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Lux, Janine; Portmann, Hannah; Sánchez García, Lucia; Erhardt, Maria; Holivololona, Lalaina; Laloli, Laura; Licheri, Manon F; Gallay, Clement; Hoepner, Robert; Croucher, Nicholas J; Straume, Daniel; Veening, Jan-Willem; Dijkman, Ronald; Heller, Manfred; Grandgirard, Denis; Leib, Stephen L; Hathaway, Lucy J (2024). Klebsiella pneumoniae peptide hijacks a Streptococcus pneumoniae permease to subvert pneumococcal growth and colonization. Communications biology, 7(425) Springer Nature 10.1038/s42003-024-06113-9
Chiffi, Gabriele; Grandgirard, Denis; Leib, Stephen L; Chrdle, Aleš; Růžek, Daniel (2023). Tick-borne encephalitis: A comprehensive review of the epidemiology, virology, and clinical picture. Reviews in medical virology, 33(5), e2470. Wiley 10.1002/rmv.2470
Müller, Annelies; Lekhuleni, Cebile; Hupp, Sabrina; du Plessis, Mignon; Holivololona, Lalaina; Babiichuk, Eduard; Leib, Stephen L.; Grandgirard, Denis; Iliev, Asparouh I.; von Gottberg, Anne; Hathaway, Lucy J. (2023). Meningitis-associated pneumococcal serotype 8, ST 53, strain is hypervirulent in a rat model and has non-haemolytic pneumolysin which can be attenuated by liposomes. Frontiers in cellular and infection microbiology, 12 Frontiers 10.3389/fcimb.2022.1106063
Ernst, Alexander; Piragyte, Indre; MP, Ayisha Marwa; Le, Ngoc Dung; Grandgirard, Denis; Leib, Stephen L.; Oates, Andrew; Mercader, Nadia (2023). Identification of side effects of COVID-19 drug candidates on embryogenesis using an integrated zebrafish screening platform. Scientific reports, 13(1), p. 17037. Springer Nature 10.1038/s41598-023-43911-3
Zimmermann, Josua; Friedli, Nicole; Bavato, Francesco; Stämpfli, Philipp; Coray, Rebecca; Baumgartner, Markus R; Grandgirard, Denis; Leib, Stephen L; Opitz, Antje; Seifritz, Erich; Stock, Ann-Kathrin; Beste, Christian; Cole, David M; Quednow, Boris B (2022). White matter alterations in chronic MDMA use: Evidence from diffusion tensor imaging and neurofilament light chain blood levels. NeuroImage: Clinical, 36, p. 103191. Elsevier 10.1016/j.nicl.2022.103191
Chiffi, Gabriele; Grandgirard, Denis; Stöckli, Sabrina; Valente, Luca G; Adamantidis, Antoine; Leib, Stephen L (2022). Tick-borne encephalitis affects sleep-wake behavior and locomotion in infant rats. Cell & bioscience, 12(1), p. 121. BioMed Central 10.1186/s13578-022-00859-7
Le, Ngoc Dung; Steinfort, Marel; Grandgirard, Denis; Maleska, Aleksandra; Leppert, David; Kuhle, Jens; Leib, Stephen L (2022). The CCR5 antagonist maraviroc exerts limited neuroprotection without improving neurofunctional outcome in experimental pneumococcal meningitis. Scientific reports, 12(1), p. 12945. Springer Nature 10.1038/s41598-022-17282-0
Guse, Kirsten; Hagemann, Nina; Thiele, Lisa; Remlinger, Jana; Salmen, Anke; Hoepner, Robert; Keller, Irene; Meyer, Patricia; Grandgirard, Denis; Leib, Stephen; Vassella, Erik; Locatelli, Giuseppe; Hermann, Dirk M; Chan, Andrew Hao-Kuang (2022). CNS Antigen-Specific Neuroinflammation Attenuates Ischemic Stroke With Involvement of Polarized Myeloid Cells. Neurology: neuroimmunology & neuroinflammation, 9(4) Wolters Kluwer Health 10.1212/NXI.0000000000001168
Prazak, Josef; Valente, Luca; Iten, Manuela; Federer, Lea; Grandgirard, Denis; Soto, Sara; Resch, Gregory; Leib, Stephen L.; Jakob, Stephan M.; Haenggi, Matthias; Cameron, David R.; Que, Yok-Ai (2022). Benefits of aerosolized phages for the treatment of pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA): an experimental study in rats. The journal of infectious diseases, 225(8), pp. 1452-1459. Oxford University Press 10.1093/infdis/jiab112
Chiffi, Gabriele; Grandgirard, Denis; Sendi, Parham; Dietmann, Anelia; Bassetti, Claudio L. A.; Leib, Stephen (2022). Sleep-Wake and Circadian Disorders after Tick-Borne Encephalitis. Microorganisms, 10(2), p. 304. MDPI 10.3390/microorganisms10020304
