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Personne, Hippolyte Jean-Claude René; Baeriswyl, Stéphane; Stocker, Achim; Javor, Sacha; Reymond, Jean-Louis (25 August 2020). X-Ray Crystallographic Studies of Short Antimicrobial Helical Peptides against Multidrug Resistant Gram-Negative Bacteria (Unpublished). In: SCS Fall meeting 2020. University of Bern. 25th August 2020.
Zamolo, Susanna Joelle; Reymond, Jean-Louis; Darbre, Tamis (22 June 2019). Peptide based vectors for CRISPR-Cas9 delivery (Unpublished). In: 26th American Peptide Symposium. Monterey, CA. 22-27 June 2019.
Capecchi, Alice; Reymond, Jean-Louis (2019). Peptide chemical space (Unpublished). In: SCS fall meeting 2019.
Zamolo, Susanna Joelle; Reymond, Jean-Louis (7 September 2018). Peptide dendrimes as delivery systems for nucleic acids (Unpublished). In: Swiss Chemical Society - Fall meeting, (Lausanne, Switzerland). Lausanne, Switzerland. 7 Sept.2018.
Zamolo, Susanna Joelle; Reymond, Jean-Louis (August 2018). Peptide dendrimes as delivery systems for nucleic acids (Unpublished). In: Swiss Summer School in Chemical Biology (Villars-sur-Ollon, Switzerland. Villars-sur-Ollon, Switzerland. 19-23 Aug.2018.
Zamolo, Susanna Joelle; Reymond, Jean-Louis (August 2018). Peptide dendrimes as delivery systems for nucleic acids (Unpublished). In: Swiss Summer School in Chemical Biology (Villars-sur-Ollon, Switzerland). Villars-sur-Ollon, Switzerland. 19-23 Aug.2018.
Zamolo, Susanna Joelle; Reymond, Jean-Louis (June 2018). Peptide dendrimes as delivery systems for nucleic acids (Unpublished). In: Summer School (5 days) Nucleic Acids in Therapy (Stockholm, Sweden). Stockholm. 25-30 Jun.2018.
Capecchi, Alice; Awale, Mahendra; Probst, Daniel; Reymond, Jean-Louis (2018). Beyond Lipinski – an analysis of the PubChem chemical space (Unpublished). In: Summer School on Machine Learning in Drug Design. Leuven, Belgium. Monday, August 20, 2018 - to Wednesday, August 22, 2018.
Michaud, Gaëlle; Bergman, Manfred Max; Salerno, Gianluca; Gillon, Emilie; Imberty, Anne; Richichi, Barbara; Nativi, Cristina; Darbre, Tamis; Reymond, Jean-Louis (June 2014). Synthesis of glycopeptide dendrimers targeting LecA, LecB, or both (Unpublished). In: COST MultiGlycoNano Meeting. Siena, Italy. 25.-28.06.2014.
Hari, Yvonne; Stucki, Silvan R.; Nyakas, Adrien; Blum, Lorenz; Reymond, Jean-Louis; Schürch, Stefan (2014). OMA & OPA – A Software Tool for Mass Spectrometric Sequencing of Nucleic Acids. CHIMIA, 68(1), p. 86. Bern: Schweizerische Chemische Gesellschaft 10.2533/chimia.2013.86
Jeanneret, Céline; Reymond, Jean-Louis (2014). Discovery of TRPV6 inhibitors using ligand based virtual screening (Unpublished). In: International Symposium on Medicinal Chemistry. Lisbon, Portugal. 07.-11.09.2014.
Simonin, Céline; Reymond, Jean-Louis (2014). Discovery of TRPV6 Inhibitors Using Ligand Based Virtual Screening (Unpublished). In: Swiss-Japanese Symposium in Chemical Biology. Berne. 02-03.10.2014.
Neier, Reinhard; Reymond, Jean-Louis (2014). A Tribute to Pierre Vogel. Arkivoc, 2014(3), pp. 1-5. Michigan Publishing 10.3998/ark.5550190.0015.301
Stach, M.; Darbre, Tamis; Reymond, Jean-Louis (2012). Membrane disrupting antimicrobial peptide dendrimers with multiple amino termini. Journal of Peptide Science, 18, S63-S64. John Wiley & Sons
Jeanneret, C.; Reymond, Jean-Louis (2012). Discovery of NHA2 Inhibitors Using Ligand Based Virtual Screening. In: NCCR TransCure Site Visit. Bern. 15.-16.10.2012.
Jeanneret, C.; Reymond, J.-L. (2012). Ligand Based Discovery of TRPV6 Inhibitors. In: NCCR TransCure Site Visit. Bern. 15.-16.10.2012.
Jeanneret, C.; Reymond, Jean-Louis (2012). Development of New TRPV6 Inhibitors. In: Präsentation anlässlich des NCCR TransCure Annual Retreat. Gruyère. 30.05.-01.06.2012.
Reymond, Jean-Louis; Darbre, Tamis (2011). Combinatorial Libraries of Dendritic Glycoclusters. In: Renaudet, O.; Spinelli, N. (eds.) Synthesis and Biological Applications of Glycoconjugates (pp. 116-128). Bentham Science Publishers
Darbre, T.; Reymond, Jean-Louis (2011). Peptide Dendrimers as Artificial Proteins. In: Campagna, S.; Ceroni, P.; Puntoriero, F. (eds.) Designing Dendrimers (pp. 505-528). Chichester: John Wiley & Sons
Tallant, Cynthia; García-Castellanos, Raquel; Marrero, Aniebrys; Canals, Francesc; Yang, Yongzheng; Reymond, Jean-Louis; Solà, Maria; Baumann, Ulrich; Gomis-Rüth, F. Xavier (2007). Activity of ulilysin, an archaeal PAPP-A-related gelatinase and IGFBP proteas. Biological chemistry, 388(1), pp. 1243-1253. Berlin: Walter de Gruyter 10.1515/BC.2007.143
Reymond, Jean-Louis (ed.) (2006). Enzyme Assays: High-throughput Screening, Genetic Selection and Fingerprinting 15. Weinheim: Wiley-VCH 10.1016/j.copbio.2004.06.008
Jordan, Olivier; Gan, Bee-Ha; Alwan, Sari; Perron, Karl; Sublet, Emmanuelle; Ducret, Verena; Ye, Hua; Borchard, Gerrit; Reymond, Jean-Louis; Patrulea, Viorica (2024). Highly Potent Cationic Chitosan Derivatives Coupled to Antimicrobial Peptide Dendrimers to Combat Pseudomonas Aeruginosa. Advanced healthcare materials, 13(19), e2304118. Wiley 10.1002/adhm.202304118
Orsi, Markus; Reymond, Jean-Louis (2024). Can large language models predict antimicrobial peptide activity and toxicity? RSC Medicinal Chemistry, 15(6), pp. 2030-2036. Royal Society of Chemistry 10.1039/d4md00159a
Brühlmann, Francis; Perry, Carmen; Griessen, Charlotte; Gunasekera, Kapila; Reymond, Jean-Louis; Naguleswaran, Arunasalam; Rottenberg, Sven; Woods, Kerry; Olias, Philipp (2024). TurboID mapping reveals the exportome of secreted intrinsically disordered proteins in the transforming parasite Theileria annulata. mBio, 15(6), e0341223. American Society for Microbiology 10.1128/mbio.03412-23
Orsi, Markus; Reymond, Jean-Louis (2024). One chiral fingerprint to find them all. Journal of cheminformatics, 16(53) Springer 10.1186/s13321-024-00849-6
Amati, Andrea Marco; Moning, Stefan Urs; Javor, Sacha; Schär, Sandra; Deutschmann, Sabina; Reymond, Jean-Louis; von Ballmoos, Christoph (2024). Overcoming Protein Orientation Mismatch Enables Efficient Nanoscale Light-Driven ATP Production. ACS synthetic biology, 13(4), pp. 1355-1364. American Chemical Society 10.1021/acssynbio.4c00058
Bonvin, Etienne; Personne, Hippolyte; Paschoud, Thierry; Reusser, Jérémie; Gan, Bee-Ha; Luscher, Alexandre; Köhler, Thilo; van Delden, Christian; Reymond, Jean-Louis (2023). Antimicrobial Peptide-Peptoid Hybrids with and without Membrane Disruption. ACS infectious diseases, 9(12), pp. 2593-2606. American Chemical Society 10.1021/acsinfecdis.3c00421
Buehler, Ye; Reymond, Jean-Louis (2023). Expanding Bioactive Fragment Space with the Generated Database GDB-13s. Journal of chemical information and modeling, 63(20), pp. 6239-6248. American Chemical Society 10.1021/acs.jcim.3c01096
Meirelles, Matheus A.; Reymond, Jean-Louis (2023). Optimizing Phosphate Couplings for Dolichyl Diphosphochitobiose to Enable Protein N ‐Glycosylation Studies. Helvetica chimica acta, 106(12) Wiley 10.1002/hlca.202300171
Orsi, Markus; Probst, Daniel; Schwaller, Philippe; Reymond, Jean-Louis (2023). Alchemical analysis of FDA approved drugs. Digital discovery, 2(5), pp. 1289-1296. Royal Society of Chemistry 10.1039/d3dd00039g
Georgiou, Christos D; McKay, Christopher; Reymond, Jean-Louis (2023). Organic Catalytic Activity as a Method for Agnostic Life Detection. Astrobiology, 23(10), pp. 1118-1127. Mary Ann Liebert 10.1089/ast.2023.0022
Kreutter, David; Reymond, Jean-Louis (2023). Multistep retrosynthesis combining a disconnection aware triple transformer loop with a route penalty score guided tree search. Chemical Science, 14(36), pp. 9959-9969. The Royal Society of Chemistry 10.1039/d3sc01604h
Cai, Xingguang; Capecchi, Alice; Olcay, Başak; Orsi, Markus; Javor, Sacha; Reymond, Jean-Louis (2023). Exploring the Sequence Space of Antimicrobial Peptide Dendrimers. Israel journal of chemistry, 63(10-11) Wiley-VCH 10.1002/ijch.202300096
Personne, Hippolyte; Paschoud, Thierry; Fulgencio, Sofia; Baeriswyl, Stéphane; Köhler, Thilo; van Delden, Christian; Stocker, Achim; Javor, Sacha; Reymond, Jean-Louis (2023). To Fold or Not to Fold: Diastereomeric Optimization of an α-Helical Antimicrobial Peptide. Journal of medicinal chemistry, 66(11), pp. 7570-7583. American Chemical Society 10.1021/acs.jmedchem.3c00460
Bloch, Joël S; John, Alan; Mao, Runyu; Mukherjee, Somnath; Boilevin, Jérémy; Irobalieva, Rossitza N; Darbre, Tamis; Scott, Nichollas E; Reymond, Jean-Louis; Kossiakoff, Anthony A; Goddard-Borger, Ethan D; Locher, Kaspar P (2023). Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase. Nature chemical biology, 19(5), pp. 575-584. Springer Nature 10.1038/s41589-022-01219-9
De Capitani, Mario M.; Ramírez, Ana S.; Rossi, Lorenzo; Alexander, J. Andrew N.; De Lorenzo, Sabrina; Locher, Kaspar P.; Reymond, Jean-Louis (2023). Synthesis and characterisation of fluorescent substrates for eukaryotic protein N-glycosylation. Tetrahedron, 136, p. 133361. Elsevier Science 10.1016/j.tet.2023.133361
