McCoy, Kathleen

Yilmaz, Bahtiyar; Mooser, Catherine; Keller, Irene; Li, Hai; Zimmermann, Jakob; Bosshard, Lars; Fuhrer, Tobias; Gomez de Agüero, Mercedes; Fernandez Trigo, Nerea; Tschanz-Lischer, Heidi; Limenitakis, Julien P.; Hardt, Wolf-Dietrich; McCoy, Kathleen; Stecher, Bärbel; Excoffier, Laurent; Sauer, Uwe; Ganal-Vonarburg, Stephanie C.; Macpherson, Andrew J. (2021). Long-term evolution and short-term adaptation of microbiota strains and sub-strains in mice. Cell host & microbe, 29(4), 650-663.e9. Cell Press 10.1016/j.chom.2021.02.001

Li, Hai; Limenitakis, Julien Periclis Jean; Greiff, Victor; Yilmaz, Bahtiyar; Schären, Olivier Pascal; Urbaniak, Camilla; Zünd, Mirjam; Lawson, Melissa; Young, Ian D.; Rupp, Sandra; Heikenwälder, Mathias; McCoy, Kathleen; Hapfelmeier, Siegfried; Ganal-Vonarburg, Stephanie C.; Macpherson, Andrew J. (2020). Mucosal or systemic microbiota exposures shape the B cell repertoire. Nature, 584(7820), pp. 274-278. Springer Nature 10.1038/s41586-020-2564-6

Moghadamrad, Sheida; Mohsin Hassan, Mohsin Hassan; McCoy, Kathleen; Kirundi, Jorum; Kellmann, Philipp; De Gottardi, Andrea (2019). Attenuated fibrosis in specific pathogen-free microbiota in experimental cholestasis- and toxin-induced liver injury. FASEB journal, 33(11), pp. 12464-12476. Federation of American Societies for Experimental Biology 10.1096/fj.201901113R

Drobek, Ales; Moudra, Alena; Mueller, Daniel; Huranova, Martina; Horkova, Veronika; Pribikova, Michaela; Ivanek, Robert; Oberle, Susanne; Zehn, Dietmar; McCoy, Kathleen; Draber, Peter; Stepanek, Ondrej (2018). Strong homeostatic TCR signals induce formation of self-tolerant virtual memory CD8 T cells. The EMBO Journal, 37(14) EMBO Press 10.15252/embj.201798518

Treise, Irina; Huber, Eva M; Klein-Rodewald, Tanja; Heinemeyer, Wolfgang; Grassmann, Simon A; Basler, Michael; Adler, Thure; Rathkolb, Birgit; Helming, Laura; Andres, Christian; Klaften, Matthias; Landbrecht, Christina; Wieland, Thomas; Strom, Tim M; McCoy, Kathleen; Macpherson, Andrew; Wolf, Eckhard; Groettrup, Marcus; Ollert, Markus; Neff, Frauke; ... (2018). Defective immuno- and thymoproteasome assembly causes severe immunodeficiency. Scientific Reports, 8(1), p. 5975. Nature Publishing Group 10.1038/s41598-018-24199-0

Kohler, Andreas; Büchi, Isabel; Melin, Nicolas; Bayer, F.; McCoy, Kathleen; Candinas, Daniel; Keogh-Stroka, Deborah M. (2018). The IL-33/ST2 axes contributes to hepatocyte proliferation and promotes development of hepatocellular carcinoma. HPB : official journal of The International Hepato-Pancreato-Biliary Association, 20(Suppl. 2), S261-S261. Elsevier 10.1016/j.hpb.2018.06.205

Hebbandi Nanjundappa, Roopa; Ronchi, Francesca; Wang, Jinguo; Clemente-Casares, Xavier; Yamanouchi, Jun; Sokke Umeshappa, Channakeshava; Yang, Yang; Blanco, Jesús; Bassolas-Molina, Helena; Salas, Azucena; Khan, Hamza; Slattery, Robyn M; Wyss, Madeleine; Mooser, Catherine; Macpherson, Andrew; Sycuro, Laura K; Serra, Pau; McKay, Derek M; McCoy, Kathleen and Santamaria, Pere (2017). A Gut Microbial Mimic that Hijacks Diabetogenic Autoreactivity to Suppress Colitis. Cell, 171(3), 655-667.e17. Cell Press 10.1016/j.cell.2017.09.022

