05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Pharmacology and Toxicology

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Portner, Susanne; Mevissen, Meike (2015). Open door day at the Swiss veterinary faculty in Bern. Schweizer Archiv für Tierheilkunde, 157(7), pp. 362-363. Huber


Lehner, Claudia; Hubbuch, Alina; Schmitt, Kira; Schuepbach-Regula, Gertraud; Willi, Barbara; Mevissen, Meike; Peter, Ruth; Muentener, Cedric R; Naegeli, Hanspeter; Schuller, Simone (2020). Effect of antimicrobial stewardship on antimicrobial prescriptions for selected diseases of dogs in Switzerland. Journal of veterinary internal medicine, 34(6), pp. 2418-2431. Wiley-Blackwell 10.1111/jvim.15906

Zielinski, Jana; Ducray, Angélique D.; Moeller, Anja M.; Murbach, Manuel; Kuster, Niels; Mevissen, Meike (2020). Effects of pulse-modulated radiofrequency magnetic field (RF-EMF) exposure on apoptosis, autophagy, oxidative stress and electron chain transport function in human neuroblastoma and murine microglial cells. Toxicology in vitro, 68, p. 104963. Elsevier 10.1016/j.tiv.2020.104963

Ducray, Angélique D.; Wiedmer, Linda; Herren, Fabienne; Widmer, Hans Rudolf; Mevissen, Meike (2020). Quantitative characterization of phenotypical markers after differentiation of SH-SY5Y cells. CNS & neurological disorders, drug targets, 19(8), pp. 618-629. Bentham Science Publishers 10.2174/1871527319666200708132716

Hubbuch, Alina; Schmitt, Kira; Lehner, Claudia; Hartnack, Sonja; Schuller, Simone; Schüpbach-Regula, Gertraud; Mevissen, Meike; Peter, Ruth; Müntener, Cedric; Naegeli, Hanspeter; Willi, Barbara (2020). Antimicrobial prescriptions in cats in Switzerland before and after the introduction of an online antimicrobial stewardship tool. BMC veterinary research, 16(1), p. 229. BioMed Central 10.1186/s12917-020-02447-8

Lutz, Bérénice; Lehner, Claudia; Schmitt, Kira; Willi, Barbara; Schüpbach, Gertraud; Mevissen, Meike; Peter, Ruth; Müntener, Cedric; Naegeli, Hanspeter; Schuller, Simone (2020). Antimicrobial prescriptions and adherence to prudent use guidelines for selected canine diseases in Switzerland in 2016. Veterinary record open, 7(1), e000370. BMJ Publishing Group 10.1136/vetreco-2019-000370

Bittner, Aniela; Ducray, Angélique Dominique; Stoffel, Michael Hubert; Felser, Andrea; Mevissen, Meike (2019). Polymer-coated nanoparticles and their effects on mitochondrial function in brain endothelial cells. Toxicology and Applied Pharmacology, 385, p. 114800. Elsevier 10.1016/j.taap.2019.114800

Di Santo, Stefano; Seiler, Stefanie; Ducray, Angélique D.; Widmer, Hans Rudolf (2019). Conditioned Medium from Endothelial Progenitor Cells promotes number of dopaminergic neurons and exerts neuroprotection in cultured ventral mesencephalic neuronal progenitor cells. Brain research, 1720, p. 146330. Elsevier 10.1016/j.brainres.2019.146330

Vimercati, Sara; Elli, S; Jagannathan, Vidya; Pandey, Amit Vikram; Peduto, Nadja; Leeb, Tosso; Mevissen, Meike (2019). In silico and in vitro analysis of genetic variants of the equine CYP3A94, CYP3A95 and CYP3A97 isoenzymes. Toxicology in vitro, 60, pp. 116-124. Elsevier 10.1016/j.tiv.2019.05.011

Bittner, Aniela; Ducray, Angélique; Widmer, Hans Rudolf; Stoffel, Michael H; Mevissen, Meike (2019). Effects of gold and PCL- or PLLA-coated silica nanoparticles on brain endothelial cells and the blood–brain barrier. Beilstein journal of nanotechnology, 10, pp. 941-954. Beilstein-Institut zur Förderung der Chemischen Wissenschaften 10.3762/bjnano.10.95

