides of trypanosome social motility. Trends in parasitology, 39(4), pp. 242-250. Elsevier 10.1016/j.pt.2023.01.001
Knüsel, Sebastian; Jenni, Aurelio; Benninger, Mattias; Bütikofer, Peter; Roditi, Isabel (2022). Persistence of Trypanosoma brucei as early procyclic forms and social motility are dependent on glycosylphosphatidylinositol transamidase. Molecular microbiology, 117(4), pp. 802-817. Wiley 10.1111/mmi.14873
Jenni, Aurelio; Knüsel, Sebastian; Nagar, Rupa; Benninger, Mattias; Häner, Robert; Ferguson, Michael A J; Roditi, Isabel; Menon, Anant K; Bütikofer, Peter (2021). Elimination of GPI2 suppresses glycosylphosphatidylinositol GlcNAc transferase activity and alters GPI glycan modification in Trypanosoma brucei. The journal of biological chemistry, 297(2), p. 100977. American Society for Biochemistry and Molecular Biology 10.1016/j.jbc.2021.100977
Haindrich, Alexander C.; Ernst, Viona; Naguleswaran, Arunasalam; Oliveres, Quentin-Florian; Roditi, Isabel; Rentsch, Doris (2021). Nutrient availability regulates proline/alanine transporters in Trypanosoma brucei. Journal of biological chemistry, 296, p. 100566. American Society for Biochemistry and Molecular Biology 10.1016/j.jbc.2021.100566
Bevkal, Shubha; Naguleswaran, Arunasalam; Rehmann, Ruth; Kaiser, Marcel; Heller, Manfred; Roditi, Isabel (2021). An Alba-domain protein required for proteome remodelling during trypanosome differentiation and host transition. PLoS pathogens, 17(1), e1009239. Public Library of Science 10.1371/journal.ppat.1009239
Shaw, Sebastian; Knüsel, Sebastian; Hoenner, Sarah; Roditi, Isabel (2020). A transient CRISPR/Cas9 expression system for genome editing in Trypanosoma brucei. BMC research notes, 13(1), p. 268. Biomed Central 10.1186/s13104-020-05089-z
Hulpia, Fabian; Mabille, Dorien; Campagnaro, Gustavo; Schumann, Gabriela; Maes, Louis; Roditi, Isabel; Hofer, Anders; de Koning, Harry; Caljon, Guy; Von Calenbergh, Serge (2019). Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness. Nature Communications, 10(1), p. 5564. Springer Nature 10.1038/s41467-019-13522-6
Shaw, Sebastian; DeMarco, Stephanie F; Rehmann, Ruth; Wenzler, Tanja; Florini, Francesca; Roditi, Isabel; Hill, Kent L (2019). Flagellar cAMP signaling controls trypanosome progression through host tissues. Nature communications, 10(1), p. 803. Nature Publishing Group 10.1038/s41467-019-08696-y
Florini, Francesca; Naguleswaran, Arunasalam; Gharib, Walid H; Bringaud, Frédéric; Roditi, Isabel (2019). Unexpected diversity in eukaryotic transcription revealed by the retrotransposon hotspot family of Trypanosoma brucei. Nucleic acids research, 47(4), pp. 1725-1739. Oxford University Press 10.1093/nar/gky1255
Naguleswaran, Arunasalam; Doiron, Nicholas; Roditi, Isabel (2018). RNA-Seq analysis validates the use of culture-derived Trypanosoma brucei and provides new markers for mammalian and insect life-cycle stages. BMC Genomics, 19(1), p. 227. BioMed Central 10.1186/s12864-018-4600-6
Naguleswaran, Arunasalam; Roditi, Isabel (2017). Rodent-free cyclical transmission of Trypanosoma brucei brucei. Molecular and biochemical parasitology, 217, pp. 16-18. Elsevier 10.1016/j.molbiopara.2017.08.005
Poch, Olivier; Frey, Joachim; Roditi, Isabel; Pommerol, Antoine; Jost, Bernhard; Thomas, Nicolas (2017). Remote Sensing of Potential Biosignatures from Rocky, Liquid, or Icy (Exo)Planetary Surfaces. Astrobiology, 17(3), pp. 231-252. Mary Ann Liebert 10.1089/ast.2016.1523
Roditi, Isabel (2016). The languages of parasite communication. Molecular and biochemical parasitology, 208(1), pp. 16-22. Elsevier 10.1016/j.molbiopara.2016.05.008
