Leumann, Christian

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Journal Article

Istrate, Andrei; Johannsen, Silke; Istrate, Alena; Sigel, Roland K O; Leumann, Christian (2019). NMR solution structure of tricyclo-DNA containing duplexes: insight into enhanced thermal stability and nuclease resistance. Nucleic acids research, 47(9), pp. 4872-4882. Oxford University Press 10.1093/nar/gkz197

Frei, Sibylle; Katolik, Adam; Leumann, Christian (2019). Synthesis, biophysical properties, and RNase H activity of 6’-difluoro[4.3.0]bicyclo-DNA. Beilstein journal of organic chemistry, 15, pp. 79-88. Beilstein-Institut 10.3762/bjoc.15.9

Imbert, Marine; Blandel, Florence; Leumann, Christian; Garcia, Luis; Goyenvalle, Aurelie (2019). Lowering Mutant Huntingtin Using Tricyclo-DNA Antisense Oligonucleotides As a Therapeutic Approach for Huntington's Disease. Nucleic acid therapeutics, 29(5), pp. 256-265. Mary Ann Liebert 10.1089/nat.2018.0775

Willi, Jessica; Küpfer, Pascal; Evéquoz, Damien; Fernandez, Guillermo; Katz, Assaf; Leumann, Christian; Polacek, Norbert (2018). Oxidative stress damages rRNA inside the ribosome and differentially affects the catalytic center. Nucleic acids research, 46(4), pp. 1945-1957. Information Retrieval Ltd. 10.1093/nar/gkx1308

Frei, Sibylle; Istrate, Andrei; Leumann, Christian (2018). 6’-Fluoro[4.3.0]bicyclo nucleic acid: synthesis, biophysical properties and molecular dynamics simulations. Beilstein journal of organic chemistry, 14, pp. 3088-3097. Beilstein-Institut 10.3762/bjoc.14.288

Istrate, Alena; Katolik, Adam; Istrate, Andrei; Leumann, Christian (2017). 2′β-Fluoro-Tricyclo Nucleic Acids (2′F-tc-ANA): Thermal Duplex Stability, Structural Studies, and RNase H Activation. Chemistry: a European journal, 23(43), pp. 10310-10318. Wiley 10.1002/chem.201701476

Diafa, Stella; Evéquoz, Damien; Leumann, Christian; Hollenstein, Marcel (2017). Enzymatic Synthesis of 7′,5′-Bicyclo-DNA Oligonucleotides. Chemistry - an Asian journal, 12(12), pp. 1347-1352. Asian Chemical Editorial Society 10.1002/asia.201700374

Evéquoz, Damien; Leumann, Christian (2017). Probing the Backbone Topology of DNA: Synthesis and Properties of 7′,5′-Bicyclo-DNA. Chemistry: a European journal, 23(33), pp. 7953-7968. Wiley 10.1002/chem.201700435

Robin, Valérie; Griffith, Graziella; Carter, John-Paul L.; Leumann, Christian; Garcia, Luis; Goyenvalle, Aurélie (2017). Efficient SMN Rescue following Subcutaneous Tricyclo-DNA Antisense Oligonucleotide Treatment. Molecular Therapy - Nucleic Acids, 7, pp. 81-89. Nature Publishing Group 10.1016/j.omtn.2017.02.009

Röthlisberger, Pascal; Kaliginediand, Veerabhadrarao; Leumann, Christian (2017). Modulation of Excess Electron Transfer through LUMO Gradients in DNA Containing Phenanthrenyl Base Surrogates. Chemistry: a European journal, 23(9), pp. 2022-2025. Wiley 10.1002/chem.201605846

Relizani, Karima; Griffith, Graziella; Echevarría, Lucía; Zarrouki, Faouzi; Facchinetti, Patricia; Vaillend, Cyrille; Leumann, Christian; Garcia, Luis; Goyenvalle, Aurélie (2017). Efficacy and Safety Profile of Tricyclo-DNA Antisense Oligonucleotides in Duchenne Muscular Dystrophy Mouse Model. Molecular Therapy - Nucleic Acids, 8, pp. 144-157. Nature Publishing Group 10.1016/j.omtn.2017.06.013

Hari, Yvonne Ilona; Leumann, Christian; Schürch, Stefan (2017). What Hinders Electron Transfer Dissociation (ETD) of DNA Cations? Journal of the American Society for Mass Spectrometry, 28(12), pp. 2677-2685. Springer 10.1007/s13361-017-1791-z

Röthlisberger, Pascal; Istrate, Alena; Marcaida Lopez, M. J.; Visini, Ricardo; Stocker, Achim; Reymond, Jean-Louis; Leumann, Christian (2016). X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair. Chemical communications, 52(26), pp. 4749-4752. Royal Society of Chemistry 10.1039/c6cc00374e

Goyenvalle, Aurelie; Leumann, Christian; Garcia, Luis (2016). Therapeutic Potential of Tricyclo-DNA antisense oligonucleotides. Journal of neuromuscular diseases, 3(2), pp. 157-167. IOS Press 10.3233/jnd-160146

Medvecky, Michal; Istrate, Alena; Leumann, Christian (2015). Synthesis and Properties of 6′-Fluoro-tricyclo-DNA. The Journal of organic chemistry, 80(7), pp. 3556-3565. American Chemical Society 10.1021/acs.joc.5b00184