Schmitt, K; Lehner, Claudia; Schuller, Simone; Schüpbach, Gertraud Irene; Mevissen, Meike; Peter, R; Müntener, C R; Naegeli, H; Willi, B (2019). Antimicrobial use for selected diseases in cats in Switzerland. BMC veterinary research, 15(1), p. 94. BioMed Central 10.1186/s12917-019-1821-0

Wiedmer, Linda; Ducray, Angélique; Frenz, Martin; Stoffel, Michael Hubert; Widmer, Hans Rudolf; Mevissen, Meike (2019). Silica nanoparticle-exposure during neuronal differentiation modulates dopaminergic and cholinergic phenotypes in SH-SY5Y cells. Journal of nanobiotechnology, 17(1), p. 46. BioMed Central 10.1186/s12951-019-0482-2

von Niederhäusern, Nicole; Ducray, Angélique; Zielinski, Jana; Murbach, Manuel; Mevissen, Meike (2019). Effects of radiofrequency electromagnetic field exposure on neuronal differentiation and mitochondrial function in SH-SY5Y cells. Toxicology in vitro, 61, p. 104609. Elsevier 10.1016/j.tiv.2019.104609

Ayrle, Hannah; Nathues, Heiko; Bieber, Anna; Durrer, Manuela; Quander, Nele; Mevissen, Meike; Walkenhorst, Michael (2019). Placebo-controlled study on the effects of oral administration of Allium sativum L in postweaning piglets. Veterinary record, 184(10), p. 316. British Veterinary Association 10.1136/vr.105131

Tresch, Milena; Mevissen, Meike; Ayrle, Hannah; Melzig, Matthias; Roosje, Petra; Walkenhorst, Michael (2019). Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review. BMC veterinary research, 15(1), p. 174. BioMed Central 10.1186/s12917-019-1854-4

Ayrle, Hannah; Mevissen, Meike; Kaske, Martin; Vögtlin, Andrea; Fricker, Raffael; Hoffmann, Bernd; Büttner, Mathias; Marinovic, Zlatko; Walkenhorst, Michael (2018). Colostral transmission of BTV-8 antibodies from dairy cows six years after vaccination. Vaccine, 36(39), pp. 5807-5810. Elsevier 10.1016/j.vaccine.2018.08.015

Sandbaumhüter, Friederike Andrea; Vimercati, Sara; Thormann, Wolfgang; Mevissen, Meike (2018). Role of the equine CYP3A94, CYP3A95 and CYP3A97 in ketamine metabolism in presence of medetomidine, diazepam and methadone studied by enantioselective capillary electrophoresis. Toxicology in vitro, 50, pp. 242-248. Elsevier 10.1016/j.tiv.2018.03.016

Di Santo, Stefano; Meyer, M; Ducray, Angélique; Andereggen, Lukas; Widmer, Hans Rudolf (2018). A combination of NT-4/5 and GDNF is favorable for cultured human nigral neural progenitor cells. Cell transplantation, 27(4), pp. 648-653. Cognizant Communication Corporation 10.1177/0963689717753188

Peter, R; Müntener, C; Demuth, D; Heim, D; Stucki, F; Mevissen, Meike; Gerspach, C; Kaske, M; Steiner, Adrian; Meylan, Mireille; Bodmer, Michèle; Schüpbach-Regula, G.; Feldmann, M; Naegeli, H (2018). [AntibioticScout.ch: Decision support for the prudent use of antimicrobials: Application in cattle]. Schweizer Archiv für Tierheilkunde, 160(4), pp. 219-226. Gesellschaft Schweizer Tierärztinnen und Tierärzte 10.17236/sat00154

Rufener, Reto; Ritler, Dominic; Zielinski, Jana; Dick, Luca; da Silva, Emerson Teixeira; da Silva Araujo, Adriele; Joekel, Deborah Elisabeth; Czock, David; Göpfert, Christine; Moraes, Adriana Marques; de Souza, Marcus Vinicius Nora; Müller, Joachim; Mevissen, Meike; Hemphill, Andrew; Lundström-Stadelmann, Britta (2018). Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis. International journal for parasitology. Drugs and drug resistance, 8(2), pp. 331-340. Elsevier 10.1016/j.ijpddr.2018.06.004

