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Engelhardt, Britta (2006). Development of the Blood-Brain Interface. In: Dermietzel, Rolf; Spray, David C; Nedergaard, Maiken (eds.) Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (pp. 9-39). Weinheim: Wiley-VCH 10.1002/9783527611225.ch1
Parakkatel, Dixy; Ruprecht, Nico; von Tengg-Kobligk, Hendrik; Engelhardt, Britta; Heverhagen, Johannes (June 2024). Investigating the role of peripheral blood mononuclear cells in gadolinium deposition in the brain (Unpublished). In: Swiss Congress of Radiology 2024 (SCR'24). Geneva. June 2024.
Berve, Kristina; Michel, Julia; Tietz, Silvia; Blatti, Claudia; Ivan, Daniela; Enzmann, Gaby; Lyck, Ruth; Deutsch, Urban; Locatelli, Giuseppe; Engelhardt, Britta (2024). Junctional adhesion molecule-A deficient mice are protected from severe experimental autoimmune encephalomyelitis. European journal of immunology, 54(6), e2350761. Wiley-VCH 10.1002/eji.202350761
Fernandez-Rojo, Manuel A; Pearen, Michael A; Burgess, Anita G; Ikonomopoulou, Maria P; Hoang-Le, Diem; Genz, Berit; Saggiomo, Silvia L; Nawaratna, Sujeevi S K; Poli, Maura; Reissmann, Regina; Gobert, Geoffrey N; Deutsch, Urban; Engelhardt, Britta; Brooks, Andrew J; Jones, Alun; Arosio, Paolo; Ramm, Grant A (2024). The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation. Science signaling, 17(830) American Association for the Advancement of Science 10.1126/scisignal.ade4335
Hansen, Cathrin E; Kamermans, Alwin; Mol, Kevin; Berve, Kristina; Rodriguez-Mogeda, Carla; Fung, Wing Ka; van Het Hof, Bert; Fontijn, Ruud D; van der Pol, Susanne M A; Michalick, Laura; Kuebler, Wolfgang M; Kenkhuis, Boyd; van Roon-Mom, Willeke; Liedtke, Wolfgang; Engelhardt, Britta; Kooij, Gijs; Witte, Maarten E; de Vries, Helga E (2024). Inflammation-induced TRPV4 channels exacerbate blood-brain barrier dysfunction in multiple sclerosis. Journal of neuroinflammation, 21(72) BioMed Central 10.1186/s12974-024-03069-9
Denes, Adam; Hansen, Cathrin E; Oezorhan, Uemit; Figuerola, Sara; de Vries, Helga E; Sorokin, Lydia; Planas, Anna M; Engelhardt, Britta; Schwaninger, Markus (2024). Endothelial cells and macrophages as allies in the healthy and diseased brain. Acta neuropathologica, 147(38) Springer-Verlag 10.1007/s00401-024-02695-0
McCloskey, Molly C; Kasap, Pelin; Trempel, Michelle; Widom, Louis P; Kuebel, Julia; Chen, Kaihua; Gaborski, Thomas R; Engelhardt, Britta; McGrath, James L (2024). Use of the MicroSiM (µSiM) Barrier Tissue Platform for Modeling the Blood-Brain Barrier. Journal of visualized experiments(203) MYJoVE Corporation 10.3791/65258
Johann, Lisa; Soldati, Sasha; Müller, Kristin; Lampe, Josephine; Marini, Federico; Klein, Matthias; Schramm, Eva; Ries, Nathalie; Schelmbauer, Carsten; Palagi, Ilaria; Karram, Khalad; Assmann, Julian C; Khan, Mahtab A; Wenzel, Jan; Schmidt, Mirko Hh; Körbelin, Jakob; Schlüter, Dirk; van Loo, Geert; Bopp, Tobias; Engelhardt, Britta; ... (2023). A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS. The journal of clinical investigation, 133(24) American Society for Clinical Investigation 10.1172/JCI168314
Pietilä, Riikka; Del Gaudio, Francesca; He, Liqun; Vázquez-Liébanas, Elisa; Vanlandewijck, Michael; Muhl, Lars; Mocci, Giuseppe; Bjørnholm, Katrine D; Lindblad, Caroline; Fletcher-Sandersjöö, Alexander; Svensson, Mikael; Thelin, Eric P; Liu, Jianping; van Voorden, A Jantine; Torres, Monica; Antila, Salli; Xin, Li; Karlström, Helena; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; ... (2023). Molecular anatomy of adult mouse leptomeninges. Neuron, 111(23), 3745-3764.e7. Elsevier 10.1016/j.neuron.2023.09.002
Stüdle, Chiara; Nishihara, Hideaki; Wischnewski, Sven; Kulsvehagen, Laila; Perriot, Sylvain; Ishikawa, Hiroshi; Schroten, Horst; Frank, Stephan; Deigendesch, Nikolaus; Du Pasquier, Renaud; Schirmer, Lucas; Pröbstel, Anne-Katrin; Engelhardt, Britta (2023). SARS-CoV-2 infects epithelial cells of the blood-cerebrospinal fluid barrier rather than endothelial cells or pericytes of the blood-brain barrier. Fluids and barriers of the CNS, 20(1), p. 76. BioMed Central 10.1186/s12987-023-00479-4
Saltarin, Federico; Wegmüller, Adrian; Bejarano, Leire; Ildiz, Eco Su; Zwicky, Pascale; Vianin, Andréj; Spadin, Florentin; Soukup, Klara; Wischnewski, Vladimir; Engelhardt, Britta; Deutsch, Urban; Marques, Ines J.; Frenz, Martin; Joyce, Johanna A.; Lyck, Ruth (2023). Compromised Blood-Brain Barrier Junctions Enhance Melanoma Cell Intercalation and Extravasation. Cancers, 15(20), p. 5071. MDPI AG 10.3390/cancers15205071
Mapunda, Josephine A; Pareja, Javier; Vladymyrov, Mykhailo; Bouillet, Elisa; Hélie, Pauline; Pleskač, Petr; Barcos, Sara; Andrae, Johanna; Vestweber, Dietmar; McDonald, Donald M; Betsholtz, Christer; Deutsch, Urban; Proulx, Steven T; Engelhardt, Britta (2023). VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation. Nature communications, 14(1), p. 5837. Nature Publishing Group 10.1038/s41467-023-41580-4
Lyck, Ruth; Nishihara, Hideaki; Aydin, Sidar; Soldati, Sasha; Engelhardt, Britta (2023). Modeling Brain Vasculature Immune Interactions In Vitro. Cold Spring Harbor perspectives in medicine, 13(9), a041185. Cold Spring Harbor Laboratory Press 10.1101/cshperspect.a041185
Lazarevic, Ivana; Soldati, Sasha; Mapunda, Josephine A; Rudolph, Henriette; Rosito, Maria; de Oliveira, Alex Cardoso; Enzmann, Gaby; Nishihara, Hideaki; Ishikawa, Hiroshi; Tenenbaum, Tobias; Schroten, Horst; Engelhardt, Britta (2023). Correction to: The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis. Fluids and barriers of the CNS, 20(1), p. 55. BioMed Central 10.1186/s12987-023-00457-w