Hirzel, Cédric; Grandgirard, Denis; Surial, Bernard; Wider, Manon F.; Leppert, David; Kuhle, Jens; Walti, Laura N.; Schefold, Joerg C.; Spinetti, Thibaud; Suter-Riniker, Franziska; Dijkman, Ronald; Leib, Stephen L (2022). Neuro-axonal injury in COVID-19: the role of systemic inflammation and SARS-CoV-2 specific immune response. Therapeutic advances in neurological disorders, 15, p. 17562864221080528. Sage 10.1177/17562864221080528
Valente, Luca G; Le, Ngoc Dung; Pitton, Melissa; Chiffi, Gabriele; Grandgirard, Denis; Jakob, Stephan M; Cameron, David R; Resch, Grégory; Que, Yok-Ai; Leib, Stephen L (2022). Efficacy assessment of a novel endolysin PlyAZ3aT for the treatment of ceftriaxone-resistant pneumococcal meningitis in an infant rat model. PLoS ONE, 17(4), e0266928. Public Library of Science 10.1371/journal.pone.0266928
Valente, Luca G.; Federer, Lea; Iten, Manuela; Grandgirard, Denis; Leib, Stephen L.; Jakob, Stephan M.; Haenggi, Matthias; Cameron, David R.; Que, Yok-Ai; Prazak, Josef (2021). Searching for synergy: combining systemic daptomycin treatment with localised phage therapy for the treatment of experimental pneumonia due to MRSA. BMC research notes, 14(1), p. 381. Biomed Central 10.1186/s13104-021-05796-1
Jebbawi, Fadi; Bellanger, Anne-Pauline; Lundström-Stadelmann, Britta; Rufener, Reto; Dosch, Michel; Goepfert, Christine; Gottstein, Bruno; Millon, Laurence; Grandgirard, Denis; Leib, Stephen L.; Beldi, Guido; Wang, Junhua (2021). Innate and adaptive immune responses following PD-L1 blockade in treating chronic murine alveolar echinococcosis. Parasite immunology, 43(8), e12834. Wiley 10.1111/pim.12834
Grüter, Basil E.; Wanderer, Stefan; Strange, Fabio; Boillat, Gwendoline; Täschler, Dominik; Rey, Jeannine; Croci, Davide M; Grandgirard, Denis; Leib, Stephen; von Gunten, Michael; Di Santo, Stefano; Widmer, Hans Rudolf; Remonda, Luca; Andereggen, Lukas; Nevzati, Edin; Coluccia, Daniel; Fandino, Javier; Marbacher, Serge (2021). Patterns of Neointima Formation After Coil or Stent Treatment in a Rat Saccular Sidewall Aneurysm Model. Stroke, 52(3), pp. 1043-1052. American Heart Association 10.1161/STROKEAHA.120.032255
Wang, Junhua; von Gunten, Stephan; Beldi, Guido; Grandgirard, Denis; Leib, Stephen L.; Gottstein, Bruno (2021). Digest the Sugar, Kill the Parasite: A New Experimental Concept in Treating Alveolar Echinococcosis. Pharmacology, 106(1-2), pp. 3-8. Karger 10.1159/000509355
Erni, Silvia T.; Gill, John C.; Palaferri, Carlotta; Fernandes, Gabriella; Buri, Michelle; Lazarides, Katherine; Grandgirard, Denis; Edge, Albert S. B.; Leib, Stephen; Roccio, Marta (2021). Hair Cell Generation in Cochlear Culture Models Mediated by Novel γ-Secretase Inhibitors. Frontiers in cell and developmental biology, 9(2256) Frontiers 10.3389/fcell.2021.710159
Muri, Lukas; Oberhänsli, Simone; Buri, Michelle; Le, Ngoc Dung; Grandgirard, Denis; Bruggmann, Rémy; Müri, René M.; Leib, Stephen L. (2020). Repetitive transcranial magnetic stimulation activates glial cells and inhibits neurogenesis after pneumococcal meningitis. PLoS ONE, 15(9), e0232863. Public Library of Science 10.1371/journal.pone.0232863
Brigger, Daniel; Riether, Carsten; van Brummelen, Robin; Mosher, Kira I; Shiu, Alicia; Ding, Zhaoqing; Zbären, Noemi; Gasser, Pascal; Guntern, Pascal; Yousef, Hanadie; Castellano, Joseph M; Storni, Federico; Graff-Radford, Neill; Britschgi, Markus; Grandgirard, Denis; Hinterbrandner, Magdalena; Siegrist, Mark; Moullan, Norman; Hofstetter, Wilhelm; Leib, Stephen L.; ... (2020). Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age. Nature metabolism, 2(8), pp. 688-702. Springer Nature 10.1038/s42255-020-0228-3
Prazák, Josef; Valente, Luca; Iten, Manuela; Grandgirard, Denis; Leib, Stephen; Jakob, Stephan M.; Hänggi, Matthias; Que, Yok-Ai; Cameron, David R. (2020). Nebulized Bacteriophages for Prophylaxis of Experimental Ventilator-Associated Pneumonia Due to Methicillin-Resistant Staphylococcus aureus. Critical care medicine, 48(7), pp. 1042-1046. Wolters Kluwer Health 10.1097/CCM.0000000000004352