Kupper, J; Walkenhorst, M; Ayrle, H; Mevissen, M.; Demuth, D; Naegeli, H (2018). Online information system for ­phytotherapy in animals. Schweizer Archiv für Tierheilkunde, 160(10), pp. 589-595. Gesellschaft Schweizer Tierärztinnen und Tierärzte 10.17236/sat00178

Peter, R; Demuth, D; Müntener, C; Lampart, M; Heim, D; Mevissen, Meike; Schüpbach, Gertraud; Schuller, Simone; Stucki, F; Willi, B; Burkhardt, W; Francey, Thierry; Nett, C; Tschuor, F; Naegeli, H (2017). AntibioticScout.ch: Eine Entscheidungshilfe für den umsichtigen Einsatz von antimikrobiellen Wirkstoffen: Anwendung in der Kleintiermedizin. Schweizer Archiv für Tierheilkunde, 159(10), pp. 525-533. Huber 10.17236/sat00129

Perruchoud, Tania; Maeschli, A; Bachmann, H; Walkenhorst, M; Schüpbach, Gertraud; Mevissen, Meike; Zanolari, Patrik (2017). Diagnosis, therapy and prophylactic measures of parturient paresis in dairy cattle: results of an online survey for Swiss veterinarians. Schweizer Archiv für Tierheilkunde, 159(6), pp. 335-343. Gesellschaft Schweizer Tierärztinnen und Tierärzte 10.17236/sat00119

Di Santo, Stefano; Seiler, Stefanie; Ducray, Angélique; Meyer, M; Widmer, Hans Rudolf (2017). A Subpopulation of Dopaminergic Neurons Coexpresses Serotonin in Ventral Mesencephalic Cultures But Not After Intrastriatal Transplantation in a Rat Model of Parkinson's Disease. Cell transplantation, 26(4), pp. 679-691. Cognizant Communication Corporation 10.3727/096368916X693707

Ducray, Angélique; Stojiljkovic, Ana; Möller, Anja-Maria; Stoffel, Michael Hubert; Widmer, Hans Rudolf; Frenz, Martin; Mevissen, Meike (2017). Uptake of silica nanoparticles in the brain and effects on neuronal differentiation using different in vitro models. Nanomedicine : nanotechnology, biology, and medicine, 13(3), pp. 1195-1204. Elsevier 10.1016/j.nano.2016.11.001

Vimercati, Sara; Büchi, Martina Corinne; Zielinski, Jana; Peduto, Nadja; Mevissen, Meike (2017). Testosterone metabolism of equine single CYPs of the 3A subfamily compared to the human CYP3A4. Toxicology in vitro, 41, pp. 83-91. Elsevier 10.1016/j.tiv.2017.02.017

Ducray, Angélique; Felser, Andrea Debora; Zielinski, Jana; Bittner, Aniela; Bürgi, Julia Verena; Nuoffer, Jean-Marc; Frenz, Martin; Mevissen, Meike (2017). Effects of silica nanoparticle exposure on mitochondrial function during neuronal differentiation. Journal of nanobiotechnology, 15(1), p. 49. BioMed Central 10.1186/s12951-017-0284-3

Mevissen, Meike; Kovacevic, Alan (2016). Pharmakologie des Herz-Kreislauf-Systems. In: Löscher, Wolfgang; Richter, Angelika (eds.) Lehrbuch der Pharmakologie und Toxikologie für die Veterinärmedizin (pp. 188-213). Enke

Mevissen, Meike; Abraham, Getu (2016). Pharmakologie des Atmungsapparates. In: Löscher, Wolfgang; Richter, Angelika (eds.) Lehrbuch der Pharmakologie und Toxikologie für die Veterinärmedizin (pp. 265-278). Enke

Parham, F; Portier, CJ; Chang, X; Mevissen, Meike (2016). The Use of Signal-Transduction and Metabolic Pathways to Predict Human Disease Targets from Electric and Magnetic Fields Using in vitro Data in Human Cell Lines. Frontiers in Public Health, 4(193), p. 193. Frontiers Research Foundation 10.3389/fpubh.2016.00193

Andres, Robert H.; Ducray, Angélique; Andereggen, Lukas; Hohl, Tabea; Schlattner, Uwe; Wallimann, Theo; Widmer, Hans Rudolf (2016). The effects of creatine supplementation on striatal neural progenitor cells depend on developmental stage. Amino acids, 48(8), pp. 1913-1927. Springer 10.1007/s00726-016-2238-8