Roditi, Isabel; Schumann-Burkard, Gabriela; Naguleswaran, Arunasalam (2016). Environmental sensing by African trypanosomes. Current opinion in microbiology, 32, pp. 26-30. Current Biology Ltd. 10.1016/j.mib.2016.04.011
Imhof, Simon; Fragoso, Cristina; Hemphill, Andrew; Von Schubert, Conrad; Li, Dong; Legant, Wesley; Betzig, Erik; Roditi, Isabel (2016). Flagellar membrane fusion and protein exchange in trypanosomes; a new form of cell-cell communication? F1000Research, 5(682), p. 682. F1000 Research Ltd 10.12688/f1000research.8249.1
Wenzler, Tanja; Schumann-Burkard, Gabriela; Schmidt, Remo S.; Mäser, Pascal; Bergner, Andreas; Roditi, Isabel; Brun, Reto (2016). A new approach to chemotherapy: drug-induced differentiation kills African trypanosomes. Scientific Reports, 6(22451), p. 22451. Nature Publishing Group 10.1038/srep22451
Imhof, Simon; Roditi, Isabel (2015). The Social Life of African Trypanosomes. Trends in parasitology, 31(10), pp. 490-498. Elsevier Current Trends 10.1016/j.pt.2015.06.012
Vanwalleghem, G; Fontaine, F; Lecordier, L; Tebabi, P; Klewe, K; Nolan, DP; Yamaryo-Botté, Y; Botté, C; Schumann-Burkard, Gabriela; Rassow, J; Roditi, Isabel; Perez-Morga, D; Pays, E (2015). Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1. Nature communications, 6(8078), p. 8078. Nature Publishing Group 10.1038/ncomms9078
de Macêdo, Juan P.; Schumann-Burkard, Gabriela; Niemann, Moritz; Barrett, Michael P.; Vial, Henri; Mäser, Pascal; Roditi, Isabel; Schneider, André; Bütikofer, Peter; Horn, David (2015). An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei. PLoS pathogens, 11(5), e1004875. Public Library of Science 10.1371/journal.ppat.1004875
Naguleswaran, Arunasalam; Gunasekera, Kapila; Schimanski, Bernd; Heller, Manfred; Hemphill, Andrew; Ochsenreiter, Torsten; Roditi, Isabel (2015). Trypanosoma brucei RRM1 is a nuclear RNA-binding protein and modulator of chromatin structure. mBio, 6(2), e00114. American Society for Microbiology 10.1128/mBio.00114-15
Imhof, Simon; Vu Nguyen, Xuan Lan; Bütikofer, Peter; Roditi, Isabel (2015). A glycosylation mutant of Trypanosoma brucei links social motility defects in vitro to impaired colonisation of tsetse in vivo. Eukaryotic cell, 14(6), pp. 588-592. American Society for Microbiology ASM 10.1128/EC.00023-15
Bühlmann, M; Walrad, Pegine; Rico, E; Ivens, A; Capewell, P; Naguleswaran, Arunasalam; Roditi, Isabel; Matthews, K (2015). NMD3 regulates both mRNA and rRNA nuclear export in African trypanosomes via an XPOI-linked pathway. Nucleic acids research, 43(9), pp. 4491-4504. Oxford University Press 10.1093/nar/gkv330
Cristodero, Marina; Schimanski, Bernd; Heller, Manfred; Roditi, Isabel (2014). Functional characterization of the trypanosome translational repressor SCD6. Biochemical journal, 457(1), pp. 57-67. Portland Press 10.1042/BJ20130747
Lecordier, Laurence; Uzureau, P; Tebabi, P; Perez-Morga, D; Nolan, D; Schumann-Burkard, Gabriela; Roditi, Isabel; Pays, E (2014). Identification of Trypanosoma brucei components involved in trypanolysis by normal human serum. Molecular microbiology, 94(3), pp. 625-636. Blackwell Science 10.1111/mmi.12783
Imhof, Simon; Knüsel, Sebastian; Gunasekera, Kapila; Vu Nguyen, Xuan Lan; Roditi, Isabel (2014). Social motility of African trypanosomes is a property of a distinct life-cycle stage that occurs early in tsetse fly transmission. PLoS pathogens, 10(10), e1004493. Public Library of Science 10.1371/journal.ppat.1004493
Knüsel, Sebastian; Roditi, Isabel (2013). Insights into the regulation of GPEET procyclin during differentiation from early to late procyclic forms of Trypanosoma brucei. Molecular and biochemical parasitology, 191(2), pp. 66-74. Elsevier 10.1016/j.molbiopara.2013.09.004