Bonvin, Etienne; Reymond, Jean-Louis (2023). Inverse Polyamidoamine (i‐PAMAM) Dendrimer Antimicrobials. Helvetica chimica acta, 106(6) Wiley 10.1002/hlca.202300035
Personne, Hippolyte; Siriwardena, Thissa N; Javor, Sacha; Reymond, Jean-Louis (2023). Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis. ACS Omega, 8(5), pp. 5050-5056. American Chemical Society 10.1021/acsomega.2c07861
Buehler, Ye; Reymond, Jean-Louis (2023). Molecular Framework Analysis of the Generated Database GDB-13s. Journal of chemical information and modeling, 63(2), pp. 484-492. American Chemical Society 10.1021/acs.jcim.2c01107
Cai, Xingguang; Orsi, Markus; Capecchi, Alice; Köhler, Thilo; van Delden, Christian; Javor, Sacha; Reymond, Jean-Louis (2022). An intrinsically disordered antimicrobial peptide dendrimer from stereorandomized virtual screening. Cell reports. Physical science, 3(12), pp. 1-15. Cell Press 10.1016/j.xcrp.2022.101161
Reymond, Jean-Louis (21 December 2022). Molecular Similarity for Drug Discovery, Target Prediction and Chemical Space Visualization. CHIMIA, 76(12), pp. 1045-1051. Swiss Chemical Society 10.2533/chimia.2022.1045
Ho, Manh Tin; Berger, Stephan; Müller, Philipp; Simonin, Céline; Reymond, Jean-Louis; von Ballmoos, Christoph; Fuster, Daniel G. (21 December 2022). Physiological and Molecular Function of the Sodium/Hydrogen Exchanger NHA2 (SLC9B2). CHIMIA, 76(12), pp. 1019-1024. Swiss Chemical Society 10.2533/chimia.2022.1019
Rossetti, Valentina; Reymond, Jean-Louis (21 December 2022). Vitaport: A Learning and Artistic Path for Public Outreach on Transporter Biology, Health and Drug Discovery. CHIMIA, 76(12), pp. 1063-1067. Swiss Chemical Society 10.2533/chimia.2022.1063
Abriel, Hugues; Reymond, Jean-Louis (2022). NCCR TransCure - Excellence in Membrane Transport Research from 2010 until 2022. CHIMIA, 76(12), p. 989. Schweizerische Chemische Gesellschaft
Ramírez, Ana S; De Capitani, Mario; Pesciullesi, Giorgio; Kowal, Julia; Bloch, Joël S; Irobalieva, Rossitza N; Reymond, Jean-Louis; Aebi, Markus; Locher, Kaspar P (2022). Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase. Nature communications, 13(1), p. 7296. Nature Publishing Group 10.1038/s41467-022-35067-x
Morstein, Johannes; Capecchi, Alice; Hinnah, Konstantin; Park, ByungUk; Petit-Jacques, Jerome; Van Lehn, Reid C; Reymond, Jean-Louis; Trauner, Dirk (2022). Medium-Chain Lipid Conjugation Facilitates Cell-Permeability and Bioactivity. Journal of the American Chemical Society, 144(40), pp. 18532-18544. American Chemical Society 10.1021/jacs.2c07833
Zhu, Di; Johannsen, Sandra; Masini, Tiziana; Simonin, Céline; Haupenthal, Jörg; Illarionov, Boris; Andreas, Anastasia; Awale, Mahendra; Gierse, Robin M; van der Laan, Tridia; van der Vlag, Ramon; Nasti, Rita; Poizat, Mael; Buhler, Eric; Reiling, Norbert; Müller, Rolf; Fischer, Markus; Reymond, Jean-Louis; Hirsch, Anna K H (2022). Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening. Chemical Science, 13(36), pp. 10686-10698. The Royal Society of Chemistry 10.1039/d2sc02371g
Zakharova, Elena; Orsi, Markus; Capecchi, Alice; Reymond, Jean-Louis (2022). Machine Learning Guided Discovery of Non-Hemolytic Membrane Disruptive Anti-Cancer Peptides. ChemMedChem, 17(17), e202200291. Wiley-VCH 10.1002/cmdc.202200291
Thakkar, Amol; Reymond, Jean-Louis (27 April 2022). Automatic Extraction of Reaction Templates for Synthesis Prediction. CHIMIA, 76(4), p. 294. Swiss Chemical Society 10.2533/chimia.2022.294
Probst, Daniel; Schwaller, Philippe; Reymond, Jean-Louis (2022). Reaction classification and yield prediction using the differential reaction fingerprint DRFP. Digital discovery, 1(2), pp. 91-97. Royal Society of Chemistry 10.1039/d1dd00006c
Patrulea, Viorica; Gan, Bee-Ha; Perron, Karl; Cai, Xingguang; Abdel-Sayed, Philippe; Sublet, Emmanuelle; Ducret, Verena; Nerhot, Natalia Porroche; Applegate, Lee Ann; Borchard, Gerrit; Reymond, Jean-Louis; Jordan, Olivier (15 March 2022). Synergistic effects of antimicrobial peptide dendrimer-chitosan polymer conjugates against Pseudomonas aeruginosa. Carbohydrate polymers, 280, p. 119025. Elsevier 10.1016/j.carbpol.2021.119025
Pujol-Giménez, Jonai; Poirier, Marion; Bühlmann, Sven; Schuppisser, Céline; Bhardwaj, Rajesh; Awale, Mahendra; Visini, Ricardo; Javor, Sacha; Hediger, Matthias; Reymond, Jean-Louis (2021). Inhibitors of Human Divalent Metal Transporters DMT1 (SLC11A2) and ZIP8 (SLC39A8) from a GDB-17 Fragment Library. ChemMedChem, 16(21), pp. 3306-3314. Wiley-VCH 10.1002/cmdc.202100467
Capecchi, Alice; Reymond, Jean-Louis (2021). Classifying natural products from plants, fungi or bacteria using the COCONUT database and machine learning. Journal of cheminformatics, 13(82), p. 1069. Springer 10.1186/s13321-021-00559-3
Erzina, Dina; Capecchi, Alice; Javor, Sacha; Reymond, Jean-Louis (2021). An Immunomodulatory Peptide Dendrimer Inspired from Glatiramer Acetate. Angewandte Chemie International Edition, 60(50), pp. 26403-26408. Wiley 10.1002/anie.202113562
Baeriswyl, Stéphane; Personne, Hippolyte; Di Bonaventura, Ivan; Köhler, Thilo; van Delden, Christian; Stocker, Achim; Javor, Sacha; Reymond, Jean-Louis (2021). A mixed chirality α-helix in a stapled bicyclic and a linear antimicrobial peptide revealed by X-ray crystallography. RSC chemical biology, 2(6), pp. 1608-1617. Royal Society of Chemistry 10.1039/D1CB00124H
Jafari, Paris; Luscher, Alexandre; Siriwardena, Thissa; Michetti, Murielle; Que, Yok-Ai; Rahme, Laurence G.; Reymond, Jean-Louis; Raffoul, Wassim; Van Delden, Christian; Applegate, Lee Ann; Köhler, Thilo (2021). Antimicrobial Peptide Dendrimers and Quorum-Sensing Inhibitors in Formulating Next-Generation Anti-Infection Cell Therapy Dressings for Burns. Molecules, 26(13), p. 3839. MDPI 10.3390/molecules26133839
Capecchi, Alice; Cai, Xingguang; Personne, Hippolyte; Köhler, Thilo; van Delden, Christian; Reymond, Jean-Louis (2021). Machine learning designs non-hemolytic antimicrobial peptides. Chemical Science, 12(26), pp. 9221-9232. The Royal Society of Chemistry 10.1039/D1SC01713F
Reymond, Jean-Louis (2021). Peptide Dendrimers: From Enzyme Models to Antimicrobials and Transfection Reagents. CHIMIA, 75(6), pp. 535-538. Schweizerische Chemische Gesellschaft 10.2533/chimia.2021.535
Kreutter, David; Schwaller, Philippe; Reymond, Jean-Louis (2021). Predicting enzymatic reactions with a molecular transformer. Chemical Science, 12(25), pp. 8648-8659. The Royal Society of Chemistry 10.1039/D1SC02362D
Eyring, Jillianne; Lin, Chia-Wei; Ngwa, Elsy Mankah; Boilevin, Jérémy; Pesciullesi, Giorgio; Locher, Kaspar P.; Darbre, Tamis; Reymond, Jean-Louis; Aebi, Markus (2021). Substrate specificities and reaction kinetics of the yeast oligosaccharyltransferase isoforms. Journal of biological chemistry, 296, p. 100809. American Society for Biochemistry and Molecular Biology 10.1016/j.jbc.2021.100809
Cai, Xingguang; Javor, Sacha; Gan, Bee Ha; Köhler, Thilo; Reymond, Jean-Louis (2021). The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4. Chemical communications, 57(46), pp. 5654-5657. Royal Society of Chemistry 10.1039/D1CC01838H
Schwaller, Philippe; Hoover, Benjamin; Reymond, Jean-Louis; Strobelt, Hendrik; Laino, Teodoro (2021). Extraction of organic chemistry grammar from unsupervised learning of chemical reactions. Science Advances, 7(15) American Association for the Advancement of Science 10.1126/sciadv.abe4166
Schwaller, Philippe; Vaucher, Alain C; Laino, Teodoro; Reymond, Jean-Louis (2021). Prediction of chemical reaction yields using deep learning. Machine learning: science and technology, 2(1), 015016. IOP Publishing 10.1088/2632-2153/abc81d
Reymond, Jean-Louis; Auberson, Yves P.; Benfatti, Fides; Zumbrunn, Cornelia (2021). Medicinal Chemistry and Chemical Biology in the Age of the Pandemic. CHIMIA, 75(3), pp. 225-226. Schweizerische Chemische Gesellschaft 10.2533/chimia.2021.225
Schwaller, Philippe; Probst, Daniel; Vaucher, Alain C.; Nair, Vishnu H.; Kreutter, David Patrick Joseph; Laino, Teodoro; Reymond, Jean-Louis (2021). Mapping the space of chemical reactions using attention-based neural networks. Nature machine intelligence, 3(2), pp. 144-152. Springer Nature 10.1038/s42256-020-00284-w
Thakkar, Amol; Chadimová, Veronika; Bjerrum, Esben Jannik; Engkvist, Ola; Reymond, Jean-Louis (2021). Retrosynthetic accessibility score (RAscore) – rapid machine learned synthesizability classification from AI driven retrosynthetic planning. Chemical Science, 12(9), pp. 3339-3349. The Royal Society of Chemistry 10.1039/D0SC05401A
Siriwardena, Thissa N.; Gan, Bee-Ha; Köhler, Thilo; van Delden, Christian; Javor, Sacha; Reymond, Jean-Louis (2021). Stereorandomization as a Method to Probe Peptide Bioactivity. ACS central science, 7(1), pp. 126-134. ACS Publications 10.1021/acscentsci.0c01135
Daralnakhla, Haneen; Saher, Osama; Zamolo, Susanna; Bazaz, Safa; P. Bost, Jeremy; Heitz, Marc; Lundin, Karin E.; EL Andaloussi, Samir; Darbre, Tamis; Reymond, Jean-Louis; Zain, Rula; Smith, C. I. Edvard (2021). Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides. Pharmaceutics, 13(1), p. 116. MDPI 10.3390/pharmaceutics13010116