Goyenvalle, Aurelie; Griffith, Graziella; Babbs, Arran; Andaloussi, Samir El; Ezzat, Kariem; Avril, Aurelie; Dugovic, Branislav; Chaussenot, Remi; Ferry, Arnaud; Voit, Thomas; Amthor, Helge; Bühr, Claudia; Schürch, Stefan; Wood, Matthew J. A.; Davies, Kay E.; Vaillend, Cyrille; Leumann, Christian; Garcia, Luis (2015). Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers. Nature medicine, 21(3), pp. 270-275. Nature Publishing Group 10.1038/nm.3765

Smith, Christine Catherine; Hollenstein, Marcel; Leumann, Christian (2014). The synthesis and application of a diazirine-modified uridine analogue for investigating RNA-protein interactions. RSC advances, 4(89), pp. 48228-48235. Royal Society of Chemistry 10.1039/c4ra08682a

Hollenstein, Marcel; Leumann, Christian (2014). Synthesis and Biochemical Characterization of Tricyclothymidine Triphosphate (tc-TTP). ChemBioChem, 15(13), pp. 1901-1904. Wiley-VCH 10.1002/cbic.201402116

Dugovic, Branislav; Leumann, Christian (2014). A 6'-Fluoro-Substituent in Bicyclo-DNA Increases Affinity to Complementary RNA Presumably by CF-HC Pseudohydrogen Bonds. The Journal of organic chemistry, 79(3), pp. 1271-1279. American Chemical Society 10.1021/jo402690j

Schnippering, Mathias; Zahn, Alain; Liu, Shi-Xia; Leumann, Christian; Decurtins, Silvio; Fermín, David J. (2009). Synthesis and electrochemical properties of TTF modified oligodeoxyribonucleotides. Chemical communications(37), p. 5552. Cambridge: Royal Society of Chemistry 10.1039/b907847a

Luisier, Samuel; Leumann, Christian (2009). Synthesis and properties of bcox-DNA. Biopolymers, 92(4), pp. 312-313. Hoboken, N.J.: John Wiley & Sons, Inc.

Zahn, Alain; Leumann, Christian (2008). Recognition Properties of Donor- and Acceptor-Modified Biphenyl-DNA. Chemistry - a European journal, 14(4), pp. 1087-1094. Weinheim: Wiley-VCH 10.1002/chem.200701345

Ivanova, Gabriela; Reigadas, Sandrine; Ittig, Damian; Arzumanov, Andrey; Andreola, Marie-Line; Leumann, Christian; Toulmé, Jean-Jacques; Gait, Michael (2007). Tricyclo-DNA Containing Oligonucleotides as Steric Block Inhibitors of HIV-1 Tat-Dependent Trans Activation and HIV-1 Infectivity. Oligonucleotides, 17(1), pp. 54-65. Larchmont, N.Y.: Mary Ann Liebert 10.1089/oli.2006.0046

Ivanova, Gabriela; Andrey, Arzumanov; Gait, Michael J.; Reigadas, Sandrine; Toulmé, Jean-Jacques; Andreola, Marie-Line; Ittig, Damian; Leumann, Christian (2007). Comparative Studies of Tricyclo-DNA- and LNA-Containing Oligonucleotides as Inhibitors of HIV-1 Gene Expression. Nucleosides, nucleotides & nucleic acids, 26(6-7), pp. 747-750. Philadelphia, Pa.: Taylor & Francis 10.1080/15257770701490928

Leumann, Christian (2006). Sugar modification as a means to increase the biological performance of oligonucleotides. Nucleic Acids Symposium Series, 50(1), pp. 55-56. Oxford University Press 10.1093/nass/nrl167

Leumann, Christian (2005). Genes under Restraint. Review of "Synthetic Nucleic Acids as Inhibitors of Gene Expression: Mechanisms, Applications and Therapeutic Implications", edited by Levon M. Khachigian, 200 p., CRC Press, 2004. ChemBioChem, 6(11), p. 2105. Wiley-VCH 10.1002/cbic.200500398

Renneberg, Dorte; Leumann, Christian (2004). Exploring Hoogsteen and reversed-Hoogsteen duplex and triplex formation with tricyclo-DNA purine sequences. ChemBioChem, 5(8), pp. 1114-1118. Wiley-VCH 10.1002/cbic.200400069

Ittig, D.; Liu, Shi-Xia; Renneberg, Dorte; Schümperli, Daniel; Leumann, Christian (2004). Nuclear antisense effects in cyclophilin A pre-mRNA splicing by oligonucleotides: A comparison of tricyclo-DNA with LNA. Nucleic acids research, 32(1), pp. 346-353. Oxford University Press 10.1093/nar/gkh187

Buchini, S.; Leumann, Christian (2004). Stable and selective recognition of three base pairs in the parallel triple-helical DNA binding motif. Angewandte Chemie (International ed.), 43(30), pp. 3925-3928. Wiley-VCH 10.1002/anie.200460159

Dawson, Philip E.; Leumann, Christian (2004). Biopolymers: Challenge complex biological function with smart chemistry. Current opinion in chemical biology, 8(6), pp. 567-569. Elsevier 10.1016/j.cbpa.2004.10.006

Leumann, Christian (2003). Synthesis and Incorporation into PNA of Fluorinated Olefinic PNA (F-OPA) Monomers. Organic letters, 5(11), pp. 1987-1990. American Chemical Society

Vonlanthen, David; Leumann, Christian (2003). Hydroxycyclopentanone derivatives from D-Mannose via ring closing metathesis: An improved synthesis of a key intermediate of Tricyclo-DNA. Synthesis - journal of synthetic organic chemistry, 2003(07), pp. 1087-1090. Thieme 10.1055/s-2003-39177