Meyer, Patricia; Grandgirard, Denis; Lehner, Marika; Haenggi, Matthias; Leib, Stephen (2020). Grafted neural progenitor cells persist in the injured site and differentiate neuronally in a rodent model of cardiac arrest-induced global brain ischemia. Stem cells and development, 29(9), pp. 574-585. Mary Ann Liebert 10.1089/scd.2019.0190
Le, Ngoc Dung; Muri, Lukas; Grandgirard, Denis; Kuhle, Jens; Leppert, David; Leib, Stephen L. (2020). Evaluation of neurofilament light chain in the cerebrospinal fluid and blood as a biomarker for neuronal damage in experimental pneumococcal meningitis. Journal of neuroinflammation, 17(1), p. 293. BioMed Central 10.1186/s12974-020-01966-3
Zbinden, Florian R.; De Ste Croix, Megan; Grandgirard, Denis; Haigh, Richard D; Vacca, Irene; Zamudio, Roxana; Goodall, Emily C A; Stephan, Roger; Oggioni, Marco R; Leib, Stephen L. (2020). Pathogenic Differences of Type 1 Restriction-Modification Allele Variants in Experimental Listeria monocytogenes Meningitis. Frontiers in cellular and infection microbiology, 10, p. 590657. Frontiers 10.3389/fcimb.2020.590657
Pan, Steven D.; Grandgirard, Denis; Leib, Stephen L. (2020). Adjuvant Cannabinoid Receptor Type 2 Agonist Modulates the Polarization of Microglia Towards a Non-Inflammatory Phenotype in Experimental Pneumococcal Meningitis. Frontiers in cellular and infection microbiology, 10 Frontiers 10.3389/fcimb.2020.588195
Prazak, Josef; Iten, Manuela; Cameron, David Robert; Save, Jonathan Florian; Grandgirard, Denis; Resch, Gregory; Göpfert, Christine; Leib, Stephen L.; Takala, Jukka; Jakob, Stephan; Que, Yok-Ai; Hänggi, Matthias (2019). Bacteriophages Improve Outcome in Experimental Staphylococcus Aureus Ventilator Associated Pneumonia. American journal of respiratory and critical care medicine, 200(9), pp. 1126-1133. American Lung Association 10.1164/rccm.201812-2372OC
Grüter, Basil Erwin; Täschler, Dominik; Strange, Fabio; Rey, Jeannine; von Gunten, Michael; Grandgirard, Denis; Leib, Stephen; Remonda, Luca; Widmer, Hans Rudolf; Nevzati, Edin; Fandino, Javier; Marbacher, Serge; Coluccia, Daniel (2019). Testing bioresorbable stent feasibility in a rat aneurysm model. Journal of neurointerventional surgery, 11(10), pp. 1050-1054. BMJ Publishing Group 10.1136/neurintsurg-2018-014697
Muri, Lukas Kilian; Leppert, David; Grandgirard, Denis; Leib, Stephen (2019). MMPs and ADAMs in neurological infectious diseases and multiple sclerosis. Cellular and molecular life sciences : CMLS, 76(16), pp. 3097-3116. Springer 10.1007/s00018-019-03174-6
Muri, Lukas Kilian; Le, Ngoc Dung; Zemp, Jonas; Grandgirard, Denis; Leib, Stephen L. (2019). Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis. Journal of neuroinflammation, 16(1), p. 156. BioMed Central 10.1186/s12974-019-1549-6
Muri, Lukas; Perny, Michael; Zemp, Jonas; Grandgirard, Denis; Leib, Stephen L. (2019). Combining Ceftriaxone with Doxycycline and Daptomycin Reduces Mortality, Neuroinflammation, Brain Damage and Hearing Loss in Infant Rat Pneumococcal Meningitis. Antimicrobial agents and chemotherapy, 63(7) American Society for Microbiology 10.1128/AAC.00220-19
Hupp, Sabrina; Grandgirard, Denis; Mitchell, Timothy J.; Leib, Stephen; Hathaway, Lucy Jane; Iliev, Asparouh I. (2019). Pneumolysin and the bacterial capsule of Streptococcus pneumoniae cooperatively inhibit taxis and motility of microglia. Journal of neuroinflammation, 16(1), p. 105. BioMed Central 10.1186/s12974-019-1491-7
Colicchio, Roberta; Pagliuca, Chiara; Ricci, Susanna; Scaglione, Elena; Grandgirard, Denis; Masouris, Ilias; Farina, Fabrizio; Pagliarulo, Caterina; Mantova, Giuseppe; Paragliola, Laura; Leib, Stephen; Koedel, Uwe; Pozzi, Gianni; Alifano, Pietro; Salvatore, Paola (2019). Virulence traits of serogroup C meningococcus and isogenic mutant, defective in surface-exposed sialic acid, in a murine model of meningitis. Infection and immunity, 87(4) American Society for Microbiology 10.1128/IAI.00688-18
