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Mutlu, Seyran; Scalise, Melanie; Philip, Stumbles; Gazdhar, Amiq; Blank, Fabian (2023). Allies or enemies? The effect of regulatory T cells and related T lymphocytes on the profibrotic environment in bleomycin-injured lung mouse models. Clinical and experimental medicine, 23(4), pp. 1075-1088. Springer 10.1007/s10238-022-00945-7
Brütsch, Salome M; Madzharova, Elizabeta; Pantasis, Sophia; Wüstemann, Till; Gurri, Selina; Steenbock, Heiko; Gazdhar, Amiq; Kuhn, Gisela; Angel, Peter; Bellusci, Saverio; Brinckmann, Jürgen; Auf dem Keller, Ulrich; Werner, Sabine; Bordoli, Mattia R (2023). Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome. Cellular and molecular life sciences : CMLS, 80(4), p. 89. Springer 10.1007/s00018-023-04735-6
Richert, Emma; Nienhaus, Andrea; Jahren, Silje Ekroll; Gazdhar, Amiq; Grab, Maximilian; Hörer, Jürgen; Carrel, Thierry; Obrist, Dominik; Heinisch, Paul Philipp (2023). Biogenic polymer-based patches for congenital cardiac surgery: a feasibility study. Frontiers in cardiovascular medicine, 10, p. 1164285. Frontiers 10.3389/fcvm.2023.1164285
Fytianos, Kleanthis; Schliep, Ronja; Mykoniati, Sofia; Khan, Petra; Hostettler, Katrin E; Tamm, Michael; Gazdhar, Amiq; Knudsen, Lars; Geiser, Thomas (2022). Anti-Fibrotic Effect of SDF-1β Overexpression in Bleomycin-Injured Rat Lung. Pharmaceutics, 14(9) MDPI 10.3390/pharmaceutics14091803
Bombaci, Giuseppe; Sarangdhar, Mayuresh Anant; Andina, Nicola; Tardivel, Aubry; Yu, Eric Chi-Wang; Mackie, Gillian M; Pugh, Matthew; Ozan, Vedat Burak; Banz, Yara; Spinetti, Thibaud; Hirzel, Cédric; Youd, Esther; Schefold, Joerg C; Taylor, Graham; Gazdhar, Amiq; Bonadies, Nicolas; Angelillo-Scherrer, Anne; Schneider, Pascal; Maslowski, Kendle M and Allam, Ramanjaneyulu (2022). LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity. Life science alliance, 5(6) EMBO Press 10.26508/lsa.202101226
Khan, Petra; Fytianos, Kleanthis; Blumer, Sabrina; Roux, Julien; Gazdhar, Amiq; Savic, Spasenija; Knudsen, Lars; Jonigk, Danny; Kuehnel, Mark P; Mykoniati, Sofia; Tamm, Michael; Geiser, Thomas; Hostettler, Katrin E (2022). Basal-Like Cell-Conditioned Medium Exerts Anti-Fibrotic Effects In Vitro and In Vivo. Frontiers in Bioengineering and Biotechnology, 10, p. 844119. Frontiers Media 10.3389/fbioe.2022.844119
Bosch-Guiteras, Núria; Uroda, Tina; Guillen-Ramirez, Hugo A.; Riedo, Rahel; Gazdhar, Amiq; Esposito, Roberta; Pulido-Quetglas, Carlos; Zimmer, Yitzhak; Medová, Michaela; Johnson, Rory (2021). Enhancing CRISPR deletion via pharmacological delay of DNA-PKcs. Genome research, 31(3), pp. 461-471. Cold Spring Harbor, N.Y 10.1101/gr.265736.120
Tamò, Luca; Fytianos, Kleanthis; Caldana, Fabienne; Simillion, Cedric; Feki, Anis; Nita, Izabela; Heller, Manfred; Geiser, Thomas; Gazdhar, Amiq (2021). Interactome Analysis of iPSC Secretome and Its Effect on Macrophages In Vitro. International journal of molecular sciences, 22(2) MDPI 10.3390/ijms22020958
Seyed Jafari, S. Morteza; Blank, Fabian; Ramser, Hallie E; Woessner, Alan E; Shafighi, Maziar; Geiser, Thomas; Quinn, Kyle P; Hunger, Robert E; Gazdhar, Amiq (2021). Efficacy of Combined in-vivo Electroporation-Mediated Gene Transfer of VEGF, HGF, and IL-10 on Skin Flap Survival, Monitored by Label-Free Optical Imaging: A Feasibility Study. Frontiers in Surgery, 8, p. 639661. Frontiers 10.3389/fsurg.2021.639661