Garzetti, Debora; Brugiroux, Sandrine; Bunk, Boyke; Pukall, Rüdiger; McCoy, Kathleen; Macpherson, Andrew; Stecher, Bärbel (2017). High-Quality Whole-Genome Sequences of the Oligo-Mouse-Microbiota Bacterial Community. Genome Announcements, 5(42) American Society for Microbiology 10.1128/genomeA.00758-17

Mamantopoulos, Michail; Ronchi, Francesca; Van Hauwermeiren, Filip; Vieira-Silva, Sara; Yilmaz, Bahtiyar; Martens, Liesbet; Saeys, Yvan; Drexler, Stefan K; Yazdi, Amir S; Raes, Jeroen; Lamkanfi, Mohamed; McCoy, Kathleen; Wullaert, Andy (2017). Nlrp6- and ASC-Dependent Inflammasomes Do Not Shape the Commensal Gut Microbiota Composition. Immunity, 47(2), 339-348.e4. Cell Press 10.1016/j.immuni.2017.07.011

Cassano, Marco; Offner, Sandra; Planet, Evarist; Piersigilli, Alessandra; Jang, Suk Min; Henry, Hugues; Geuking, Markus; Mooser, Catherine; McCoy, Kathleen; Macpherson, Andrew; Trono, Didier (2017). Polyphenic trait promotes liver cancer in a model of epigenetic instability in mice. Hepatology, 66(1), pp. 235-251. Wiley Interscience 10.1002/hep.29182

Perruzza, Lisa; Gargari, Giorgio; Proiett, Michele; Fosso, Bruno; D’Erchia, Anna Maria; Faliti, Caterina Elisa; Rezzonico-Jost, Tanja; Scribano, Daniela; Maur, Laura; Colombo, Diego; Pellegrin, Giovanni; Moregol, Annalisa; Mooser, Catherine; Pesole, Graziano; Nicolett, Mauro; Norata, Giuseppe Danilo; Geuking, Markus; McCoy, Kathleen; Guglielmett, Simone and Grassi, Fabio (2017). T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by sensing Microbiota-Derived Extracellular ATP. Cell reports, 18(11), pp. 2566-2575. Cell Press 10.1016/j.celrep.2017.02.061

De Riva, Alessandra; Wållberg, Maja; Ronchi, Francesca; Coulson, Richard; Sage, Andrew; Thorne, Lucy; Goodfellow, Ian; McCoy, Kathleen; Azuma, Miyuki; Cooke, Anne; Busch, Robert (2017). Regulation of type 1 diabetes development and B-cell activation in nonobese diabetic mice by early life exposure to a diabetogenic environment. PLoS ONE, 12(8), e0181964. Public Library of Science 10.1371/journal.pone.0181964

Gil-Cruz, Cristina; Perez-Shibayama, Christian; Onder, Lucas; Chai, Qian; Cupovic, Jovana; Cheng, Hung-Wei; Novkovic, Mario; Lang, Philipp A; Geuking, Markus; McCoy, Kathleen; Abe, Shinya; Cui, Guangwei; Ikuta, Koichi; Scandella, Elke; Ludewig, Burkhard (2016). Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs. Nature immunology, 17(12), pp. 1388-1396. Macmillan Publishers Limited 10.1038/ni.3566

Brugiroux, Sandrine; Beutler, Markus; Pfann, Carina; Garzetti, Debora; Ruscheweyh, Hans-Joachim; Ring, Diana; Diehl, Manuel; Herp, Simone; Lötscher, Yvonne; Hussain, Saib; Bunk, Boyke; Pukall, Rüdiger; Huson, Daniel H; Münch, Philipp C; McHardy, Alice C; McCoy, Kathleen; Macpherson, Andrew; Loy, Alexander; Clavel, Thomas; Berry, David; ... (2016). Genome-guided design of a defined mouse microbiota that confers colonization resistance against Salmonella enterica serovar Typhimurium. Nature microbiology, 2, p. 16215. Springer Nature 10.1038/nmicrobiol.2016.215