Erni, Silvia T.; Fernandes, Gabriella; Buri, Michelle; Perny, Michael; Rutten, Rolf Jan; van Noort, Johannes M; Senn, Pascal; Grandgirard, Denis; Roccio, Marta; Leib, Stephen (2019). Anti-inflammatory and Oto-Protective Effect of the Small Heat Shock Protein Alpha B-Crystallin (HspB5) in Experimental Pneumococcal Meningitis. Frontiers in neurology, 10(570), p. 570. Frontiers Media S.A. 10.3389/fneur.2019.00570
Muri, Lukas; Grandgirard, Denis; Buri, Michelle; Perny, Michael; Leib, Stephen (2018). Combined effect of non-bacteriolytic antibiotic and inhibition of matrix metalloproteinases prevents brain injury and preserves learning, memory and hearing function in experimental paediatric pneumococcal meningitis. Journal of neuroinflammation, 15(1), p. 233. BioMed Central 10.1186/s12974-018-1272-8
Nasher, Fauzy; Förster, Sunniva; Yildirim, Efe C; Grandgirard, Denis; Leib, Stephen; Heller, Manfred; Hathaway, Lucy (2018). Foreign peptide triggers boost in pneumococcal metabolism and growth. BMC microbiology, 18(1), p. 23. BioMed Central 10.1186/s12866-018-1167-y
Glas, Michael; Frick, Tamara; Springe, Dirk; Putzu, Alessandro; Zürcher, Patrick; Grandgirard, Denis; Leib, Stephen; Jakob, Stephan; Takala, Jukka; Hänggi, Matthias (2018). Neuroprotection with the P53-Inhibitor Pifithrin-μ After Cardiac Arrest in a Rodent Model. Shock, 49(2), pp. 229-234. Lippincott Williams & Wilkins 10.1097/SHK.0000000000000917
Bewersdorf, Jan P; Grandgirard, Denis; Koedel, Uwe; Leib, Stephen (2018). Novel and preclinical treatment strategies in pneumococcal meningitis. Current opinion in infectious diseases, 31(1), pp. 85-92. Lippincott Williams & Wilkins 10.1097/QCO.0000000000000416
Ruppen, Corinne; Mercier, Thomas; Grandgirard, Denis; Leib, Stephen; El Haj, Cristina; Murillo, Oscar; Decosterd, Laurent; Sendi, Parham (2018). Is Penicillin Plus Gentamicin Synergistic Against Sessile Group B Streptococcal Isolates? An Study With an Experimental Model of Foreign-Body Infection. Frontiers in Microbiology, 9, p. 919. Frontiers 10.3389/fmicb.2018.00919
Lenz, Nicole; Engler, Olivier; Grandgirard, Denis; Leib, Stephen L.; Ackermann-Gäumann, Rahel (2018). Evaluation of antivirals against tick-borne encephalitis virus in organotypic brain slices of rat cerebellum. PLoS ONE, 13(10), e0205294. Public Library of Science 10.1371/journal.pone.0205294
Perny, Michael; Solyga, Magdalena; Grandgirard, Denis; Roccio, Marta; Leib, Stephen; Senn, Pascal (2017). Streptococcus pneumoniae-induced ototoxicity in organ of Corti explant cultures. Hearing research, 350, pp. 100-109. Elsevier 10.1016/j.heares.2017.04.012
Jenkinson, Stephen P.; Grandgirard, Denis; Heidemann, Martina; Tscherter, Anne; Avondet, Marc-André; Leib, Stephen (2017). Embryonic Stem Cell-Derived Neurons Grown on Multi-Electrode Arrays as a Novel In vitro Bioassay for the Detection of Clostridium botulinum Neurotoxins. Frontiers in Pharmacology, 8(73) Frontiers 10.3389/fphar.2017.00073
Sendi, Parham; Hirzel, Cédric; Pfister, Stefan; Ackermann-Gäumann, Rahel; Grandgirard, Denis; Hewer, Ekkehard; Nirkko, Arto Christian (2017). Fatal Outcome of Tick-borne Encephalitis after Vaccine Failure. Frontiers in neurology, 8(119), p. 119. Frontiers Media S.A. 10.3389/fneur.2017.00119
Perny, Michael; Roccio, Marta; Grandgirard, Denis; Solyga, Magdalena; Senn, Pascal; Leib, Stephen (2016). The Severity of Infection Determines the Localization of Damage and Extent of Sensorineural Hearing Loss in Experimental Pneumococcal Meningitis. Journal of neuroscience, 36(29), pp. 7740-7749. Society for Neuroscience 10.1523/JNEUROSCI.0554-16.2016
Curiao, Tânia; Marchi, Emmanuela; Grandgirard, Denis; León-Sampedro, Ricardo; Viti, Carlo; Leib, Stephen; Baquero, Fernando; Oggioni, Marco R; Martinez, José Luis; Coque, Teresa M (2016). Multiple adaptive routes of Salmonella enterica Typhimurium to biocide and antibiotic exposure. BMC Genomics, 17(491), p. 491. BioMed Central 10.1186/s12864-016-2778-z
Bürki, Sarah Elisabeth; Grandgirard, Denis; Datta, Alexandre N; Hackenberg, Annette; Martin, Florence; Schmitt-Mechelke, Thomas; Leib, Stephen L; Steinlin, Maja (2016). Inflammatory markers in pediatric stroke: An attempt to better understanding the pathophysiology. European journal of paediatric neurology, 20(2), pp. 252-260. Elsevier 10.1016/j.ejpn.2015.12.006
