Takala, Jukka

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2019

Wernerman, Jan; Christopher, Kenneth B; Annane, Djillali; Casaer, Michael P; Coopersmith, Craig M; Deane, Adam M; De Waele, Elisabeth; Elke, Gunnar; Ichai, Carole; Karvellas, Constantine J; McClave, Stephen A; Oudemans-van Straaten, Heleen M; Rooyackers, Olav; Stapleton, Renee D; Takala, Jukka; van Zanten, Arthur R H; Wischmeyer, Paul E; Preiser, Jean-Charles; Vincent, Jean-Louis (2019). Metabolic support in the critically ill: a consensus of 19. Critical care, 23(1), p. 318. BioMed Central 10.1186/s13054-019-2597-0

Merz, Tobias; Cioccari, Luca; Frey, Pascal Marcel; Bloch, Andreas; Berger, David; Zante, Björn; Jakob, Stephan; Takala, Jukka (2019). Correction to: Continual hemodynamic monitoring with a single-use transesophageal echocardiography probe in critically ill patients with shock: a randomized controlled clinical trial. Intensive care medicine, 45(9), p. 1330. Springer-Verlag 10.1007/s00134-019-05700-3

Merz, Tobias; Cioccari, Luca; Frey, Pascal Marcel; Bloch, Andreas; Berger, David; Zante, Björn; Jakob, Stephan; Takala, Jukka (2019). Continual hemodynamic monitoring with a single-use transesophageal echocardiography probe in critically ill patients with shock: a randomized controlled clinical trial. Intensive care medicine, 45(8), pp. 1093-1102. Springer-Verlag 10.1007/s00134-019-05670-6

Shehabi, Yahya; Howe, Belinda D; Bellomo, Rinaldo; Arabi, Yaseen M; Bailey, Michael; Bass, Frances E; Bin Kadiman, Suhaini; McArthur, Colin J; Murray, Lynnette; Reade, Michael C; Seppelt, Ian M; Takala, Jukka; Wise, Matt P; Webb, Steven A (2019). Early Sedation with Dexmedetomidine in Critically Ill Patients. The New England journal of medicine, 380(26), pp. 2506-2517. Massachusetts Medical Society 10.1056/NEJMoa1904710

Werner Möller, Per; Sondergaard, Soren; Jakob, Stephan; Takala, Jukka; Berger, David (2019). Effect of volume status on the estimation of mean systemic filling pressure. Journal of applied physiology, 126(6), pp. 1503-1513. American Physiological Society 10.1152/japplphysiol.00897.2018

Werner Möller, Per; Hana, Anisa; Heinisch, Paul Philipp; Liu, Shengchen; Djafarzadeh, Siamak; Hänggi, Matthias; Bloch, Andreas; Takala, Jukka; Jakob, Stephan; Berger, David (2019). The Effects of Vasoconstriction and Volume Expansion on Veno-Arterial ECMO Flow. Shock, 51(5), pp. 650-658. Lippincott Williams & Wilkins 10.1097/SHK.0000000000001197

Schefold, Joerg C.; Messmer, Anna S.; Wenger, Stefanie; Müller, Lionel; von Haehling, Stephan; Doehner, Wolfram; McPhee, Jamie S; Fux, Michaela; Rösler, Kai M; Scheidegger, Olivier; Olariu, Radu; Z'Graggen, Werner; Rezzi, Serge; Grathwohl, Dominik; Konz, Tobias; Takala, Jukka; Cuenoud, Bernard; Jakob, Stephan M. (2019). Nutrient pattern analysis in critically ill patients using Omics technology (NAChO) - Study protocol for a prospective observational study. Medicine, 98(1), e13937. Lippincott Williams & Wilkins 10.1097/MD.0000000000013937

Berger, David; Werner Möller, Per; Takala, Jukka (2019). Reply to “Is the Guytonian framework justified in explaining heart lung interactions?” and “Venous return, mean systemic pressure and getting the right answer for the wrong reason”. Annals of translational medicine, 7(8), p. 186. AME Publishing Company 10.21037/atm.2019.04.50

2018

Krag, Mette; Marker, Søren; Perner, Anders; Wetterslev, Jørn; Wise, Matt P; Schefold, Joerg C.; Keus, Frederik; Guttormsen, Anne B; Bendel, Stepani; Borthwick, Mark; Lange, Theis; Rasmussen, Bodil S; Siegemund, Martin; Bundgaard, Helle; Elkmann, Thomas; Jensen, Jacob V; Nielsen, Rune D; Liboriussen, Lisbeth; Bestle, Morten H; Elkjær, Jeanie M; ... (2018). Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU. The New England journal of medicine, 379(23), pp. 2199-2208. Massachusetts Medical Society 10.1056/NEJMoa1714919

Gorrasi, José Antonio; Jakob, Stephan; Tovar, Luis Antonio; Balsiger, Bruno Markus; Brandt, Sebastian; Brügger, Lukas; Bracht, Hendrik; Takala, Jukka (2018). Perioperative Fluid Accumulation Impairs Intestinal Contractility to a Smilar Extent as Peritonitis and Endotoxemia. Shock, 50(6), pp. 735-740. Lippincott Williams & Wilkins 10.1097/SHK.0000000000001088

Cioccari, Luca; Zante, Bjoern; Bloch, Andreas; Berger, David; Limacher, Andreas; Jakob, Stephan M; Takala, Jukka; Merz, Tobias M (2018). Correction to: Effects of hemodynamic monitoring using a single-use transesophageal echocardiography probe in critically ill patients - study protocol for a randomized controlled trial. [correction]. Trials, 19(1), p. 587. BioMed Central 10.1186/s13063-018-3001-0

Cioccari, Luca; Zante, Bjoern; Bloch, Andreas; Berger, David; Limacher, Andreas; Jakob, Stephan M; Takala, Jukka; Merz, Tobias M (2018). Effects of hemodynamic monitoring using a single-use transesophageal echocardiography probe in critically ill patients - study protocol for a randomized controlled trial. Trials, 19(1), p. 362. BioMed Central 10.1186/s13063-018-2714-4

Schefold, Joerg C.; Zürcher, Patrick; Takala, Jukka (2018). The authors reply. Critical care medicine, 46(7), e727-e728. Lippincott Williams & Wilkins 10.1097/CCM.0000000000003163

Aneman, Anders; Brechot, Nicholas; Brodie, Daniel; Colreavy, Frances; Fraser, John; Gomersall, Charles; McCanny, Peter; Moller-Sorensen, Peter Hasse; Takala, Jukka; Valchanov, Kamen; Vallely, Michael (2018). Advances in critical care management of patients undergoing cardiac surgery. Intensive care medicine, 44(6), pp. 799-810. Springer-Verlag 10.1007/s00134-018-5182-0

Zürcher, Patrick; Takala, Jukka; Schefold, Joerg C. (2018). The authors reply. Critical care medicine, 46(4), e344-e345. Lippincott Williams & Wilkins 10.1097/CCM.0000000000002978

Sommerstein, Rami; Merz, Tobias; Jakob, Stephan; Takala, Jukka; Marschall, Jonas (2018). Decontamination of Extracorporeal Membrane Oxygenator Devices With an Intensified Disinfection Protocol: How Strict Is Too Strict? Infection control and hospital epidemiology, 39(3), pp. 366-367. Cambridge University Press 10.1017/ice.2017.283

Glas, Michael; Frick, Tamara; Springe, Dirk; Putzu, Alessandro; Zürcher, Patrick; Grandgirard, Denis; Leib, Stephen; Jakob, Stephan; Takala, Jukka; Hänggi, Matthias (2018). Neuroprotection with the P53-Inhibitor Pifithrin-μ After Cardiac Arrest in a Rodent Model. Shock, 49(2), pp. 229-234. Lippincott Williams & Wilkins 10.1097/SHK.0000000000000917

Berger, David; Takala, Jukka (2018). Determinants of systemic venous return and the impact of positive pressure ventilation. Annals of translational medicine, 6(18), p. 350. AME Publishing Company 10.21037/atm.2018.05.27

Eggmann, Sabrina; Verra, Martin L.; Luder, Gere; Takala, Jukka; Jakob, Stephan (2018). Effects of early, combined endurance and resistance training in mechanically ventilated, critically ill patients: A randomised controlled trial. PLoS ONE, 13(11), e0207428. Public Library of Science 10.1371/journal.pone.0207428

2017

Schefold, Joerg C.; Berger, David; Zürcher, Patrick; Lensch, Michael; Perren, Andrea; Jakob, Stephan; Parviainen, Ilkka; Takala, Jukka (2017). Dysphagia in Mechanically Ventilated ICU Patients (DYnAMICS): A Prospective Observational Trial. Critical care medicine, 45(12), pp. 2061-2069. Lippincott Williams & Wilkins 10.1097/CCM.0000000000002765

Shehabi, Yahya; Forbes, Andrew B; Arabi, Yaseen; Bass, Frances; Bellomo, Rinaldo; Kadiman, Suhaini; Howe, Belinda D; McArthur, Colin; Reade, Michael C; Seppelt, Ian; Takala, Jukka; Webb, Steve; Wise, Matthew P (2017). The SPICE III study protocol and analysis plan: a randomised trial of early goaldirected sedation compared with standard care in mechanically ventilated patients. Critical care and resuscitation, 19(4), pp. 318-326. College of Intensive Care Medicine of Australia and New Zealand