Ruzgys, Paulius; Böhringer, Stephan; Dokumaci, Ayse Sila; Hari, Yvonne; Schürch, Christian M; Brühl, Frido; Schürch, Stefan; Szidat, Sönke; Riether, Carsten; Šatkauskas, Saulius; Geiser, Thomas; Hradetzky, David; Gazdhar, Amiq (2021). Electrospray Mediated Localized and Targeted Chemotherapy in a Mouse Model of Lung Cancer. Frontiers in Pharmacology, 12, p. 643492. Frontiers 10.3389/fphar.2021.643492
Dane, D Merrill; Cao, Khoa; Zhang, Yu-An; Kernstine, Kemp; Gazdhar, Amiq; Geiser, Thomas; Hsia, Connie C W (2020). Inhalational delivery of induced pluripotent stem cell secretome improves postpneumonectomy lung structure and function. Journal of applied physiology, 129(5), pp. 1051-1061. American Physiological Society 10.1152/japplphysiol.00205.2020
Sutter, Marco A.; Cremona, Tiziana P; Nita, Izabela; Cavarra, Eleonora; Lungarella, Giuseppe; Lewis, Eli C; Schittny, Johannes C.; Geiser, Thomas; Gazdhar, Amiq (2020). In Vivo Electroporation-Mediated, Intrahepatic Alpha1 Antitrypsin Gene Transfer Reduces Pulmonary Emphysema in Pallid Mice. Pharmaceutics, 12(9) MDPI 10.3390/pharmaceutics12090793
Boesch, Maximilian; Baty, Florent; Brutsche, Martin H; Tamm, Michael; Roux, Julien; Knudsen, Lars; Gazdhar, Amiq; Geiser, Thomas; Khan, Petra; Hostettler, Katrin E (2020). Transcriptomic profiling reveals disease-specific characteristics of epithelial cells in idiopathic pulmonary fibrosis. Respiratory research, 21(1), p. 165. BioMed Central 10.1186/s12931-020-01414-z
Gantenbein, Benjamin; Tang, Shirley; Guerrero, Julien; Higuita-Castro, Natalia; Salazar-Puerta, Ana I; Croft, Andreas S.; Gazdhar, Amiq; Purmessur, Devina (2020). Non-viral Gene Delivery Methods for Bone and Joints. Frontiers in Bioengineering and Biotechnology, 8, p. 598466. Frontiers Media 10.3389/fbioe.2020.598466
Pierog, Jaroslaw Stanislaw; Fytianos, Kleanthis; Tamò, Luca Giuseppe Athos; Simillion, Cedric André Marie; Taddeo, Adriano; Kocher, Gregor; Gugger, Mathias; Grodzki, Tomasz; Heller, Manfred; Blank, Fabian; Geiser, Thomas; Schmid, Ralph; Gazdhar, Amiq (2019). Stem cell secretome attenuates acute rejection in rat lung allotransplant. Interactive cardiovascular and thoracic surgery, 28(5), pp. 812-818. Oxford University Press 10.1093/icvts/ivy306
Jaeger, Veronika K; Lebrecht, Dirk; Nicholson, Andrew G; Wells, Athol; Bhayani, Harshil; Gazdhar, Amiq; Tamm, Michael; Venhoff, Nils; Geiser, Thomas; Walker, Ulrich A (2019). Mitochondrial DNA mutations and respiratory chain dysfunction in idiopathic and connective tissue disease-related lung fibrosis. Scientific Reports, 9(1), p. 5500. Nature Publishing Group 10.1038/s41598-019-41933-4
Schögler, Aline; Caliaro, Oliver Stephan; Brügger, Melanie; Oliveira Esteves, Blandina I.; Nita, Izabela; Gazdhar, Amiq; Geiser, Thomas; Alves, Marco P. (2019). Modulation of the unfolded protein response pathway as an antiviral approach in airway epithelial cells. Antiviral research, 162, pp. 44-50. Elsevier 10.1016/j.antiviral.2018.12.007
Tamò, Luca; Hibaoui, Youssef; Kallol, Sampada; Alves, Marco; Albrecht, Christiane; Hostettler, Katrin E; Feki, Anis; Rougier, Jean-Sébastien; Abriel, Hugues; Knudsen, Lars; Gazdhar, Amiq; Geiser, Thomas (2018). Generation of an alveolar epithelial type II cell line from induced pluripotent stem cells. American journal of physiology - lung cellular and molecular physiology, 315(6), L921-L932. American Physiological Society 10.1152/ajplung.00357.2017