Bally, Lia; Grandgirard, Denis; Leib, Stephen (2016). Inhibition of Hippocampal Regeneration by Adjuvant Dexamethasone in Experimental Infant Rat Pneumococcal Meningitis. Antimicrobial agents and chemotherapy, 60(3), pp. 1841-1846. American Society for Microbiology 10.1128/AAC.02429-15
Hathaway, Lucy Jane; Grandgirard, Denis; Valente, Luca Gabriele; Täuber, Martin G.; Leib, Stephen (2016). Streptococcus pneumoniae capsule determines disease severity in experimental pneumococcal meningitis. Open Biology, 6(3) The Royal Society Publishing 10.1098/rsob.150269
Zürcher, Patrick; Springe, Dirk; Grandgirard, Denis; Leib, Stephen; Grossholz, Marius; Jakob, Stephan; Takala, Jukka; Hänggi, Matthias (2016). A randomized trial of the effects of the noble gases helium and argon on neuroprotection in a rodent cardiac arrest model. BMC neurology, 16, p. 43. BioMed Central 10.1186/s12883-016-0565-8
Baumgartner, Denja; Aebi, Susanne; Grandgirard, Denis; Leib, Stephen; Draeger, Annette; Babiychuk, Eduard; Hathaway, Lucy Jane (2016). Clinical Streptococcus pneumoniae isolates induce differing CXCL8 responses from human nasopharyngeal epithelial cells which are reduced by liposomes. BMC microbiology, 16(1), p. 154. BioMed Central 10.1186/s12866-016-0777-5
Frick, Tamara; Springe, Dirk; Grandgirard, Denis; Leib, Stephen; Hänggi, Matthias (2015). An improved simple rat model for global cerebral ischaemia by induced cardiac arrest. Neurological research, 38(4), pp. 373-380. Maney 10.1179/1743132815Y.0000000090
Liechti, Fabian D; Grandgirard, Denis; Leib, Stephen (2015). Bacterial meningitis: insights into pathogenesis and evaluation of new treatment options: a perspective from experimental studies. Future microbiology, 10(7), pp. 1195-1213. Future Medicine 10.2217/fmb.15.43
Liechti, F D; Grandgirard, Denis; Leib, Stephen (2015). The antidepressant fluoxetine protects the hippocampus from brain damage in experimental pneumococcal meningitis. Neuroscience, 297, pp. 89-94. Elsevier 10.1016/j.neuroscience.2015.03.056
Grandgirard, Denis; Furi, Leonardo; Ciusa, Maria Laura; Baldassarri, Lucilla; Knight, Daniel R; Morrissey, Ian; Largiadèr, Carlo Rodolfo; Leib, Stephen; Oggioni, Marco R (2015). Mutations upstream of fabI in triclosan resistant Staphylococcus aureus strains are associated with elevated fabI gene expression. BMC Genomics, 16(345), p. 345. BioMed Central 10.1186/s12864-015-1544-y
Wang, Junhua; Vuitton, Dominique A; Müller, Norbert; Hemphill, Andrew; Spiliotis, Markus; Blagosklonov, Oleg; Grandgirard, Denis; Leib, Stephen; Shalev, Itay; Levy, Gary; Lu, Xiaomei; Lin, Renyong; Wen, Hao; Gottstein, Bruno (2015). Deletion of Fibrinogen-like Protein 2 (FGL-2), a Novel CD4+ CD25+ Treg Effector Molecule, Leads to Improved Control of Echinococcus multilocularis Infection in Mice. PLoS neglected tropical diseases, 9(5), e0003755. Public Library of Science 10.1371/journal.pntd.0003755
Bendel, Stepani; Springe, Dirk; Pereira, Adriano José; Grandgirard, Denis; Leib, Stephen; Putzu, Alessandro; Schlickeiser, Jannis; Jakob, Stephan M.; Takala, Jukka; Hänggi, Matthias (2015). Do different anesthesia regimes affect hippocampal apoptosis and neurologic deficits in a rodent cardiac arrest model? BMC anesthesiology, 15(2), p. 2. BioMed Central 10.1186/1471-2253-15-2
Liechti, Fabian D; Bächtold, Fabian; Grandgirard, Denis; Leppert, David; Leib, Stephen (2015). The matrix metalloproteinase inhibitor RS-130830 attenuates brain injury in experimental pneumococcal meningitis. Journal of neuroinflammation, 12(43), p. 43. BioMed Central 10.1186/s12974-015-0257-0
Ricci, Susanna; Grandgirard, Denis; Wenzel, Michael; Braccini, Tiziana; Salvatore, Paola; Oggioni, Marco R; Leib, Stephen; Koedel, Uwe (2014). Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis. BMC infectious diseases, 14(726), p. 726. BioMed Central 10.1186/s12879-014-0726-6