Jakob, Stephan; Takala, Jukka (2017). Subcellular Energetics and Metabolism: A Cross-Species Framework. Anesthesia and analgesia, 125(6), p. 2160. Lippincott Williams & Wilkins 10.1213/ANE.0000000000002476

Werner Möller, Per; Winkler, Berhard; Hurni, Samuel; Heinisch, Paul Philipp; Bloch, Andreas; Sondergaard, Soren; Jakob, Stephan; Takala, Jukka; Berger, David (2017). Right atrial pressure and venous return during cardiopulmonary bypass. American journal of physiology - heart and circulatory physiology, 313(2), H408-H420. American Physiological Society 10.1152/ajpheart.00081.2017

Bloch, Andreas; Kohler, Andreas; Posthaus, Horst; Berger, David; Santos, Laura; Jakob, Stephan; Takala, Jukka; Hänggi, Matthias (2017). Gastrointestinal Impedance Spectroscopy to Detect Hypoperfusion During Hemorrhage. Shock, 48(2), pp. 185-195. Lippincott Williams & Wilkins 10.1097/SHK.0000000000000824

Jakob, Stephan M; Bütikofer, Lukas; Berger, David; Coslovsky, Michael; Takala, Jukka (2017). A randomized controlled pilot study to evaluate the effect of an enteral formulation designed to improve gastrointestinal tolerance in the critically ill patient-the SPIRIT trial. Critical care, 21(1), p. 140. BioMed Central 10.1186/s13054-017-1730-1

De Marchis, Gian Marco; Schaad, Chris; Fung, Christian; Beck, Jürgen; Gralla, Jan; Takala, Jukka; Jakob, Stephan (2017). Gender-related differences in aneurysmal subarachnoid hemorrhage: A hospital based study. Clinical neurology and neurosurgery, 157, pp. 82-87. Elsevier 10.1016/j.clineuro.2017.04.009

Corrêa, Thiago Domingos; Pereira, Adriano José; Brandt, Sebastian; Vuda, Madhusudanarao; Djafarzadeh, Siamak; Takala, Jukka; Jakob, Stephan (2017). Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis. Critical care, 21(1), p. 105. BioMed Central 10.1186/s13054-017-1691-4

Jakob, Stephan; Takala, Jukka (2017). Comments on Teboul and Scheeren: understanding the Haldane effect. Intensive care medicine, 43(4), p. 597. Springer 10.1007/s00134-017-4697-0

Berger, David; Werner Möller, Per; Blöchlinger, Stefan; Bloch, Andreas; Jakob, Stephan; Takala, Jukka (21 March 2017). P106 Methodological issues for the determination of mean systemic filling pressure at the end of life. Critical care, 21(Suppl1), p. 41. BioMed Central

Werner Möller, Per; Jakob, Stephan; Takala, Jukka; Berger, David (21 March 2017). P108 Right atrial pressure as back-pressure to venous return. Critical care, 21(Suppl 1), pp. 41-42. BioMed Central

Varis, Elina; Pettilä, Ville Yrjö Olavi; Poukkanen, Meri; Jakob, Stephan; Karlsson, Sari; Perner, Anders; Takala, Jukka; Wilkman, Erika (2017). Evolution of Blood Lactate and 90-Day Mortality in Septic Shock. A Post Hoc Analysis of the Finnaki Study. Shock, 47(5), pp. 574-581. Lippincott Williams & Wilkins 10.1097/SHK.0000000000000772

Brander, Lukas; Moerer, Onnen; Hedenstierna, Göran; Beck, Jennifer; Takala, Jukka; Slutsky, Arthur S; Sinderby, Christer (2017). NEURAL CONTROL OF VENTILATION PREVENTS BOTH OVER-DISTENSION AND DE-RECRUITMENT OF EXPERIMENTALLY INJURED LUNGS. Respiratory physiology & neurobiology, 237, pp. 57-67. Elsevier 10.1016/j.resp.2016.12.010

Merz, Tobias; Pereira, Adriano J; Schürch, Roger; Schefold, Joerg C.; Jakob, Stephan; Takala, Jukka; Djafarzadeh, Siamak (2017). Mitochondrial function of immune cells in septic shock: A prospective observational cohort study. PLoS ONE, 12(6), e0178946. Public Library of Science 10.1371/journal.pone.0178946

2016

Bloch, Andreas; Berger, David; Takala, Jukka (2016). Understanding circulatory failure in sepsis. Intensive care medicine, 42(12), pp. 2077-2079. Springer 10.1007/s00134-016-4514-1

Pettilä, Ville Yrjö Olavi; Jakob, Stephan; Takala, Jukka (2016). The new sepsis/septic shock-3 definition is just not enough - more detailed research is needed. Acta anaesthesiologica Scandinavica, 60(10), pp. 1344-1346. Wiley-Blackwell 10.1111/aas.12777

Carrel, Thierry; Englberger, Lars; Takala, Jukka (2016). What's new in surgical treatment of infective endocarditis? Intensive care medicine, 42(12), pp. 2052-2054. Springer 10.1007/s00134-016-4542-x

Cioccari, Luca; Luethi, Nora; Weber, Ulrike; Hilton, Andrew; Takala, Jukka; Bellomo, Rinaldo (2016). The native cardiac output in human sepsis: a systematic review. Critical care and resuscitation, 18(3), pp. 148-156. College of Intensive Care Medicine of Australia and New Zealand

Eggmann, Sabrina; Verra, Martin L; Luder, Gere; Takala, Jukka; Jakob, Stephan (2016). Effects of early, combined endurance and resistance training in mechanically ventilated, critically ill patients: a study protocol for a randomised controlled trial. Trials, 17, p. 403. BioMed Central 10.1186/s13063-016-1533-8

Djafarzadeh, Siamak; Vuda, Madhusudanarao; Jeger, Victor; Takala, Jukka; Jakob, Stephan (2016). The Effects of Fentanyl on Hepatic Mitochondrial Function. Anesthesia and analgesia, 123(2), pp. 311-325. International Anesthesia Research Society 10.1213/ANE.0000000000001280

Pettilä, Ville Yrjö Olavi; Hjortrup, Peter Buhl; Jakob, Stephan; Wilkman, Erika; Perner, Anders; Takala, Jukka (2016). Control groups in recent septic shock trials: a systematic review. Intensive care medicine, 42(12), pp. 1912-1921. Springer 10.1007/s00134-016-4444-y

Berger, David; Werner Möller, Per; Weber, Alberto; Bloch, Andreas; Bloechlinger, Stefan; Hänggi, Matthias; Sondergaard, Soren; Jakob, Stephan; Magder, Sheldon; Takala, Jukka (2016). Effect of PEEP, blood volume, and inspiratory hold maneuvers on venous return. American journal of physiology - heart and circulatory physiology, 311(3), H794-H806. American Physiological Society 10.1152/ajpheart.00931.2015

Löffel, Lukas; Burkhard, Fiona C.; Takala, Jukka; Wüthrich, Patrick Yves (2016). Impact of a Potassium-enriched, Chloride-depleted 5% Glucose Solution on Gastrointestinal Function after Major Abdominopelvic Surgery: Results of a Randomized Controlled Trial. Anesthesiology, 125(4), p. 1. Lippincott Williams & Wilkins 10.1097/ALN.0000000000001238

Bakker, Jan; Takala, Jukka (2016). Vasopressor therapy: not like antibiotics! Intensive care medicine, 42(7), pp. 1195-1196. Springer 10.1007/s00134-016-4335-2

Vincent, Jean-Louis; Takala, Jukka; Moreno, Rui P; Sakr, Yasser; Marshall, John C (2016). The Richmond Agitation-Sedation Scale Should Not Be Used to Evaluate Neurologic Function. Critical care medicine, 44(6), e450. Lippincott Williams & Wilkins 10.1097/CCM.0000000000001597

Vincent, Jean-Louis; Shehabi, Yahya; Walsh, Timothy S; Pandharipande, Pratik P; Ball, Jonathan A; Spronk, Peter; Longrois, Dan; Strøm, Thomas; Conti, Giorgio; Funk, Georg-Christian; Badenes, Rafael; Mantz, Jean; Spies, Claudia; Takala, Jukka (2016). Comfort and patient-centred care without excessive sedation: the eCASH concept. Intensive care medicine, 42(6), pp. 962-971. Springer 10.1007/s00134-016-4297-4

Takala, Jukka; Jakob, Stephan (2016). Oxygen transport in the critically ill. In: Webb, Andrew; Angus, Derek; Finfer, Simon; Gattinoni, Luciano; Singer, Mervyn (eds.) Oxford Textbook of Critical Care (pp. 636-639). Oxford University Press

Takala, Jukka (2016). Resource management and budgeting in critical care. In: Webb, Andrew; Angus, Derek; Finfer, Simon; Gattinoni, Luciano; Singer, Mervyn (eds.) Oxford Textbook of Critical Care (pp. 90-93). Oxford University Press 10.1093/med/9780199600830.003.0021