Zielinski, Jana; Möller, Anja-Maria; Frenz, Martin; Mevissen, Meike (2016). Evaluation of endocytosis of silica particles used in biodegradable implants in the brain. Nanomedicine-Nanotechnology Biology and Medicine, 12(6), pp. 1603-1613. Elsevier 10.1016/j.nano.2016.02.009

Ayrle, Hannah; Mevissen, Meike; Kaske, Martin; Nathues, Heiko; Grützner, Niels; Melzig, Matthias; Walkenhorst, Michael (2016). Medicinal plants - prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review. BMC veterinary research, 12(1), p. 89. BioMed Central 10.1186/s12917-016-0714-8

Stojiljkovic, Ana; Kuehni-Boghenbor, K.; Gaschen, Véronique; Schüpbach, Gertraud; Mevissen, Meike; Kinnear, C.; Möller, A.-M.; Stoffel, Michael Hubert (2016). High-content analysis of factors affecting gold nanoparticle uptake by neuronal and microglial cells in culture. Nanoscale, 8(37), pp. 16650-16661. Royal Society of Chemistry 10.1039/C6NR05723C

Ruth, Peter; Müntener, Cedric; Demuth, Daniel; Heim, Dagmar; Mevissen, Meike; Schüpbach, Gertraud; Schuller, Simone; Stucki, Flurina; Willi, Barbara; Nägeli, Hans-Peter (2016). AntibioticScout: Online tool for antimicrobial stewardship in veterinary medicine. Schweizer Archiv für Tierheilkunde, 158(12), pp. 805-810. Huber 10.17236/sat00095

Zielinski, Jana; Mevissen, Meike (2015). Inhibition of in vitro metabolism of testosterone in human, dog and horse liver microsomes to investigate species differences. Toxicology in vitro, 29(3), pp. 468-478. Elsevier 10.1016/j.tiv.2014.12.018

Schediwy, Marion; Mevissen, Meike; Demuth, Daniel; Kupper, Jacqueline; Nägeli, Hanspeter (2015). [New causes of animal poisoning in Switzerland]. Schweizer Archiv für Tierheilkunde, 157(3), pp. 147-152. Gesellschaft Schweizer Tierärztinnen und Tierärzte

Dettwiler, Ramona; Schmitz, Andrea; Plattet, Philippe; Zielinski, Jana; Mevissen, Meike (2014). Heterologous expression of equine CYP3A94 and investigation of a tunable system to regulate co-expressed NADPH P450 oxidoreductase levels. PLoS ONE, 9(11), e113540. Public Library of Science 10.1371/journal.pone.0113540

Balmer, Sandra; Vögtlin, Andrea; Thür, Barbara; Büchi, Martina Corinne; Abril Gaona, Carlos; Houmard, Matthias; Danuser, Jürg; Schwermer, Heinzpeter (2014). Serosurveillance of Schmallenberg virus in Switzerland using bulk tank milk samples. Preventive veterinary medicine, 116(4), pp. 370-379. Elsevier 10.1016/j.prevetmed.2014.03.026

Koch, Franziska; Möller, Anja-Maria; Frenz, Martin; Pieles, Uwe; Kühni, Kathrin; Mevissen, Meike (2014). An in vitro toxicity evaluation of gold-, PLLA- and PCL-coated silica nanoparticles in neuronal cells for nanoparticle-assisted laser-tissue soldering. Toxicology in vitro, 28(5), pp. 990-998. Elsevier 10.1016/j.tiv.2014.04.010

Schmitz, Andrea; Zielinski, Jana; Dick, B.; Mevissen, Meike (2014). In vitro metabolism of testosterone in the horse liver and involvement of equine CYPs 3A89, 3A94 and 3A95. Journal of veterinary pharmacology and therapeutics, 37(4), pp. 338-347. Blackwell Scientific Publications 10.1111/jvp.12106