Uchimura, Yasuhiro; Wyss, Madeleine; Brugiroux, Sandrine; Limenitakis, Julien Periclis Jean; Stecher, Bärbel; McCoy, Kathleen; Macpherson, Andrew (2016). Complete Genome Sequences of 12 Species of Stable Defined Moderately Diverse Mouse Microbiota 2. Genome Announcements, 4(5) American Society for Microbiology 10.1128/genomeA.00951-16

Gomez de Agüero Tamargo, Maria de la Mercedes; Ganal-Vonarburg, Stephanie C; Fuhrer, Tobias; Rupp, Sandra Carina; Uchimura, Yasuhiro; Li, Hai; Steinert, Anna; Heikenwalder, Mathias; Hapfelmeier, Siegfried Hektor; Sauer, Uwe; McCoy, Kathleen; Macpherson, Andrew (2016). The maternal microbiota drives early postnatal innate immune development. Science, 351(6279), pp. 1296-1302. American Association for the Advancement of Science 10.1126/science.aad2571

Brasseit, J.; Althaus-Steiner, E.; Faderl, M.; Dickgreber, N.; Saurer, L.; Genitsch, V.; Dolowschiak, T.; Li, Hai; Finke, D.; Hardt, W.-D.; McCoy, Kathleen; Macpherson, Andrew; Corazza, N.; Noti, M.; Mueller, C. (2016). CD4 T cells are required for both development and maintenance of disease in a new mouse model of reversible colitis. Mucosal immunology, 9(3), pp. 689-701. Nature Publishing Group 10.1038/mi.2015.93

Zaiss, Mario M; Rapin, Alexis; Lebon, Luc; Dubey, Lalit Kumar; Mosconi, Ilaria; Sarter, Kerstin; Piersigilli, Alessandra; Menin, Laure; Walker, Alan W; Rougemont, Jacques; Paerewijck, Oonagh; Geldhof, Peter; McCoy, Kathleen; Macpherson, Andrew; Croese, John; Giacomin, Paul R; Loukas, Alex; Junt, Tobias; Marsland, Benjamin J and Harris, Nicola L (2015). The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation. Immunity, 43(5), pp. 998-1010. Cell Press 10.1016/j.immuni.2015.09.012

Macpherson, Andrew; McCoy, Kathleen (2015). Independence Day for IgA. Immunity, 43(3), pp. 416-418. Cell Press 10.1016/j.immuni.2015.08.024

McCoy, Kathleen; Köller, Yasmin (2015). New developments providing mechanistic insight into the impact of the microbiota on allergic disease. Clinical immunology, 159(2), pp. 170-176. Elsevier 10.1016/j.clim.2015.05.007

Macpherson, Andrew; Köller, Yasmin; McCoy, Kathleen (2015). The bilateral responsiveness between intestinal microbes and IgA. Trends in immunology, 36(8), pp. 460-470. Elsevier 10.1016/j.it.2015.06.006

Mager, Lukas; Riether, Carsten; Schürch, Christian; Banz Wälti, Yara; Wasmer, Marie-Hélène Christin; Stuber Roos, Regula; Theocharides, Alexandre; Li, Xiaohong; Xia, Yu; Saito, Hirohisa; Nakae, Susumu; Baerlocher, Gabriela M.; Manz, Markus G; McCoy, Kathleen; Macpherson, Andrew; Ochsenbein, Adrian; Beutler, Bruce; Krebs, Philippe (2015). IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms. Journal of clinical investigation, 125(7), pp. 2579-2591. American Society for Clinical Investigation 10.1172/JCI77347

Moghadamrad, Sheida; McCoy, Kathleen; Geuking, Markus; Sägesser, Hans; Kirundi, Jorum; Macpherson, Andrew; De Gottardi, Andrea (2015). Attenuated portal hypertension in germ-free mice: Function of bacterial flora on the development of mesenteric lymphatic and blood vessels. Hepatology, 61(5), pp. 1685-1695. Wiley Interscience 10.1002/hep.27698