Zante, Björn; Dietler, Roland; Takala, Jukka (2016). Internal reporting system: we must look behind the curtain. Intensive care medicine, 42(6), p. 1100. Springer 10.1007/s00134-016-4289-4

Berger, David; Blöchlinger, Stefan; von Haehling, Stephan; Doehner, Wolfram; Takala, Jukka; Z'Graggen, Werner Josef; Schefold, Joerg C. (2016). Dysfunction of respiratory muscles in critically ill patients on the intensive care unit. Journal of cachexia, sarcopenia and muscle, 7(4), pp. 403-412. Wiley 10.1002/jcsm.12108

Takala, Jukka (2016). Volume responsive, but does the patient need volume? Intensive care medicine, 42(9), pp. 1461-1463. Springer 10.1007/s00134-015-4172-8

Bechtel-Grosch, Ursina; Béguelin, Charles Antoine; Berezowska, Sabina Anna; Dufour, Jean-François; Takala, Jukka; Schefold, Joerg C. (2016). Fulminant hepatic and multiple organ failure following acute viral tonsillitis: a case report. Journal of medical case reports, 10(7), p. 7. BioMed Central 10.1186/s13256-015-0777-3

Zürcher, Patrick; Springe, Dirk; Grandgirard, Denis; Leib, Stephen; Grossholz, Marius; Jakob, Stephan; Takala, Jukka; Hänggi, Matthias (2016). A randomized trial of the effects of the noble gases helium and argon on neuroprotection in a rodent cardiac arrest model. BMC neurology, 16, p. 43. BioMed Central 10.1186/s12883-016-0565-8

Berger, David; Takala, Jukka (2016). Hypotension and hypovolemia during hemodialysis: is the usual suspect innocent? Critical care, 20(1), p. 140. BioMed Central 10.1186/s13054-016-1307-4

Pettilä, Ville Yrjö Olavi; Merz, Tobias Michael; Wilkman, Erika; Perner, Anders; Karlsson, Sari; Lange, Theis; Hästbacka, Johanna; Hjortrup, Peter Buhl; Kuitunen, Anne; Jakob, Stephan; Takala, Jukka (2016). Targeted tissue perfusion versus macrocirculation-guided standard care in patients with septic shock (TARTARE-2S): study protocol and statistical analysis plan for a randomized controlled trial. Trials, 17(384), p. 384. BioMed Central 10.1186/s13063-016-1515-x

Berger, David; Werner Möller, Per; Takala, Jukka (2016). Reply to “Letter to the editor: Why persist in the fallacy that mean systemic pressure drives venous return?”. American journal of physiology - heart and circulatory physiology, 311(5), H1336-H1337. American Physiological Society 10.1152/ajpheart.00622.2016

2015

Cioccari, Luca; Gautschi, Matthias; Etter, Reto; Weck, Anja; Takala, Jukka (2015). Further Concerns About Glutamine: A Case Report on Hyperammonemic Encephalopathy. Critical care medicine, 43(10), e458-e460. Lippincott Williams & Wilkins 10.1097/CCM.0000000000001151

Wiest, Reiner; Niess, Jan Hendrik; Rothen, Hans Ulrich; Merz, Tobias Michael; Takala, Jukka; Malinka, Thomas; Seiler, Christian A. (October 2015). Non-CO2-insufflation and acute abdominal compartment during emergency endoscopy contributing to fatal outcome in advanced obstructive tumor of the gastro-esophageal junction with severe bleeding (Unpublished). In: SGG annual congress. Interlaken. 01.-02.10.2015.

Fung, Christian; Inglin, Fabienne; Murek, Michael Konrad; Balmer, Mathias; Abu-Isa, Janine; Z'Graggen, Werner Josef; Ozdoba, Christoph; Gralla, Jan; Jakob, Stephan; Takala, Jukka; Beck, Jürgen; Raabe, Andreas (2015). Reconsidering the logic of World Federation of Neurosurgical Societies grading in patients with severe subarachnoid hemorrhage. Journal of neurosurgery, 124(2), pp. 299-304. American Association of Neurological Surgeons 10.3171/2015.2.JNS14614

Merz, Tobias Michael; Pichler Hefti, Jacqueline Renée; Hefti, Urs; Huber, Andreas; Jakob, Stephan; Takala, Jukka; Djafarzadeh, Siamak (2015). Changes in mitochondrial enzymatic activities of monocytes during prolonged hypobaric hypoxia and influence of antioxidants: A randomized controlled study. Redox report, 20(5), pp. 234-240. Maney Publishing 10.1179/1351000215Y.0000000007

Bloechlinger, Stefan; Berger, David; Bryner, Jürg; Roost, Eva; Jakob, Stephan; Dünser, Martin W; Takala, Jukka (2015). Changes in Left Ventricular Torsion Early Postoperatively After Aortic Valve Replacement and at Long-Term Follow-up. Journal of cardiothoracic and vascular anesthesia, 29(4), pp. 860-867. Elsevier 10.1053/j.jvca.2015.01.010

Coslovsky, Michael; Takala, Jukka; Exadaktylos, Aristomenis; Martinolli, Luca; Merz, Tobias M (2015). A clinical prediction model to identify patients at high risk of death in the emergency department. Intensive care medicine, 41(6), pp. 1029-1036. Springer 10.1007/s00134-015-3737-x

Bendel, Stepani; Springe, Dirk; Pereira, Adriano José; Grandgirard, Denis; Leib, Stephen; Putzu, Alessandro; Schlickeiser, Jannis; Jakob, Stephan M.; Takala, Jukka; Hänggi, Matthias (2015). Do different anesthesia regimes affect hippocampal apoptosis and neurologic deficits in a rodent cardiac arrest model? BMC anesthesiology, 15(2), p. 2. BioMed Central 10.1186/1471-2253-15-2

Zante, Björn; Reineke, David; Venetz, Philipp; Englberger, Lars; Von Tengg-Kobligk, Hendrik; Takala, Jukka; Carrel, Thierry (2015). Biatrial enlargement: 6,000 ml intracardiac blood volume. Intensive care medicine, 41(1), pp. 136-138. Springer 10.1007/s00134-014-3443-0

Ackermann, Karin; Brander, Lukas; Tuchscherer, Daniel; Schröder, Ralph; Jakob, Stephan; Takala, Jukka; Z'Graggen, Werner Josef (2015). Esophageal versus surface recording of diaphragm compound muscle action potential. Muscle & nerve, 51(4), pp. 598-600. John Wiley & Sons 10.1002/mus.24577

Corrêa, Thiago Domingos; Takala, Jukka; Jakob, Stephan (2015). Is lactate clearance impaired in septic shock? Critical care, 19(306), p. 306. BioMed Central 10.1186/s13054-015-1039-x

Corrêa, Thiago Domingos; Jakob, Stephan; Takala, Jukka (2015). Arterial blood pressure targets in septic shock: is it time to move to an individualized approach? Critical care, 19(264), p. 264. BioMed Central 10.1186/s13054-015-0958-x

Turunen, Heidi; Jakob, Stephan; Ruokonen, Esko; Kaukonen, Kirsi-Maija; Sarapohja, Toni; Apajasalo, Marjo; Takala, Jukka (2015). Dexmedetomidine versus standard care sedation with propofol or midazolam in intensive care: an economic evaluation. Critical care, 19(67), p. 67. BioMed Central 10.1186/s13054-015-0787-y

Corrêa, Thiago D; Takala, Jukka; Jakob, Stephan (2015). Angiotensin II in septic shock. Critical care, 19(98), p. 98. BioMed Central 10.1186/s13054-015-0802-3

Jeger, Victor; Brandt, Sebastian; Porta, Francesca; Jakob, Stephan; Takala, Jukka; Djafarzadeh, Siamak (2015). Dose response of endotoxin on hepatocyte and muscle mitochondrial respiration in vitro. BioMed research international, 2015, p. 353074. Hindawi Publishing Corporation 10.1155/2015/353074

2014

Marbacher, Serge; Neuschmelting, Volker; Andereggen, Lukas; Widmer, Hans Rudolf; von Gunten, Michael; Takala, Jukka; Jakob, Stephan; Fandino, Javier (2014). Early brain injury linearly correlates with reduction in cerebral perfusion pressure during the hyperacute phase of subarachnoid hemorrhage. Intensive care medicine experimental, 2(1), p. 30. Springer 10.1186/s40635-014-0030-1

Andereggen, Lukas; Neuschmelting, Volker; von Gunten, Michael; Widmer, Hans Rudolf; Takala, Jukka; Jakob, Stephan; Fandino, Javier; Marbacher, Serge (2014). The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects. Journal of visualized experiments(92), e52132. MYJoVE Corporation 10.3791/52132

Hänggi, Matthias; Jakob, Stephan; Takala, Jukka (2014). Sedation level and prevalence of delirium: response to Brummel and Ely. Intensive care medicine, 40(1), p. 136. Springer 10.1007/s00134-013-3092-8

Berger, David; Blöchlinger, Stefan; Takala, Jukka; Sinderby, Christer; Brander, Lukas (2014). Heart-lung interactions during neurally adjusted ventilatory assist. Critical care, 18(5), p. 499. BioMed Central 10.1186/s13054-014-0499-8