Gonzalez-Fierro, Carmen; Fonte, Coralie; Dufourd, Eloïse; Cazaentre, Vincent; Aydin, Sidar; Engelhardt, Britta; Caspi, Rachel R; Xu, Biying; Martin-Blondel, Guillaume; Spicer, Julie A; Trapani, Joseph A; Bauer, Jan; Liblau, Roland S; Bost, Chloé (2023). Effects of a Small-Molecule Perforin Inhibitor in a Mouse Model of CD8 T Cell-Mediated Neuroinflammation. Neurology: Neuroimmunology and Neuroinflammation, 10(4) Wolters Kluwer Health 10.1212/NXI.0000000000200117
Lazarevic, Ivana; Soldati, Sasha; Mapunda, Josephine A; Rudolph, Henriette; Rosito, Maria; Cardoso de Oliveira, Alex; Enzmann, Gaby; Nishihara, Hideaki; Ishikawa, Hiroshi; Tenenbaum, Tobias; Schroten, Horst; Engelhardt, Britta (2023). The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis. Fluids and barriers of the CNS, 20(1), p. 39. BioMed Central 10.1186/s12987-023-00441-4
Aydin, Sidar; Pareja, Javier; Schallenberg, Vivianne M; Klopstein, Armelle; Gruber, Thomas; Page, Nicolas; Bouillet, Elisa; Blanchard, Nicolas; Liblau, Roland; Körbelin, Jakob; Schwaninger, Markus; Johnson, Aaron J; Schenk, Mirjam; Deutsch, Urban; Merkler, Doron; Engelhardt, Britta (2023). Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown. Nature communications, 14(1), p. 3106. Nature Publishing Group 10.1038/s41467-023-38703-2
Soldati, Sasha; Bär, Alexander; Vladymyrov, Mykhailo; Glavin, Dale; McGrath, James L; Gosselet, Fabien; Nishihara, Hideaki; Goelz, Susan; Engelhardt, Britta (2023). High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro. Journal of neuroinflammation, 20(1), p. 123. BioMed Central 10.1186/s12974-023-02797-8
Matsuo, Kinya; Engelhardt, Britta; Nishihara, Hideaki (2023). Differentiation of Human Induced Pluripotent Stem Cells to Brain Microvascular Endothelial Cell-Like Cells with a Mature Immune Phenotype. Journal of visualized experiments(195) MYJoVE Corporation 10.3791/65134
Spera, Irene; Cousin, Nikola; Ries, Miriam; Kedracka, Anna; Castillo, Alina; Aleandri, Simone; Vladymyrov, Mykhailo; Mapunda, Josephine A; Engelhardt, Britta; Luciani, Paola; Detmar, Michael; Proulx, Steven T (2023). Open pathways for cerebrospinal fluid outflow at the cribriform plate along the olfactory nerves. EBioMedicine, 91(104558), p. 104558. Elsevier 10.1016/j.ebiom.2023.104558
Li, Zhilin; Antila, Salli; Nurmi, Harri; Chilov, Dmitri; Korhonen, Emilia A; Fang, Shentong; Karaman, Sinem; Engelhardt, Britta; Alitalo, Kari (2023). Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation. Science immunology, 8(82), eabq0375. American Association for the Advancement of Science 10.1126/sciimmunol.abq0375
C Ivan, Daniela; Berve, Kristina Carolin; Walthert, Sabrina; Monaco, Gianni; Borst, Katharina; Bouillet, Elisa; Ferreira, Filipa; Lee, Henry; Steudler, Jasmin; Buch, Thorsten; Prinz, Marco; Engelhardt, Britta; Locatelli, Giuseppe (2023). Insulin-like growth factor-1 receptor controls the function of CNS-resident macrophages and their contribution to neuroinflammation. Acta neuropathologica communications, 11(1), p. 35. 10.1186/s40478-023-01535-8
Proulx, Steven T; Engelhardt, Britta (2023). Macrophages clear the way for CNS fluid flow. The lancet. Neurology, 22(3), pp. 194-195. Elsevier 10.1016/S1474-4422(23)00028-5
van Os, Lisette; Engelhardt, Britta; Guenat, Olivier T. (2023). Integration of immune cells in organs-on-chips: a tutorial. Frontiers in Bioengineering and Biotechnology, 11, p. 1191104. Frontiers Media 10.3389/fbioe.2023.1191104
Nishihara, Hideaki; Perriot, Sylvain; Gastfriend, Benjamin D; Steinfort, Marel; Cibien, Celine; Soldati, Sasha; Matsuo, Kinya; Guimbal, Sarah; Mathias, Amandine; Palecek, Sean P; Shusta, Eric V; Du Pasquier, Renaud; Engelhardt, Britta (2022). Intrinsic blood-brain barrier dysfunction contributes to multiple sclerosis pathogenesis. Brain : a journal of neurology, 145(12), pp. 4334-4348. Oxford University Press 10.1093/brain/awac019
Bagatella, Stefano; Haghayegh Jahromi, Neda; Monney, Camille; Polidori, Margherita; Gall, Flavio Max; Marchionatti, Emma; Serra, Fabienne; Riedl, Rainer; Engelhardt, Britta; Oevermann, Anna (2022). Bovine neutrophil chemotaxis to Listeria monocytogenes in neurolisteriosis depends on microglia-released rather than bacterial factors. Journal of neuroinflammation, 19(1), p. 304. BioMed Central 10.1186/s12974-022-02653-1
Ineichen, Benjamin V; Okar, Serhat V; Proulx, Steven T; Engelhardt, Britta; Lassmann, Hans; Reich, Daniel S (2022). Perivascular spaces and their role in neuroinflammation. Neuron, 110(21), pp. 3566-3581. Cell Press 10.1016/j.neuron.2022.10.024
Steudler, Jasmin; Ecott, Timothy; Ivan, Daniela C; Bouillet, Elisa; Walthert, Sabrina; Berve, Kristina; Dick, Tobias P; Engelhardt, Britta; Locatelli, Giuseppe (2022). Autoimmune neuroinflammation triggers mitochondrial oxidation in oligodendrocytes. GLIA, 70(11), pp. 2045-2061. Wiley-Blackwell 10.1002/glia.24235
Carare, Roxana O; Engelhardt, Britta; Perry, Victor Hugh; Kalaria, Raj (2022). In memoriam, Roy Weller (1938-2022). Acta neuropathologica, 144(5), pp. 803-806. Springer-Verlag 10.1007/s00401-022-02502-8
Kemble, Alicia M; Hornsperger, Benoit; Ruf, Iris; Richter, Hans; Benz, Jörg; Kuhn, Bernd; Heer, Dominik; Wittwer, Matthias; Engelhardt, Britta; Grether, Uwe; Collin, Ludovic (2022). A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature. PLoS ONE, 17(9), e0268590. Public Library of Science 10.1371/journal.pone.0268590