Maffioli, Carola; Grandgirard, Denis; Engler, Olivier; Leib, Stephen (2014). A tick-borne encephalitis model in infant rats infected with langat virus. Journal of neuropathology and experimental neurology, 73(12), pp. 1107-1115. Lippincott Williams & Wilkins 10.1097/NEN.0000000000000131
Coutinho, Leonam G; Christen, Stephan; Bellac, Caroline L; Fontes, Fabrícia; de Souza, Fladjule; Grandgirard, Denis; Leib, Stephen; Agnez-Lima, Lucymara F (2014). The kynurenine pathway is involved in bacterial meningitis. Journal of neuroinflammation, 11(169), p. 169. BioMed Central 10.1186/s12974-014-0169-4
Liechti, Fabian D; Grandgirard, Denis; Leppert, David; Leib, Stephen (2014). Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis. Infection and immunity, 82(4), pp. 1710-1718. American Society for Microbiology 10.1128/IAI.00073-14
Hirt-Minkowski, Patricia; Marti, Hans-Peter; Hönger, Gideon; Grandgirard, Denis; Leib, Stephen; Amico, Patrizia; Schaub, Stefan (2014). Correlation of serum and urinary matrix metalloproteases/tissue inhibitors of metalloproteases with subclinical allograft fibrosis in renal transplantation. Transplant immunology, 30(1), pp. 1-6. Elsevier 10.1016/j.trim.2013.11.004
Liechti, Fabian D; Stüdle, Nicolas; Theurillat, Regula; Grandgirard, Denis; Thormann, Wolfgang; Leib, Stephen (2014). The mood-stabilizer lithium prevents hippocampal apoptosis and improves spatial memory in experimental meningitis. PLoS ONE, 9(11), e113607. Public Library of Science 10.1371/journal.pone.0113607
Coutinho, Leonam G; Grandgirard, Denis; Leib, Stephen L.; Agnez-Lima, Lucymara F (2013). Cerebrospinal-fluid cytokine and chemokine profile in patients with pneumococcal and meningococcal meningitis. BMC infectious diseases, 13(1), p. 326. BioMed Central 10.1186/1471-2334-13-326
Comim, Clarissa M; Barichello, Tatiana; Grandgirard, Denis; Dal-Pizzol, Felipe; Quevedo, João; Leib, Stephen L. (2013). Caspase-3 mediates in part hippocampal apoptosis in sepsis. Molecular neurobiology, 47(1), pp. 394-398. Clifton, N.J.: Humana Press 10.1007/s12035-012-8354-x
Monney, Thierry; Grandgirard, Denis; Leib, Stephen; Hemphill, Andrew (2013). Use of a Th1 Stimulator Adjuvant for Vaccination against Neospora caninum Infection in the Pregnant Mouse Model. Pathogens, 2(2), pp. 193-208. MDPI AG 10.3390/pathogens2020193
Grandgirard, Denis; Gäumann, Rahel; Coulibaly, Boubacar; Dangy, Jean-Pierre; Sie, Ali; Junghanss, Thomas; Schudel, Hans; Pluschke, Gerd; Leib, Stephen L. (2013). The causative pathogen determines the inflammatory profile in cerebrospinal fluid and outcome in patients with bacterial meningitis. Mediators of inflammation, 2013, p. 312476. Hindawi Publishing Corp. 10.1155/2013/312476
Maffioli, Carola; Grandgirard, Denis; Engler, Olivier; Leib, Stephen L. (2012). SiRNA inhibits replication of Langat virus, a member of the tick-borne encephalitis virus complex in organotypic rat brain slices. PLoS ONE, 7(9), e44703. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0044703
Monney, Thierry; Debache, Karim; Grandgirard, Denis; Leib, Stephen L.; Hemphill, Andrew (2012). Vaccination with the recombinant chimeric antigen recNcMIC3-1-R induces a non-protective Th2-type immune response in the pregnant mouse model for N. caninum infection. Vaccine, 30(46), pp. 6588-94. Amsterdam: Elsevier 10.1016/j.vaccine.2012.08.024
Grandgirard, Denis; Burri, Melchior; Agyeman, Philipp; Leib, Stephen (2012). Adjunctive daptomycin attenuates brain damage and hearing loss more efficiently than rifampin in infant rat pneumococcal meningitis. Antimicrobial agents and chemotherapy, 56(8), pp. 4289-95. Washington, D.C.: American Society for Microbiology 10.1128/AAC.00674-12
Sury, Matthias D.; Vorlet-Fawer, Lorianne; Agarinis, Claudia; Yousefi, Shida; Grandgirard, Denis; Leib, Stephen L.; Christen, Stephan (2011). Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis. Neurobiology of disease, 41(1), pp. 201-208. Amsterdam: Elsevier 10.1016/j.nbd.2010.09.007