Pereira, A. J.; Jeger, V.; Fahrner, R.; Djafarzadeh, Siamak; Lensch, Michael; Takala, Jukka; Jakob, Stephan (2014). Interference of angiotensin II and enalapril with hepatic blood flow regulation. American journal of physiology - gastrointestinal and liver physiology, 307(6), G655-G663. American Physiological Society 10.1152/ajpgi.00150.2014

Corrêa, Thiago D.; Jeger, Victor; Pereira, Adriano José; Takala, Jukka; Djafarzadeh, Siamak; Jakob, Stephan (2014). Angiotensin II in Septic Shock: effects on tissue perfusion, organ function, and mitochondrial respiration in a porcine model of fecal peritonitis. Critical care medicine, 42(8), e550-e559. Lippincott Williams & Wilkins 10.1097/CCM.0000000000000397

Lima, Alexandre; Takala, Jukka (2014). Clinical significance of monitoring perfusion in non-vital organs. Intensive care medicine, 40(7), pp. 1052-1054. Springer 10.1007/s00134-014-3345-1

Takala, Jukka (2014). Reply: Is the Glass of Delirium Half Full or Half Empty? American journal of respiratory and critical care medicine, 189(11), p. 1444. American Lung Association 10.1164/rccm.201404-0642LE

Ackermann, Karin; Bostock, Hugh; Brander, Lukas; Schröder, Ralph; Djafarzadeh, Siamak; Tuchscherer, Daniel; Jakob, Stephan; Takala, Jukka; Z'Graggen, Werner Josef (2014). Early changes of muscle membrane properties in porcine faecal peritonitis. Critical care, 18(4), p. 484. BioMed Central 10.1186/s13054-014-0484-2

Takala, Jukka (2014). Of Delirium and Sedation. American journal of respiratory and critical care medicine, 189(6), pp. 622-624. American Lung Association 10.1164/rccm.201401-0195ED

Jakob, Stephan; Ruokonen, E.; Takala, Jukka (2014). Efficacy of dexmedetomidine compared with midazolam for sedation in adult intensive care patients. British journal of anaesthesia, 112(3), pp. 581-582. Oxford University Press 10.1093/bja/aeu032

Etter, Reto; Takala, Jukka; Merz, Tobias Michael (2014). Intensive care without walls - introduction of a Medical Emergency Team system in a Swiss tertiary care centre. Swiss medical weekly, 144(w14027), w14027. EMH Schweizerischer Ärzteverlag 10.4414/smw.2014.14027

2013

Takala, Jukka (2013). Night-time intensivists - waste of resources or failure of process optimization? Critical care, 17(6), p. 472. BioMed Central 10.1186/cc13170

Bloechlinger, Stefan; Berger, David; Bryner, Jürg; Wiegand, Jan; Dünser, Martin W.; Takala, Jukka (2013). Left ventricular torsion abnormalities in septic shock and corrective effect of volume loading: a pilot study. Canadian journal of cardiology, 29(12), pp. 1665-1671. Canadian Cardiology Publications 10.1016/j.cjca.2013.10.007

Dünser, Martin W.; Takala, Jukka; Brunauer, Andreas; Bakker, Jan (2013). Re-thinking resuscitation: leaving blood pressure cosmetics behind and moving forward to permissive hypotension and a tissue perfusion-based approach. Critical care, 17(5), p. 326. BioMed Central 10.1186/cc12727

Gorrasi, José; Eleftheriadis, Anestis; Takala, Jukka; Brandt, Sebastian; Djafarzadeh, Siamak; Brügger, Lukas; Bracht, Hendrik; Jakob, Stephan (2013). Different Contribution of Splanchnic Organs to Hyperlactatemia in Fecal Peritonitis and Cardiac Tamponade. BioMed research international, 2013, pp. 1-8. Hindawi Publishing Corporation 10.1155/2013/251084

Astin, Ronan; Bentham, Robert; Djafarzadeh, Siamak; Horscroft, James A.; Kuc, Rhoda E.; Leung, Po Sing; Skipworth, James R. A.; Vicencio, Jose M.; Davenport, Anthony P.; Murray, Andrew J.; Takala, Jukka; Jakob, Stephan; Montgomery, Hugh; Szabadkai, Gyorgy (2013). No evidence for a local renin-angiotensin system in liver mitochondria. Scientific Reports, 3(1), p. 2467. Nature Publishing Group 10.1038/srep02467

Takala, Jukka; Hartog, Christiane; Reinhart, Konrad (2013). Safety of modern starches used during surgery: misleading conclusions. Anesthesia and analgesia, 117(2), pp. 527-528. Lippincott Williams & Wilkins 10.1213/ANE.0b013e318296913f

Shehabi, Yahya; Bellomo, Rinaldo; Mehta, Sangeeta; Riker, Richard; Takala, Jukka (2013). Intensive care sedation: the past, present and the future. Critical care, 17(3), p. 322. BioMed Central 10.1186/cc12679

Corrêa, Thiago Domingos; Takala, Jukka; Jakob, Stephan (2013). Target blood pressure in sepsis: between a rock and a hard place. Critical care, 17(3), p. 433. BioMed Central 10.1186/cc12692

Jeger, Victor; Djafarzadeh, Siamak; Jakob, Stephan; Takala, Jukka (2013). Mitochondrial function in sepsis. European journal of clinical investigation, 43(5), pp. 532-542. Wiley-Blackwell 10.1111/eci.12069

Cioccari, Luca; Baur, Hans-Rudolf; Berger, David; Wiegand, Jan; Takala, Jukka; Merz, Tobias Michael (2013). Hemodynamic assessment of critically ill patients using a miniaturized transesophageal echocardiography probe. Critical care, 17(3), R121. BioMed Central 10.1186/cc12793

Corrêa, Thiago Domingos; Vuda, Madhusudanarao; Takala, Jukka; Djafarzadeh, Siamak; Silva, Eliézer; Jakob, Stephan (2013). Increasing mean arterial blood pressure in sepsis: effects on fluid balance, vasopressor load and renal function. Critical care, 17(1), R21. BioMed Central 10.1186/cc12495

Lehmann, Laura; Bendel, Stepani; Uehlinger, Dominik E; Takala, Jukka; Schafer, Margaret; Reinert, Michael; Jakob, Stephan M (2013). Randomized, Double-Blind Trial of the Effect of Fluid Composition on Electrolyte, Acid-Base, and Fluid Homeostasis in Patients Early After Subarachnoid Hemorrhage. Neurocritical care, 18(1), pp. 5-12. New York, N.Y.: Humana Press Inc 10.1007/s12028-012-9764-3

Torgersen, Christian-Erik; Meichtry, Jurka; Schmittinger, Christian A; Blöchlinger, Stefan; Jakob, Stephan M; Takala, Jukka; Dünser, Martin Wolfgang (2013). Haemodynamic variables and functional outcome in hypothermic patients following out-of-hospital cardiac arrest. Resuscitation, 84(6), pp. 798-804. Shannon: Elsevier Science Ireland 10.1016/j.resuscitation.2012.10.012

Hänggi, Matthias; Blum, Sina; Brechbuehl, Ruth; Brunello, Anna; Jakob, Stephan; Takala, Jukka (2013). Effect of sedation level on the prevalence of delirium when assessed with CAM-ICU and ICDSC. Intensive care medicine, 39(12), pp. 2171-2179. Springer Berlin Heidelberg 10.1007/s00134-013-3034-5

2012

Vuda, Madhusudanarao; Brander, Lukas; Schröeder, Ralph; Jakob, Stephan M; Takala, Jukka; Djafarzadeh, Siamak (2012). Effects of catecholamines on hepatic and skeletal muscle mitochondrial respiration after prolonged exposure to faecal peritonitis in pigs. Innate immunity, 18(2), pp. 217-30. Los Angeles, Calif.: Sage Publications 10.1177/1753425911398279

Haenggi, Matthias; Andermatt, Anna; Anthamatten, Claudia; Galimanis, Aikaterini; Mono, Marie-Louise; Alfieri, Alexander; Fung, Christian; Takala, Jukka (2012). Co2-dependent vasomotor reactivity of cerebral arteries in patients with severe traumatic brain injury: time course and effect of augmentation of cardiac output with dobutamine. Journal of neurotrauma, 29(9), pp. 1779-84. New York, N.Y.: M.A. Liebert 10.1089/neu.2011.1809

Jakob, Stephan M; Bracht, Hendrik; Porta, Francesca; Balsiger, Bruno M; Brander, Lukas; Knuesel, Rafael; Feng, Hong-Qiang; Kolarova, Anna; Ma, Yingmin; Takala, Jukka (2012). Effects of cardiac preload reduction and dobutamine on hepatosplanchnic blood flow regulation in porcine endotoxemia. American journal of physiology - gastrointestinal and liver physiology, 303(2), G247-55. Bethesda, Md.: American Physiological Society 10.1152/ajpgi.00433.2011

Jakob, Stephan M; Ruokonen, Esko; Grounds, R Michael; Sarapohja, Toni; Garratt, Chris; Pocock, Stuart J; Bratty, J Raymond; Takala, Jukka; Dexmedetomidine for Long-Term Sedation, Investigators (2012). Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA - the journal of the American Medical Association, 307(11), pp. 1151-60. Chicago, Ill.: American Medical Association 10.1001/jama.2012.304