Lorusso, Girieca; Wyss, Christof B; Kuonen, François; Vannini, Nicola; Billottet, Clotilde; Duffey, Nathalie; Pineau, Raphael; Lan, Qiang; Wirapati, Pratyaksha; Barras, David; Tancredi, Alessandro; Lyck, Ruth; Lehr, Hans-Anton; Engelhardt, Britta; Delorenzi, Mauro; Bikfalvi, Andreas; Rüegg, Curzio (2022). Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation. Science translational medicine, 14(661), eaax8933. American Association for the Advancement of Science 10.1126/scitranslmed.aax8933
McCloskey, Molly C; Kasap, Pelin; Ahmad, S Danial; Su, Shiuan-Haur; Chen, Kaihua; Mansouri, Mehran; Ramesh, Natalie; Nishihara, Hideaki; Belyaev, Yury; Abhyankar, Vinay V; Begolo, Stefano; Singer, Benjamin H; Webb, Kevin F; Kurabayashi, Katsuo; Flax, Jonathan; Waugh, Richard E; Engelhardt, Britta; McGrath, James L (2022). The Modular μSiM: a Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro. Advanced healthcare materials, 11(18), e2200804. Wiley 10.1002/adhm.202200804
Proulx, Steven T.; Engelhardt, Britta (2022). Central nervous system zoning: How brain barriers establish subdivisions for CNS immune privilege and immune surveillance. Journal of internal medicine, 292(1), pp. 47-67. Wiley 10.1111/joim.13469
Cousins, Oliver; Hodges, Angela; Schubert, Julia; Veronese, Mattia; Turkheimer, Federico; Miyan, Jaleel; Engelhardt, Britta; Roncaroli, Federico (2022). The Blood-CSF-Brain Route of Neurological Disease: The Indirect Pathway into the Brain. Neuropathology and applied neurobiology, 48(4), e12789. Wiley 10.1111/nan.12789
Engelhardt, Britta; Comabella, Manuel; Chan, Andrew (2022). Multiple Sclerosis: Immunopathological heterogeneity and its implications. European journal of immunology, 52(6), pp. 869-881. Wiley-VCH 10.1002/eji.202149757
Holder, Brianna M; Tolan, Shaina E; Heinrich, Kaleb K; Miller, Kaitlin C; Hudson, Natalie; Nehra, Geetika; Pizzo, Michelle E; Storck, Steffen E; Elmquist, William F; Engelhardt, Britta; Loryan, Irena; Toborek, Michal; Bauer, Bjoern; Hartz, Anika M S; Kim, Brandon J (2022). Brain barriers virtual: an interim solution or future opportunity? Fluids and barriers of the CNS, 19(1), p. 19. BioMed Central 10.1186/s12987-022-00314-2
Mapunda, Josephine A; Tibar, Houyam; Regragui, Wafa; Engelhardt, Britta (2022). How Does the Immune System Enter the Brain? Frontiers in immunology, 13(805657), p. 805657. Frontiers Research Foundation 10.3389/fimmu.2022.805657
Martinez-Salazar, Maria; Holwerda, Melle; Stüdle, Chiara; Piragyte, Indre; Mercader, Nadia; Engelhardt, Britta; Rieben, Robert; Döring, Yvonne (2022). COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences. Frontiers in cell and developmental biology, 10, p. 824851. Frontiers 10.3389/fcell.2022.824851
Marchetti, Luca; Francisco, David; Soldati, Sasha; Haghayegh Jahromi, Neda; Barcos, Sara; Gruber, Isabelle; Pareja R., Javier; Thiriot, Aude; von Andrian, Ulrich; Deutsch, Urban; Lyck, Ruth; Bruggmann, Rémy; Engelhardt, Britta (2022). ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro. European journal of immunology, 52(1), pp. 161-177. Wiley 10.1002/eji.202149238
Nishihara, Hideaki; Engelhardt, Britta (2022). Brain Barriers and Multiple Sclerosis: Novel Treatment Approaches from a Brain Barriers Perspective. Handbook of experimental pharmacology, 273, pp. 295-329. Springer 10.1007/164_2020_407
Galoppin, Manon; Kari, Saniya; Soldati, Sasha; Pal, Arindam; Rival, Manon; Engelhardt, Britta; Astier, Anne; Thouvenot, Eric (2022). Full spectrum of vitamin D immunomodulation in multiple sclerosis: mechanisms and therapeutic implications. Brain Communications, 4(4), fcac171. Oxford University Press 10.1093/braincomms/fcac171
Gastfriend, Benjamin D; Nishihara, Hideaki; Canfield, Scott G; Foreman, Koji L; Engelhardt, Britta; Palecek, Sean P; Shusta, Eric V (2021). Wnt signaling mediates acquisition of blood-brain barrier properties in naïve endothelium derived from human pluripotent stem cells. eLife, 10 eLife Sciences Publications 10.7554/eLife.70992
Thomsen, Tanja; Reissmann, Regina; Kaba, Elisa; Engelhardt, Britta; Klok, Harm-Anton (2021). Covalent and Noncovalent Conjugation of Degradable Polymer Nanoparticles to T Lymphocytes. Biomacromolecules, 22(8), pp. 3416-3430. American Chemical Society 10.1021/acs.biomac.1c00488
Engelhardt, Britta (2021). Private immune protection at the border of the central nervous system. Nature, 596(7870), pp. 38-40. Springer Nature 10.1038/d41586-021-01962-4
Nishihara, Hideaki; Gastfriend, Benjamin D; Kasap, Pelin; Palecek, Sean P; Shusta, Eric V; Engelhardt, Britta (2021). Differentiation of human pluripotent stem cells to brain microvascular endothelial cell-like cells suitable to study immune cell interactions. STAR protocols, 2(2), p. 100563. Elsevier 10.1016/j.xpro.2021.100563
Derada Troletti, Claudio; Enzmann, Gaby; Chiurchiù, Valerio; Kamermans, Alwin; Tietz, Silvia Martina; Norris, Paul C; Haghayegh Jahromi, Neda; Leuti, Alessandro; van der Pol, Susanne M A; Schouten, Marijn; Serhan, Charles N; de Vries, Helga E; Engelhardt, Britta; Kooij, Gijs (2021). Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome. Cell reports, 35(9), p. 109201. Cell Press 10.1016/j.celrep.2021.109201