Büchi, Martina Corinne; Abril Gaona, Carlos; Vögtlin, Andrea; Schwermer, Heinzpeter (2014). Prevalence of antibodies against bluetongue virus serotype 8 in bulk-tank milk samples from dairy cattle herds located in risk areas for bluetongue virus transmission after a vaccination programme in Switzerland. Berliner und Münchener tierärztliche Wochenschrift, 127(3-4), pp. 158-162. Schlütersche

Scinicariello, Franco; Buser, Melanie C; Mevissen, Meike; Portier, Christopher J (2013). Blood lead level association with lower body weight in NHANES 1999-2006. Toxicology and Applied Pharmacology, 273(3), pp. 516-23. Elsevier 10.1016/j.taap.2013.09.022

Stefanski, Anja; Mevissen, Meike; Möller, A.-M.; Kühni-Boghenbor, Kathrin; Schmitz, Andrea (2013). Induction of cytochrome P450 enzymes in primary equine hepatocyte culture. Toxicology in vitro, 27(7), pp. 2023-2030. Elsevier 10.1016/j.tiv.2013.07.009

Peters, Laureen; Demmel, Steffi; Pusch, G.; Buters, J. T. M.; Thormann, W.; Zielinski, Jana; Leeb, Tosso; Mevissen, Meike; Schmitz, Andrea (2013). Equine cytochrome P450 2B6--genomic identification, expression and functional characterization with ketamine. Toxicology and Applied Pharmacology, 266(1), pp. 101-8. Elsevier 10.1016/j.taap.2012.10.028

Hemphill, Andrew; Debache, Karim; Monney, Thierry; Schorer, Michelle; Gouinaud, Christophe; Alaeddine, Ferial; Müller, Norbert; Müller, Joachim (2013). Proteins mediating the Neospora caninum-host cell interaction as targets for vaccination. Frontiers in Bioscience (Elite Edition), 5, pp. 23-36. Frontiers in Bioscience

Prause, A.S.; Guionaud, Christophe; Stoffel, Michael Hubert; Portier, C.J.; Mevissen, Meike (2010). Expression and function of 5-hydroxytryptamine 4 receptors in smooth muscle preparations from the duodenum, ileum, and pelvic flexure of horses without gastrointestinal tract disease. American journal of veterinary research, 71(12), pp. 1432-42. Chicago, Ill.: American Veterinary Medical Association 10.2460/ajvr.71.12.1432

Schmitz, Andrea; Demmel, Steffi; Peters, Laureen M.; Leeb, Tosso; Mevissen, Meike; Haase, Bianca (2010). Comparative human-horse sequence analysis of the CYP3A subfamily gene cluster. Animal genetics, 41, pp. 72-79. Oxford: Blackwell 10.1111/j.1365-2052.2010.02111.x

Debache, Karim; Alaeddine, Ferial; Guionaud, Christophe; Monney, Thierry; Müller, Joachim; Strohbusch, Maria; Leib, Stephen L.; Grandgirard, Denis; Hemphill, Andrew (2009). Vaccination with recombinant NcROP2 combined with recombinant NcMIC1 and NcMIC3 reduces cerebral infection and vertical transmission in mice experimentally infected with Neospora caninum tachyzoites. International journal for parasitology, 39(12), pp. 1373-1384. Kidlington, UK: Elsevier 10.1016/j.ijpara.2009.04.006

Prause, Andrea S.; Stoffel, Michael Hubert; Portier, Christopher J.; Mevissen, Meike (2009). Expression and function of 5-HT7 receptors in smooth muscle preparations from equine duodenum, ileum, and pelvic flexure. Research in veterinary science, 87(2), pp. 292-299. London: Association for Veterinary Teaching and Research Work 10.1016/j.rvsc.2009.03.009

Mevissen, M.; Burgener, I.A. (2009). Pharmakologie des Atmungsapparates. In: Frey, Hans-Hasso; Löscher, Wolfgang (eds.) Lehrbuch der Pharmakologie und Toxikologie für die Veterinärmedizin (pp. 254-260). Stuttgart: Enke Verlag

Mevissen, M.; Kovacevic, A. (2009). Pharmakologie des Herz-Kreislauf-Systems. In: Frey, Hans-Hasso; Löscher, Wolfgang (eds.) Lehrbuch der Pharmakologie und Toxikologie für die Veterinärmedizin (pp. 175-220). Stuttgart: Enke Verlag