Capecchi, Alice; Reymond, Jean-Louis (2021). Peptides in chemical space. Medicine in drug discovery, 9, p. 100081. Elsevier 10.1016/j.medidd.2021.100081
Meier, Kris; Arús-Pous, Josep; Reymond, Jean-Louis (2021). A Potent and Selective Janus Kinase Inhibitor with a Chiral 3D‐Shaped Triquinazine Ring System from Chemical Space. Angewandte Chemie (International ed.), 60(4), pp. 2074-2077. Wiley-VCH 10.1002/anie.202012049
Thakkar, Amol; Johansson, Simon; Jorner, Kjell; Buttar, David; Reymond, Jean-Louis; Engkvist, Ola (2021). Artificial intelligence and automation in computer aided synthesis planning. Reaction chemistry & engineering, 6(1), pp. 27-51. Royal Society of Chemistry 10.1039/D0RE00340A
Gan, Bee-Ha; Cai, Xingguang; Javor, Sacha; Köhler, Thilo; Reymond, Jean-Louis (2020). Synergistic Effect of Propidium Iodide and Small Molecule Antibiotics with the Antimicrobial Peptide Dendrimer G3KL against Gram-Negative Bacteria. Molecules, 25(23), p. 5643. MDPI 10.3390/molecules25235643
Bhardwaj, Rajesh; Lindinger, Sonja; Neuberger, Arthur; Nadezhdin, Kirill D.; Singh, Appu K.; R. Cunha, Micael; Derler, Isabella; Gyimesi, Gergely; Reymond, Jean-Louis; Hediger, Matthias A.; Romanin, Christoph; Sobolevsky, Alexander I. (2020). Inactivation-mimicking block of the epithelial calcium channel TRPV6. Science Advances, 6(48), eabe1508. American Association for the Advancement of Science 10.1126/sciadv.abe1508
Genheden, Samuel; Thakkar, Amol; Chadimová, Veronika; Reymond, Jean-Louis; Engkvist, Ola; Bjerrum, Esben (2020). AiZynthFinder: a fast, robust and flexible open-source software for retrosynthetic planning. Journal of cheminformatics, 12(1) Springer 10.1186/s13321-020-00472-1
Fitzner, Martin; Wuitschik, Georg; Koller, Raffael J.; Adam, Jean-Michel; Schindler, Torsten; Reymond, Jean-Louis (2020). What can reaction databases teach us about Buchwald–Hartwig cross-couplings? Chemical Science, 11(48), pp. 13085-13093. The Royal Society of Chemistry 10.1039/d0sc04074f
Capecchi, Alice; Reymond, Jean-Louis (2020). Assigning the Origin of Microbial Natural Products by Chemical Space Map and Machine Learning. Biomolecules, 10(10), p. 1385. MDPI 10.3390/biom10101385
Pesciullesi, Giorgio; Schwaller, Philippe; Laino, Teodoro; Reymond, Jean-Louis (2020). Transfer learning enables the molecular transformer to predict regio- and stereoselective reactions on carbohydrates. Nature Communications, 11(1) Springer Nature 10.1038/s41467-020-18671-7
Rodrigues Cunha, Micael; Bhardwaj, Rajesh; Carrel, Aline Lucie; Lindinger, Sonja; Romanin, Christoph; Parise-Filho, Roberto; Hediger, Matthias A.; Reymond, Jean-Louis (2020). Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor. RSC Medicinal Chemistry, 11(9), pp. 1032-1040. Royal Society of Chemistry 10.1039/D0MD00145G
Stoklosa, Paulina; Probst, Daniel; Reymond, Jean-Louis; Peinelt, Christine (2020). The name tells the story: Two-pore channels. Cell calcium, 89, p. 102215. Elsevier 10.1016/j.ceca.2020.102215
Capecchi, Alice; Probst, Daniel; Reymond, Jean-Louis (2020). One molecular fingerprint to rule them all: drugs, biomolecules, and the metabolome. Journal of cheminformatics, 12(1) Springer 10.1186/s13321-020-00445-4
Poirier, Marion; Pujol-Giménez, Jonai; Manatschal, Cristina; Bühlmann, Sven; Embaby, Ahmed; Javor, Sacha; Hediger, Matthias A.; Reymond, Jean-Louis (2020). Pyrazolyl-pyrimidones inhibit the function of human solute carrier protein SLC11A2 (hDMT1) by metal chelation. RSC Medicinal Chemistry, 11(9), pp. 1023-1031. Royal Society of Chemistry 10.1039/D0MD00085J
Arús-Pous, Josep; Patronov, Atanas; Bjerrum, Esben Jannik; Tyrchan, Christian; Reymond, Jean-Louis; Chen, Hongming; Engkvist, Ola (2020). SMILES-based deep generative scaffold decorator for de-novo drug design. Journal of cheminformatics, 12(1) Springer 10.1186/s13321-020-00441-8
Heitz, Marc; Zamolo, Susanna; Javor, Sacha; Reymond, Jean-Louis (2020). Fluorescent Peptide Dendrimers for siRNA Transfection: Tracking pH Responsive Aggregation, siRNA Binding, and Cell Penetration. Bioconjugate chemistry, 31(6), pp. 1671-1684. American Chemical Society 10.1021/acs.bioconjchem.0c00231
Thakkar, Amol; Selmi, Nidhal; Reymond, Jean-Louis; Engkvist, Ola; Bjerrum, Esben Jannik (2020). “Ring Breaker”: Neural Network Driven Synthesis Prediction of the Ring System Chemical Space. Journal of medicinal chemistry, 63(16), pp. 8791-8808. American Chemical Society 10.1021/acs.jmedchem.9b01919
Meier, Kris; Bühlmann, Sven; Arús-Pous, Josep; Reymond, Jean-Louis (2020). The Generated Databases (GDBs) as a Source of 3D-shaped Building Blocks for Use in Medicinal Chemistry and Drug Discovery. CHIMIA, 74(4), pp. 241-246. Schweizerische Chemische Gesellschaft 10.2533/chimia.2020.241
Bloch, Joël S.; Pesciullesi, Giorgio; Boilevin, Jérémy; Nosol, Kamil; Irobalieva, Rossitza N.; Darbre, Tamis; Aebi, Markus; Kossiakoff, Anthony A.; Reymond, Jean-Louis; Locher, Kaspar P. (2020). Structure and mechanism of the ER-based glucosyltransferase ALG6. Nature, 579(7799), pp. 443-447. Springer Nature 10.1038/s41586-020-2044-z
Probst, Daniel; Reymond, Jean-Louis (2020). Visualization of very large high-dimensional data sets as minimum spanning trees. Journal of cheminformatics, 12(1) Springer 10.1186/s13321-020-0416-x
Bühlmann, Sven; Reymond, Jean-Louis (2020). ChEMBL-Likeness Score and Database GDBChEMBL. Frontiers in Chemistry, 8(46) Frontiers Media 10.3389/fchem.2020.00046
Ben Jeddou, Fatma; Falconnet, Léna; Luscher, Alexandre; Siriwardena, Thissa; Reymond, Jean-Louis; van Delden, Christian; Köhler, Thilo (2020). Adaptive and Mutational Responses to Peptide Dendrimer Antimicrobials in Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 64(4) American Society for Microbiology 10.1128/AAC.02040-19
Capecchi, Alice; Zhang, Alain; Reymond, Jean-Louis (2020). Populating Chemical Space with Peptides Using a Genetic Algorithm. Journal of chemical information and modeling, 60(1), pp. 121-132. American Chemical Society 10.1021/acs.jcim.9b01014
Thakkar, Amol; Kogej, Thierry; Reymond, Jean-Louis; Engkvist, Ola; Bjerrum, Esben Jannik (2020). Datasets and their influence on the development of computer assisted synthesis planning tools in the pharmaceutical domain. Chemical Science, 11(1), pp. 154-168. The Royal Society of Chemistry 10.1039/C9SC04944D
Zamolo, Susanna J.; Darbre, Tamis; Reymond, Jean-Louis (2020). Transfecting tissue models with CRISPR/Cas9 plasmid DNA using peptide dendrimers. Chemical communications, 56(80), pp. 11981-11984. Royal Society of Chemistry 10.1039/D0CC04750C
Schwaller, Philippe; Probst, Daniel; Vaucher, Alain C.; Nair, Vishnu H; Laino, Teodoro; Reymond, Jean-Louis (26 December 2019). Data-Driven Chemical Reaction Classification, Fingerprinting and Clustering using Attention-Based Neural Networks ChemRxiv 10.26434/chemrxiv.9897365.v2
Manatschal, Cristina; Pujol-Giménez, Jonai; Poirier, Marion; Reymond, Jean-Louis; Hediger, Matthias A.; Dutzler, Raimund (2019). Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds. eLife, 8 eLife Sciences Publications 10.7554/eLife.51913
Arús-Pous, Josep; Awale, Mahendra; Probst, Daniel; Reymond, Jean-Louis (2019). Exploring Chemical Space with Machine Learning. CHIMIA, 73(12), pp. 1018-1023. Schweizerische Chemische Gesellschaft 10.2533/chimia.2019.1018
R. Cunha, Micael; Bhardwaj, Rajesh; Lindinger, Sonja; Butorac, Carmen; Romanin, Christoph; Hediger, Matthias; Reymond, Jean-Louis (2019). Photoswitchable Inhibitor of the Calcium Channel TRPV6. ACS medicinal chemistry letters, 10(9), pp. 1341-1345. American Chemical Society 10.1021/acsmedchemlett.9b00298
Delalande, Clémence; Awale, Mahendra; Rubin, Matthias; Probst, Daniel; Ozhathil, Lijo C.; Gertsch, Jürg; Abriel, Hugues; Reymond, Jean-Louis (2019). Optimizing TRPM4 inhibitors in the MHFP6 chemical space. European journal of medicinal chemistry, 166, pp. 167-177. Elsevier 10.1016/j.ejmech.2019.01.048
Borgström, A.; Kiener, M.; Kappel, S.; Hauert, B.; Delalande, C.; Zoni, E.; Reymond, J.; Thalmann, G. N.; Peinelt, C.; Kruithof-de Julio, M. (15 March 2019). Investigation of TRPM4 and store-operated calcium entry in prostate cancer cell systems and a primary prostate cancer stem cell model. European Urology Supplements, 18(1), e342-e342. Elsevier https://doi.org/10.1016/S1569-9056(19)30254-4
Awale, Mahendra; Reymond, Jean-Louis (2019). Web-Based Tools for Polypharmacology Prediction. In: Ziegler, Slava; Waldmann, Herbert (eds.) Systems Chemical Biology. Methods in molecular biology: Vol. 1888 (pp. 255-272). Humana Press 10.1007/978-1-4939-8891-4_15
Awale, Mahendra; Reymond, Jean-Louis (2019). The Polypharmacology Browser PPB2: Target Prediction Combining Nearest Neighbors with Machine Learning. Journal of chemical information and modeling, 59(1), pp. 10-17. American Chemical Society 10.1021/acs.jcim.8b00524
Siriwardena, Thissa N.; Lüscher, Alexandre; Köhler, Thilo; van Delden, Christian; Javor, Sacha; Reymond, Jean-Louis (2019). Antimicrobial Peptide Dendrimer Chimera. Helvetica chimica acta, 102(4), e1900034. Wiley 10.1002/hlca.201900034