Schumann Burkard, Gabriela; Käser, Sandro; de Araújo, Patricia; Schimanski, Bernd; Naguleswaran, Arunasalam; Knüsel, Sebastian; Heller, Manfred; Roditi, Isabel (2013). Nucleolar proteins regulate stage-specific gene expression and ribosomal RNA maturation in Trypanosoma brucei. Molecular microbiology, 88(4), pp. 827-840. Blackwell Science 10.1111/mmi.12227
Morand, Sabine; Renggli, Christina Kunz; Roditi, Isabel; Vassella, Erik (2012). MAP kinase kinase 1 (MKK1) is essential for transmission of Trypanosoma brucei by Glossina morsitans. Molecular and biochemical parasitology, 186(1), pp. 73-6. Amsterdam: Elsevier 10.1016/j.molbiopara.2012.09.001
Schumann Burkard, Gabriela; Jutzi, Pascal; Roditi, Isabel (2011). Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters. Molecular and biochemical parasitology, 175(1), pp. 91-94. Amsterdam: Elsevier 10.1016/j.molbiopara.2010.09.002
Mani, Jan; Güttinger, Andreas; Schimanski, Bernd; Heller, Manfred; Acosta-Serrano, Alvaro; Pescher, Pascale; Späth, Gerald; Roditi, Isabel (2011). Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteins that interact with the translation machinery. PLoS ONE, 6(7), e22463. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0022463
Aeby, Eric; Ullu, Elisabetta; Yepiskoposyan, Hasmik; Schimanski, Bernd; Roditi, Isabel; Mühlemann, Oliver; Schneider, André (2010). tRNASec is transcribed by RNA polymerase II in Trypanosoma brucei but not in humans. Nucleic acids research, 38(17), pp. 5833-5843. London: Oxford University Press 10.1093/nar/gkq345
Nilsson, Daniel; Gunasekera, Kapila; Mani, Jan; Osteras, Magne; Farinelli, Laurent; Baerlocher, Loic; Roditi, Isabel; Ochsenreiter, Torsten (2010). Spliced leader trapping reveals widespread alternative splicing patterns in the highly dynamic transcriptome of Trypanosoma brucei. PLoS pathogens, 6(8), e1001037. San Francisco, Calif.: Public Library of Science 10.1371/journal.ppat.1001037
Oberle, Michael; Balmer, Oliver; Brun, Reto; Roditi, Isabel (2010). Bottlenecks and the maintenance of minor genotypes during the life cycle of Trypanosoma brucei. PLoS pathogens, 6(7), e1001023. San Francisco, Calif.: Public Library of Science 10.1371/journal.ppat.1001023
Vassella, Erik; Oberle, Michael; Urwyler, Simon; Renggli, Christina Kunz; Studer, Erwin; Hemphill, Andrew; Fragoso, Cristina; Bütikofer, Peter; Brun, Reto; Roditi, Isabel (2009). Major surface glycoproteins of insect forms of Trypanosoma brucei are not essential for cyclical transmission by tsetse. PLoS ONE, 4(2), e4493. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0004493
Rufener, Lucien; Mäser, Pascal; Roditi, Isabel; Kaminsky, Ronald (2009). Haemonchus contortus acetylcholine receptors of the DEG-3 subfamily and their role in sensitivity to monepantel. PLoS pathogens, 5(4), e1000380. San Francisco, Calif.: Public Library of Science 10.1371/journal.ppat.1000380
Fragoso, Cristina M.; Schumann Burkard, Gabriela; Oberle, Michael; Kunz Renggli, Christina; Hilzinger, Karen; Roditi, Isabel (2009). PSSA-2, a Membrane-Spanning Phosphoprotein of Trypanosoma brucei, Is Required for Efficient Maturation of Infection. PLoS ONE, 4(9), e7074. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0007074
Haenni, Simon; Studer, Erwin; Schumann Burkard, Gabriela; Roditi, Isabel (2009). Bidirectional silencing of RNA polymerase I transcription by a strand switch region in Trypanosoma brucei. Nucleic acids research, 37(15), pp. 5007-5018. London: Oxford University Press 10.1093/nar/gkp513
Goldshmidt, Hanoch; Sheiner, Lilach; Bütikofer, Peter; Roditi, Isabel; Uliel, Shai; Günzel, Mark; Engstler, Markus; Michaeli, Shulamit (2008). Role of protein translocation pathways across the endoplasmic reticulum in Trypanosoma brucei. Journal of biological chemistry, 283(46), pp. 32085-32098. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M801499200