Trafelet, Huldreich; Parel, Serge P; Leumann, Christian (2003). Oligodeoxynucleotide Duplexes Containing (5′S)-5′-C-Alkyl-Modified 2′-Deoxynucleosides: Can an Alkyl Zipper across the DNA Minor-Groove Enhance Duplex Stability? Helvetica chimica acta, 86(11), pp. 3671-3687. Verlag Helvetica Chimica Acta 10.1002/hlca.200390311

Mayer, Alain; Leumann, Christian (2003). A short, efficient synthesis of 2'-deoxypseudoisocytidine based on Heck-chemistry. Nucleosides, nucleotides & nucleic acids, 22(10), pp. 1919-1925. Taylor & Francis 10.1081/NCN-120025239

Hollenstein, Marcel; Gautschi, Daniel; Leumann, Christian (2003). Fluorinated peptide nucleic acid. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1191-1194. Taylor & Francis 10.1081/NCN-120022833

Hirtz, C.; Leumann, Christian (2003). Synthetic studies towards a novel, chemical stable, abasic site analogue of DNA. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1203-1206. Taylor & Francis 10.1081/NCN-120022836

Häberli, A.; Mayer, Alain; Leumann, Christian (2003). Pyrrolidino-DNA. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1187-1189. Taylor & Francis 10.1081/NCN-120022832

Gautschi, Daniel; Leumann, Christian (2003). Olefinic peptide nucleic acid (OPA). Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1211-1213. Taylor & Francis 10.1081/NCN-120022838

Buchini, S.; Leumann, Christian (2003). New nucleoside analogues for the recognition of pyrimidine-purine inversion sites. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1199-1201. Taylor & Francis 10.1081/NCN-120022835

Buchini, S.; Leumann, Christian (2003). Recent improvements in antigene technology. Current opinion in chemical biology, 7(6), pp. 717-726. Elsevier 10.1016/j.cbpa.2003.10.007

Buchini, S.; Leumann, Christian (2003). Dual recognition of a pyrimidine-purine inversion site: synthesis and binding properties of triplex forming oligonucleotides containing 2'-aminoethoxy-5-methyl-1 H -pyrimidin-2-one ribonucleosides. Tetrahedron letters, 44(27), pp. 5065-5068. Elsevier 10.1016/S0040-4039(03)01135-3

Brotschi, C.; Leumann, Christian (2003). Transition metal ligands as novel DNA-base substitutes. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1195-1197. Taylor & Francis 10.1081/NCN-120022834

Brotschi, C.; Leumann, Christian (2003). DNA with Hydrophobic Base Substitutes: A Stable, Zipperlike Recognition Motif Based On Interstrand-Stacking Interactions. Angewandte Chemie (International ed.), 42(14), pp. 1655-1658. Wiley-VCH 10.1002/anie.200250516

Becaud, J.; Pompizi, I.; Leumann, Christian (2003). Propagation of melting cooperativity along the phosphodiester backbone of DNA. Journal of the American Chemical Society, 125(50), pp. 15338-15342. American Chemical Society 10.1021/ja035313j

Ahn, D. R.; Mosimann, Markus; Leumann, Christian (2003). Synthesis of cyclopentane amide DNA (cpa-DNA) and its pairing properties. Journal of organic chemistry, 68(20), pp. 7693-7699. American Chemical Society 10.1021/jo034143q

Ahn, D. R.; Mosimann, Markus; Leumann, Christian (2003). Synthesis of a cyclopentane amide DNA analogue and its base pairing properties. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1207-1210. Taylor & Francis 10.1081/NCN-120022837

Schürch, Stefan; Bernal-Mendez, E.; Leumann, Christian (2002). Electrospray tandem mass spectrometry of mixed-sequence RNA/DNA oligonucleotides. Journal of the American Society for Mass Spectrometry, 13(8), pp. 936-945. Springer 10.1016/s1044-0305(02)00413-0

Renneberg, Dorte; Leumann, Christian (2002). Watson-Crick base-pairing properties of tricyclo-DNA. Journal of the American Chemical Society, 124(21), pp. 5993-6002. American Chemical Society 10.1021/ja025569+

Prévot, I.; Leumann, Christian (2002). Evaluation of novel third strand bases for the recognition of a C-G base-pair in the parallel DNA triple-helical binding motif. Helvetica chimica acta, 85(2), pp. 502-515. Verlag Helvetica Chimica Acta 10.1002/1522-2675(200202)85:2<502::AID-HLCA502>3.0.CO;2-L

Leumann, Christian (2002). DNA analogues:from supramolecular principles to biological properties. Bioorganic & medicinal chemistry, 10(4), pp. 841-854. Elsevier 10.1016/S0968-0896(01)00348-0

Keller, B. M.; Leumann, Christian (2002). Synthesis and incorporation into a-DNA of a novel conformationally constrained alpha-nucleoside analogue. Synthesis - journal of synthetic organic chemistry, 2002(06), pp. 789-796. Thieme 10.1055/s-2002-25755

Häberli, A.; Leumann, Christian (2002). DNA binding properties of oligodeoxynucleotides containing pyrrolidino C-nucleosides. Organic letters, 4(19), pp. 3275-3278. American Chemical Society 10.1021/ol026537u