Hamminger, Patricia; Marchetti, Luca; Preglej, Teresa; Platzer, René; Zhu, Ci; Kamnev, Anton; Rica, Ramona; Stolz, Valentina; Sandner, Lisa; Alteneder, Marlis; Kaba, Elisa; Waltenberger, Darina; Huppa, Johannes B; Trauner, Michael; Bock, Christoph; Lyck, Ruth; Bauer, Jan; Dupré, Loïc; Seiser, Christian; Boucheron, Nicole; ... (2021). Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases. Journal of autoimmunity, 119, p. 102610. Elsevier 10.1016/j.jaut.2021.102610
Baier, Felix Alexander; Sánchez-Taltavull, Daniel; Yarahmadov, Tural; Castellà, Cristina Gómez; Jebbawi, Fadi; Keogh, Adrian; Tombolini, Riccardo; Odriozola, Adolfo; Castro Dias, Mariana; Deutsch, Urban; Furuse, Mikio; Engelhardt, Britta; Zuber, Benoît; Odermatt, Alex; Candinas, Daniel; Keogh-Stroka, Deborah M. (2021). Loss of claudin-3 impairs hepatic metabolism, biliary barrier function and cell proliferation in the murine liver. Cellular and molecular gastroenterology and hepatology, 12(2), pp. 745-767. Elsevier 10.1016/j.jcmgh.2021.04.003
Reynoso-Moreno, Ines; Tietz, Silvia; Vallini, Erika; Engelhardt, Britta; Gertsch, Jürg; Chicca, Andrea (2021). Selective Endocannabinoid Reuptake Inhibitor WOBE437 Reduces Disease Progression in a Mouse Model of Multiple Sclerosis. ACS pharmacology & translational science, 4(2), pp. 765-779. ACS Publications 10.1021/acsptsci.0c00214
Ayer, Maxime; Burri, Olivier; Guiet, Romain; Seitz, Arne; Kaba, Elisa; Engelhardt, Britta; Klok, Harm-Anton (2021). Biotin-NeutrAvidin Mediated Immobilization of Polymer Micro- and Nanoparticles on T Lymphocytes. Bioconjugate chemistry, 32(3), pp. 541-552. American Chemical Society 10.1021/acs.bioconjchem.1c00026
Imeri, Faik; Stepanovska Tanturovska, Bisera; Zivkovic, Aleksandra; Enzmann, Gaby; Schwalm, Stephanie; Pfeilschifter, Josef; Homann, Thomas; Kleuser, Burkhard; Engelhardt, Britta; Stark, Holger; Huwiler, Andrea (2021). Novel compounds with dual S1P receptor agonist and histamine H3 receptor antagonist activities act protective in a mouse model of multiple sclerosis. Neuropharmacology, 186, p. 108464. Elsevier 10.1016/j.neuropharm.2021.108464
Ayer, Maxime; Schuster, Markus; Gruber, Isabelle; Blatti, Claudia; Kaba, Elisa; Enzmann, Gaby; Burri, Olivier; Guiet, Romain; Seitz, Arne; Engelhardt, Britta; Klok, Harm-Anton (2021). T Cell-Mediated Transport of Polymer Nanoparticles across the Blood-Brain Barrier. Advanced healthcare materials, 10(2), e2001375. Wiley 10.1002/adhm.202001375
Castro Dias, Mariana; Odriozola Quesada, Adolfo; Soldati, Sasha; Bösch, Fabio; Gruber, Isabelle; Hildbrand, Tobias; Sönmez, Derya; Khire, Tejas; Witz, Guillaume; McGrath, James L.; Piontek, Jörg; Kondoh, Masuo; Deutsch, Urban; Zuber, Benoît; Engelhardt, Britta (2021). Brain endothelial tricellular junctions as novel sites for T cell diapedesis across the blood–brain barrier. Journal of cell science, 134(8) Company of Biologists Limited 10.1242/jcs.253880
Sasson, Esther; Anzi, Shira; Bell, Batia; Yakovian, Oren; Zorsky, Meshi; Deutsch, Urban; Engelhardt, Britta; Sherman, Eilon; Vatine, Gad; Dzikowski, Ron; Ben-Zvi, Ayal (2021). Nano-scale architecture of blood-brain barrier tight-junctions. eLife, 10 eLife Sciences Publications 10.7554/eLife.63253
Nishihara, Hideaki; Gastfriend, Benjamin D; Soldati, Sasha; Perriot, Sylvain; Mathias, Amandine; Sano, Yasuteru; Shimizu, Fumitaka; Gosselet, Fabien; Kanda, Takashi; Palecek, Sean P; Du Pasquier, Renaud; Shusta, Eric V; Engelhardt, Britta (2020). Advancing human induced pluripotent stem cell-derived blood-brain barrier models for studying immune cell interactions. FASEB journal, 34(12), pp. 16693-16715. Federation of American Societies for Experimental Biology 10.1096/fj.202001507RR
Locatelli, Giuseppe; Engelhardt, Britta (2020). Microglia Get a Little Help from "Th"-eir Friends. Immunity, 53(3), pp. 484-486. Cell Press 10.1016/j.immuni.2020.08.011
Stepanovska, Bisera; Zivkovic, Aleksandra; Enzmann, Gaby; Tietz, Silvia; Homann, Thomas; Kleuser, Burkhard; Engelhardt, Britta; Stark, Holger; Huwiler, Andrea (2020). Morpholino Analogues of Fingolimod as Novel and Selective S1P1 Ligands with In Vivo Efficacy in a Mouse Model of Experimental Antigen-Induced Encephalomyelitis. International journal of molecular sciences, 21(18), pp. 1-17. MDPI 10.3390/ijms21186463
Francisco, David M F; Marchetti, Luca; Rodríguez-Lorenzo, Sabela; Frías-Anaya, Eduardo; Figueiredo, Ricardo M; Winter, Peter; Romero, Ignacio Andres; de Vries, Helga E; Engelhardt, Britta; Bruggmann, Rémy (2020). Advancing brain barriers RNA sequencing: guidelines from experimental design to publication. Fluids and barriers of the CNS, 17(1), p. 51. BioMed Central 10.1186/s12987-020-00207-2
Heymans, Marjolein; Figueiredo, Ricardo; Dehouck, Lucie; Francisco, David; Sano, Yasuteru; Shimizu, Fumitaka; Kanda, Takashi; Bruggmann, Rémy; Engelhardt, Britta; Winter, Peter; Gosselet, Fabien; Culot, Maxime (2020). Contribution of brain pericytes in blood-brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells. Fluids and barriers of the CNS, 17(1), p. 48. BioMed Central 10.1186/s12987-020-00208-1
Bruggisser, Julia; Tarek, Basma; Wyder, Marianne; Müller, Philipp; von Ballmoos, Christoph; Witz, Guillaume; Enzmann, Gaby; Deutsch, Urban; Engelhardt, Britta; Posthaus, Horst (2020). CD31 (PECAM-1) Serves as the Endothelial Cell-Specific Receptor of Clostridium perfringens β-Toxin. Cell host & microbe, 28(1), pp. 69-78. Cell Press 10.1016/j.chom.2020.05.003