Baeriswyl, Stéphane; Gan, Bee Ha; Siriwardena, Thissa N.; Visini, Ricardo; Robadey, Maurane; Javor, Sacha; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2019). X-ray Crystal Structures of Short Antimicrobial Peptides as Pseudomonas aeruginosa Lectin B Complexes. ACS Chemical Biology, 14(4), pp. 758-766. American Chemical Society 10.1021/acschembio.9b00047
Capecchi, Alice; Awale, Mahendra; Probst, Daniel; Reymond, Jean-Louis (2019). PubChem and ChEMBL beyond Lipinski. Molecular informatics, 38(5), p. 1900016. Wiley 10.1002/minf.201900016
Arús-Pous, Josep; Blaschke, Thomas; Ulander, Silas; Reymond, Jean-Louis; Chen, Hongming; Engkvist, Ola (2019). Exploring the GDB-13 chemical space using deep generative models. Journal of cheminformatics, 11(1), p. 20. Springer 10.1186/s13321-019-0341-z
Morstein, Johannes; Awale, Mahendra; Reymond, Jean-Louis; Trauner, Dirk (2019). Mapping the Azolog Space Enables the Optical Control of New Biological Targets. ACS central science, 5(4), pp. 607-618. ACS Publications 10.1021/acscentsci.8b00881
Awale, Mahendra; Sirockin, Finton; Stiefl, Nikolaus; Reymond, Jean-Louis (2019). Drug Analogs from Fragment-Based Long Short-Term Memory Generative Neural Networks. Journal of chemical information and modeling, 59(4), pp. 1347-1356. American Chemical Society 10.1021/acs.jcim.8b00902
Awale, Mahendra; Sirockin, Finton; Stiefl, Nikolaus; Reymond, Jean-Louis (2019). Medicinal Chemistry Aware Database GDBMedChem. Molecular informatics, 38(8-9), p. 1900031. Wiley 10.1002/minf.201900031
Arús-Pous, Josep; Johansson, Simon Viet; Prykhodko, Oleksii; Bjerrum, Esben Jannik; Tyrchan, Christian; Reymond, Jean-Louis; Chen, Hongming; Engkvist, Ola (2019). Randomized SMILES strings improve the quality of molecular generative models. Journal of cheminformatics, 11(1) Springer 10.1186/s13321-019-0393-0
Heitz, Marc; Javor, Sacha; Darbre, Tamis; Reymond, Jean-Louis (2019). Stereoselective pH Responsive Peptide Dendrimers for siRNA Transfection. Bioconjugate chemistry, 30(8), pp. 2165-2182. American Chemical Society 10.1021/acs.bioconjchem.9b00403
Baeriswyl, Stéphane; Javor, Sacha; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2019). X‐Ray Crystal Structure of a Second‐Generation Peptide Dendrimer in Complex with Pseudomonas aeruginosa Lectin LecB. Helvetica chimica acta, 102(9) Wiley 10.1002/hlca.201900178
Taouai, Marwa; Chakroun, Khouloud; Sommer, Roman; Michaud, Gaelle; Giacalone, David; Ben Maaouia, Mohamed Amine; Vallin-Butruille, Aurélie; Mathiron, David; Abidi, Rym; Darbre, Tamis; Cragg, Peter J.; Mullié, Catherine; Reymond, Jean-Louis; O’Toole, George A.; Benazza, Mohammed (2019). Glycocluster Tetrahydroxamic Acids Exhibiting Unprecedented Inhibition of Pseudomonas aeruginosa Biofilms. Journal of medicinal chemistry, 62(17), pp. 7722-7738. American Chemical Society 10.1021/acs.jmedchem.9b00481
Gan, Bee Ha; Siriwardena, Thissa N.; Javor, Sacha; Darbre, Tamis; Reymond, Jean-Louis (2019). Fluorescence Imaging of Bacterial Killing by Antimicrobial Peptide Dendrimer G3KL. ACS infectious diseases, 5(12), pp. 2164-2173. American Chemical Society 10.1021/acsinfecdis.9b00299
Han, Xiao; Liu, Yujie; Ma, Yibing; Zhang, Mengqing; He, Zhengjin; Siriwardena, Thissa N.; Xu, Haijin; Bai, Yanling; Zhang, Xiuming; Reymond, Jean-Louis; Qiao, Mingqiang (2019). Peptide dendrimers G3KL and TNS18 inhibit Pseudomonas aeruginosa biofilms. Applied microbiology and biotechnology, 103(14), pp. 5821-5830. Springer 10.1007/s00253-019-09801-3
Probst, Daniel; Reymond, Jean-Louis (2018). A probabilistic molecular fingerprint for big data settings. Journal of cheminformatics, 10(1) BioMed Central 10.1186/s13321-018-0321-8
Poirier, Marion; Awale, Mahendra; Rölli, Matthias A.; Giuffredi, Guy T.; Ruddigkeit, Lars; Evensen, Lasse; Stooss, Amandine; Calarco, Serafina; Lorens, James B.; Charles, Roch-Philippe; Reymond, Jean-Louis (2018). Identifying Lysophosphatidic Acid Acyltransferase β (LPAAT-β) as the Target of a Nanomolar Angiogenesis Inhibitor from a Phenotypic Screen Using the Polypharmacology Browser PPB2. ChemMedChem, 14(2), pp. 224-236. Wiley-VCH 10.1002/cmdc.201800554
Napiórkowska, Maja; Boilevin, Jérémy; Darbre, Tamis; Reymond, Jean-Louis; Locher, Kaspar P. (2018). Structure of bacterial oligosaccharyltransferase PglB bound to a reactive LLO and an inhibitory peptide. Scientific Reports, 8(1) Nature Publishing Group 10.1038/s41598-018-34534-0
Pompilio, Arianna; Geminiani, Cristina; Mantini, Paolo; Siriwardena, Thissa N.; Di Bonaventura, Ivan; Reymond, Jean Louis; Di Bonaventura, Giovanni (2018). Peptide dendrimers as “lead compounds” for the treatment of chronic lung infections by Pseudomonas aeruginosa in cystic fibrosis patients: in vitro and in vivo studies. Infection and drug resistance, 11, pp. 1767-1782. Dove Medical Press 10.2147/IDR.S168868
Saher, Osama; Rocha, Cristina S.J.; Zaghloul, Eman M.; Wiklander, Oscar P.B.; Zamolo, Susanna; Heitz, Marc; Ezzat, Kariem; Gupta, Dhanu; Reymond, Jean-Louis; Zain, Rula; Hollfelder, Florian; Darbre, Tamis; Lundin, Karin E.; EL Andaloussi, Samir; Smith, C.I. Edvard (2018). Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity. European journal of pharmaceutics and biopharmaceutics, 132, pp. 29-40. Elsevier 10.1016/j.ejpb.2018.09.002
Probst, Daniel; Reymond, Jean-Louis (2018). Exploring DrugBank in Virtual Reality Chemical Space. Journal of chemical information and modeling, 58(9), pp. 1731-1735. American Chemical Society 10.1021/acs.jcim.8b00402
Boilevin, Jérémy M.; Reymond, Jean-Louis (2018). Synthesis of Lipid-Linked Oligosaccharides (LLOs) and Their Phosphonate Analogues as Probes To Study Protein Glycosylation Enzymes. Synthesis - journal of synthetic organic chemistry, 50(14), pp. 2631-2654. Thieme 10.1055/s-0037-1609735
Ozhathil, Lijo Cherian; Delalande, Clémence Marie Sandrine; Bianchi, Beatrice; Nemeth, Gabor; Kappel, Sven; Thomet, Urs; Ross, Daniela; Simonin, Céline; Rubin, Matthias; Gertsch, Jürg; Lochner, Martin; Peinelt, Christine; Reymond, Jean-Louis; Abriel, Hugues (2018). Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. British journal of pharmacology, 175(12), pp. 2504-2519. Wiley-Blackwell 10.1111/bph.14220
Siriwardena, Thissa N.; Capecchi, Alice; Gan, Bee-Ha; Jin, Xian; He, Runze; Wei, Dengwen; Ma, Lan; Köhler, Thilo; van Delden, Christian; Javor, Sacha; Reymond, Jean-Louis (2018). Optimizing Antimicrobial Peptide Dendrimers in Chemical Space. Angewandte Chemie (International ed.), 57(28), pp. 8483-8487. Wiley-VCH 10.1002/anie.201802837
Di Bonaventura, Ivan; Baeriswyl, Stéphane; Capecchi, Alice; Gan, Bee-Ha; Jin, Xian; Siriwardena, Thissa N.; He, Runze; Köhler, Thilo; Pompilio, Arianna; Di Bonaventura, Giovanni; van Delden, Christian; Javor, Sacha; Reymond, Jean-Louis (2018). An antimicrobial bicyclic peptide from chemical space against multidrug resistant Gram-negative bacteria. Chemical communications, 54(40), pp. 5130-5133. Royal Society of Chemistry 10.1039/C8CC02412J
Probst, Daniel; Reymond, Jean-Louis (2018). FUn: A Framework for Interactive Visualizations of Large, High Dimensional Datasets on the Web. Bioinformatics, 34(8), pp. 1433-1435. Oxford University Press 10.1093/bioinformatics/btx760
Ramírez, Ana S.; Boilevin, Jérémy; Mehdipour, Ahmad Reza; Hummer, Gerhard; Darbre, Tamis; Reymond, Jean-Louis; Locher, Kaspar P. (2018). Structural basis of the molecular ruler mechanism of a bacterial glycosyltransferase. Nature communications, 9(1) Nature Publishing Group 10.1038/s41467-018-02880-2
Lin, Arkadii; Horvath, Dragos; Afonina, Valentina; Marcou, Gilles; Reymond, Jean-Louis; Varnek, Alexandre (2018). Mapping of the Available Chemical Space versus the Chemical Universe of Lead-Like Compounds. ChemMedChem, 13(6), pp. 540-554. Wiley-VCH 10.1002/cmdc.201700561
Siriwardena, Thissa Appuhamilage Nuwan; Stach, Michaela; He, Runze; Gan, Bee Ha; Javor, Sacha; Heitz, Marc; Ma, Lan; Cai, Xiangjun; Chen, Peng; Wei, Dengwen; Li, Hongtao; Ma, Jun; Koehler, Thilo; van Delden, Christian; Darbre, Tamis; Reymond, Jean-Louis (2018). Lipidated Peptide Dendrimers Killing Multidrug Resistant Bacteria. Journal of the American Chemical Society, 140(1), pp. 423-432. American Chemical Society 10.1021/jacs.7b11037
Probst, Daniel; Reymond, Jean-Louis (2018). SmilesDrawer: Parsing and Drawing SMILES-Encoded Molecular Structures Using Client-Side JavaScript. Journal of chemical information and modeling, 58(1), pp. 1-7. American Chemical Society 10.1021/acs.jcim.7b00425
Arús-Pous, Josep; Probst, Daniel; Reymond, Jean-Louis (2018). Deep Learning Invades Drug Design and Synthesis. CHIMIA, 72(1), pp. 70-71. Schweizerische Chemische Gesellschaft 10.2533/chimia.2018.70
Langron, Emily; Simone, Michela I; Delalande, Clémence Marie Sandrine; Reymond, Jean-Louis; Selwood, David L; Vergani, Paola (2017). Improved fluorescence assays to measure the defects associated with F508del-CFTR allow identification of new active compounds. British journal of pharmacology, 174(7), pp. 525-539. Wiley-Blackwell 10.1111/bph.13715