Bernal-Méndez, E.; Leumann, Christian (2002). Stability and kinetics of nucleic acid triplexes with chimaeric DNA/RNA third strands. Biochemistry, 41(41), pp. 12343-12349. American Chemical Society 10.1021/bi025937m

Ahn, D. R.; Egger, A.; Lehmann, C.; Pitsch, S.; Leumann, Christian (2002). Bicyclo[3.2.1]amide-DNA: a chiral, non-chiroselective base-pairing system. Chemistry - a European journal, 8(23), pp. 5312-5322. Wiley-VCH 10.1002/1521-3765(20021202)8:23<5312::AID-CHEM5312>3.0.CO;2-M

Trafelet, H. U.; Stulz, E.; Leumann, Christian (2001). Synthesis of (5' S )-5'- C -Alkyl-2'-deoxynucleosides. Helvetica chimica acta, 84(1), pp. 87-105. Verlag Helvetica Chimica Acta 10.1002/1522-2675(20010131)84:1<87::AID-HLCA87>3.0.CO;2-1

Parel, S. P.; Marfurt, J.; Leumann, Christian (2001). DNA triple-helix formation at pyrimidine-purine inversion sites. Nucleosides, nucleotides & nucleic acids, 20(4-7), pp. 411-417. Taylor & Francis 10.1081/NCN-100002315

Parel, S. P.; Leumann, Christian (2001). Triple-helix formation in the antiparallel binding motif of oligodeoxynucleotides containing N(9)- and N(7)-2-aminopurine deoxynucleosides. Nucleic acids research, 29(11), pp. 2260-2267. Information Retrieval Ltd. 10.1093/nar/29.11.2260

Leumann, Christian (2001). Conformationally Restricted Oligonucleotide Analogues 'Made in Bern': A Mini Review. CHIMIA, 55(12), pp. 1041-1044. Bern: Schweizerische Chemische Gesellschaft

Leumann, Christian (2001). Design and Evaluation of Oligonucleotide Analogues. CHIMIA, 55(4), pp. 295-301. Bern: Schweizerische Chemische Gesellschaft

Häberli, A.; Leumann, Christian (2001). Synthesis of pyrrolidine C-nucleosides via Heck reaction. Organic letters, 3(3), pp. 489-492. American Chemical Society 10.1021/ol007029s

Brotschi, C.; Häberli, A.; Leumann, Christian (2001). A Stable DNA Duplex Containing a Non-Hydrogen-Bonding and Non-Shape-Complementary Base Couple: Interstrand Stacking as the Stability Determining Factor. Angewandte Chemie (International ed.), 40(16), pp. 3012-3014. Wiley-VCH 10.1002/1521-3773%2820010817%2940:16%3C3012::AID-ANIE3012%3E3.0.CO;2-Y

Bernal-Méndez, E.; Leumann, Christian (2001). Conformational diversity versus nucleic acid triplex stability, a combinatorial study. Journal of biological chemistry, 276(38), pp. 35320-35327. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M105794200

Stulz, E.; Bürgi, Hans-Beat; Leumann, Christian (2000). Zr(IV)-tetraphenylporphyrinates as nuclease mimicks: structural kinetic and mechanistic studies on phosphate diester transesterifications. Chemistry - a European journal, 6(3), pp. 523-536. Wiley-VCH 10.1002/(SICI)1521-3765(20000204)6:3<523::AID-CHEM523>3.0.CO;2-1

Schütz, Rolf; Cantin, Michel; Roberts, Christopher; Greiner, Beate; Uhlmann, Eugen; Leumann, Christian (2000). Olefinic Peptide Nucleic Acids (OPAs): New Aspects of the Molecular Recognition of DNA by PNA. Angewandte Chemie (International ed.), 39(7), pp. 1250-1253. Wiley-VCH 10.1002/(sici)1521-3773(20000403)39:7<1250::aid-anie1250>3.0.co;2-e

Pompizi, I.; Häberli, A.; Leumann, Christian (2000). Oligodeoxynucleotides containing conformationally constrained abasic sites: a UV- and fluorescence spectroscopic investigation on duplex stability and structure. Nucleic acids research, 28(14), pp. 2702-2708. Information Retrieval Ltd. 10.1093/nar/28.14.2702

Parel, S. P.; Leumann, Christian (2000). Synthesis and pairing properties of oligodeoxynucleotides containing N7-(purine-2-amine deoxynucleosides). Helvetica chimica acta, 83(9), pp. 2514-2526. Verlag Helvetica Chimica Acta 10.1002/1522-2675(20000906)83:9<2514::AID-HLCA2514>3.0.CO;2-X

Keller, B. M.; Leumann, Christian (2000). Bicyclo-[3.2.1]-DNA: On the Structural and Energetic Role of the Furanose Subunit in Complementary Strand Recognition of DNA. Angewandte Chemie (International ed.), 39(13), pp. 2278-2281. Wiley-VCH

Stulz, E.; Leumann, Christian (1999). X-ray structure and solvolytic activity towards phosphate diesters of a zirconium(IV) complex. Journal of the Chemical Society, Chemical Communications(3), pp. 239-240. Royal Society of Chemistry 10.1039/a809101c

Steffens, R.; Leumann, Christian (1999). Synthesis and Thermodynamic and Biophysical Properties of Tricyclo-DNA. Journal of the American Chemical Society, 121(14), pp. 3249-3255. American Chemical Society 10.1021/ja983570w