Hahn, Julia; Günter, Manina; Schuhmacher, Juliane; Bieber, Kristin; Pöschel, Simone; Schütz, Monika; Engelhardt, Britta; Oster, Henrik; Sina, Christian; Lange, Tanja; Autenrieth, Stella E (2020). Sleep enhances numbers and function of monocytes and improves bacterial infection outcome in mice. Brain, behavior, and immunity, 87, pp. 329-338. Elsevier 10.1016/j.bbi.2020.01.001
Li, Zhilin; Korhonen, Emilia A; Merlini, Arianna; Strauss, Judith; Wihuri, Eleonoora; Nurmi, Harri; Antila, Salli; Paech, Jennifer; Deutsch, Urban; Engelhardt, Britta; Chintharlapalli, Sudhakar; Koh, Gou Young; Flügel, Alexander; Alitalo, Kari (2020). Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS. The journal of clinical investigation, 130(4), pp. 1977-1990. American Society for Clinical Investigation 10.1172/JCI130308
Marchetti, Luca; Engelhardt, Britta (2020). Immune cell trafficking across the blood-brain barrier in the absence and presence of neuroinflammation. Vascular biology (Bristol, England), 2(1), H1-H18. 10.1530/VB-19-0033
Nishihara, Hideaki; Soldati, Sasha; Mossu, Adrien; Rosito, Maria; Rudolph, Henriette; Muller, William A; Latorre, Daniela; Sallusto, Federica; Sospedra, Mireia; Martin, Roland; Ishikawa, Hiroshi; Tenenbaum, Tobias; Schroten, Horst; Gosselet, Fabien; Engelhardt, Britta (2020). Human CD4+ T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro. Fluids and barriers of the CNS, 17(1), p. 3. BioMed Central 10.1186/s12987-019-0165-2
Haghayegh Jahromi, Neda; Marchetti, Luca; Moalli, Federica; Duc, Donovan; Basso, Camilla; Tardent, Heidi; Kaba, Elisa; Deutsch, Urban; Pot, Caroline; Sallusto, Federica; Stein, Jens V.; Engelhardt, Britta (2020). Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis. Frontiers in immunology, 10(3056), p. 3056. Frontiers Research Foundation 10.3389/fimmu.2019.03056
Thiele née Schrewe, Lisa; Guse, Kirsten; Tietz, Silvia; Remlinger, Jana; Demir, Seray; Pedreiturria, Xiomara; Hoepner, Robert; Salmen, Anke; Pistor, Maximilian; Turner, Timothy; Engelhardt, Britta; Hermann, Dirk M; Lühder, Fred; Wiese, Stefan; Chan, Andrew (2020). Functional relevance of the multi-drug transporter abcg2 on teriflunomide therapy in an animal model of multiple sclerosis. Journal of neuroinflammation, 17(1), p. 9. BioMed Central 10.1186/s12974-019-1677-z
Hlushchuk, Ruslan; Haberthür, David; Soukup, Petr; Barré, Sebastien F.; Khoma, Oleksiy-Zakhar; Schittny, Johannes; Haghayegh Jahromi, Neda; Bouchet, Audrey; Engelhardt, Britta; Djonov, Valentin Georgiev (2020). Innovative high-resolution microCT imaging of animal brain vasculature. Brain structure & function, 225(9), pp. 2885-2895. Springer 10.1007/s00429-020-02158-8
Gericke, Christoph; Mallone, Anna; Engelhardt, Britta; Nitsch, Roger M; Ferretti, Maria Teresa (2020). Oligomeric Forms of Human Amyloid-Beta(1-42) Inhibit Antigen Presentation. Frontiers in immunology, 11, p. 1029. Frontiers Research Foundation 10.3389/fimmu.2020.01029
Van Laethem, François; Saba, Ingrid; Lu, Jinghua; Bhattacharya, Abhisek; Tai, Xuguang; Guinter, Terry I; Engelhardt, Britta; Alag, Amala; Rojano, Mirelle; Ashe, Jennifer M; Hanada, Ken-Ichi; Yang, James C; Sun, Peter D; Singer, Alfred (2020). Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus. Frontiers in immunology, 11, p. 1216. Frontiers Research Foundation 10.3389/fimmu.2020.01216
Vladymyrov, Mykhailo; Haghayegh Jahromi, Neda; Kaba, Elisa; Engelhardt, Britta; Ariga, Akitaka (2020). VivoFollow 2: Distortion-Free Multiphoton Intravital Imaging. Frontiers in physics, 7 Frontiers Media 10.3389/fphy.2019.00222
Engelhardt, Britta (2020). Maternal Infection Impairs Fetal Brain Development via Choroid Plexus Inflammation. Developmental cell, 55(5), pp. 519-521. Cell Press 10.1016/j.devcel.2020.11.011
Garnier, Arnaud; Laffont, Sophie; Garnier, Laure; Kaba, Elisa; Deutsch, Urban; Engelhardt, Britta; Guéry, Jean-Charles (2019). CD49d/CD29-integrin controls the accumulation of plasmacytoid dendritic cells into the CNS during neuroinflammation. European journal of immunology, 49(11), pp. 2030-2043. Wiley-VCH 10.1002/eji.201948086
Castro Dias, Mariana; Mapunda, Josephine A.; Vladymyrov, Mykhailo; Engelhardt, Britta (2019). Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers. International journal of molecular sciences, 20(21) MDPI 10.3390/ijms20215372
Cossarizza, Andrea; Chang, Hyun-Dong; Radbruch, Andreas; Acs, Andreas; Adam, Dieter; Adam-Klages, Sabine; Agace, William W; Aghaeepour, Nima; Akdis, Mübeccel; Allez, Matthieu; Almeida, Larissa Nogueira; Alvisi, Giorgia; Anderson, Graham; Andrä, Immanuel; Annunziato, Francesco; Anselmo, Achille; Bacher, Petra; Baldari, Cosima T; Bari, Sudipto; Barnaba, Vincenzo; ... (2019). Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). European journal of immunology, 49(10), pp. 1457-1973. Wiley-VCH 10.1002/eji.201970107
Castro Dias, Mariana; Coisne, Caroline; Baden, Pascale; Enzmann, Gaby; Garrett, Lillian; Becker, Lore; Hölter, Sabine M; Hrabě de Angelis, Martin; Deutsch, Urban; Engelhardt, Britta (2019). Claudin-12 is not required for blood-brain barrier tight junction function. Fluids and barriers of the CNS, 16(1), p. 30. BioMed Central 10.1186/s12987-019-0150-9
Castro Dias, Mariana; Coisne, Caroline; Lazarevic, Ivana; Baden, Pascale; Hata, Masaki; Iwamoto, Noriko; Ferreira Francisco, David Miguel; Vanlandewijck, Michael; He, Liqun; Baier, Felix A.; Stroka, Deborah; Bruggmann, Rémy; Lyck, Ruth; Enzmann, Gaby; Deutsch, Urban; Betsholtz, Christer; Furuse, Mikio; Tsukita, Shoichiro; Engelhardt, Britta (2019). Publisher Correction: Claudin-3-deficient C57BL/6J mice display intact brain barriers. Scientific reports, 9(1), p. 10702. Springer Nature 10.1038/s41598-019-43511-0