Ramírez, Ana S; Boilevin, Jérémy; Biswas, Rasomoy; Gan, Bee Ha; Janser, Daniel; Aebi, Markus; Darbre, Tamis; Reymond, Jean-Louis; Locher, Kaspar P (2017). Characterization of the single-subunit oligosaccharyltransferase STT3A from Trypanosoma brucei using synthetic peptides and lipid-linked oligosaccharide analogs. Glycobiology, 27(6), pp. 525-535. Oxford University Press 10.1093/glycob/cwx017
Awale, Mahendra; Reymond, Jean-Louis (2017). The polypharmacology browser: a web-based multi-fingerprint target prediction tool using ChEMBL bioactivity data. Journal of cheminformatics, 9(11), p. 11. BioMed Central 10.1186/s13321-017-0199-x
Awale, Mahendra; Probst, Daniel; Reymond, Jean-Louis (2017). WebMolCS: A Web-Based Interface for Visualizing Molecules in Three-Dimensional Chemical Spaces. Journal of chemical information and modeling, 57(4), pp. 643-649. American Chemical Society 10.1021/acs.jcim.6b00690
Visini, Ricardo; Awale, Mahendra; Reymond, Jean-Louis (2017). Fragment Database FDB-17. Journal of chemical information and modeling, 57(4), pp. 700-709. American Chemical Society 10.1021/acs.jcim.7b00020
Heitz, Marc; Kwok, Albert; Eggimann, GabrielaA.; Hollfelder, Florian; Darbre, Tamis; Reymond, Jean-Louis (2017). Peptide Dendrimer–Lipid Conjugates as DNA and siRNA Transfection Reagents: Role of Charge Distribution Across Generations. CHIMIA, 71(4), pp. 220-225. Schweizerische Chemische Gesellschaft 10.2533/chimia.2017.220
Ramírez, Ana S; Boilevin, Jérémy; Lin, Chia-Wei; Gan, Bee Ha; Janser, Daniel; Aebi, Markus; Darbre, Tamis; Reymond, Jean-Louis; Locher, Kaspar P (2017). Chemo-enzymatic synthesis of lipid-linked GlcNAc2Man5 oligosaccharides using recombinant Alg1, Alg2 and Alg11 proteins. Glycobiology, 27(8), pp. 726-733. Oxford University Press 10.1093/glycob/cwx045
Di Bonaventura, Ivan; Jin, Xian; Visini, Ricardo; Probst, Daniel; Javor, Sacha; Gan, Bee-Ha; Michaud, Gaëlle; Natalello, Antonino; Doglia, Silvia Maria; Köhler, Thilo; van Delden, Christian; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2017). Chemical space guided discovery of antimicrobial bridged bicyclic peptides against Pseudomonas aeruginosa and its biofilms. Chemical Science, 8(10), pp. 6784-6798. The Royal Society of Chemistry 10.1039/C7SC01314K
He, Runze; Di Bonaventura, Ivan; Visini, Ricardo; Gan, Bee-Ha; Fu, Yongchun; Probst, Daniel; Lüscher, Alexandre; Köhler, Thilo; van Delden, Christian; Stocker, Achim; Hong, Wenjing; Darbre, Tamis; Reymond, Jean-Louis (2017). Design, crystal structure and atomic force microscopy study of thioether ligated d , l -cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa. Chemical Science, 8(11), pp. 7464-7475. The Royal Society of Chemistry 10.1039/C7SC01599B
Sebastián-Pérez, Víctor; Roca, Carlos; Awale, Mahendra; Reymond, Jean-Louis; Martinez, Ana; Gil, Carmen; Campillo, Nuria E. (2017). Medicinal and Biological Chemistry (MBC) Library: An Efficient Source of New Hits. Journal of chemical information and modeling, 57(9), pp. 2143-2151. American Chemical Society 10.1021/acs.jcim.7b00401
Probst, Daniel; Heitz, Marc; Poirier, Marion; Gan, Bee Ha; Delalande, Clémence Marie Sandrine; Reymond, Jean-Louis (2017). Frontiers in Medicinal Chemistry 2017 in Bern, Switzerland. ChemMedChem, 12(19), pp. 1645-1651. Wiley-VCH 10.1002/cmdc.201700306
Visini, Ricardo; Arus Pous, Josep; Awale, Mahendra; Reymond, Jean-Louis (2017). Virtual Exploration of the Ring Systems Chemical Universe. Journal of chemical information and modeling, 57(11), pp. 2707-2718. American Chemical Society 10.1021/acs.jcim.7b00457
Napiórkowska, Maja; Boilevin, Jérémy; Sovdat, Tina; Darbre, Tamis; Reymond, Jean-Louis; Aebi, Markus; Locher, Kaspar P (2017). Molecular basis of lipid-linked oligosaccharide recognition and processing by bacterial oligosaccharyltransferase. Nature structural & molecular biology, 24(12), pp. 1100-1106. Nature Publishing Group 10.1038/nsmb.3491
Awale, Mahendra; Visini, Ricardo; Probst, Daniel; Arus Pous, Josep; Reymond, Jean-Louis (2017). Chemical Space: Big Data Challenge for Molecular Diversity. CHIMIA, 71(10), pp. 661-666. Schweizerische Chemische Gesellschaft 10.2533/chimia.2017.661
Kilchmann, Falco; Marcaida, Maria; Sachin, Kotak; Schick, Thomas; Boss, Silvan; Awale, Mahendra; Gönczy, Pierre; Reymond, Jean-Louis (2016). Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening. Journal of medicinal chemistry, 59(15), pp. 7188-7211. American Chemical Society 10.1021/acs.jmedchem.6b00709
Röthlisberger, Pascal; Istrate, Alena; Marcaida Lopez, M. J.; Visini, Ricardo; Stocker, Achim; Reymond, Jean-Louis; Leumann, Christian (2016). X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair. Chemical communications, 52(26), pp. 4749-4752. Royal Society of Chemistry 10.1039/c6cc00374e
Michaud, Gaëlle; Visini, Ricardo; Bergman, Manfred Max; Salerno, Gianluca; Bosco, Rosa; Gillon, Emilie; Richichi, Barbara; Nativi, Cristina; Imberty, Anne; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2016). Overcoming antibiotic resistance in Pseudomonas aeruginosa biofilms using glycopeptide dendrimers. Chemical Science, 7(1), pp. 166-182. The Royal Society of Chemistry 10.1039/c5sc03635f
Awale, Mahendra; Reymond, Jean-Louis (2016). Web-based 3D-visualization of the DrugBank chemical space. Journal of cheminformatics, 8, p. 25. Springer 10.1186/s13321-016-0138-2
Kwok, Albert; Eggimann, Gabriela A.; Heitz, Marc; Reymond, Jean-Louis; Hollfelder, Florian; Darbre, Tamis (2016). Efficient Transfection of siRNA by Peptide Dendrimer-Lipid Conjugates. ChemBioChem, 17(23), pp. 2223-2229. Wiley-VCH 10.1002/cbic.201600485
Tetko, Igor V.; Engkvist, Ola; Koch, Uwe; Reymond, Jean-Louis; Chen, Hongming (2016). BIGCHEM: Challenges and Opportunities for Big Data Analysis in Chemistry. Molecular informatics, 35(11-12), pp. 615-621. Wiley 10.1002/minf.201600073
Bürgi, Justus; Bertrand, Sonia; Marger, Fabrice; Bertrand, Daniel; Reymond, Jean-Louis (2016). Fluorescent Agonists of the α 7 Nicotinic Acetylcholine Receptor Derived from 3-Amino-Quinuclidine. Helvetica chimica acta, 99(10), pp. 790-804. Verlag Helvetica Chimica Acta 10.1002/hlca.201600120
Abdel-Sayed, Philippe; Kaeppli, Ariane; Siriwardena, Thissa; Darbre, Tamis; Perron, Karl; Jafari, Paris; Reymond, Jean-Louis; Pioletti, Dominique P.; Applegate, Lee Ann (2016). Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages. Scientific Reports, 6(22020), p. 22020. Nature Publishing Group 10.1038/srep22020
Reymond, Jean-Louis; Visini, Ricardo; Awale, Mahendra (2016). Enumeration of Chemical Fragment Space. In: Erlanson, Daniel A.; Jahnke, Wolfgang (eds.) Fragment-based Drug Discovery Lessons and Outlook. Methods and Principles in Medicinal Chemistry (pp. 57-74). Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA 10.1002/9783527683604.ch03
Pires, João; Siriwardena, Thissa N.; Stach, Michaela; Tinguely, Regula; Kasraian Fard, Sara; Luzzaro, Francesco; Leib, Stephen; Darbre, Tamis; Reymond, Jean-Louis; Endimiani, Andrea (2015). In Vitro Activity of the Novel Antimicrobial Peptide Dendrimer G3KL against Multidrug-Resistant Acinetobacter baumannii and Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 59(12), pp. 7915-7918. American Society for Microbiology 10.1128/AAC.01853-15
Bergman, Manfred Max; Michaud, Gaëlle; Visini, Ricardo; Jin, Xian; Gillon, Emilie; Stocker, Achim; Imberty, Anne; Darbre, Tamis; Reymond, Jean-Louis (2015). Multivalency effects in Pseudomonas aeruginosa biofilm inhibition and dispersal by glycopeptide dendrimers targeting lectin LecA. Organic & biomolecular chemistry, 14(1), pp. 138-148. Royal Society of Chemistry 10.1039/C5OB01682G
Visini, Ricardo; Bergman, Manfred Max; Michaud, Gaelle; Pertici, Francesca; Fu, Ou; Pukin, Aliaksei; Branson, Thomas; Thies-Weesie, Dominique; Kemmink, Johan; Gillon, Emilie; Imberty, Anne; Stocker, Achim; Darbre, Tamis; Pieters, Roland; Reymond, Jean-Louis (2015). Structural Insight into Multivalent Galactoside Binding to Pseudomonas aeroginosa lectin LecA. ACS Chemical Biology, 10(11), pp. 2455-2462. American Chemical Society 10.1021/acschembio.5b00302
González Salgado, Amaia; Steinmann, Michael Eduard; Major, Louise L; Sigel, Erwin; Reymond, Jean-Louis; Smith, Terry K; Bütikofer, Peter (2015). Trypanosoma brucei Bloodstream Forms Depend upon Uptake of myo-Inositol for Golgi Complex Phosphatidylinositol Synthesis and Normal Cell Growth. Eukaryotic cell, 14(6), pp. 616-624. American Society for Microbiology ASM 10.1128/EC.00038-15
Giannini, Federico; Bartoloni, Marco; Paul, Lydia E. H.; Süss-Fink, Georg; Reymond, Jean-Louis; Furrer, Julien (2015). Cytotoxic peptide conjugates of dinuclear arene ruthenium trithiolato complexes. Medicinal chemistry communications - MedChemComm, 6(2), pp. 347-350. Royal Society of Chemistry 10.1039/c4md00433g
He, Runze; Reymond, Jean-Louis (2015). Activity and structure studies of antimicrobial cyclic peptides with L,D- architecture linked by a phenyl group (Unpublished). In: SCG Fall Meeting 2015. EPFL Lausanne. 2015.