Simon, H.; Förtsch, I.; Burckhardt, G.; Gabrielyan, A.; Birch-Hirschfeld, E.; Stelzner, A.; Prévot-Halter, I.; Leumann, Christian; Zimmer, C. (1999). Triple helix formation inhibits DNA gyrase activity. Antisense and Nucleic Acid Drug Development, 9(6), pp. 527-531. Mary Ann Liebert 10.1089/oli.1.1999.9.527

Roberts, C. D.; Schütz, R.; Leumann, Christian (1999). The synthesis of a thymine containing E-olefinic peptide nucleic acid (OPA) monomer. Synlett, 1999(6), pp. 819-821. Thieme 10.1055/s-1999-2711

Roberts, C. D.; Epple, C.; Leumann, Christian (1999). Bicyclo[3.2.1]-DNA: a DNA analog containing a rigid backbone and a flexible base-pairing region. Nucleosides & Nucleotides, 1999(18), pp. 1413-1415. Dekker 10.1080/07328319908044736

Prévot-Halter, I.; Leumann, Christian (1999). Selective Recognition of a C-G base-pair in the parallel DNA triple-helical binding motif. Bioorganic and medicinal chemistry letters, 9(18), pp. 2657-2660. Pergamon 10.1016/S0960-894X(99)00451-5

Meier, Roland; Grüschow, S.; Leumann, Christian (1999). Nucleic acid analogs with restricted conformational flexibility in the sugar-phosphate backbone (Bicyclo-DNA). Part 7. Synthesis and properties of oligodeoxynucleotides containing [(3'S,5'S,6'R)-6'-amino-2'-deoxy-3',5'-ethano-beta-D-ribofuranosyl]thymine (6'-amino-bicyclothymidine). Helvetica chimica acta, 82(11), pp. 1813-1828. Verlag Helvetica Chimica Acta 10.1002/(SICI)1522-2675(19991110)82:11<1813::AID-HLCA1813>3.0.CO;2-0

Egger, A.; Leumann, Christian (1999). Bicyclo[3.2.1]amide-DNA: Synthesis and base-pairing properties. Synlett, 1999(Sup. 1), pp. 913-916. Thieme 10.1055/s-1999-3113

Sauter, Guido; Stulz, Eugen; Leumann, Christian (1998). Distamycin-NA: A DNA Analog with an Aromatic Heterocyclic Polyamide Backbone. Part 1. Synthesis and structural analysis of monomers and dimers containing the nucleobase uracil. Helvetica chimica acta, 81(1), pp. 14-34. Verlag Helvetica Chimica Acta 10.1002/hlca.19980810103

Sauter, Guido; Leumann, Christian (1998). Distamycin-NA: A DNA analog with an aromatic heterocyclic polyamide backbone. Part 2. Solid-phase synthesis of distamycin-NAs containing the nucleobase uracil: Unexpected solvent participation in the coupling step. Helvetica chimica acta, 81(5-8), pp. 916-931. Verlag Helvetica Chimica Acta 10.1002/hlca.19980810512

Marfurt, Judith; Leumann, Christian (1998). Evidence for C−H⋅⋅⋅O Hydrogen Bond Assisted Recognition of a Pyrimidine Base in the Parallel DNA Triple-Helical Motif. Angewandte Chemie (International ed.), 37(1-2), pp. 175-177. Wiley-VCH 10.1002/(sici)1521-3773(19980202)37:1/2<175::aid-anie175>3.0.co;2-p

Guo, M. J.; Hildbrand, S.; Leumann, Christian; McLaughlin, L. W.; Waring, M. J. (1998). Inhibition of DNA polymerase reaction by pyrimidine nucleotide analogues lacking the 2-keto group. Nucleic acids research, 26(8), pp. 1863-1869. Oxford University Press 10.1093/nar/26.8.1863

Groebke, Katrin; Hunziker, Jürg; Fraser, William; Peng, Ling; Diederichsen, Ulf; Zimmermann, Kaspar; Holzner, Armin; Leumann, Christian; Eschenmoser, Albert (1998). Warum Pentose- und nicht Hexose-Nucleinsäuren??. Teil V. (Purin-Purin)-Basenpaarung in der homo-DNS-Reihe: Guanin, Isoguanin, 2,6-Diaminopurin und Xanthin. Helvetica chimica acta, 81(3-4), pp. 375-474. Verlag Helvetica Chimica Acta 10.1002/hlca.19980810302

Epple, C.; Leumann, Christian; Stoeckli-Evans, H. (1998). (1'S,5'S,6'R,8'S)-1-[6'-Acetoxy-8'-hydroxy-2'-oxabicyclo[3.2.1]oct-5'-yl)oxymethyl]-N4-ben zoylcytosine. Acta Crystallographica, Section C: Crystal Structure Communications, 54(8), pp. 1141-1143. International Union of Crystallography 10.1107/S010827019800184X

Epple, C.; Leumann, Christian (1998). Bicyclo[3.2.1]-DNA, a new DNA analog with a rigid backbone and flexibly linked bases: pairing properties with complementary DNA. Chemistry & biology, 5(4), pp. 209-216. Current Biology Ltd. 10.1016/S1074-5521(98)90634-2

Egger, A.; Hunziker, J.; Rihs, G.; Leumann, Christian (1998). Synthesis of bridgehead-functionalized bicyclo[3.2.1]octanes via intramolecular titanium- and tributylstannane-induced pinacol coupling. Helvetica chimica acta, 81(3-4), pp. 734-743. Verlag Helvetica Chimica Acta 10.1002/hlca.19980810323