Tietz, Silvia; Engelhardt, Britta (2019). Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo. Journal of visualized experiments(145) MYJoVE Corporation 10.3791/59249
Enzmann, Gaby; Adelfio, Roberto; Godel, Aurélie; Haghayegh Jahromi, Neda; Tietz, Silvia; Burgener, Sabrina S.; Deutsch, Urban; Wekerle, Hartmut; Benarafa, Charaf; Engelhardt, Britta (2019). The Genetic Background of Mice Influences the Effects of Cigarette Smoke on Onset and Severity of Experimental Autoimmune Encephalomyelitis. International journal of molecular sciences, 20(6) MDPI 10.3390/ijms20061433
Mota Castro Dias, Mariana; Coisne, Caroline Marie; Lazarevic, Ivana; Baden, Pascale; Hata, Masaki; Iwamoto, Noriko; Francisco, David Miguel Ferreira; Vanlandewijck, Michael; He, Liqun; Baier, Felix Alexander; Keogh-Stroka, Deborah M.; Bruggmann, Rémy; Lyck, Ruth; Enzmann, Gaby; Deutsch, Urban; Betsholtz, Christer; Furuse, Mikio; Tsukita, Shoichiro; Engelhardt, Britta (2019). Claudin-3-deficient C57BL/6J mice display intact brain barriers. Scientific Reports, 9(1), p. 203. Nature Publishing Group 10.1038/s41598-018-36731-3
Mossu, Adrien; Rosito, Maria; Khire, Tejas; Li Chung, Hung; Nishihara, Hideaki; Gruber, Isabelle; Luke, Emma; Dehouck, Lucie; Sallusto, Federica; Gosselet, Fabien; McGrath, James L; Engelhardt, Britta (2019). A silicon nanomembrane platform for the visualization of immune cell trafficking across the human blood-brain barrier under flow. Journal of cerebral blood flow and metabolism, 39(3), pp. 395-410. Sage 10.1177/0271678X18820584
Wimmer, Isabella; Tietz, Silvia; Nishihara, Hideaki; Deutsch, Urban; Sallusto, Federica; Gosselet, Fabien; Lyck, Ruth; Muller, William A; Lassmann, Hans; Engelhardt, Britta (2019). PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation. Frontiers in immunology, 10, p. 711. Frontiers Research Foundation 10.3389/fimmu.2019.00711
Enzmann, Gaby; Pavlidou, Sofia; Vaas, Markus; Klohs, Jan; Engelhardt, Britta (2018). ICAM-1 C57BL/6 Mice Are Not Protected from Experimental Ischemic Stroke. Translational stroke research, 9(6), pp. 608-621. Springer 10.1007/s12975-018-0612-4
Evangelopoulos, Maria Eleftheria; Miclea, Andrei; Schrewe, Lisa; Briner, Myriam; Salmen, Anke; Engelhardt, Britta; Huwiler, Andrea; Chan, Andrew; Hoepner, Robert (2018). Frequency and clinical characteristics of Multiple Sclerosis rebounds after withdrawal of Fingolimod. CNS neuroscience & therapeutics, 24(10), pp. 984-986. Wiley 10.1111/cns.12992
Tietz, Silvia; Périnat, Therese; Greene, Gretchen Thompson; Enzmann, Gaby; Deutsch, Urban; Adams, Ralf; Imhof, Beat; Aurrand-Lions, Michel; Engelhardt, Britta (2018). Lack of junctional adhesion molecule (JAM)-B ameliorates experimental autoimmune encephalomyelitis. Brain, behavior, and immunity, 73, pp. 3-20. Elsevier 10.1016/j.bbi.2018.06.014
Roth, Stefan; Singh, Vikramjeet; Tiedt, Steffen; Schindler, Lisa; Huber, Georg; Geerlof, Arie; Antoine, Daniel J; Anfray, Antoine; Orset, Cyrille; Gauberti, Maxime; Fournier, Antoine; Holdt, Lesca M; Harris, Helena Erlandsson; Engelhardt, Britta; Bianchi, Marco E; Vivien, Denis; Haffner, Christof; Bernhagen, Jürgen; Dichgans, Martin and Liesz, Arthur (2018). Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke. Science translational medicine, 10(432) American Association for the Advancement of Science 10.1126/scitranslmed.aao1313
Engelhardt, Britta (2018). Cluster: barriers of the central nervous system. Acta neuropathologica, 135(3), pp. 307-310. Springer-Verlag 10.1007/s00401-018-1816-0
Ghersi-Egea, Jean-François; Strazielle, Nathalie; Catala, Martin; Silva-Vargas, Violeta; Doetsch, Fiona; Engelhardt, Britta (2018). Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease. Acta neuropathologica, 135(3), pp. 337-361. Springer-Verlag 10.1007/s00401-018-1807-1
Uster, Stephanie Sarah; Matos Coelho, Fernanda; Aeberli, Daniel; Stein, Jens Volker; Hofstetter, Wilhelm; Engelhardt, Britta; Seitz, Michael (2018). TNFα blockade mediates bone protection in antigen-induced arthritis by reducing osteoclast precursor supply. Bone, 107, pp. 56-65. Elsevier 10.1016/j.bone.2017.10.020
Enzmann, Gaby; Kargaran, Soghra; Engelhardt, Britta (2018). Ischemia-reperfusion injury in stroke: impact of the brain barriers and brain immune privilege on neutrophil function. Therapeutic advances in neurological disorders, 11, p. 1756286418794184. Sage 10.1177/1756286418794184
Llovera, Gemma; Benakis, Corinne; Enzmann, Gaby; Cai, Ruiyao; Arzberger, Thomas; Ghasemigharagoz, Alireza; Mao, Xiang; Malik, Rainer; Lazarevic, Ivana; Liebscher, Sabine; Ertürk, Ali; Meissner, Lilja; Vivien, Denis; Haffner, Christof; Plesnila, Nikolaus; Montaner, Joan; Engelhardt, Britta; Liesz, Arthur (2017). The choroid plexus is a key cerebral invasion route for T cells after stroke. Acta neuropathologica, 134(6), pp. 851-868. Springer 10.1007/s00401-017-1758-y
Zaretsky, Irina; Atrakchi, Ofir; Mazor, Roei D; Stoler-Barak, Liat; Biram, Adi; Feigelson, Sara W; Gitlin, Alexander D; Engelhardt, Britta; Shulman, Ziv (2017). ICAMs support B cell interactions with T follicular helper cells and promote clonal selection. The Journal of experimental medicine, 214(11), pp. 3435-3448. Rockefeller Univ. Press 10.1084/jem.20171129