Jin, Xian; Awale, Mahendra; Zasso, Michaël; Kostro, Daniel; Patiny, Luc; Reymond, Jean-Louis (2015). PDB-Explorer: a web-based interactive map of the protein data bank in shape space. BMC bioinformatics, 16(1), 16:339. BioMed Central 10.1186/s12859-015-0776-9
Simonin, Céline; Awale, Mahendra; Brand, Michael; van Deursen, Ruud; Schwartz, Julian; Fine, Michael; Kovacs, Gergely; Häfliger, Pascal; Gyimesi, Gergely; Sithampari, Abilashan; Charles, Roch-Philippe; Hediger, Matthias; Reymond, Jean-Louis (2015). Optimization of TRPV6 Calcium Channel Inhibitors Using a 3D Ligand-Based Virtual Screening Method. Angewandte Chemie (International ed.), 54(49), pp. 14748-14752. Wiley-VCH 10.1002/anie.201507320
Perez, Camilo; Gerber, Sabina; Boilevin, Jérémy; Bucher, Monika; Darbre, Tamis; Aebi, Markus; Reymond, Jean-Louis; Locher, Kaspar P. (2015). Structure and mechanism of an active lipid-linked oligosaccharide flippase. Nature, 524(7566), pp. 433-438. Macmillan Journals Ltd. 10.1038/nature14953
Awale, Mahendra; Reymond, Jean-Louis (2015). Similarity Mapplet: Interactive Visualization of the Directory of Useful Decoys and ChEMBL in High Dimensional Chemical Spaces. Journal of chemical information and modeling, 55(8), pp. 1509-1516. American Chemical Society 10.1021/acs.jcim.5b00182
Bartoloni, Marco; Jin, Xian; Marcaida, Maria José; Banha, João; Di Bonaventura, Ivan; Bongoni, Swathi; Bartho, Kathrin; Gräbner, Olivia; Sefkow, Michael; Darbre, Tamis; Reymond, Jean-Louis (2015). Bridged bicyclic peptides as potential drug scaffolds: synthesis, structure, protein binding and stability. Chemical Science, 6(10), pp. 5473-5490. The Royal Society of Chemistry 10.1039/C5SC01699A
Reymond, Jean-Louis (2015). Articles of Significant Interest Selected from This Issue by the Editors. Eukaryotic cell, 14(6), p. 527. American Society for Microbiology ASM 10.1128/EC.00075-15
Montalbetti, Nicolas; Simonin, Alexandre; Simonin, Céline; Awale, Mahendra; Reymond, Jean-Louis; Hediger, Matthias (2015). Discovery and characterization of a novel non-competitive inhibitor of the divalent metal transporter DMT1/SLC11A2. Biochemical pharmacology, 96(3), pp. 216-224. Elsevier 10.1016/j.bcp.2015.05.002
Reymond, Jean-Louis (2015). The Chemical Space Project. Accounts of chemical research, 48(3), pp. 722-730. American Chemical Society 10.1021/ar500432k
Awale, Mahendra; Jin, Xian; Reymond, Jean-Louis (2015). Stereoselective virtual screening of the ZINC database using atom pair 3D-fingerprints. Journal of cheminformatics, 7(1), p. 3. Springer 10.1186/s13321-014-0051-5
He, Runze; Reymond, Jean-Louis (11 September 2014). Synergistic folding and potency increase in an antimicrobial peptide pair against Pseudomonas aeruginosa (Unpublished). In: 2014 SCG fall Meeting. Universität Zürich. 11.09.2014.
Naegeli, A.; Michaud, Gaëlle; Schubert, M.; Lin, C.-W.; Lizak, C.; Darbre, Tamis; Reymond, Jean-Louis; Aebi, M. (2014). Substrate Specificity of Cytoplasmic N-Glycosyltransferase. Journal of biological chemistry, 289(35), pp. 24521-24532. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M114.579326
Awale, Mahendra; Reymond, Jean-Louis (2014). Atom Pair 2D-Fingerprints Perceive 3D-Molecular Shape and Pharmacophores for Very Fast Virtual Screening of ZINC and GDB-17. Journal of chemical information and modeling, 54(7), pp. 1892-1907. American Chemical Society 10.1021/ci500232g
Ruddigkeit, Lars; Awale, Mahendra; Reymond, Jean-Louis (2014). Expanding the fragrance chemical space for virtual screening. Journal of cheminformatics, 6(1), p. 27. Springer 10.1186/1758-2946-6-27
Bürgi, Justus; Awale, Mahendra; Boss, Silvan D.; Schaer, Tifany; Marger, Fabrice; Viveros Paredes, Juan Manuel; Bertrand, Sonia; Gertsch, Jürg; Bertrand, Daniel; Reymond, Jean-Louis (2014). Discovery of Potent Positive Allosteric Modulators of the α3β2 Nicotinic Acetylcholine Receptor by a Chemical Space Walk in ChEMBL. ACS chemical neuroscience, 5(5), pp. 346-359. American Chemical Society 10.1021/cn4002297
Awale, Mahendra; Reymond, Jean-Louis (2014). A multi-fingerprint browser for the ZINC database. Nucleic acids research, 42(W1), W234-W239. Information Retrieval Ltd. 10.1093/nar/gku379
Kouri, Tina M.; Awale, Mahendra; Slyby, James K.; Reymond, Jean-Louis; Mehta, Dinesh P. (2014). “Social” Network of Isomers Based on Bond Count Distance: Algorithms. Journal of chemical information and modeling, 54(1), pp. 57-68. American Chemical Society 10.1021/ci4005173
Bartoloni, Marco; Waltersperger, Sandro; Bumann, Mario; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2014). Stereoselective synthesis and structure determination of a bicyclo[3.3.2]decapeptide. Arkivoc, 2014(3), p. 113. Michigan Publishing 10.3998/ark.5550190.p008.500
Lüscher, Benjamin; Clemençon, Benjamin; Marini, Camilla; Huang, Xiao; Sager, Ruth; Jeanneret, Céline; Reymond, Jean-Louis; Albrecht, Christiane; Hediger, Matthias; Surbek, Daniel; Baumann, Marc Ulrich (January 2014). Placental Uric Acid Transport System: Glucose Transporter 9 (SLC2A9). Reproductive sciences, 21(3), 303A-303A. Sage
Stach, Michaela; Siriwardena, Thissa; Köhler, Thilo; van Delden, Christian; Darbre, Tamis; Reymond, Jean-Louis (2014). Combining Topology and Sequence Design for the Discovery of Potent Antimicrobial Peptide Dendrimers against Multidrug-Resistant Pseudomonas aeruginosa. Angewandte Chemie (International ed.), 53(47), pp. 12827-12831. Wiley-VCH 10.1002/anie.201409270
Lizak, C.; Gerber, Sabine; Zinne, D.; Michaud, Gaëlle; Schubert, M.; Chen, F.; Bucherer, Monika; Darbre, Tamis; Zenobi, R.; Reymond, Jean-Louis; Locher, K. P. (2014). A Catalytically Essential Motif in External Loop 5 of the Bacterial Oligosaccharyltransferase PglB. Journal of biological chemistry, 289(2), pp. 735-746. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M113.524751
Eggimann, Gabriela A.; Blattes, Emilyne; Buschor, Stefanie; Biswas, Rasomoy; Kammer, Stephan M.; Darbre, Tamis; Reymond, Jean-Louis (2014). Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells. Chemical communications, 50(55), pp. 7254-7257. Royal Society of Chemistry 10.1039/C4CC02780A
Ruddigkeit, Lars; Reymond, Jean-Louis (2014). The Chemical Space of Flavours. In: Martinez-Mayorga, Karina; Medina-Franco, José Luis (eds.) Foodinformatics - Applications of Chemical Information to Food Chemistry (pp. 83-96). Heidelberg, Germany: Springer 10.1007/978-3-319-10226-9_2
Reymond, Jean-Louis; Ruddigkeit, Lars; Awale, Mahendra (2014). Considerations on the Drug-Like Chemical Space. In: Jacoby, Edgar (ed.) Computational Chemogenomics (pp. 39-64). Singapore: Pan Stanford Publishing
Bernardi, Anna; Jiménez-Barbero, Jesus; Casnati, Alessandro; De Castro, Cristina; Darbre, Tamis; Fieschi, Franck; Finne, Jukka; Funken, Horst; Jaeger, Karl-Erich; Lahmann, Martina; Lindhorst, Thisbe K.; Marradi, Marco; Messner, Paul; Molinaro, Antonio; Murphy, Paul V.; Nativi, Cristina; Oscarson, Stefan; Penadés, Soledad; Peri, Francesco; Pieters, Roland J.; ... (2013). Multivalent glycoconjugates as anti-pathogenic agents. Chemical Society reviews, 42(11), pp. 4709-4727. Royal Society of Chemistry 10.1039/C2CS35408J
Nyakas, Adrien; Blum, Lorenz C.; Stucki, Silvan R.; Reymond, Jean-Louis; Schürch, Stefan (2013). OMA and OPA—Software-Supported Mass Spectra Analysis of Native and Modified Nucleic Acids. Journal of the American Society for Mass Spectrometry, 24(2), pp. 249-256. Springer-Verlag 10.1007/s13361-012-0529-1
Awale, Mahendra; van Deursen, Ruud; Reymond, Jean-Louis (2013). MQN-Mapplet: Visualization of Chemical Space with Interactive Maps of DrugBank, ChEMBL, PubChem, GDB-11, and GDB-13. Journal of chemical information and modeling, 53(2), pp. 509-518. American Chemical Society 10.1021/ci300513m
Geotti-Bianchini, Piero; Darbre, Tamis; Reymond, Jean-Louis (2013). pH-tuned metal coordination and peroxidase activity of a peptide dendrimer enzyme model with a Fe(ii)bipyridine at its core. Organic & biomolecular chemistry, 11(2), pp. 344-352. Royal Society of Chemistry 10.1039/c2ob26551f