Steffens, R.; Leumann, Christian (1997). Tricyclo-DNA: A phosphodiester-backbone based DNA analog exhibiting strong complementary base-pairing properties. Journal of the American Chemical Society, 119(47), pp. 11548-11549. American Chemical Society 10.1021/ja972597x

Steffens, R.; Leumann, Christian (1997). Nucleic-acid analogs with constraint conformational flexibility in the sugar-phosphate backbone "Tricyclo-DNA". Part 1. Preparation of [(5'R,6'R)-2-deoxy-3',5'-ethano-5',6'-methano-beta-D-ribofuranosyl]thymine and -adenine, and the corresponding phosphoramidites for oligonucleotide synthesis. Helvetica chimica acta, 80(8), pp. 2426-2439. Verlag Helvetica Chimica Acta 10.1002/hlca.19970800812

Marfurt, J.; Parel, S. P.; Leumann, Christian (1997). Strong, specific, monodentate G-C base-pair recognition by N7-inosine derivatives in the pyrimidine-purine-pyrimidine triple-helical binding motif. Nucleic acids research, 25(10), pp. 1875-1882. Oxford University Press 10.1093/nar/25.10.1875

Hildbrand, S.; Blaser, A.; Parel, S. P.; Leumann, Christian (1997). 5-Substituted 2-Aminopyridine C-nucleosides as protonated cytidine equivalents: Increasing efficiency and selectivity in DNA triple helix formation. Journal of the American Chemical Society, 119(24), pp. 5499-5511. American Chemical Society 10.1021/ja9704904

Cantin, M.; Schütz, R.; Leumann, Christian (1997). Synthesis of the monomeric building blocks of Z-olefinic PNA (Z-OPA) containing the bases adenine and thymine. Tetrahedron letters, 38(24), pp. 4211-4214. Elsevier 10.1016/S0040-4039(97)00871-X

Savithri, D.; Leumann, Christian; Scheffold, R. (1996). Synthesis of a building block for a nucleic acid analog with a chiral flexible peptide backbone. Helvetica chimica acta, 79(1), pp. 288-294. Verlag Helvetica Chimica Acta 10.1002/hlca.19960790128

Marfurt, J.; Stulz, E.; Trafelet, H. U.; Zingg, A.; Leumann, Christian; Hazenkamp, M.; Judd, R.; Schenker, S.; Strouse, G.; Ward, T. R.; Förtsch, M.; Hauser, Jürg; Bürgi, Hans-Beat (1996). 7-(2'-deoxy-alpha-D-ribofuranosyl)-hypoxanthine. Acta Crystallographica, Section C: Crystal Structure Communications, 52(3), pp. 713-716. Wiley-Blackwell 10.1107/S0108270195012662

Marfurt, J.; Hunziker, Jürg; Leumann, Christian (1996). Recognition of a G-C base pair by alpha-N7-deoxyinosine within the pyrimidine-purine-pyrimidine triple helical motif. Bioorganic and medicinal chemistry letters, 6(24), pp. 3021-3024. Pergamon 10.1016/S0960-894X(96)00561-6

Litten, J. C.; Leumann, Christian (1996). Nucleic-Acid analogs with restricted conformational flexibility in the sugar-phosphate backbone (Bicyclo-DNA), Part 6, Probing the influence of torsion angle gamma on DNA duplex stability: Synthesis and properties of oligodeoxynucleotides containing [(3'S,5'S)-2'-deoxy-3',5'-ethano- -D-ribofuranosyl]adenine and -thymine (5'epi-bicyclodeoxynucleosides). Helvetica chimica acta, 79(4), pp. 1129-1146. Verlag Helvetica Chimica Acta 10.1002/hlca.19960790421

Hildbrand, Stefan; Leumann, Christian; Scheffold, Rolf (1996). Synthesis of Carbocyclic C-Nucleosides Containing Nonnatural Pyrimidine Bases. Helvetica chimica acta, 79(3), pp. 702-709. Verlag Helvetica Chimica Acta 10.1002/hlca.19960790312

Hildbrand, Stefan; Leumann, Christian (1996). Enhancing DNA Triple Helix Stability at Neutral pH by the Use of Oligonucleotides Containing a More Basic Deoxycytidine Analog. Angewandte Chemie (International ed.), 35(17), pp. 1968-1970. Wiley-VCH 10.1002/anie.199619681

Bolli, M.; Trafelet, H. U.; Leumann, Christian (1996). Watson-Crick base-pairing properties of bicyclo-DNA. Nucleic acids research, 24(23), pp. 4660-4667. Oxford University Press 10.1093/nar/24.23.4660

Bolli, M.; Litten, C.; Schütz, R.; Leumann, Christian (1996). Bicyclo-DNA: a Hoogsteen-selective pairing system. Chemistry & biology, 3(3), pp. 197-206. Current Biology Ltd. 10.1016/S1074-5521(96)90263-X

Litten, J. C.; Epple, C.; Leumann, Christian (1995). Bicyclo-Oligonucleotides with Inverted Configuration at C(5'): Synthesis and Properties. Bioorganic and medicinal chemistry letters, 5(12), pp. 1231-1234. Pergamon 10.1016/0960-894X(95)00201-4