Bornancin, Frédéric; Renner, Florian; Touil, Ratiba; Sic, Heiko; Kolb, Yeter; Touil-Allaoui, Ismahane; Rush, James S; Smith, Paul A; Bigaud, Marc; Junker-Walker, Ursula; Burkhart, Christoph; Dawson, Janet; Niwa, Satoru; Katopodis, Andreas; Nuesslein-Hildesheim, Barbara; Weckbecker, Gisbert; Zenke, Gerhard; Kinzel, Bernd; Traggiai, Elisabetta; Brenner, Dirk; ... (2015). Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation. Journal of immunology, 194(8), pp. 3723-3734. American Association of Immunologists 10.4049/jimmunol.1402254

Juillerat, Pascal; Peter, M; Macpherson, James; Slack, Emma; Patuto, Nicola; Cahenzli, Julia; Seibold, Frank Werner; McCoy, Kathleen; Macpherson, Andrew (February 2015). Measurement of functional blocade of TNF-alpha by anti-TNF agents is a stronger predictor than trough levels and anti-drug antibodies: 2-year prospective clinical data (Unpublished). In: European Crohn’s and colitis organization congress (ECCO). Barcelona. Februar 2015.

Macpherson, Andrew; McCoy, Kathleen (2015). Standardised animal models of host microbial mutualism. Mucosal immunology, 8(3), pp. 476-486. Nature Publishing Group 10.1038/mi.2014.113

Li, Hai; Limenitakis, Julien Periclis Jean; Fuhrer, Tobias; Geuking, Markus; Lawson, Melissa A; Wyss, Madeleine; Brugiroux, Sandrine; Keller, Irene; Macpherson, Jamie A; Rupp, Sandra; Stolp, Bettina; Stein, Jens Volker; Stecher, Bärbel; Sauer, Uwe; McCoy, Kathleen; Macpherson, Andrew (2015). The outer mucus layer hosts a distinct intestinal microbial niche. Nature communications, 6, p. 8292. Nature Publishing Group 10.1038/ncomms9292

Juillerat, Pascal; Andrew, Peter; Macpherson, James; Slack, Emma; Seibold, Frank Werner; Cahenzli, Julia; McCoy, Kathleen; Macpherson, Andrew (2015). Measurement of functional blocade of TNF-alpha by anti-TNF agents is a stronger predictor than trough levels and anti-drug antibodies: 2-year prospective clinical data. Gastroenterology, 148(4), pp. 850-1. Elsevier

McCoy, Kathleen (December 2014). Microbial colonisation in early-life impacts innate and adaptive immunity (Unpublished). In: British Society for Immunology Annual Congress. Brighton, UK. December 2014.

Proietti, Michele; Cornacchione, Vanessa; Rezzonico Jost, Tanja; Romagnani, Andrea; Faliti, Caterina Elisa; Perruzza, Lisa; Rigoni, Rosita; Radaelli, Enrico; Caprioli, Flavio; Preziuso, Silvia; Brannetti, Barbara; Thelen, Marcus; McCoy, Kathleen; Slack, Emma; Traggiai, Elisabetta; Grassi, Fabio (2014). ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in Peyer's patches to promote host-microbiota mutualism. Immunity, 41(5), pp. 789-801. Cell Press 10.1016/j.immuni.2014.10.010

Balmer, Maria L; Schürch, Christian; Saito, Yasuyuki; Geuking, Markus; Li, Hai; Cuenca, Miguelangel; Kovtonyuk, Larisa V; McCoy, Kathleen; Hapfelmeier, Siegfried; Ochsenbein, Adrian; Manz, Markus G; Slack, Emma; Macpherson, Andrew (2014). Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling. Journal of immunology, 193(10), pp. 5273-5283. American Association of Immunologists 10.4049/jimmunol.1400762

McCoy, Kathleen (November 2014). Microbial colonisation in early-life: impact on innate and adaptive immunity (Unpublished). In: Global Health Institute, EPFL Seminar Series. Lausanne, CH. November 2014.