Kadam, Rameshwar U.; Bergman, Manfred Max; Garg, Divita; Gabrieli, Gabriele; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2013). Structure-Based Optimization of the Terminal Tripeptide in Glycopeptide Dendrimer Inhibitors of Pseudomonas aeruginosa Biofilms Targeting LecA. Chemistry - a European journal, 19(50), pp. 17054-17063. Wiley-VCH 10.1002/chem.201302587
Kadam, Rameshwar U.; Garg, Divita; Schwartz, Julian; Visini, Ricardo; Sattler, Michael; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2013). CH−π “T-Shape” Interaction with Histidine Explains Binding of Aromatic Galactosides to Pseudomonas aeruginosa Lectin LecA. ACS Chemical Biology, 8(9), pp. 1925-1930. American Chemical Society 10.1021/cb400303w
Ravi, Harish Kumar; Stach, Michaela; Soares, Thereza; Darbre, Tamis; Reymond, Jean-Louis; Cascella, Michele (2013). Electrostatics and Flexibility Drive Membrane Recognition and Early Penetration by Antimicrobial Peptide Dendrimer bH1. Chemical communications, 49(78), pp. 8821-8823. Royal Society of Chemistry 10.1039/C3CC44912B
Ruddigkeit, Lars; Blum, Lorenz C.; Reymond, Jean-Louis (2013). Visualization and Virtual Screening of the Chemical Universe Database GDB-17. Journal of chemical information and modeling, 53(1), pp. 56-65. American Chemical Society 10.1021/ci300535x
Reymond, Jean-Louis; Bergman, Manfred Max; Darbre, Tamis (2013). Glycopeptide dendrimers as Pseudomonas aeruginosa biofilm inhibitors. Chemical Society reviews, 42(11), pp. 4814-4822. Royal Society of Chemistry 10.1039/c3cs35504g
Gerber, S.; Lizak, C.; Michaud, Gaëlle; Bucher, M.; Darbre, Tamis; Aebi, M.; Reymond, Jean-Louis; Locher, K. P. (2013). Mechanism of bacterial oligosaccharyltransferase: in vitro quantification of sequon binding and catalysis. Journal of biological chemistry, 288(13), pp. 8849-8861. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M112.445940
Heinisch, Tillmann; Langowska, Karolina; Tanner, Pascal; Reymond, Jean-Louis; Meier, Wolfgang; Palivan, Cornelia; Ward, Thomas R. (2013). Fluorescence-Based Assay for the Optimization of the Activity of Artificial Transfer Hydrogenase within a Biocompatible Compartment. ChemCatChem, 5(3), pp. 720-723. WILEY-VCH 10.1002/cctc.201200834
Kwok, Albert; Eggimann, Gabriela; Reymond, Jean-Louis; Darbre, Tamis; Hollfelder, Florian (2013). Peptide Dendrimer/Lipid Hybrid Systems Are Efficient DNA Transfection Reagents: Structure–Activity Relationships Highlight the Role of Charge Distribution Across Dendrimer Generations. ACS nano, 7(5), pp. 4668-4682. American Chemical Society 10.1021/nn400343z
Schwartz, Julian; Awale, Mahendra; Reymond, Jean-Louis (2013). SMIfp (SMILES fingerprint) Chemical Space for Virtual Screening and Visualization of Large Databases of Organic Molecules. Journal of chemical information and modeling, 53(8), pp. 1979-1989. American Chemical Society 10.1021/ci400206h
Eggimann, Gabriela; Buschor, Stefanie; Darbre, Tamis; Reymond, Jean-Louis (2013). Convergent synthesis and cellular uptake of multivalent cell penetrating peptides derived from Tat, Antp, pVEC, TP10 and SAP. Organic & biomolecular chemistry, 11(39), pp. 6717-6733. Royal Society of Chemistry 10.1039/c3ob41023d
Lizak, Christian; Gerber, Sabina; Michaud, Gaëlle; Schubert, Mario; Fan, Yao-Yun; Bucher, Monika; Darbre, Tamis; Aebi, Markus; Reymond, Jean-Louis; Locher, Kaspar P. (2013). Unexpected reactivity and mechanism of carboxamide activation in bacterial N-linked protein glycosylation. Nature communications, 4(2627), p. 2627. Nature Publishing Group 10.1038/ncomms3627
Reymond, Jean-Louis; Darbre, Tamis (2013). Expanding the Topological Space of Bioactive Peptides. CHIMIA, 67(12), pp. 864-867. Bern: Schweizerische Chemische Gesellschaft 10.2533/chimia.2013.864
Bartoloni, M.; Darbre, Tamis; Reymond, Jean-Louis (2012). Synthesis and structure determination of bicyclic bridged peptides. Journal of Peptide Science, 18(S1), S170-S170. John Wiley & Sons
Blattes, E.; Bartoloni, M.; Darbre, Tamis; Reymond, Jean-Louis (2012). Biological applications of bicyclic peptides. Journal of Peptide Science, 18(Supplement), S93-S93. John Wiley & Sons 10.1002/psc.2449
Darbre, Tamis; Reymond, Jean-Louis (2012). Dendritic glycopeptides as Pseudomonas aeruginosa biofilm inhibitors. Journal of Peptide Science, 18, S55-S56. Chichester: John Wiley & Sons
Eggimann, G.; Buschor, S.; Darbre, Tamis; Reymond, Jean-Louis (2012). Branched and Dendritic Cell Penetrating Peptides. Journal of Peptide Science, 18, S152-S152. Chichester: John Wiley & Sons
Reymond, Jean-Louis; Darbre, Tamis (2012). Peptide and glycopeptide dendrimer apple trees as enzyme models and for biomedical applications. Organic & biomolecular chemistry, 10(8), pp. 1483-1492. Cambridge: Royal Society of Chemistry 10.1039/c2ob06938e
Stach, Michaela; Maillard, Noélie; Kadam, Rameshwar; Kalbermatter, David; Meury, M.; Page, Malcolm; Fotiadis, Dimitrios José; Darbre, Tamis; Reymond, Jean-Louis (2012). Membrane disrupting antimicrobial peptide dendrimers with multiple amino termini. Medicinal chemistry communications - MedChemComm, 3(1), pp. 86-89. Cambridge: Royal Society of Chemistry 10.1039/c1md00272d
Reymond, Jean-Louis (2012). Screening Methods for Enzymes. In: Carreira, Eric M.; Yamamoto, Hisashi (eds.) Comprehensive Chirality. Volume 7: Synthetic Methods VI - Enzymatic and Semi-Enzymatic (pp. 6-20). Amsterdam: Elsevier 10.1016/B978-0-08-095167-6.00702-3
Kadam, Rameshwar U.; Bergman, Manfred Max; Hurley, Matthew; Garg, Divita; Cacciarini, Martina; Swiderska, Magdalena A.; Nativi, Cristina; Sattler, Michael; Smyth, Alan R.; Williams, Paul; Camara, Miguel; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2011). A Glycopeptide Dendrimer Inhibitor of the Galactose-Specific Lectin LecA and of Pseudomonas aeruginosa Biofilms. Angewandte Chemie (International ed.), 50(45), pp. 10631-10635. Weinheim: Wiley-VCH 10.1002/anie.201104342
Blum, Lorenz C.; van Deursen, Ruud; Reymond, Jean-Louis (2011). Visualisation and subsets of the chemical universe database GDB-13 for virtual screening. Journal of computer-aided molecular design, 25(7), pp. 637-647. Dordrecht: Springer Netherlands 10.1007/s10822-011-9436-y
van Deursen, Ruud; Blum, Lorenz C.; Reymond, Jean-Louis (2011). Visualisation of the chemical space of fragments, lead-like and drug-like molecules in PubChem. Journal of computer-aided molecular design, 25(7), pp. 649-662. Dordrecht: Springer Netherlands 10.1007/s10822-011-9437-x
Maillard, N.; Biswas, Rasomoy; Darbre, Tamis; Reymond, Jean-Louis (2011). Combinatorial Discovery of Peptide Dendrimer Enzyme Models Hydrolyzing Isobutyryl Fluorescein. ACS combinatorial science, 13(3), pp. 310-320. Washington, D.C.: American Chemical Society 10.1021/co200006z
Uhlich, N.A.; Darbre, Tamis; Reymond, Jean-Louis (2011). Peptide dendrimer enzyme models for ester hydrolysis and aldolizationprepared by convergent thioether ligation. Organic & biomolecular chemistry, 9(20), pp. 7071-7084. Cambridge: Royal Society of Chemistry 10.1039/c1ob05877k
Johansson, Emma M.V.; Dubois, Joëlle; Darbre, Tamis; Reymond, Jean-Louis (2010). Glycopeptide dendrimer colchicine conjugates targeting cancer cells. Bioorganic & medicinal chemistry, 18(17), pp. 6589-6597. Amsterdam: Elsevier 10.1016/j.bmc.2010.04.026
Uhlich, Nicolas A.; Natalello, Antonino; Kadam, Rameshwar U.; Doglia, Silvia M.; Reymond, Jean-Louis; Darbre, Tamis (2010). Structure and Binding of Peptide-Dendrimer Ligands to Vitamin B12. ChemBioChem, 11(3), pp. 358-365. Weinheim: Wiley-VCH 10.1002/cbic.200900657
van Dursen, Ruud; Blum, Lorenz C.; Reymond, Jean-Louis (2010). A Searchable Map of Pubchem. Journal of chemical information and modeling, 50(11), pp. 1924-1934. Washington, D.C.: American Chemical Society 10.1021/ci100237q
Biswas, Rasomoy; Maillard, Noélie; Kofoed, Jacob; Reymond, Jean-Louis (2010). Comparing dendritic with linear esterase peptides by screening SPOT arrays for catalysis. Chemical communications, 46(46), p. 8746. Cambridge: Royal Society of Chemistry 10.1039/c0cc02700f