Bolli, Martin; Lubini, Paolo; Leumann, Christian (1995). Nucleic-Acid Analogs with Restricted Conformational Flexibility in the Sugar-Phosphate Backbone (‘Bicyclo-DNA’). Part 5. Synthesis, Characterization, and Pairing Properties of Oligo-αlpha-D-(bicyclodeoxynucleotides) of the Bases Adenine and Thymine (αlpha-Bicyclo-DNA). Helvetica chimica acta, 78(8), pp. 2077-2096. Verlag Helvetica Chimica Acta 10.1002/hlca.19950780816

Bolli, Martin; Leumann, Christian (1995). Triple-Helix Formation of Oligodeoxynucleotides Containing [(3′S,5′R)-2′-Deoxy-3′,5′-ethano-β-D-ribofuranosyl]nucleosides (“Bicyclo-deoxynucleosides”). Angewandte Chemie (International ed.), 34(6), pp. 694-696. Wiley-VCH 10.1002/anie.199506941

Tarköy, M.; Bolli, M.; Leumann, Christian (1994). Nucleic acid analogues with restricted conformational flexibility in the sugar phosphate backbone (bicyclo-DNA), Part 3, Synthesis, pairing properties and calorimetric determination of duplex and triplex stability of decanucleotides from (3'S,5'R)-2-Deoxy-3',5'-ethano-beta-D-ribofuranosyladenine and thymine. Helvetica chimica acta, 77(3), pp. 716-744. Verlag Helvetica Chimica Acta 10.1002/hlca.19940770315

Tarköy, Markus; Leumann, Christian (1993). Synthesis and Pairing Properties of Decanucleotides from (3′S,5′R)-2′-Deoxy-3′, 5′-ethano-β-D-ribofuranosyladenine and -thymine. Angewandte Chemie (International ed.), 32(10), pp. 1432-1434. Wiley-VCH 10.1002/anie.199314321

Tarköy, M.; Bolli, M.; Schweizer, B.; Leumann, Christian (1993). Nucleic Acid analogues with constraint conformational flexibility in the sugar phosphate backbone (bicyclo-DNA), Part I, Preparation of (3'S,5'R)-2'-Deoxy-3',5'-ethano-beta-D-ribofuranosyl-nucleosides (Bicyclonucleosides). Helvetica chimica acta, 76(1), pp. 481-510. Verlag Helvetica Chimica Acta 10.1002/hlca.19930760132

Otting, G.; Billeter, M.; Wüthrich, K.; Roth, H. J.; Leumann, Christian; Eschenmoser, A. (1993). Warum Pentose und nicht Hexose-Nucleinsäuren? TeilIV, Homo-DNS: 1H-,13C-,31P- und 15N NMR spektroskopische Untersuchungen von ddGlc (A-A-A-A-A-T-T-T-T-T) in wässriger Lösung. Helvetica chimica acta, 76(8), pp. 2701-2756. Verlag Helvetica Chimica Acta 10.1002/hlca.19930760802

Hunziker, Jürg; Roth, H. J.; Böhringer, M.; Giger, A.; Diederichsen, U.; Göbel, M.; Krishnan, R.; Jaun, B.; Leumann, Christian; Eschenmoser, A. (1993). Warum Pentose und nicht Hexose-Nucleinsäuren?, Teil III, Oligo,2',3'-dideoxy-beta-D-glucopyranosyl)-nucleotide (Homo-DNS): Paarungseigenschaften. Helvetica chimica acta, 76(1), pp. 259-352. Verlag Helvetica Chimica Acta 10.1002/hlca.19930760119

Egli, M.; Lubini, P.; Bolli, M.; Dobler, M.; Leumann, Christian (1993). Crystal structure of a parallel duplex of a deoxycytidyl-(3'-5')-deoxycytidine analogue containing intranucleosidyl C(3')-C(5') ethylene bridges. Journal of the American Chemical Society, 115(13), pp. 5855-5856. American Chemical Society 10.1021/ja00066a076

Neidlein, U.; Leumann, Christian (1992). Antiparallel thymine-thymine duplexes in oligonucleotides containing alfa- and beta-thymidine. Tetrahedron letters, 33(52), pp. 8057-8060. Elsevier 10.1016/S0040-4039(00)74716-2

Böhringer, M.; Roth, H. J.; Hunziker, J.; Göbel, M.; Krishnan, R.; Giger, A.; Schweizer, B.; Schreiber, J.; Leumann, Christian; Eschenmoser, A. (1992). Warum Pentose und nicht Hexose-Nucleinsäuren? Teil II, Oligonucleotide aus 2',3'-dideoxy-beta-D-glucopyranosylbausteinen ("Homo-DNS): Herstellung. Helvetica chimica acta, 75(5), pp. 1416-1477. Verlag Helvetica Chimica Acta 10.1002/hlca.19920750503

Venugopalan, Paloth; Venkatesan, K.; Klausen, Jörg; Novotny-Bregger, Elisabeth; Leumann, Christian; Eschenmoser, Albert; Dunitz, Jack D. (1991). On the Methyl-Transfer Reaction in Crystalline Methyl 2-(Methylthio)benzenesulfonate: a Thermally Induced Non-Topochemical Solid-State Reaction. Helvetica chimica acta, 74(3), pp. 662-669. Verlag Helvetica Chimica Acta 10.1002/hlca.19910740323

Groebke, Katrin; Leumann, Christian (1990). A Method for Preparing Oligodeoxynucleotides Containing an Apurinic Site. Helvetica chimica acta, 73(3), pp. 608-617. Verlag Helvetica Chimica Acta 10.1002/hlca.19900730309