Brügger, Lukas E; Beldi, Guido; Stalder, Michael; Porta, Francesca; Candinas, Daniel; Takala, Jukka; Jakob, Stephan M (2012). Postoperative splanchnic blood flow redistribution in response to fluid challenges in the presence and absence of endotoxemia in a porcine model. Shock, 37(1), pp. 116-21. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/SHK.0b013e31823917eb

Takala, Jukka (2012). Hemodynamic support: focus on monitoring tools or treatments? Critical care medicine, 40(4), pp. 1359-60. Baltimore, Md.: Lippincott Williams & Wilkins 10.1097/CCM.0b013e318241031b

Vincent, Jean-Louis; Takala, Jukka; Flaatten, Hans (2012). Impact of reimbursement schemes on quality of care: a European perspective. American journal of respiratory and critical care medicine, 185(2), pp. 119-21. New York, N.Y.: American Lung Association 10.1164/rccm.201108-1472ED

Corrêa, Thiago D; Vuda, Madhusudanarao; Blaser, Annika Reintam; Takala, Jukka; Djafarzadeh, Siamak; Dünser, Martin W; Silva, Eliézer; Lensch, Michael; Wilkens, Ludwig; Jakob, Stephan M (2012). Effect of treatment delay on disease severity and need for resuscitation in porcine fecal peritonitis. Critical care medicine, 40(10), pp. 2841-9. Baltimore, Md.: Lippincott Williams & Wilkins 10.1097/CCM.0b013e31825b916b

Marbacher, Serge; Andereggen, Lukas; Neuschmelting, Volker; Widmer, Hans Rudolf; von Gunten, Michael; Takala, Jukka; Jakob, Stephan M; Fandino, Javier (2012). A new rabbit model for the study of early brain injury after subarachnoid hemorrhage. Journal of neuroscience methods, 208(2), pp. 138-45. Amsterdam: Elsevier 10.1016/j.jneumeth.2012.05.010

Regueira, T; Djafarzadeh, S; Brandt, S; Gorrasi, J; Borotto, E; Porta, F; Takala, J; Bracht, H; Shaw, S; Lepper, P M; Jakob, S M (2012). Oxygen transport and mitochondrial function in porcine septic shock, cardiogenic shock, and hypoxaemia. Acta anaesthesiologica Scandinavica, 56(7), pp. 846-59. Oxford: Wiley-Blackwell 10.1111/j.1399-6576.2012.02706.x

Ganter, C C; Hochuli, R; Bossard, M; Etter, Reto; Takala, J; Uehlinger, D E; Jakob, S M (2012). Forced fluid removal in critically ill patients with acute kidney injury. Acta anaesthesiologica Scandinavica, 56(9), pp. 1183-90. Oxford: Wiley-Blackwell 10.1111/j.1399-6576.2012.02734.x

Carrel, T; Englberger, L; Martinelli, M V; Takala, J; Boesch, C; Sigurdadottir, V; Gygax, E; Kadner, A; Mohacsi, P (2012). Continuous flow left ventricular assist devices: a valid option for heart failure patients. Swiss medical weekly, 142, w13701. Muttenz: EMH Schweizerischer Ärzteverlag 10.4414/smw.2012.13701

Djafarzadeh, Siamak; Vuda, Madhusudanarao; Takala, Jukka; Jakob, Stephan M (2012). Effect of remifentanil on mitochondrial oxygen consumption of cultured human hepatocytes. PLoS ONE, 7(9), e45195. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0045195

2011

Z'graggen, W J; Brander, L; Tuchscherer, D; Scheidegger, O; Takala, J; Bostock, H (2011). Muscle membrane dysfunction in critical illness myopathy assessed by velocity recovery cycles. Clinical neurophysiology, 122(4), pp. 834-41. Amsterdam: Elsevier 10.1016/j.clinph.2010.09.024

Djafarzadeh, Siamak; Vuda, Madhusudanarao; Takala, Jukka; Ochs, Matthias; Jakob, Stephan M (2011). Toll-like receptor-3-induced mitochondrial dysfunction in cultured human hepatocytes. Mitochondrion, 11(1), pp. 83-8. Amsterdam: Elsevier 10.1016/j.mito.2010.07.010

Haenggi, Matthias; Barthelmes, Daniel; Ulmer, Hanno; Takala, Jukka; Jakob, Stephan M (2011). Comparison of non-calibrated pulse-contour analysis with continuous thermodilution for cardiac output assessment in patients with induced hypothermia after cardiac arrest. Resuscitation, 82(4), pp. 423-6. Shannon: Elsevier Science Ireland 10.1016/j.resuscitation.2010.12.015

Marbacher, Serge; Sherif, Camillo; Neuschmelting, Volker; Schläppi, Janine-Ai; Takala, Jukka; Jakob, Stephan; Fandino, Javier (2011). Preliminary results of an ICP-controlled subarachnoid hemorrhage rabbit model for the study of delayed cerebral vasospasm. Acta neurochirurgica - supplementa, 110(Pt 1), pp. 163-5. Wien: Springer 10.1007/978-3-7091-0353-1_28

Torgersen, Christian; Dünser, Martin W; Schmittinger, Christian A; Pettilä, Ville; Ruokonen, Esko; Wenzel, Volker; Jakob, Stephan M; Takala, Jukka (2011). Current approach to the haemodynamic management of septic shock patients in European intensive care units: a cross-sectional, self-reported questionnaire-based survey. European journal of anaesthesiology, 28(4), pp. 284-90. Philadelphia, Pa.: Lippincott Williams & Wilkins 10.1097/EJA.0b013e3283405062

Merz, Tobias M; Etter, Reto; Mende, Ludger; Barthelmes, Daniel; Wiegand, Jan; Martinolli, Luca; Takala, Jukka (2011). Risk assessment in the first fifteen minutes: a prospective cohort study of a simple physiological scoring system in the emergency department. Critical care, 15(1), R25. London: BioMed Central 10.1186/cc9972

Reinhart, Konrad; Takala, Jukka (2011). Hydroxyethyl starches: what do we still know? Anesthesia and analgesia, 112(3), pp. 507-11. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1213/ANE.0b013e3182099c49

Wiegand, Jan A; Torgersen, Christian; Bloechlinger, Stefan; Takala, Jukka; Dünser, Martin W (2011). Influenza A(H1N1) infection and severe cardiac dysfunction in adults: A case series. Wiener klinische Wochenschrift, 123(3-4), pp. 120-3. Wien: Springer-Verlag 10.1007/s00508-010-1520-0

Ververidis, D; Van Gils, M; Passath, C; Takala, J; Brander, L (2011). Identification of adequate neurally adjusted ventilatory assist (NAVA) during systematic increases in the NAVA level. IEEE transactions on biomedical engineering, 58(9), pp. 2598-606. New York, N.Y.: Institute of Electrical and Electronics Engineers IEEE 10.1109/TBME.2011.2159790

Takala, Jukka; Ruokonen, Esko; Tenhunen, Jyrki J; Parviainen, Ilkka; Jakob, Stephan M (2011). Early non-invasive cardiac output monitoring in hemodynamically unstable intensive care patients: A multi-center randomized controlled trial. Critical care, 15(3), R148. London: BioMed Central 10.1186/cc10273

Takala, Jukka (2011). Surgery: risky business? Anesthesia and analgesia, 112(4), pp. 745-6. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1213/ANE.0b013e3181fe495f

Tuchscherer, Daniel; Z'graggen, Werner J; Passath, Christina; Takala, Jukka; Sinderby, Christer; Brander, Lukas (2011). Neurally adjusted ventilatory assist in patients with critical illness-associated polyneuromyopathy. Intensive care medicine, 37(12), pp. 1951-61. Berlin: Springer-Verlag 10.1007/s00134-011-2376-0

Hofmann, Eveline; Marbach, Serge; Jakob, Stephan M; Takala, Jukka; Remonda, Luca; Fandino, Javier (2011). Incidence of vasospasm, outcome, and quality of life after endovascular and surgical treatment of ruptured intracranial aneurysms: results of a single-center prospective study in Switzerland. ISRN vascular medicine, 2011 New York, N.Y.: International Scholarly Research Network ISRN

2010

Brunello, Anna-Giulia; Haenggi, Matthias; Wigger, Oliver; Porta, Francesca; Takala, Jukka; Jakob, Stephan M (2010). Usefulness of a clinical diagnosis of ICU-acquired paresis to predict outcome in patients with SIRS and acute respiratory failure. Intensive care medicine, 36(1), pp. 66-74. Berlin: Springer-Verlag 10.1007/s00134-009-1645-7

Spirig, Rolf; Djafarzadeh, Siamak; Regueira, Tomas; Shaw, Sidney G; von Garnier, Christophe; Takala, Jukka; Jakob, Stephan M; Rieben, Robert; Lepper, Philipp M (2010). Effects of TLR agonists on the hypoxia-regulated transcription factor HIF-1alpha and dendritic cell maturation under normoxic conditions. PLoS ONE, 5(6), e0010983. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0010983