Stefka, Andrew T; Feehley, Taylor; Tripathi, Prabhanshu; Qiu, Ju; McCoy, Kathleen; Mazmanian, Sarkis K; Tjota, Melissa Y; Seo, Goo-Young; Cao, Severine; Theriault, Betty R; Antonopoulos, Dionysios A; Zhou, Liang; Chang, Eugene B; Fu, Yang-Xin; Nagler, Cathryn R (2014). Commensal bacteria protect against food allergen sensitization. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 111(36), pp. 13145-13150. National Academy of Sciences NAS 10.1073/pnas.1412008111

Malinka, Thomas; Keogh, Adrian; Kudira, Ramesh; Moghadamrad, Sheida; McCoy, Kathleen; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (September 2014). Liver regeneration is not impacted in the absence of intestinal microbiota (Unpublished). In: Schweizerische Gesellschaft für Gastroenterologie (SGG) - Schweizerische Gesellschaft für Viszeralchirurgie (SGVC) Annual Congress. Interlaken. 11.-12.9.2014.

Malinka, Thomas; Keogh, Adrian; Kudira, Ramesh; Moghadamrad, Sheida; McCoy, Kathleen; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (September 2014). Travel Award: Liver regeneration is not impacted in the absence of intestinal microbiota (Unpublished). In: Schweizerische Gesellschaft für Gastroenterologie (SGG) - Schweizerische Gesellschaft für Viszeralchirurgie (SGVC) Annual Congress. Interlaken. 11.-12.9.2014.

Chu, Derek K; Jimenez-Saiz, Rodrigo; Verschoor, Christopher P; Walker, Tina D; Goncharova, Susanna; Llop-Guevara, Alba; Shen, Pamela; Gordon, Melissa E; Barra, Nicole G; Bassett, Jennifer D; Kong, Joshua; Fattouh, Ramzi; McCoy, Kathleen; Bowdish, Dawn M; Erjefält, Jonas S; Pabst, Oliver; Humbles, Alison A; Kolbeck, Roland; Waserman, Susan and Jordana, Manel (2014). Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo. Journal of experimental medicine, 211(8), pp. 1657-1672. Rockefeller University Press 10.1084/jem.20131800

McCoy, Kathleen (July 2014). Microbial conditioning during early-life impact s immune regulation (Unpublished). In: 7th Seeon Conference ‘Microbiota, Probiota and Host’. Monastry Seeon/Chiemsee, Germany. July 2014.

McCoy, Kathleen (June 2014). Microbial conditioning during early-life impact s immune regulation (Unpublished). In: 2014 Prairie Infectious Immunology Meeting. Lake Hecla, Manitoba, Canada. June 2014.

Malinka, Thomas; Keogh, Adrian; Kudira, Ramesh; Moghadamrad, Sheida; McCoy, Kathleen; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (May 2014). Liver regeneration is not impacted in the absence of intestinal microbiota. (Unpublished). In: Annual meeting of the Swiss Surgical Society. Bern. 21.-23.05.2014.

Juillerat, Pascal; Andrew, Peter Michael; Macpherson, James; Slack, Emma; Cahenzli, Julia; Seibold, Frank Werner; McCoy, Kathleen; Macpherson, Andrew (May 2014). CD62L (L-Selectin) Shedding for Assessment of Functional Blockade of TNF-Alpha in Anti-TNF treated Inflammatory Bowel Disease Patients: Clinical Feasibility and Perspectives. Gastroenterology, 146(5), p. 239. Elsevier

Lécuyer, Emelyne; Rakotobe, Sabine; Lengliné-Garnier, Hélène; Lebreton, Corinne; Picard, Marion; Juste, Catherine; Fritzen, Rémi; Eberl, Gérard; McCoy, Kathleen; Macpherson, Andrew; Reynaud, Claude-Agnès; Cerf-Bensussan, Nadine; Gaboriau-Routhiau, Valérie (2014). Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses. Immunity, 40(4), pp. 608-620. Cell Press 10.1016/j.immuni.2014.03.009

Juillerat, Pascal; Andrew, Peter Michael; Macpherson, J; Slack, Emma; Patuto, Nicola; Cahenzli, Julia; McCoy, Kathleen; Macpherson, Andrew (February 2014). CD62L (L-selectin) shedding for assessment of functional blockade of TNF alpha in anti-TNF treated IBD patients: clinical feasibility and perspectives (DOP060). Journal of Crohn's & Colitis, 8(Suppl1), pp. 43-44. Elsevier 10.1016/S1873-9946(14)60085-4

McCoy, Kathleen (January 2014). Introduction to Gnotobiology (Unpublished). In: 10th Swiss Experimental Surgery Symposium. Bern, CH. January 2014.