Shokat, K. M.; Leumann, Christian; Sugasawara, R.; Schultz, P. G. (1989). A new strategy for the generation of catalytic antibodies. Nature, 338(6212), pp. 269-271. Macmillan Journals Ltd. 10.1038/338269a0

Shokat, Kevan M.; Leumann, Christian; Sugasawara, Renee; Schultz, Peter G. (1988). An Antibody-Mediated Redox Reaction. Angewandte Chemie (International ed.), 27(9), pp. 1172-1174. Wiley-VCH 10.1002/anie.198811721

Leumann, Christian; Früh, Thomas; Göbel, Michael; Eschenmoser, Albert (1987). Chemistry of Pyrrocorphins: Biomimetic Regioselectivity of C-Methylation at the Ligand Periphery of Magnesium(II) Uropyrrocorphinate(Type I)-octanitriles. Angewandte Chemie (International ed.), 26(3), pp. 261-264. Wiley-VCH 10.1002/anie.198702611

Leumann, Christian; Eschenmoser, Albert (1984). Chemistry of pyrrocorphins: methylative opening of the macrocycle between rings A and D, a side reaction in the peripheral C-methylation of a 20-methyl-pyrrocorphinate. Journal of the Chemical Society, Chemical Communications(9), p. 583. Royal Society of Chemistry 10.1039/c39840000583

Leumann, Christian; Hilpert, Kurt; Schreiber, Jakob; Eschenmoser, Albert (1983). Chemistry of pyrrocorphins: C-methylations at the periphery of pyrrocorphins and related corphinoid ligand systems. Journal of the Chemical Society, Chemical Communications(23), p. 1404. Royal Society of Chemistry 10.1039/c39830001404

Hilpert, Kurt; Leumann, Christian; Davis, Anthony P.; Eschenmoser, Albert (1983). Chemistry of pyrrocorphins: synthesis of isobacteriochlorins and pyrrocorphins bearing a methyl group at the meso position between rings A and D. Journal of the Chemical Society, Chemical Communications(23), p. 1401. Royal Society of Chemistry 10.1039/c39830001401

Book Section

Diafa, Stella; Evéquoz, Damien; Leumann, Christian; Hollenstein, Marcel (2019). Synthesis and Enzymatic Characterization of Sugar-Modified Nucleoside Triphosphate Analogs. In: Shank, Nathaniel (ed.) Non-Natural Nucleic Acids. Methods in Molecular Biology: Vol. 1973 (pp. 1-13). New York, NY: Springer New York 10.1007/978-1-4939-9216-4_1

Leumann, Christian (2012). Selbstreplizierende Moleküle und der Ursprung des Lebens: Evolution im Reagenzglas. In: Dubach, Martina (ed.) Evolution wohin? Die Folgen der darwinschen Theorie (pp. 71-84). Zürich: vdf Hochschulverlag

Hunziker, Jürg; Leumann, Christian (1995). Nucleic Acid Analogues: Synthesis and Properties. In: Ernst, Beat; Leumann, Christian (eds.) Modern Synthetic Methods 1995 (pp. 331-417). Basel: Verlag Helvetica Chimica Acta

Bolli, M.; Lubini, P.; Tarköy, M.; Leumann, Christian (1994). Synthesis characterization and pairing properties of an alpha-DNA-analogue with restricted conformational flexibility in the sugar-phosphate backbone: (alpha-bicyclo-DNA). In: Sanghvi, Yogesh S.; Cook, P. Dan (eds.) Carbohydrate modifications in antisense research. ACS Symposium Series: Vol. 580 (pp. 100-117). Washington: American Chemical Society 10.1021/bk-1994-0580.ch007

Conference or Workshop Item

Hari, Yvonne; Leumann, Christian; Schürch, Stefan (15 September 2016). Gas-phase properties of natural and modified nucleic acid duplexes. CHIMIA, 70(7/8). Schweizerische Chemische Gesellschaft

Koch, Miriam; Küpfer, Pascal; Leumann, Christian; Polacek, Norbert; Willi, Jessica (9 July 2016). Oxidized bases in the ribosome's peptidyl transferase center and their effects on translation (Unpublished). In: EMBO Conference Ribosome – Structure and Function 2016. Strasbourg, France. 06.-10.07.2016.

Hari, Yvonne; Schürch, Stefan; Leumann, Christian (4 September 2015). Elucidation of the gas-phase structure of a sugar-modified DNA analogue (Unpublished). In: SCS Fall Meeting. Lausanne. 04.09.2015.

Imbert, M.; Griffith, G.; Benchaouir, R.; Beley, C.; Dugovic, Branislav; Leumann, Christian; Garcia Popa-Lisseanu, Ana Maria; Goyenvalle, A. (2015). Therapeutic strategies for Huntington's. Human Gene Therapy, 26(10), A80-A81. Mary Ann Liebert

Goyenvalle, A.; Hofstetter, Robin Valentin; Garcia, L.; Dugovic, Branislav; Leumann, Christian (2014). Tricyclo-DNA for the treatment of neuromuscular diseases. Neuromuscular disorders, 24(Supplement 1), S3. Elsevier

Goyenvalle, A.; Babbs, A.; Avril, A.; Griffiths, G.; Dugovic, B.; Davies, K.E.; Leumann, Christian; Garcia, L. (October 2012). Tricyclo-DNA: A promising chemistry for the synthesis of antisense molecules for splice-switching approaches in DMD. Neuromuscular disorders, 22(9-10), p. 907. Elsevier 10.1016/j.nmd.2012.06.340

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