Daudel, Fritz; Gorrasi, José; Bracht, Hendrik; Brandt, Sebastian; Krejci, Vladimir; Jakob, Stephan M; Takala, Jukka; Rothen, Hans Ulrich (2010). Effects of lung recruitment maneuvers on splanchnic organ perfusion during endotoxin-induced pulmonary arterial hypertension. Shock, 34(5), pp. 488-94. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/SHK.0b013e3181e03bfb

Brügger, Lukas E; Beldi, Guido; Beck, Mario; Porta, Francesca; Bracht, Hendrik; Candinas, Daniel; Takala, Jukka; Jakob, Stephan M (2010). Splanchnic vasoregulation after major abdominal surgery in pigs. World journal of surgery, 34(9), pp. 2057-63. New York, N.Y.: Springer

Barthelmes, D; Jakob, S M; Laitinen, S; Rahikainen, S; Ahonen, H; Takala, J (2010). Effect of site of lactate infusion on regional lactate exchange in pigs. British journal of anaesthesia, 105(5), pp. 627-34. Oxford: Oxford University Press 10.1093/bja/aeq214

Wyler von Ballmoos, Moritz; Takala, Jukka; Roeck, Margareta; Porta, Francesca; Tueller, David; Ganter, Christoph C; Schröder, Ralph; Bracht, Hendrik; Baenziger, Bertram; Jakob, Stephan M (2010). Pulse-pressure variation and hemodynamic response in patients with elevated pulmonary artery pressure: a clinical study. Critical care, 14(3), R111. London: BioMed Central 10.1186/cc9060

Passath, Christina; Takala, Jukka; Tuchscherer, Daniel; Jakob, Stephan M; Sinderby, Christer; Brander, Lukas (2010). Physiologic response to changing positive end-expiratory pressure during neurally adjusted ventilatory assist in sedated, critically ill adults. Chest, 138(3), pp. 578-87. Northbrook, Ill.: American College of Chest Physicians 10.1378/chest.10-0286

Dahlqvist, Mats B; Andres, Robert H; Raabe, Andreas; Jakob, Stephan M; Takala, Jukka; Dünser, Martin W (2010). Brain herniation in a patient with apparently normal intracranial pressure: a case report. Journal of medical case reports, 4, p. 297. London: BioMed Central

Daudel, Fritz; Tüller, David; Krähenbühl, Stefanie; Jakob, Stephan M; Takala, Jukka (2010). Pulse pressure variation and volume responsiveness during acutely increased pulmonary artery pressure: an experimental study. Critical care, 14(3), R122. London: BioMed Central 10.1186/cc9080

Torgersen, C; Schmittinger, C A; Takala, J; Jakob, S M; Dünser, M W (2010). The association between early hemodynamic variables and outcome in normothermic comatose patients following cardiac arrest. Acta anaesthesiologica Scandinavica, 54(8), pp. 1027-35. Oxford: Wiley-Blackwell 10.1111/j.1399-6576.2010.02273.x

Marbacher, Serge; Sherif, Camillo; Neuschmelting, Volker; Schläppi, Janine-Ai; Takala, Jukka; Jakob, Stephan M; Fandino, Javier (2010). Extra-intracranial blood shunt mimicking aneurysm rupture: intracranial-pressure-controlled rabbit subarachnoid hemorrhage model. Journal of neuroscience methods, 191(2), pp. 227-33. Amsterdam: Elsevier 10.1016/j.jneumeth.2010.07.004

Jakob, Stephan M; Knuesel, Rafael; Tenhunen, Jyrki J; Pradl, Richard; Takala, Jukka (2010). Increasing abdominal pressure with and without PEEP: effects on intra-peritoneal, intra-organ and intra-vascular pressures. BMC gastroenterology, 10, p. 70. London: BioMed Central 10.1186/1471-230X-10-70

Takala, Jukka (2010). Should we target blood pressure in sepsis? Critical care medicine, 38(10 Suppl), S613-9. Baltimore, Md.: Lippincott Williams & Wilkins 10.1097/CCM.0b013e3181f2430c

2009

Ruokonen, Esko; Parviainen, Ilkka; Jakob, Stephan M; Nunes, Silvia; Kaukonen, Maija; Shepherd, Stephen T; Sarapohja, Toni; Bratty, J Raymond; Takala, Jukka (2009). Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation. Intensive care medicine, 35(2), pp. 282-90. Berlin: Springer-Verlag 10.1007/s00134-008-1296-0

Ganter, Christoph; Buser, Christof; Haenggi, Matthias; Mattes, Hanswilly; Takala, Jukka; Jakob, Stephan (2009). Inverse thermodilution with conventional pulmonary artery catheters for the assessment of cerebral, hepatic, renal, and femoral blood flow. Shock, 32(2), pp. 194-200. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/SHK.0b013e318194c73a

Neuschmelting, Volker; Fathi, Ali-Reza; Hidalgo Staub, Eveline Teresa; Marbacher, Serge; Schroth, Gerhard; Takala, Jukka; Jakob, Stephan M; Fandino, Javier (2009). Norepinephrine-induced hypertension dilates vasospastic basilar artery after subarachnoid haemorrhage in rabbits. Acta neurochirurgica, 151(5), pp. 487-93. Wien: Springer Vienna 10.1007/s00701-009-0287-4

Brandt, S; Regueira, T; Bracht, H; Porta, F; Takala, J; Hiltebrand, LB; Beldi, G; Lepper, MP; Brügger, LE; Kessler, U; Jakob St, M (2009). Effect of fluid resuscitation on mortality and organ function in experimental sepsis models. Critical care, 13(6), R186. London: BioMed Central 10.1186/cc8179

von Gunten, Stephan; Jakob, Stephan M; Geering, Barbara; Takala, Jukka; Simon, Hans-Uwe (2009). Different patterns of Siglec-9-mediated neutrophil death responses in septic shock. Shock, 32(4), pp. 386-92. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/SHK.0b013e3181a1bc98

Stricker, Kay H; Takala, Jukka; Hullin, Roger; Ganter, Christoph C (2009). When drugs disappear from the patient: elimination of intravenous medication by hemodiafiltration. Anesthesia and analgesia, 109(5), pp. 1640-3. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1213/ANE.0b013e3181b9db63

Haenggi, Matthias; Ypparila-Wolters, Heidi; Buerki, Sarah; Schlauri, Rebekka; Korhonen, Ilkka; Takala, Jukka; Jakob, Stephan M (2009). Auditory event-related potentials, bispectral index, and entropy for the discrimination of different levels of sedation in intensive care unit patients. Anesthesia and analgesia, 109(3), pp. 807-16. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1213/ane.0b013e3181acc85d

Barthelmes, Daniel; Parviainen, Ilkka; Vainio, Pauli; Vanninen, Ritva; Takala, Jukka; Ikonen, Aki; Tueller, David; Jakob, Stephan M (2009). Assessment of splanchnic blood flow using magnetic resonance imaging. European journal of gastroenterology & hepatology, 21(6), pp. 693-700. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/MEG.0b013e32831a86e0

Brander, Lukas; Haltmeier, Tobias; Suter, Anna; Studer, Peter; Inderbitzin, Daniel; Candinas, Daniel; Vogt, Andreas; Henzen, Christoph; Takala, Jukka; Jakob, Stephan M (2009). Peri-operative adrenocortical response to low-dose (1 microg) ACTH and relation to postoperative complications in patients undergoing elective abdominal surgery. Surgery, 146(1), pp. 88-99. New York, N.Y.: Elsevier 10.1016/j.surg.2009.01.018

Regueira, Tomas; Lepper, Philipp M; Brandt, Sebastian; Ochs, Matthias; Vuda, Madhusudanarao; Takala, Jukka; Jakob, Stephan M; Djafarzadeh, Siamak (2009). Hypoxia inducible factor-1 alpha induction by tumour necrosis factor-alpha, but not by toll-like receptor agonists, modulates cellular respiration in cultured human hepatocytes. Liver international, 29(10), pp. 1582-92. Oxford: Blackwell Munksgaard 10.1111/j.1478-3231.2009.02109.x

Daudel, Fritz; Kessler, Ulf; Folly, Hélène; Lienert, Jasmin S; Takala, Jukka; Jakob, Stephan M (2009). Thromboelastometry for the assessment of coagulation abnormalities in early and established adult sepsis: a prospective cohort study. Critical care, 13(2), R42. London: BioMed Central 10.1186/cc7765

Dünser, Martin W; Takala, Jukka; Ulmer, Hanno; Mayr, Viktoria D; Luckner, Günter; Jochberger, Stefan; Daudel, Fritz; Lepper, Philipp; Hasibeder, Walter R; Jakob, Stephan M (2009). Arterial blood pressure during early sepsis and outcome. Intensive care medicine, 35(7), pp. 1225-33. Berlin: Springer-Verlag 10.1007/s00134-009-1427-2

Dünser, Martin W; Ruokonen, Esko; Pettilä, Ville; Ulmer, Hanno; Torgersen, Christian; Schmittinger, Christian A; Jakob, Stephan; Takala, Jukka (2009). Association of arterial blood pressure and vasopressor load with septic shock mortality: a post hoc analysis of a multicenter trial. Critical care, 13(6), R181. London: BioMed Central 10.1186/cc8167