Woehrl, Bianca; Klein, Matthias; Grandgirard, Denis; Koedel, Uwe; Leib, Stephen (2011). Bacterial meningitis: current therapy and possible future treatment options. Expert review of anti-infective therapy, 9(11), pp. 1053-1065. London: Expert Reviews 10.1586/ERI.11.129
Hofer, Sandra; Grandgirard, Denis; Burri, Denise; Fröhlich, Tanja K.; Leib, Stephen L. (2011). Bacterial meningitis impairs hippocampal neurogenesis. Journal of neuropathology and experimental neurology, 70(10), pp. 890-899. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/NEN.0b013e3182303f31
Monney, Thierry; Rütti, David; Schorer, Michelle; Debache, Karim; Grandgirard, Denis; Leib, Stephen L.; Hemphill, Andrew (2011). RecNcMIC3-1-R is a microneme- and rhoptry-based chimeric antigen that protects against acute neosporosis and limits cerebral parasite load in the mouse model for Neospora caninum infection. Vaccine, 29(40), pp. 6967-6975. Amsterdam: Elsevier 10.1016/j.vaccine.2011.07.038
Blaser, Cornelia; Wittwer, Matthias; Grandgirard, Denis; Leib, Stephen L. (2011). Adjunctive dexamethasone affects the expression of genes related to inflammation, neurogenesis and apoptosis in infant rat pneumococcal meningitis. PLoS ONE, 6(3), e17840. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0017840
Margos, M.C.; Grandgirard, Denis; Leib, Stephen; Gottstein, Bruno (2011). In vitro induction of lymph node cell proliferation by mouse bone marrow dendritic cells following stimulation with different Echinococcus multilocularis antigens. Journal of helminthology, 85(2), pp. 128-137. Cambridge: Cambridge University Press 10.1017/S0022149X10000878
Grandgirard, Denis; Leib, Stephen L. (2010). Meningitis in neonates: bench to bedside. Clinics in perinatology, 37(3), pp. 655-676. New York, N.Y.: Elsevier 10.1016/j.clp.2010.05.004
Wittwer, Matthias; Grandgirard, Denis; Rohrbach, Janine; Leib, Stephen L. (2010). Tracking the transcriptional host response from the acute to the regenerative phase of experimental pneumococcal meningitis. BMC infectious diseases, 10(176), p. 176. London: BioMed Central 10.1186/1471-2334-10-176
Blaser, Cornelia; Klein, Matthias; Grandgirard, Denis; Wittwer, Matthias; Peltola, Heikki; Weigand, Michael; Koedel, Uwe; Leib, Stephen L. (2010). Adjuvant glycerol is not beneficial in experimental pneumococcal meningitis. BMC infectious diseases, 10(84), p. 84. London: BioMed Central 10.1186/1471-2334-10-84
Grandgirard, Denis; Oberson, Kevin; Bühlmann, Angela; Gäumann, Rahel; Leib, Stephen L. (2010). Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis. Antimicrobial agents and chemotherapy, 54(3), pp. 1323-1326. Washington, D.C.: American Society for Microbiology 10.1128/AAC.00812-09
Debache, Karim; Alaeddine, Ferial; Guionaud, Christophe; Monney, Thierry; Müller, Joachim; Strohbusch, Maria; Leib, Stephen L.; Grandgirard, Denis; Hemphill, Andrew (2009). Vaccination with recombinant NcROP2 combined with recombinant NcMIC1 and NcMIC3 reduces cerebral infection and vertical transmission in mice experimentally infected with Neospora caninum tachyzoites. International journal for parasitology, 39(12), pp. 1373-1384. Kidlington, UK: Elsevier 10.1016/j.ijpara.2009.04.006
Sellner, Johann; Grandgirard, Denis; Gianinazzi, Christian; Landmann, Regine M.; Leib, Stephen L. (2009). Effects of Toll-like receptor 2 agonist Pam(3)CysSK(4) on inflammation and brain damage in experimental pneumococcal meningitis. Journal of neuroimmunology, 206(1-2), pp. 28-31. Amsterdam: Elsevier 10.1016/j.jneuroim.2008.10.004
Gehre, F.; Leib, Stephen L.; Grandgirard, Denis; Kummer, Jürg; Bühlmann, Angela; Simon, Franziska; Gäumann, R.; Kharat, A. S.; Täuber, Martin G.; Tomasz, A. (2008). Essential role of choline for pneumococcal virulence in an experimental model of meningitis. Internal medicine journal, 264(2), pp. 143-154. Sydney: Blackwell 10.1111/j.1365-2796.2008.01930.x