Khan, Petra; Fytianos, Kleanthis; Tamò, Luca Giuseppe Athos; Roth, Michael; Tamm, Michael; Geiser, Thomas; Gazdhar, Amiq; Hostettler, Katrin E (2018). Culture of human alveolar epithelial type II cells by sprouting. Respiratory research, 19(1), p. 204. BioMed Central 10.1186/s12931-018-0906-9
Hradetzky, David; Boehringer, Stephan; Ruzgys, Paulius; Satkauskas, Saulius; Geiser, Thomas; Gazdhar, Amiq (2018). Method for analysis of electrospray for gene transfer and the impact on cell viability of A549 alveolar epithelial like cells. IEEE Engineering in Medicine and Biology Society conference proceedings, 2018, pp. 5725-5728. IEEE Service Center 10.1109/EMBC.2018.8513643
Jafari, Morteza; Jabbary Lak, Fatemeh; Gazdhar, Amiq; Shafighi, Maziar; Borradori, Luca; Hunger, Robert (2018). Application of electrochemotherapy in the management of primary and metastatic cutaneous malignant tumours: a systematic review and meta-analysis. European journal of dermatology EJD, 28(3), pp. 287-313. John Libbey Eurotext 10.1684/ejd.2018.3291
Tamò, Luca Giuseppe Athos; Simillion, Cedric; Hibaoui, Youssef; Feki, Anis; Gugger, Mathias; Prasse, Antje; Jäger, Benedikt; Goldmann, Torsten; Geiser, Thomas; Gazdhar, Amiq (2018). Gene Network Analysis of Interstitial Macrophages After Treatment with Induced Pluripotent Stem Cells Secretome (iPSC-cm) in the Bleomycin Injured Rat Lung. Stem cell reviews and reports, 14(3), pp. 412-424. Springer 10.1007/s12015-017-9790-9
Jafari, Morteza; Shafighi, Maziar; Beltraminelli, Helmut; Weber, Benedikt; Schmid, Ralph; Geiser, Thomas; Gazdhar, Amiq; Hunger, Robert (2018). Efficacy of In Vivo Electroporation-Mediated IL-10 Gene Delivery on Survival of Skin Flaps. The Journal of Membrane Biology, 251(2), pp. 211-219. Springer 10.1007/s00232-017-9974-x
Gazdhar, Amiq; Ravikumar, Priya; Pastor, Johanne; Heller, Manfred; Ye, Jianfeng; Zhang, Jianning; Moe, Orson W; Geiser, Thomas; Hsia, Connie C W (2018). Alpha-Klotho Enrichment in Induced Pluripotent Stem Cell Secretome Contributes to Antioxidative Protection in Acute Lung Injury. Stem cells, 36(4), pp. 616-625. AlphaMed Press 10.1002/stem.2752
Boehringer, Stephan; Ruzgys, Paulius; Tamò, Luca Giuseppe Athos; Šatkauskas, Saulius; Geiser, Thomas; Gazdhar, Amiq; Hradetzky, David (2018). A new electrospray method for targeted gene delivery. Scientific Reports, 8(1), p. 4031. Nature Publishing Group 10.1038/s41598-018-22280-2
Pierog, Jaroslaw Stanislaw; Tamò, Luca Giuseppe Athos; Fakin, Richard; Kocher, Gregor; Gugger, Mathias; Grodzki, Tomasz; Geiser, Thomas; Gazdhar, Amiq; Schmid, Ralph (2018). Bone marrow stem cells modified with human interleukin 10 attenuate acute rejection in rat lung allotransplantation. European journal of cardio-thoracic surgery, 53(1), pp. 194-200. Oxford University Press 10.1093/ejcts/ezx257
Jafari, Morteza; Shafighi, Maziar; Beltraminelli, Helmut; Geiser, Thomas; Hunger, Robert; Gazdhar, Amiq (2017). Improvement of Flap Necrosis in a Rat Random Skin Flap Model by In Vivo Electroporation-Mediated HGF Gene Transfer. Plastic and reconstructive surgery, 139(5), 1116e-1127e. Lippincott Williams & Wilkins 10.1097/PRS.0000000000003259