Mathias, Amandine; Perriot, Sylvain; Canales, Mathieu; Blatti, Claudia; Gaubicher, Coline; Schluep, Myriam; Engelhardt, Britta; Du Pasquier, Renaud (2017). Impaired T-cell migration to the CNS under fingolimod and dimethyl fumarate. Neurology: Neuroimmunology and Neuroinflammation, 4(6), e401. Wolters Kluwer Health 10.1212/NXI.0000000000000401
Daneman, Richard; Engelhardt, Britta (2017). Brain barriers in health and disease. Neurobiology of disease, 107, pp. 1-3. Elsevier 10.1016/j.nbd.2017.05.008
Vaas, Markus; Enzmann, Gaby; Périnat, Therese; Siler, Ulrich; Reichenbach, Janine; Licha, Kai; Kipar, Anja; Rudin, Markus; Engelhardt, Britta; Klohs, Jan (2017). Non-invasive near-infrared fluorescence imaging of the neutrophil response in a mouse model of transient cerebral ischaemia. Journal of cerebral blood flow and metabolism, 37(8), pp. 2833-2847. Nature Publishing Group 10.1177/0271678X16676825
Lyck, Ruth; Lécuyer, Marc-André; Abadier, Michael Magdy Labib; Wyss, Christof B.; Matti, Christoph; Rosito, Maria; Enzmann, Gaby; Zeis, Thomas; Michel, Laure; García Martín, Ana B; Sallusto, Federica; Gosselet, Fabien; Deutsch, Urban; Weiner, Joshua A.; Schaeren-Wiemers, Nicole; Prat, Alexandres; Engelhardt, Britta (2017). ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood–brain barrier. Journal of cerebral blood flow and metabolism, 37(8), pp. 2894-2909. Nature Publishing Group 10.1177/0271678X16678639
Atangana, Etienne; Schneider, Ulf C; Blecharz, Kinga; Magrini, Salima; Wagner, Josephin; Nieminen-Kelhä, Melina; Kremenetskaia, Irina; Heppner, Frank L; Engelhardt, Britta; Vajkoczy, Peter (2017). Intravascular Inflammation Triggers Intracerebral Activated Microglia and Contributes to Secondary Brain Injury After Experimental Subarachnoid Hemorrhage (eSAH). Translational stroke research, 8(2), pp. 144-156. Springer 10.1007/s12975-016-0485-3
Engelhardt, Britta; Vajkoczy, Peter; Weller, Roy O (2017). The movers and shapers in immune privilege of the CNS. Nature immunology, 18(2), pp. 123-131. Nature Publishing Group 10.1038/ni.3666
Lécuyer, Marc-André; Saint-Laurent, Olivia; Bourbonnière, Lyne; Larouche, Sandra; Larochelle, Catherine; Michel, Laure; Charabati, Marc; Abadier, Michael Magdy Labib; Zandee, Stephanie; Haghayegh Jahromi, Neda; Gowing, Elizabeth; Pittet, Camille; Lyck, Ruth; Engelhardt, Britta; Prat, Alexandre (2017). Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 114(4), E524-E533. National Academy of Sciences NAS 10.1073/pnas.1614336114
Haghayegh Jahromi, Neda; Tardent, Heidi; Enzmann, Gaby; Deutsch, Urban; Kawakami, Naoto; Bittner, Stefan; Vestweber, Dietmar; Zipp, Frauke; Stein, Jens Volker; Engelhardt, Britta (2017). A Novel Cervical Spinal Cord Window Preparation Allows for Two-Photon Imaging of T-Cell Interactions with the Cervical Spinal Cord Microvasculature during Experimental Autoimmune Encephalomyelitis. Frontiers in immunology, 8, p. 406. 10.3389/fimmu.2017.00406
Pavlicek, David; Krebs, Jörg; Capossela, Simona; Bertolo, Alessandro; Engelhardt, Britta; Pannek, Jürgen; Stoyanov, Jivko (2017). Immunosenescence in persons with spinal cord injury in relation to urinary tract infections -a cross-sectional study. Immunity & ageing, 14(22), p. 22. BioMed Central 10.1186/s12979-017-0103-6
Cossarizza, Andrea; Chang, Hyun-Dong; Radbruch, Andreas; Akdis, Mübeccel; Andrä, Immanuel; Annunziato, Francesco; Bacher, Petra; Barnaba, Vincenzo; Battistini, Luca; Bauer, Wolfgang M; Baumgart, Sabine; Becher, Burkhard; Beisker, Wolfgang; Berek, Claudia; Blanco, Alfonso; Borsellino, Giovanna; Boulais, Philip E; Brinkman, Ryan R; Büscher, Martin; Busch, Dirk H; ... (2017). Guidelines for the use of flow cytometry and cell sorting in immunological studies. European journal of immunology, 47(10), pp. 1584-1797. Wiley-VCH 10.1002/eji.201646632
Tietz, Silvia; Zwahlen, Marcel; Haghayegh Jahromi, Neda; Baden, Pascale; Lazarevic, Ivana; Enzmann, Gaby; Engelhardt, Britta (2016). Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences. European journal of immunology, 46(10), pp. 2481-2483. Wiley-VCH 10.1002/eji.201546272
Engelhardt, Britta; Carare, Roxana O; Bechmann, Ingo; Flügel, Alexander; Laman, Jon D; Weller, Roy O (2016). Vascular, glial, and lymphatic immune gateways of the central nervous system. Acta neuropathologica, 132(3), pp. 317-338. Springer 10.1007/s00401-016-1606-5
Martin, Roland; Sospedra, Mireia; Rosito, Maria; Engelhardt, Britta (2016). Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis. European journal of immunology, 46(9), pp. 2078-2090. Wiley-VCH 10.1002/eji.201646485
Rudolph, Henriette; Klopstein, Armelle; Gruber, Isabelle Manuela; Blatti, Claudia; Lyck, Ruth; Engelhardt, Britta (2016). Postarrest stalling rather than crawling favors CD8(+) over CD4(+) T-cell migration across the blood-brain barrier under flow in vitro. European journal of immunology, 46(9), pp. 2187-2203. Wiley-VCH 10.1002/eji.201546251
Fan, Zhichao; McArdle, Sara; Marki, Alex; Mikulski, Zbigniew; Gutierrez, Edgar; Engelhardt, Britta; Deutsch, Urban; Ginsberg, Mark; Groisman, Alex; Ley, Klaus (2016). Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis. Nature communications, 7, p. 12658. Nature Publishing Group 10.1038/ncomms12658
Petrovich, Ekaterina; Feigelson, Sara W; Stoler-Barak, Liat; Hatzav, Miki; Solomon, Adam; Bar-Shai, Amir; Ilan, Neta; Li, Jin-Ping; Engelhardt, Britta; Vlodavsky, Israel; Alon, Ronen (2016). Lung ICAM-1 and ICAM-2 support spontaneous intravascular effector lymphocyte entrapment but are not required for neutrophil entrapment or emigration inside endotoxin-inflamed lungs. FASEB journal, 30(5), pp. 1767-1778. Federation of American Societies for Experimental Biology 10.1096/fj.201500046