Haenggi, Matthias; Ypparila-Wolters, Heidi; Hauser, Kathrin; Caviezel, Claudio; Takala, Jukka; Korhonen, Ilkka; Jakob, Stephan M (2009). Intra- and inter-individual variation of BIS-index and Entropy during controlled sedation with midazolam/remifentanil and dexmedetomidine/remifentanil in healthy volunteers: an interventional study. Critical care, 13(1), R20. London: BioMed Central 10.1186/cc7723

Torgersen, Christian; Schmittinger, Christian A; Wagner, Sarah; Ulmer, Hanno; Takala, Jukka; Jakob, Stephan M; Dünser, Martin W (2009). Hemodynamic variables and mortality in cardiogenic shock: a retrospective cohort study. Critical care, 13(5), R157. London: BioMed Central 10.1186/cc8114

Jakob, Stephan M; Takala, Jukka (2009). Physical and occupational therapy during sedation stops. Lancet, 373(9678), pp. 1824-6. London: Elsevier 10.1016/S0140-6736(09)60866-7

Takala, Jukka; Jakob, Stephan M (2009). Shedding light on microcirculation? Intensive care medicine, 35(3), pp. 394-6. Berlin: Springer-Verlag 10.1007/s00134-008-1386-z

Jakob, Stephan M; Parviainen, Ilkka; Ruokonen, Esko; Hinder, Raffael; Uusaro, Ari; Takala, Jukka (2009). Increased splanchnic oxygen extraction because of routine nursing procedures. Critical care medicine, 37(2), pp. 483-9. Baltimore, Md.: Lippincott Williams & Wilkins 10.1097/CCM.0b013e3181958821

Porta, Francesca; Bracht, Hendrik; Weikert, Christian; Beck, Mario; Takala, Jukka; Brandt, Sebastian; Hiltebrand, Luzius B; Jakob, Stephan M (2009). Effects of endotoxin and catecholamines on hepatic mitochondrial respiration. Inflammation, 32(5), pp. 315-21. New York, N.Y.: Springer US; http://www.springer-ny.com 10.1007/s10753-009-9138-y

Takala, Jukka (2009). Better conduct of clinical trials: the control group in critical care trials. Critical care medicine, 37(1 Suppl), S80-90. Baltimore, Md.: Lippincott Williams & Wilkins 10.1097/CCM.0b013e3181922bf4

2008

Nyberg, A; Jakob, S M; Seeman-Lodding, H; Porta, F; Bracht, H; Bischofberger, H; Jern, C; Takala, J; Aneman, A (2008). Time- and dose-related regional fluxes of tissue-type plasminogen activator in anesthetized endotoxemic pigs. Acta anaesthesiologica Scandinavica, 52(1), pp. 57-64. Oxford: Wiley-Blackwell 10.1111/j.1399-6576.2007.01481.x

Etter, Reto; Ludwig, Roger; Lersch, Friedrich; Takala, Jukka; Merz, Tobias M (2008). Early prognostic value of the medical emergency team calling criteria in patients admitted to intensive care from the emergency department. Critical care medicine, 36(3), pp. 775-81. Baltimore, Md.: Lippincott Williams & Wilkins 10.1097/CCM.0B013E3181643C15

Bracht, Hendrik; Krejci, Vladimir; Hiltebrand, Luzius; Brandt, Sebastian; Sigurdsson, Gisli; Ali, Syed Z; Takala, Jukka; Jakob, Stephan M (2008). Orthogonal polarization spectroscopy to detect mesenteric hypoperfusion. Intensive care medicine, 34(10), pp. 1883-90. Berlin: Springer-Verlag 10.1007/s00134-008-1130-8

Taniguchi, Yoshie; Bracht, Hendrik; Porta, Francesca; Krejci, Vladimir; Ali, Sayed Z; Beck, Mario; Mettler, Daniel; Takala, Jukka; Jakob, Stephan M (2008). Thermodilution and esophageal Doppler ultrasound in the assessment of blood flow changes induced by endotoxin and dobutamine. Journal of trauma - injury, infection, and critical care, 65(1), pp. 175-82. Baltimore, Md.: Lippincott, Williams, & Wilkins 10.1097/TA.0b013e31815eb0ff

Ali, Syed Z; Bracht, Hendrik; Krejci, Vladimir; Beck, Mario; Stalder, Michael; Hiltebrand, Luzius; Takala, Jukka; Brandt, Sebastian; Jakob, Stephan M (2008). The immediate and sustained effects of volume challenge on regional blood flows in pigs. Anesthesia and analgesia, 106(2), 595-600, table of contents. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1213/ane.0b013e31816064d2

Regueira, Tomas; Bänziger, Bertram; Djafarzadeh, Siamak; Brandt, Sebastian; Gorrasi, Jose; Takala, Jukka; Lepper, Philipp M; Jakob, Stephan M (2008). Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration. Critical care, 12(4), R88. London: BioMed Central 10.1186/cc6956

Taussky, Philipp; Widmer, Hans Rudolf; Takala, Jukka; Fandino, Javier (2008). Outcome after acute traumatic subdural and epidural haematoma in Switzerland: a single-centre experience. Swiss medical weekly, 138(19-20), pp. 281-5. Muttenz: EMH Schweizerischer Ärzteverlag

Hänggi, Matthias; Ypparila-Wolters, Heidi; Bieri, Christine; Steiner, Carola; Takala, Jukka; Korhonen, Ilkka; Jakob, Stephan M (2008). Entropy and bispectral index for assessment of sedation, analgesia and the effects of unpleasant stimuli in critically ill patients: an observational study. Critical care, 12(5), R119. London: BioMed Central 10.1186/cc7015

Takala, Jukka; Dellinger, R Philip; Koskinen, Kati; St Andre, Arthur; Read, Martyn; Levy, Mitchell; Jakob, Stephan M; Mello, Patricia Veiga C; Friolet, Raymond; Ruokonen, Esko (2008). Development and simultaneous application of multiple care protocols in critical care: a multicenter feasibility study. Intensive care medicine, 34(8), pp. 1401-10. Berlin: Springer-Verlag 10.1007/s00134-008-1084-x

Merz, Tobias M; Schär, Pascale; Bühlmann, Michael; Takala, Jukka; Rothen, Hans U (2008). Resource use and outcome in critically ill patients with hematological malignancy: a retrospective cohort study. Critical care, 12(3), R75. London: BioMed Central 10.1186/cc6921

Suter, Peter M; Takala, Jukka (2008). Science, medicine and industry: are we getting out of the black hole in sepsis research? Intensive care medicine, 34(11), pp. 1950-4. Berlin: Springer-Verlag 10.1007/s00134-008-1302-6

Vincent, Jean-Louis; Pinsky, Michael R; Sprung, Charles L; Levy, Mitchell; Marini, John J; Payen, Didier; Rhodes, Andrew; Takala, Jukka (2008). The pulmonary artery catheter: in medio virtus. Critical care medicine, 36(11), pp. 3093-6. Baltimore, Md.: Lippincott Williams & Wilkins 10.1097/CCM.0b013e31818c10c7

Rothen, Hans Ulrich; Takala, Jukka (2008). Can outcome prediction data change patient outcomes and organizational outcomes? Current opinion in critical care, 14(5), pp. 513-9. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/MCC.0b013e32830864e9

Brandt, S; Takala, J; Lepper, PM (2008). The role of hypoxia and inflammation in the expression and regulation of proteins regulating iron metabolism. In: , (ed.) Yearbook of Intensive Care and Emergency Medicine (pp. 473-480). Heidelberg: Springer Verlag

2007

Krejci, Vladimir; Hiltebrand, Luzius B; Jakob, Stephan M; Takala, Jukka; Sigurdsson, Gisli H (2007). Vasopressin in septic shock: effects on pancreatic, renal, and hepatic blood flow. Critical care, 11(6), R129. London: BioMed Central 10.1186/cc6197

Jakob, Stephan M; Parviainen, Ilkka; Ruokonen, Esko; Kogan, Alexander; Takala, Jukka (2007). TONOMETRY REVISITED: PERFUSION-RELATED, METABOLIC, AND RESPIRATORY COMPONENTS OF GASTRIC MUCOSAL ACIDOSIS IN ACUTE CARDIORESPIRATORY FAILURE. Shock, 29(5), pp. 543-548. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/SHK.0b013e31815d0c10

Jakob, Stephan M; Lubszky, Szabina; Friolet, Raymond; Rothen, Hans Ulrich; Kolarova, Anna; Takala, Jukka (2007). Sedation and weaning from mechanical ventilation: effects of process optimization outside a clinical trial. Journal of critical care, 22(3), pp. 219-28. New York, N.Y.: Elsevier 10.1016/j.jcrc.2007.01.001

Knuesel, Rafael; Takala, Jukka; Brander, Lukas; Haenggi, Matthias; Bracht, Hendrik; Porta, Francesca; Jakob, Stephan M (2007). Intraperitoneal microdialysis: critique of an editorial. Critical care medicine, 35(7), 1802; discussion 1802. Baltimore, Md.: Lippincott Williams & Wilkins 10.1097/01.CCM.0000269345.99949.3D

Hiltebrand, Luzius B; Krejci, Vladimir; Jakob, Stephan M; Takala, Jukka; Sigurdsson, Gisli H (2007). Effects of vasopressin on microcirculatory blood flow in the gastrointestinal tract in anesthetized pigs in septic shock. Anesthesiology, 106(6), pp. 1156-67. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/01.anes.0000267599.02140.86