Nita, Izabela Magdalena; Hostettler, Katrin; Tamò, Luca Giuseppe Athos; Medova, Michaela; Bombaci, Giuseppe; Zhong, Jun; Allam, Ramanjaneyulu; Zimmer, Yitzhak; Roth, Michael; Geiser, Thomas; Gazdhar, Amiq (2017). Hepatocyte growth factor secreted by bone marrow stem cell reduce ER stress and improves repair in alveolar epithelial II cells. Scientific Reports, 7(41901), p. 41901. Nature Publishing Group 10.1038/srep41901
Hostettler, Katrin E; Gazdhar, Amiq; Khan, Petra; Savic, Spasenija; Tamò, Luca Giuseppe Athos; Lardinois, Didier; Roth, Michael; Tamm, Michael; Geiser, Thomas (2017). Multipotent mesenchymal stem cells in lung fibrosis. PLoS ONE, 12(8), e0181946. Public Library of Science 10.1371/journal.pone.0181946
Gazdhar, Amiq; Blank, Fabian; Cesson, Valerie; Lovis, Alban; Aubert, John David; Lazor, Romain; Spertini, Francois; Wilson, Anne; Hostettler, Katrin; Nicod, Laurent P; Obregon, Carolina (2017). Human Bronchial Epithelial Cells Induce CD141/CD123/DC-SIGN/FLT3 Monocytes That Promote Allogeneic Th17 Differentiation. Frontiers in immunology, 8(447), p. 447. Frontiers Research Foundation 10.3389/fimmu.2017.00447
Gazdhar, Amiq; Temuri, Almas; Knudsen, Lars; Gugger, Mathias; Schmid, Ralph A.; Ochs, Matthias; Geiser, Thomas (2013). Targeted gene transfer of hepatocyte growth factor to alveolar type II epithelial cells reduces lung fibrosis in rats. Human gene therapy, 24(1), pp. 105-116. Mary Ann Liebert Inc. 10.1089/hum.2012.098
Felder, Marcel; Sallin, Pauline; Barbe, Laurent; Haenni, Beat; Gazdhar, Amiq; Geiser, Thomas; Guenat, Olivier (2012). Microfluidic wound-healing assay to assess the regenerative effect of HGF on wounded alveolar epithelium. Lab on a chip, 12(3), pp. 640-6. Cambridge: Royal Society of Chemistry 10.1039/c1lc20879a
Leuenberger, Alexandra; Gazdhar, Amiq; Herrmann, Gudrun; Ochs, Matthias; Geiser, Thomas; Knudsen, Lars (2012). Cell-specific expression of human HGF by alveolar type II cells induces remodeling of septal wall tissue in the lung: a morphometric study. Journal of applied physiology, 113(5), pp. 799-807. Bethesda, Md.: American Physiological Society 10.1152/japplphysiol.00411.2012
Goepfert, Christine; Gazdhar, Amiq; Frey, Felix J; Frey, Brigitte M (2011). Effect of electroporation-mediated diphtheria toxin A expression on PSA positive human prostate xenograft tumors in SCID mice. Prostate, 71(8), pp. 872-80. Hoboken, N.J.: Wiley-Blackwell 10.1002/pros.21303
Fakin, Richard; Hamacher, Jürg; Gugger, Mathias; Gazdhar, Amiq; Moser, Helen; Schmid, Ralph Alexander (2011). Prolonged amelioration of acute lung allograft rejection by sequential overexpression of human interleukin-10 and hepatocyte growth factor in rats. Experimental lung research, 37(9), pp. 555-62. New York, N.Y.: Informa Healthcare 10.3109/01902148.2011.601785
Ayuni, Erick L; Gazdhar, Amiq; Giraud, Marie Noelle; Kadner, Alexander; Gugger, Mathias; Cecchini, Marco; Caus, Thierry; Carrel, Thierry P; Schmid, Ralph A; Tevaearai, Hendrik T (2010). In vivo electroporation mediated gene delivery to the beating heart. PLoS ONE, 5(12), e14467. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0014467
Gaschen, Annina; Lang, Doris; Kalberer, Markus; Savi, Melanie; Geiser, Thomas; Gazdhar, Amiq; Lehr, Claus-Michael; Bur, Michael; Dommen, Josef; Baltensperger, Urs; Geiser, Marianne (2010). Cellular responses after exposure of lung cell cultures to secondary organic aerosol particles. Environmental science & technology, 44(4), pp. 1424-30. Washington, D.C.: ACS Publications 10.1021/es902261m