Garcia-Delgado, Noemi; Bertrand, Sonia; Nguyen, Kong T.; van Deursen, Ruud; Bertrand, Daniel; Reymond, Jean-Louis (2010). Exploring a7-Nicotinic Receptor Ligand Diversity by Scaffold Enumeration from the Chemical Universe Database GDB. ACS medicinal chemistry letters, 1(8), pp. 422-426. Washington, D.C.: American Chemical Society 10.1021/ml100125f
Reymond, Jean-Louis (2010). Selected papers from the Biotrans 2009 Conference. Journal of molecular catalysis. B - enzymatic, 65(1-4), pp. 1-2. Amsterdam: Elsevier 10.1016/j.molcatb.2010.05.006
Reymond, Jean-Louis; Sheldon, Roger A. (2010). Future turnovers in enzyme catalysis. Current opinion in chemical biology, 14(2), pp. 113-114. Amsterdam: Elsevier 10.1016/j.cbpa.2010.02.019
Reymond, Jean-Louis; van Deursen, Ruud; Blum, Lorenz C.; Ruddigkeit, Lars (2010). Chemical space as a source for new drugs. Medicinal chemistry communications - MedChemComm, 1(1), p. 30. Cambridge: Royal Society of Chemistry 10.1039/c0md00020e
Uhlich, Nicolas A.; Sommer, Peter; Bühr, Claudia; Schürch, Stefan; Reymond, Jean-Louis; Darbre, Tamis (2009). Remote Control of Bipyridine-Metal Coordination within a Peptide Dendrimer. Chemical communications(41), p. 6237. Cambridge: Royal Society of Chemistry 10.1039/b912291e
Javor, Sacha; Reymond, Jean-Louis (2009). Structure Activity Relationship Studies in Single-Site-Esterase Peptide Dendrimers. Israel journal of chemistry, 49(1), pp. 129-136. Weinheim: Wiley-VCH 10.1560/IJC.49.1.129
Blum, Lorenz C.; Reymond, Jean-Louis (2009). 970 Million Drug-like Small Molecules for Virtual Screening in the Chemical Universe Database GDB-13 (Communication). Journal of the American Chemical Society, 131(25), pp. 8732-8733. Washington, D.C.: American Chemical Society 10.1021/ja902302h
Sommer, Peter; Fluxa, Viviana S.; Darbre, Tamis; Reymond, Jean-Louis (2009). Proteolysis of Peptide Dendrimers. ChemBioChem, 10(9), pp. 1527-1536. Weinheim: Wiley-VCH 10.1002/cbic.200900060
Dolphin, Gunnar T.; Renaudet, Olivier; Ouberai, Myriam; Dumy, Pascal; Garcia, Julian; Reymond, Jean-Louis (2009). Phenolic oxime oligomers inhibit Alzheimer's amyloid fibril formation and disaggregate fibrils in vitro. ChemBioChem, 10(8), pp. 1325-1329. Weinheim: Wiley-VCH 10.1002/cbic.200900044
Maillard, Noélie; Darbre, Tamis; Reymond, Jean-Louis (2009). Identification of Catalytic Peptide Dendrimers by "Off-Bead" in Silica High-Throughput Screening of Combinatorial Libraries. Journal of combinatorial chemistry, 11(4), pp. 667-675. Washington, D.C.: American Chemical Society 10.1021/cc9000289
Nguyen, Kong Thong; Luethi, Erika; Syed, Salahuddin; Urwyler, Stephan; Bertrand, Sonia; Berrand, Daniel; Reymond, Jean-Louis (2009). 3-(Aminomethyl)piperazine-2,5-dione as a novel NMDA glycine site inhibitor from the chemical universe database GDB. Bioorganic and medicinal chemistry letters, 19(14), pp. 3832-3835. New York, N.Y.: Pergamon 10.1016/j.bmcl.2009.04.021
Javor, Sacha; Reymond, Jean-Louis (2009). Molecular dynamics and docking studies of single site esterase peptide dendrimers. Journal of organic chemistry, 74(10), pp. 3665-3674. Washington, D.C.: American Chemical Society 10.1021/jo802743c
Reymond, Jean-Louis; Nguyen, Kong Thong (2009). Exploration of Chemical Space for Drug Discovery by Database Generation. Chimica oggi / Chemistry today, 27(2), pp. 37-40. Milano: TeknoScienze
Kolomiets, Elena; Swiderska, Magdalena A.; Kadam, Rameshwar U.; Johansson, Emma M.V.; Jaeger, Karl-Erich; Darbre, Tamis; Reymond, Jean-Louis (2009). Glycopeptide dendrimers with high affinity for the fucose binding lectin PA-IIL from Pseudomonas aeruginosa. ChemMedChem, 4(4), pp. 562-569. Weinheim: Wiley-VCH 10.1002/cmdc.200800380
Maillard, Noélie; Clouet, Anthony; Darbre, Tamis; Reymond, Jean-Louis (2009). Combinatorial Libraries of Peptide Dendrimers: Design, Synthesis, On-Bead High-Throughput Screening, Bead Decoding and Characterization. Nature protocols, 4(2), pp. 132-142. London: Nature Publishing Group 10.1038/nprot.2008.241
Reymond, Jean-Louis; Fluxa, Viviana S.; Maillard, Noélie (2009). Enzyme Assays. Chemical communications(1), pp. 34-46. Cambridge: Royal Society of Chemistry 10.1039/b813732c
Fluxa, Viviana S.; Reymond, Jean-Louis (2009). On-bed cyclization in a combinatorial library of 15.625 octapeptides. Bioorganic & medicinal chemistry, 17(3), pp. 1018-1025. Amsterdam: Elsevier 10.1016/j.bmc.2008.01.045
Reymond, Jean-Louis (2008). Colorimetric and Fluorescence-Based Screening. In: Lutz, Stefan; Bornscheuner, Uwe Theo (eds.) Protein Engineering Handbook (pp. 669-711). Weinheim: Wiley-VCH
Reymond, Jean-Louis; Streit, W. (2008). The Search for New Enzymes. In: Gotor, Vincente; Alfonso, Ignacio; Garcia-Uridales, Eduardo (eds.) Asymmetric Organic Synthesis with Enzymes (pp. 65-86). Weinheim: Wiley-VCH
Reymond, Jean-Louis (2008). Fluorescence Assays for Biotransformations. In: Fessner, Wolf-Dieter; Anthonsen, Thorleif (eds.) Modern Biocatalysis (pp. 1-16). Weinheim: Wiley-VCH
Javor, Sacha; Natalello, Antonino; Doglia, Silvia Maria; Reymond, Jean-Louis (2008). a-Helix Stabilization within a Peptide Dendrimer [Communication]. Journal of the American Chemical Society, 130(51), pp. 17248-17249. Washington, D.C.: American Chemical Society 10.1021/ja8076236
Johansson, Emma M.V.; Crusz, Shanika A.; Kolomiets, Elena; Buts, Lieven; Kadam, Rameshwar U.; Cacciarini, Martina; Bartels, Kai-Malte; Diggle, Stephen P.; Cámara, Miguel; Williams, Paul; Loris, Remy; Nativi, Cristina; Rosenau, Frank; Jaeger, Karl-Erich; Darbre, Tamis; Reymond, Jean-Louis (2008). Inhibition and Dispersion of Pseudomonas aeruginosa Biofilms by Glycopeptide Dendrimers Targeting the Fucose-Specific Lectin LecB. Chemistry & biology, 15(12), pp. 1249-1257. San Francisco, Calif.: Current Biology Ltd. 10.1016/j.chembiol.2008.10.009
Duléry, Vincent; Uhlich, Nicolas A.; Maillard, Noélie; Fluxa, Viviana S.; Garcia, Julian; Dumy, Pascal; Renaudet, Olivier; Reymond, Jean-Louis; Darbre, Tamis (2008). A cyclodecapeptide ligand to vitamin B12. Organic & biomolecular chemistry, 6(22), pp. 4134-4141. Cambridge: Royal Society of Chemistry 10.1039/b811234g
Darbre, Tamis; Reymond, Jean-Louis (2008). Glycopeptide dendrimers for biomedical applications. Current topics in medicinal chemistry, 8(14), pp. 1286-1293. Hilversum: Bentham Science Publishers 10.2174/156802608785849058
Nguyen, Kong Thong; Syed, Salahuddin; Urwyler, Stephan; Bertrand, Sonia; Bertrand, Daniel; Reymond, Jean-Louis (2008). Discovery of NMDA Glycine Site Inhibitors from the Chemical Universe Database GDB. ChemMedChem, 3(10), pp. 1520-1524. Weinheim: Wiley-VCH 10.1002/cmdc.200800198
Fluxa, Viviana S.; Wahler, Denis; Reymond, Jean-Louis (2008). Enzyme assay and activity fingerprinting of hydrolases with red-chromogenic adrenaline test. Nature protocols, 3(8), pp. 1270-1277. London: Nature Publishing Group 10.1038/nprot.2008.106
Sommer, Peter; Uhlich, Nicolas; Reymond, Jean-Louis; Darbre, Tamis (2008). A Peptide Dendrimer Model for Vitamin B(12). ChemBioChem, 9(5), pp. 689-693. Weinheim: Wiley-VCH 10.1002/cbic.200700606
Reymond, Jean-Louis (2008). Substrate Arrays for Fluorescence-Based Enzyme Fingerpringing and High-Throughput Screening. Annals of the New York Academy of Sciences, 1130(1), pp. 12-20. Boston, Mass.: Blackwell 10.1196/annals.1430.000
Swiderska, Magdalena; Reymond, Jean-Louis (2008). A dendritic signal amplifier (commentary). Nature chemistry, 1(7), pp. 527-528. London: Nature Publishing Group 10.1038/nchem.385
Nguyen, Kong Thong; Blum, Lorenz C.; van Deursen, Ruud; Reymond, Jean-Louis (2008). Classification of Organic Molecules by Molecular Quantum Numbers (Communication). ChemMedChem, 4(11), pp. 1803-1805. Weinheim: Wiley-VCH 10.1002/cmdc.200900317
Zheng, Lei; Baumann, Ulrich; Reymond, Jean-Louis (2004). An efficient one-step site-directed and site-saturation mutagenesis protocol. Nucleic acids research, 32(14), e115-e115. Oxford University Press 10.1093/nar/gnh110
Zheng, Lei; Baumann, Ulrich; Reymond, Jean-Louis (2003). Production of a Functional Catalytic Antibody ScFv-NusA Fusion Protein in Bacterial Cytoplasm. Journal of Biochemistry, 133(5), pp. 577-581. Japanese Biochemical Society 10.1093/jb/mvg074