Bracht, Hendrik; Hänggi, Matthias; Jeker, Barbara; Wegmüller, Ninja; Porta, Francesca; Tüller, David; Takala, Jukka; Jakob, Stephan M (2007). Incidence of low central venous oxygen saturation during unplanned admissions in a multidisciplinary intensive care unit: an observational study. Critical care, 11(1), R2. London: BioMed Central 10.1186/cc5144

Rothen, Hans U; Stricker, Kay; Einfalt, Johanna; Bauer, Peter; Metnitz, Philip G H; Moreno, Rui P; Takala, Jukka (2007). Variability in outcome and resource use in intensive care units. Intensive care medicine, 33(8), pp. 1329-36. Berlin: Springer-Verlag 10.1007/s00134-007-0690-3

Takala, Jukka (2007). Hypoxemia due to increased venous admixture: influence of cardiac output on oxygenation. Intensive care medicine, 33(5), pp. 908-11. Berlin: Springer Berlin Heidelberg 10.1007/s00134-007-0546-x

Takala, Jukka (2007). Hemodynamic management of the critically ill patient: craft meets science. Current opinion in critical care, 13(5), pp. 519-20. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/MCC.0b013e3282f00f1f

2006

Porta, Francesca; Takala, Jukka; Weikert, Christian; Bracht, Hendrik; Kolarova, Anna; Lauterburg, Bernhard H; Borotto, Erika; Jakob, Stephan M (2006). Effects of prolonged endotoxemia on liver, skeletal muscle and kidney mitochondrial function. Critical care, 10(4), R118. London: BioMed Central 10.1186/cc5013

Krejci, Vladimir; Hiltebrand, Luzius; Büchi, Conradin; Ali, Syed Z; Contaldo, Claudio; Takala, Jukka; Sigurdsson, Gisli H; Jakob, Stephan M (2006). Decreasing gut wall glucose as an early marker of impaired intestinal perfusion. Critical care medicine, 34(9), pp. 2406-14. Baltimore, Md.: Lippincott Williams & Wilkins 10.1097/01.CCM.0000233855.34344.29

Knuesel, Rafael; Takala, Jukka; Brander, Lukas; Haenggi, Matthias; Bracht, Hendrik; Porta, Francesca; Jakob, Stephan M (2006). Membrane microdialysis: Evaluation of a new method to assess splanchnic tissue metabolism. Critical care medicine, 34(10), pp. 2638-45. Baltimore, Md.: Lippincott Williams & Wilkins 10.1097/01.CCM.0000239430.73826.23

Brander, Lukas; Jakob, Stephan M; Knuesel, Rafael; Savolainen, Hannu; Widmer, Matthias K; Schmidli, Juerg; Takala, Jukka (2006). Effects of low abdominal blood flow and dobutamine on blood flow distribution and on the hepatic arterial buffer response in anaesthetized pigs. Shock, 25(4), pp. 402-13. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/01.0000217813.50104.5d

Brander, Lukas; Takala, Jukka (2006). Tracheal tear and tension pneumothorax complicating bronchoscopy-guided percutaneous tracheostomy. Heart & lung, 35(2), pp. 144-5. New York, N.Y.: Elsevier 10.1016/j.hrtlng.2005.09.007

Ganter, CG; Jakob, SM; Takala, J (2006). Pulmonary capillary pressure. A review. Minerva anestesiologica, 72(1-2), pp. 21-36. Torino: Minerva Medica

Haenggi, Matthias; Ypparila, Heidi; Hauser, Kathrin; Caviezel, Claudio; Korhonen, Ilkka; Takala, Jukka; Jakob, Stephan M (2006). The effects of dexmedetomidine/remifentanil and midazolam/remifentanil on auditory-evoked potentials and electroencephalogram at light-to-moderate sedation levels in healthy subjects. Anesthesia and analgesia, 103(5), pp. 1163-9. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1213/01.ane.0000237394.21087.85

Porta, Francesca; Takala, Jukka; Weikert, Christian; Kaufmann, Priska; Krahenbuhl, Stephan; Jakob, Stephan M (2006). Effect of endotoxin, dobutamine and dopamine on muscle mitochondrial respiration in vitro. Journal of endotoxin research, 12(6), pp. 358-66. London: Sage 10.1179/096805106X153952

Takala, Jukka (2006). The pulmonary artery catheter: the tool versus treatments based on the tool. Critical care, 10(4), p. 162. London: BioMed Central 10.1186/cc5021

Collaborative Study Group on Perioperative ScvO2 Monitoring (KIM, H; Haenggi, M; Jakob, SM; Loher, S; Raeber, C; Takala, J) (2006). Multicentre study on peri- and postoperative central venous oxygen saturation in high-risk surgical patients. Critical care, 10(6), R158. London: BioMed Central 10.1186/cc5094

Nunes, S; Valta, P; Takala, J (2006). Changes in respiratory mechanics and gas exchange during the acute respiratory distress syndrome. Acta anaesthesiologica Scandinavica, 50(1), pp. 80-91. Oxford: Wiley-Blackwell 10.1111/j.1399-6576.2005.00767.x

Mayr, Viktoria D; Dünser, Martin W; Greil, Veronika; Jochberger, Stefan; Luckner, Günter; Ulmer, Hanno; Friesenecker, Barbara E; Takala, Jukka; Hasibeder, Walter R (2006). Causes of death and determinants of outcome in critically ill patients. Critical care, 10(6), R154. London: BioMed Central 10.1186/cc5086

Parviainen, I; Jakob, SM; Suistomaa, M; Takala, J; The, Scandinavian Society of Anaesthesiology; Intensive, Care Medicine (SSAI) (2006). Practical sources of error in measuring pulmonary artery occlusion pressure: a study in participants of a special intensivist training program of The Scandinavian Society of Anaesthesiology and Intensive Care Medicine (SSAI). Acta anaesthesiologica Scandinavica, 50(5), pp. 600-3. Oxford: Wiley-Blackwell 10.1111/j.1399-6576.2006.01008.x

Pachl, J; Svoboda, P; Jacobs, F; Vandewoude, K; van der Hoven, B; Spronk, P; Masterson, G; Malbrain, M; Aoun, M; Garbino, J; Takala, J; Drgona, L; Burnie, J; Matthews, R; Mycograb, Invasive Candidiasis Study Group (2006). A randomized, blinded, multicenter trial of lipid-associated amphotericin B alone versus in combination with an antibody-based inhibitor of heat shock protein 90 in patients with invasive candidiasis. Clinical infectious diseases, 42(10), pp. 1404-13. Cary, N.C.: The University of Chicago Press 10.1086/503428

Gorrasi, J; Takala, J; Jakob, S (2006). The vascular bed during critical illness: evaluation in animal models. In: , (ed.) (119-128.). Heidelberg: Springer Verlag

Regli, B; Takala, J (2006). The patient process as the basis for the design of an ICU. In: Fink MP, Suter PM (ed.) (pp. 115-132). Heidelberg: Springer Verlag

Takala, J (2006). Introduction: What is Critical Care Medicine? In: Albert RK, Slutsky A (ed.) CLINICAL CRITICAL CARE MEDICINE (xv-xvi). Mosby

Takala, J (2006). Clinical assessment of the acutely unstable patient. In: Albert RK, Slutsky A (ed.) CLINICAL CRITICAL CARE MEDICINE (pp. 187-198). Mosby

Wurz, J; Takala, J (2006). ICU design of the future: Focus on flexibility. ICU management - the official management and practice journal, 6(4), p. 29. Brussels: Euromedical Communications

Albert, Richard K; Slutsky, Arthur S; Ranieri, Marco; Takala, Jukka; Torres, Antoni (eds.) (2006). Clinical Critical Care Medicine. Philadelphia: Mosby

2003

Knüsel, Rafael Matthias; Jakob, Stephan M.; Brander, Lukas; Bracht, Hendrik; Siegenthaler, Andreas; Takala, Jukka (2003). Changes in regional blood flow and pCO2 gradients during isolated abdominal aortic blood flow reduction. Intensive care medicine, 29(12), pp. 2255-2265. Springer-Verlag 10.1007/s00134-003-1954-1

Röck, Margareta Anna; Jakob, Stephan M.; Böhlen, Thomas; Brander, Lukas; Knuesel, Rafael; Takala, Jukka (2003). Change in stroke volume in response to fluid challenge: assessment using esophageal Doppler. Intensive care medicine, 29(10), pp. 1729-1735. Springer-Verlag 10.1007/s00134-003-1720-4

Nunes, Silvia; Ruokonen, Esko; Takala, Jukka (2003). Pulmonary capillary pressures during the acute respiratory distress syndrome. Intensive care medicine, 29(12), pp. 2174-2179. Springer-Verlag 10.1007/s00134-003-2036-0

2000

Uusaro, A.; Lahtinen, P.; Parviainen, I.; Takala, J. (2000). Gastric mucosal end‐tidal Pco2 difference as a continuous indicator of splanchnic perfusion. British journal of anaesthesia, 85(4), pp. 563-569. Oxford University Press 10.1093/bja/85.4.563

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