Beshay, Morris; Gazdhar, Amiq; Gugger, Mathias; Reymond, Marc; Schmid, Ralph A (2009). The feasibility of non-viral gene transfer to the diaphragm in vivo. Development, growth & differentiation, 51(6), pp. 547-553. Richmond (Aus.): Blackwell Publishing Asia 10.1111/j.1440-169X.2009.01117.x
Hoksch, Beatrix; Rufer, Benjamin; Gazdhar, Amiq; Bilici, Murat; Beshay, Morris; Gugger, Matthias; Schmid, Ralph Alexander (2009). Taurolidine in the prevention and therapy of lung metastases. European journal of cardio-thoracic surgery, 36(6), pp. 1058-63. Oxford: Elsevier Science B.V. 10.1016/j.ejcts.2009.04.065
Carboni, Giovanni L; Fahrner, Rene; Gazdhar, Amiq; Printzen, Gert; Schmid, Ralph Alexander; Hoksch, Beatrix (2008). Comparison of procalcitonin and CrP in the postoperative course after lung decortication. European journal of cardio-thoracic surgery, 33(5), pp. 777-80. Oxford: Elsevier Science B.V. 10.1016/j.ejcts.2008.02.013
Gazdhar, Amiq; Fachinger, Patrick; van Leer, Coretta; Pierog, Jaroslaw; Gugger, Mathias; Friis, Robert; Schmid, Ralph A; Geiser, Thomas (2007). Gene transfer of hepatocyte growth factor by electroporation reduces bleomycin-induced lung fibrosis. American journal of physiology - lung cellular and molecular physiology, 292(2), L529-36. Bethesda, Md.: American Physiological Society 10.1152/ajplung.00082.2006
Stammberger, Uz; Bilici, Murat; Gugger, Mathias; Gazdhar, Amiq; Hamacher, Jürg; Hyde, Stephen C; Schmid, Ralph A (2006). Prolonged amelioration of acute lung allograft rejection by overexpression of human interleukin-10 under control of a long acting ubiquitin C promoter in rats. Journal of heart and lung transplantation, 25(12), pp. 1474-9. New York, N.Y.: Elsevier 10.1016/j.healun.2006.09.004
Gazdhar, Amiq; Bilici, Murat; Pierog, Jaroslaw; Ayuni, Erick L; Gugger, Mathias; Wetterwald, Antoinette; Cecchini, Marco; Schmid, Ralph Alexander (2006). In vivo electroporation and ubiquitin promoter--a protocol for sustained gene expression in the lung. Journal of gene medicine, 8(7), pp. 910-8. Chichester: Wiley 10.1002/jgm.911
Tavakoli, Reza; Gazdhar, Amiq; Pierog, Jaroslaw; Bogdanova, Anna; Gugger, Mathias; Pringle, Ian A; Gill, Deborah R; Hyde, Stephen C; Genoni, Michele; Schmid, Ralph A (2006). Electroporation-mediated interleukin-10 overexpression in skeletal muscle reduces acute rejection in rat cardiac allografts. Journal of gene medicine, 8(2), pp. 242-8. Chichester: Wiley 10.1002/jgm.859
Pierog, Jaroslaw; Gazdhar, Amiq; Stammberger, Uz; Gugger, Matthias; Hyde, Steven; Mathiesen, Iacob; Grodzki, Tomasz; Schmid, Ralph A. (2005). Synergistic effect of low dose Cyclosporine A and human interleukin 10 overexpression on acute rejection in rat lung allotransplantation. European journal of cardio-thoracic surgery, 27(6), pp. 1030-1035. Elsevier Science B.V. 10.1016/j.ejcts.2005.03.008
Ozan, Vedat Burak; Tschirren, Anna-Barbara; Gazdhar, Amiq; Geiser, Thomas (31 March 2022). Induced pluripotent stem cell derived alveolar lung organoids (Unpublished). In: SSP / SSTS Poster Walk: InfSSP/SSTS - SSSSC Joint Annual Meeting 2022ections, interstitial and obstructive lung diseases. Lucerne. 31.03.2022.