Geuking, Markus; Köller, Yasmin; Rupp, Sandra; McCoy, Kathleen (2014). The interplay between the gut microbiota and the immune system. Gut microbes, 5(3), pp. 411-418. Landes Bioscience 10.4161/gmic.29330

Ronchi, Francesca; Rupp, Sandra; Steinert, Anna; Wyss, Madeleine; McCoy, Kathleen; Macpherson, Andrew (2014). Microbiota-mediated fine-tuning of the threshold of intestinal inflammasome activation in host-microbial mutualism (Unpublished). In: EMIG2014. Glasgow, UK.

Juillerat, Pascal; Andrew, Peter Michael; Macpherson, James; Slack, Emma; Cahenzli, Julia; Seibold, F.; McCoy, Kathleen; Macpherson, Andrew (2014). CD62L (L-selectin) shedding for assessment of functional blockade of TNF alpha in anti-TNF treated IBD patients: clinical feasibility and perspectives. United european gastroenterology journal, 2(1suppl), A45-A46. Sage

Juillerat, Pascal; Andrew, Peter Michael; Macpherson, James; Slack, Emma; Cahenzli, Julia; Seibold, Frank Werner; McCoy, Kathleen; Macpherson, Andrew (2014). CD62L (L-Selectin) Shedding for Assessment of Functional Blockade of TNF-Alpha in Anti-TNF treated Inflammatory Bowel Disease Patients: Clinical Feasibility and Perspectives. Swiss medical weekly, 144(Suppl206), 3S-3S. EMH Schweizerischer Ärzteverlag

Mosconi, I.; Geuking, Markus; Zaiss, M. M.; Massacand, Jonathan; Aschwanden, C.; Kwong Chung, Cheong Kwet Choy; McCoy, Kathleen; Harris, N. L. (2013). Intestinal bacteria induce TSLP to promote mutualistic T-cell responses. Mucosal immunology, 6(6), pp. 1157-1167. Nature Publishing Group 10.1038/mi.2013.12

Macpherson, Andrew; McCoy, Kathleen (2013). Stratification and compartmentalisation of immunoglobulin responses to commensal intestinal microbes. Seminars in immunology, 25(5), pp. 358-363. W.B. Saunders 10.1016/j.smim.2013.09.004

Cahenzli, Julia; Köller, Yasmin; Wyss, Madeleine; Geuking, Markus; McCoy, Kathleen (2013). Intestinal Microbial Diversity during Early-Life Colonization Shapes Long-Term IgE Levels. Cell host & microbe, 14(5), pp. 559-570. Cell Press 10.1016/j.chom.2013.10.004

Geuking, Markus B.; McCoy, Kathleen; Macpherson, Andrew J. (2013). Metabolites from intestinal microbes shape Treg. Cell research, 23(12), pp. 1339-1340. Nature Publishing Group 10.1038/cr.2013.125

Markle, J. G. M.; Frank, D. N.; Mortin-Toth, S.; Robertson, C. E.; Feazel, L. M.; Rolle-Kampczyk, U.; von Bergen, Melanie; McCoy, Kathleen; Macpherson, Andrew; Danska, J. S. (2013). Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity. Science, 339(6123), pp. 1084-1088. American Association for the Advancement of Science 10.1126/science.1233521

Cahenzli, Julia; Balmer, Maria Luisa; McCoy, Kathleen (2012). Microbial-immune cross-talk and regulation of the immune system. Immunology, 138(1), pp. 12-22. Wiley-Blackwell 10.1111/j.1365-2567.2012.03624.x