Löscher, Wolfgang; Wahnschaffe, Ulrich; Mevissen, Meike; Lerchl, Alexander; Stamm, Andreas (2009). Effects of Weak Alternating Magnetic Fields on Nocturnal Melatonin Production and Mammary Carcinogenesis in Rats. Oncology - international journal of cancer research and treatment, 51(3), pp. 288-295. Karger 10.1159/000227352

Chaignat, Valérie; Danuser, Hansjörg; Stoffel, Michael Hubert; Z'Brun, Sebastian; Studer, U E; Mevissen, Meike (2008). Effects of a non-selective COX inhibitor and selective COX-2 inhibitors on contractility of human and porcine ureters in vitro and in vivo. British journal of pharmacology, 154(6), pp. 1297-307. Oxford: Wiley-Blackwell 10.1038/bjp.2008.193

Peterbauer, Christoph; Larenza, Paula M; Knobloch, Monika; Theurillat, Regula; Thormann, Wolfgang; Mevissen, Meike; Spadavecchia, Claudia (2008). Effects of a low dose infusion of racemic and S-ketamine on the nociceptive withdrawal reflex in standing ponies. Veterinary anaesthesia and analgesia, 35(5), pp. 414-23. Oxford: Blackwell Science 10.1111/j.1467-2995.2008.00402.x

Prause, Andrea; Guionaud, C T; Klukowska-Rötzler, J; Giulotto, E; Magnani, E; Chowdhary, B P; Philipp, U; Leeb, Tosso; Mevissen, Meike (2007). Chromosomal assignment of five equine HTR genes by FISH and RH mapping. Animal genetics, 38(1), pp. 83-4. Oxford: Blackwell 10.1111/j.1365-2052.2006.01546.x

Haase, Bianca; Brooks, Samantha A; Schlumbaum, Angela; Azor, Pedro J; Bailey, Ernest; Alaeddine, Ferial; Mevissen, Meike; Burger, Dominik; Poncet, Pierre-André; Rieder, Stefan; Leeb, Tosso (2007). Allelic Heterogeneity at the Equine KIT Locus in Dominant White (W) Horses. PLoS genetics, 3(11), e195. San Francisco, Calif.: Public Library of Science 10.1371/journal.pgen.0030195

Buehler, M; Steiner, Adrian; Meylan, Mireille; Portier, C J; Mevissen, Meike (2007). In vitro effects of bethanechol on smooth muscle preparations from abomasal fundus, corpus, and antrum of dairy cows. Research in veterinary science, 84(3), pp. 444-451. London: Association for Veterinary Teaching and Research Work 10.1016/j.rvsc.2007.05.012

Knobloch, M; Portier, C J; Levionnois, O L; Theurillat, R; Thormann, W; Spadavecchia, C; Mevissen, M (2006). Antinociceptive effects, metabolism and disposition of ketamine in ponies under target-controlled drug infusion. Toxicology and Applied Pharmacology, 216(3), pp. 373-86. Amsterdam: Elsevier 10.1016/j.taap.2006.06.011

Stoffel, Michael Hubert; Monnard, Christel Wicki; Steiner, Adrian; Mevissen, Meike; Meylan, Mireille (2006). Distribution of muscarinic receptor subtypes and interstitial cells of Cajal in the gastrointestinal tract of healthy dairy cows. American journal of veterinary research, 67(12), pp. 1992-1997. Chicago, Ill.: American Veterinary Medical Association 10.2460/ajvr.67.12.1992

Levionnois, Olivier; Iff, I; Moens, Y (2006). Successful treatment of hypoxemia by an alveolar recruitment maneuver in a horse during general anaesthesia for colic surgery. Pferdeheilkunde, 22(3), pp. 333-336. Baden-Baden: Hippiatrika Verlagsgesellschaft

Löscher, Wolfgang; Mevissen, Meike (1995). Linear relationship between flux density and tumor co-promoting effect of prolonged magnetic field exposure in a breast cancer model. Cancer letters, 96(2), pp. 175-180. Elsevier 10.1016/0304-3835(95)03926-n

Löscher, Wolfgang; Mevissen, Meike (1994). Animal studies on the role of 50/60-hertz magnetic fields in carcinogenesis. Life sciences, 54(21), pp. 1531-1543. Elsevier 10.1016/0024-3205(94)90024-8

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