Sellner, Johann; Greeve, Isabell; Findling, Oliver; Kamm, Christian P.; Minten, Carsten; Engelhardt, Britta; Grandgirard, Denis; Leib, Stephen L.; Mattle, Heinrich P (2008). Effect of interferon-beta and atorvastatin on Th1/Th2 cytokines in multiple sclerosis. Neurochemistry international, 53(1-2), pp. 17-21. Amsterdam: Elsevier 10.1016/j.neuint.2008.04.004
Grandgirard, Denis; Loeffler, Jutta M.; Fischetti, Vincent A.; Leib, Stephen L. (2008). Phage lytic enzyme Cpl-1 for antibacterial therapy in experimental pneumococcal meningitis. Journal of infectious diseases, 197(11), pp. 1519-1522. Cary, N.C.: The University of Chicago Press 10.1086/587942
Sellner, Johann; Greeve, I; Findling, O; Grandgirard, Denis; Leib, Stephen L.; Mattle, H P (2008). Atorvastatin does not alter serum levels of sCD95 and sCD95L in multiple sclerosis. Clinical and experimental immunology, 152(2), pp. 280-284. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2249.2008.03630.x
Grandgirard, Denis; Steiner, Oliver; Täuber, Martin G.; Leib, Stephen L. (2007). An infant mouse model of brain damage in pneumococcal meningitis. Acta neuropathologica, 114(6), pp. 609-617. Berlin: Springer-Verlag 10.1007/s00401-007-0304-8
Grandgirard, Denis; Schürch, Christian; Cottagnoud, Philippe; Leib, Stephen L. (2007). Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis. Antimicrobial agents and chemotherapy, 51(6), pp. 2173-2178. Washington, D.C.: American Society for Microbiology 10.1128/AAC.01014-06
Grandgirard, Denis; Leib, Stephen L. (2006). Strategies to prevent neuronal damage in paediatric bacterial meningitis. Current opinion in pediatrics, 18(2), pp. 112-118. Philadelphia, Pa.: Lippincott Williams & Wilkins 10.1097/01.mop.0000193292.09894.b7
Rhême, Céline; Ehrengruber, Markus U; Grandgirard, Denis (2005). Alphaviral cytotoxicity and its implication in vector development. Experimental physiology, 90(1), pp. 45-52. Blackwell 10.1113/expphysiol.2004.028142
Gianinazzi, Christian; Grandgirard, Denis; Simon, Franziska; Imboden, Hans; Joss, Philipp; Täuber, Martin G.; Leib, Stephen (2004). Apoptosis of hippocampal neurons in organotypic slice culture models: direct effect of bacteria revisited. Journal of neuropathology and experimental neurology, 63(6), pp. 610-617. Lippincott Williams & Wilkins
Gianinazzi, Christian; Grandgirard, Denis; Imboden, Hans; Egger, Lotti; Meli, Damian N; Bifrare, Yoeng-Delphine; Joss, Philipp; Täuber, Martin G.; Borner, Christoph; Leib, Stephen (2003). Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis. Acta neuropathologica, 105(5), pp. 499-507. Springer 10.1007/s00401-003-0672-7
Grandgirard, Denis; Studer, Erwin; Monney, Laurent; Belser, Tanja; Fellay, Isabelle; Borner, Christoph; Michel, Marcel R. (1998). Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2. EMBO journal, 17(5), pp. 1268-1278. Nature Publishing Group 10.1093/emboj/17.5.1268
Le, Ngoc Dung; Ricci, Susanna; Grandgirard, Denis; Leib, Stephen L (2023). Experimental meningitis by Streptococcus pneumoniae and Neisseria meningitidis in rodents. In: Handbook of Animal Models in Neurological Disorders (pp. 329-341). Elsevier 10.1016/B978-0-323-89833-1.00050-1
Agyeman, Philipp; Grandgirard, Denis; Leib, Stephen (2017). Neuroinflammation in Bacterial Meningitis. In: Lyck, R; Enzmann, G (eds.) The Blood Brain Barrier and Inflammation. Progress in Inflammation Research (pp. 213-252). Springer Nature 10.1007/978-3-319-45514-3_10
Agyeman, Philipp; Grandgirard, Denis; Leib, Stephen (2014). Pathogenesis and Pathophysiology of Bacterial Infections. In: Scheld, Michael; Whitley, Richard J.; Marra, Christina M. (eds.) Infections of the Central Nervous System (pp. 341-364). Philadelphia, PA, USA: Lippincott Williams & Wilkins
Baranger, Kévin; Rivera, Santiago; Liechti, Fabian D; Grandgirard, Denis; Bigas, Judit; Seco, Jesús; Tarrago, Teresa; Leib, Stephen; Khrestchatisky, Michel (2014). Endogenous and synthetic MMP inhibitors in CNS physiopathology. In: Dityatev, Alexander; Wehrle-Haller, Bernhard; Pitkänen, Asla (eds.) Brain Extracellular Matrix in Health and Disease. Progress in Brain Research: Vol. 214 (pp. 313-351). Elsevier 10.1016/B978-0-444-63486-3.00014-1