Roditi, Isabel; Lehane, Michael (2008). Interactions between trypanosomes and tsetse flies. Current opinion in microbiology, 11(4), pp. 345-351. London: Current Biology Ltd. 10.1016/j.mib.2008.06.006
Güttinger, Andreas; Schwab, Claudia; Morand, Sabine; Roditi, Isabel; Vassella, Erik (2007). A mitogen-activated protein kinase of Trypanosoma brucei confers resistance to temperature stress. Molecular and biochemical parasitology, 153(2), pp. 203-206. Amsterdam: Elsevier 10.1016/j.molbiopara.2007.02.001
Burkard, Gabriela; Fragoso, Cristina; Roditi, Isabel (2007). Highly efficient stable transformation of bloodstream forms of Trypanosoma brucei. Molecular and biochemical parasitology, 153(2), pp. 220-223. Amsterdam: Elsevier 10.1016/j.molbiopara.2007.02.008
Spoerri, Iris; Chadwick, Ruth; Renggli, Christina; Matthews, Keith; Roditi, Isabel; Burkard, Gabriela (2007). Role of the stage-regulated nucleoside transporter TbNT10 in differentiation and adenosine uptake in Trypanosoma brucei. Molecular and biochemical parasitology, 154(1), pp. 110-4. Amsterdam: Elsevier 10.1016/j.molbiopara.2007.04.006
Urwyler, Simon; Studer, Erwin; Renggli, Christina; Roditi, Isabel (2007). A family of stage-specific alanine-rich proteins on the surface of epimastigote forms of Trypanosoma brucei. Molecular microbiology, 63(1), pp. 218-28. Oxford: Blackwell Science 10.1111/j.1365-2958.2006.05492.x
Domenicali Pfister, Debora; Burkard, Gabriela; Morand, Sabine; Renggli, Christina Kunz; Roditi, Isabel; Vassella, Erik (2006). A Mitogen-activated protein kinase controls differentiation of bloodstream forms of Trypanosoma brucei. Eukaryotic cell, 5(7), pp. 1126-35. Washington, D.C.: American Society for Microbiology ASM 10.1128/EC.00094-06
Utz, Silvia; Roditi, Isabel; Kunz Renggli, Christina; Almeida, Igor C; Acosta-Serrano, Alvaro; Bütikofer, Peter (2006). Trypanosoma congolense procyclins: unmasking cryptic major surface glycoproteins in procyclic forms. Eukaryotic cell, 5(8), pp. 1430-40. Washington, D.C.: American Society for Microbiology ASM 10.1128/EC.00067-06
Haenni, Simon; Kunz Renggli, Christina; Fragoso, Cristina; Oberle, Michael; Roditi, Isabel (2006). The procyclin-associated genes of Trypanosoma brucei are not essential for cyclical transmission by tsetse. Molecular and biochemical parasitology, 150(2), pp. 144-156. Amsterdam: Elsevier 10.1016/j.molbiopara.2006.07.005
Urwyler, Simon; Vassella, Erik; Abbeele, Jan Van Den; Kunz Renggli, Christina; Blundell, Pat; Barry, J. David; Roditi, Isabel (2005). Expression of Procyclin mRNAs during Cyclical Transmission of Trypanosoma brucei. PLoS pathogens, 1(3), e22. Public Library of Science 10.1371/journal.ppat.0010022
Weynants, V; Gilson, D; Furger, A; Collins, R A; Mertens, P; De Bolle, X; Heussler, Volker; Roditi, Isabel; Howard, C J; Dobbelaere, A E; Letesson, J J (1998). Production and characterisation of monoclonal antibodies specific for bovine interleukin-4. Veterinary immunology and immunopathology, 66(2), pp. 99-112. Elsevier 10.1016/S0165-2427(98)00184-6
Naguleswaran, Arunasalam; Alves Fernandes, Paula; Bevkal Subramanyaswamy, Shubha; Rehmann, Ruth; Nicholson, Pamela; Roditi, Isabel (2021). Draft genome of Trypanosoma b. brucei EATRO1125 (AnTaR1 serodeme) strain [Dataset]. In: EATRO1125 (AnTaR1 serodeme) pseudo chromosomes.
Naguleswaran, Arunasalam; Alves Fernandes, Paula; Bevkal Subramanyaswamy, Shubha; Rehmann, Ruth; Nicholson, Pamela; Roditi, Isabel (2021). Trypanosoma brucei EATRO1125 draft genome assembly (Contigs) [Dataset]. In: Trypanosoma brucei (EATRO1125) genome contigs.