Fytianos, Kleanthis; Gazdhar, Amiq; Geiser, Thomas (29 September 2020). Anti-fibrotic effect of SDF-1 over expression in bleomycin injured rat lung (Unpublished). In: SGP Bern.
Mutlu, Seyran Mathilde; Fytianos, Kleanthis; Ferrié, Céline; Tschirren, Anna-Barbara; Gazdhar, Amiq; Blank, Fabian (23 September 2020). Regulatory T cells in Bleomycin injured Mouse lung (Unpublished). In: SGP Bern.
Khan, Petra; Roux, Julien; Savic, Spasenija; Knudsen, Lars; Jonigk, Danny; Kuehnel, Mark; Gazdhar, Amiq; Geiser, Thomas; Tamm, Michael; Hostettler, Katrin Esther (6 September 2020). Fibrosis-specific stem-like cells in peripheral IPF lung: Characteristics and potential role. European respiratory journal, 56(Suppl. 64), p. 3360. European Respiratory Society 10.1183/13993003.congress-2020.3360
Fytianos, Kleanthis; Gazdhar, Amiq; Geiser, Thomas (6 September 2020). Anti-fibrotic effect of SDF-1 over expression in bleomycin injured rat lung (Unpublished). In: ERS International Congress 2020 – VIRTUAL. 05. September 2020 - 09. September 2020.
Fytianos, Kleanthis; Gazdhar, Amiq; Geiser, Thomas (6 September 2020). Anti-fibrotic effect of SDF-1 over expression in bleomycin injured rat lung (Unpublished). In: ERS International Congress 2020 – VIRTUAL.
Felder, Marcel; Sallin, Pauline; Barbe, Laurent; Gazdhar, Amiq; Geiser, Thomas; Guenat, Olivier Thierry (2011). Lung on Chip: In vitro HGF effects on injured alveolar A549 epithelial cells in microfluidic system. European respiratory journal, 38(Suppl 55), P4585. European Respiratory Society
Marconi, Emanuele; Schoeni, Anna; Barbe, Laurent; Gazdhar, Amiq; Geiser, Thomas; Guenat, Olivier Thierry (2011). Lung on a chip: Co-culture of alveolar epithelial cells and bone marrow derived stromal stem cells in a microfluidic system. European respiratory journal, 38(Suppl 55), P4585. European Respiratory Society
Bombaci, Giuseppe; Sarangdhar, Mayuresh Anant; Andina, Nicola; Tardivel, Aubry Bernard Maurice; Chi-Wang Yu, Eric; Mackie, Gillian M.; Pugh, Matthew; Ozan, Vedat Burak; Banz, Yara; Spinetti, Thibaud; Hirzel, Cédric; Youd, Esther; Schefold, Joerg C.; Taylor, Graham; Gazdhar, Amiq; Bonadies, Nicolas; Angelillo-Scherrer, Anne; Schneider, Pascal; Maslowski, Kendle M. and Allam, Ramanjaneyulu (26 August 2021). LRR protein RNH1 dampens the inflammasome activation and is associated with adverse clinical outcomes in COVID-19 patients (In Press) (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2021.04.12.438219