Feretti, MT; Merlini, M; Späni, C; Gericke, C; Schweizer, N; Enzmann, Gaby; Engelhardt, Britta; Kulic, L; Suter, T; Nitsch, RM (2016). T-cell brain infiltration and immature antigen-presenting cells in transgenic models of Alzheimer’s disease-like cerebral amyloidosis. Brain, behavior, and immunity, 54, pp. 211-225. Elsevier 10.1016/j.bbi.2016.02.009
Imeri, Faik; Schwalm, Stephanie; Lyck, Ruth; Zivkovic, Aleksandra; Stark, Holger; Engelhardt, Britta; Pfeilschifter, Josef; Huwiler, Andrea (2016). Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments. Neuropharmacology, 105, pp. 341-350. Elsevier 10.1016/j.neuropharm.2016.01.031
Mundt, Sarah; Engelhardt, Britta; Kirk, Christopher J; Groettrup, Marcus; Basler, Michael (2016). Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis. European journal of immunology, 46(1), pp. 104-113. Wiley-VCH 10.1002/eji.201545578
Lopes Pinheiro, Melissa A; Kooij, Gijs; Mizee, Mark R; Kamermans, Alwin; Enzmann, Gaby; Lyck, Ruth; Schwaninger, Markus; Engelhardt, Britta; de Vries, Helga E (2016). Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke. Biochimica et biophysica acta - molecular basis of disease, 1862(3), pp. 461-471. Elsevier 10.1016/j.bbadis.2015.10.018
Lazarevic, Ivana; Engelhardt, Britta (2016). Modeling immune functions of the mouse blood-cerebrospinal fluid barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suited to study immune cell migration across this brain barrier. Fluids and barriers of the CNS, 13(2), p. 2. BioMed Central 10.1186/s12987-016-0027-0
Alonso, Angelika; Eisele, Philipp; Ebert, Anne D; Griebe, Martin; Engelhardt, Britta; Szabo, Kristina; Hennerici, Michael G; Gass, Achim (2015). Leptomeningeal contrast enhancement and blood-CSF barrier dysfunction in aseptic meningitis. Neurology: Neuroimmunology and Neuroinflammation, 2(6), e164. Wolters Kluwer Health 10.1212/NXI.0000000000000164
Martin-Blondel, Guillaume; Pignolet, Béatrice; Tietz, Silvia; Yshii, Lidia; Gebauer, Christina; Périnat, Therese; Van Weddingen, Isabelle; Blatti, Claudia; Engelhardt, Britta; Liblau, Roland (2015). Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the α4β1-integrin. European journal of immunology, 45(12), pp. 3302-3312. Wiley-VCH 10.1002/eji.201545632
Wälchli, Thomas; Wacker, Andrin; Frei, Karl; Regli, Luca; Schwab, Martin E; Hoerstrup, Simon P; Gerhardt, Holger; Engelhardt, Britta (2015). Wiring the Vascular Network with Neural Cues: A CNS Perspective. Neuron, 87(2), pp. 271-296. Cell Press 10.1016/j.neuron.2015.06.038
Staat, Christian; Coisne, Caroline Marie; Dabrowski, Sebastian; Stamatovic, Svetlana M; Andjelkovic, Anuska V; Wolburg, Hartwig; Engelhardt, Britta; Blasig, Ingolf E (2015). Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers. Biomaterials, 54, pp. 9-20. Elsevier 10.1016/j.biomaterials.2015.03.007
Tietz, Silvia; Engelhardt, Britta (2015). Brain barriers: Crosstalk between complex tight junctions and adherens junctions. Journal of cell biology, 209(4), pp. 493-506. Rockefeller Institute Press 10.1083/jcb.201412147
Eisele, Philipp; Griebe, Martin; Szabo, Kristina; Wolf, Marc E; Alonso, Angelika; Engelhardt, Britta; Hennerici, Michael G; Gass, Achim (2015). Investigation of leptomeningeal enhancement in MS: A postcontrast FLAIR MRI study. Neurology, 84(8), pp. 770-775. Lippincott Williams & Wilkins 10.1212/WNL.0000000000001286
Abadier, Michael Magdy Labib; Haghayegh Jahromi, Neda; Cardoso Alves, Ludmila; Boscacci, Rémy; Vestweber, Dietmar; Barnum, Scott; Deutsch, Urban; Engelhardt, Britta; Lyck, Ruth (2015). Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier. European journal of immunology, 45(4), pp. 1043-1058. Wiley-VCH 10.1002/eji.201445125
Steiner, Esther; Enzmann, Gaby; Lyck, Ruth; Lin, Shuo; Rüegg, Markus A; Kröger, Stephan; Engelhardt, Britta (2014). The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions. Cell and tissue research, 358(2), pp. 465-479. Springer 10.1007/s00441-014-1969-7
Imeri, Faik; Fallegger, Daniel; Zivkovic, Aleksandra; Schwalm, Stephanie; Enzmann, Gaby; Blankenbach, Kira; Meyer zu Heringdorf, Dagmar; Homann, Thomas; Kleuser, Burkhard; Pfeilschifter, Josef; Engelhardt, Britta; Stark, Holger; Huwiler, Andrea (2014). Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice. Neuropharmacology, 85, pp. 314-327. Elsevier 10.1016/j.neuropharm.2014.05.012
Aubé, Benoit; Lévesque, Sébastien A; Paré, Alexandre; Chamma, Émilie; Kébir, Hania; Gorina Mendiz, Roser; Lécuyer, Marc-André; Alvarez, Jorge I; De Koninck, Yves; Engelhardt, Britta; Prat, Alexandre; Côté, Daniel; Lacroix, Steve (2014). Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases. Journal of immunology, 193(5), pp. 2438-2454. American Association of Immunologists 10.4049/jimmunol.1400401
Sathiyanadan, Karthik; Coisne, Caroline Marie; Enzmann, Gaby; Deutsch, Urban; Engelhardt, Britta (2014). PSGL-1 and E/P-selectins are essential for T-cell rolling in inflamed CNS microvessels but dispensable for initiation of EAE. European journal of immunology, 44(8), pp. 2287-2294. Wiley-VCH 10.1002/eji.201344214
Engelhardt, Britta; Liebner, Stefan (2014). Novel insights into the development and maintenance of the blood-brain barrier. Cell and tissue research, 355(3), pp. 687-699. Springer 10.1007/s00441-014-1811-2
Gorina Mendiz, Roser; Lyck, Ruth; Vestweber, Dietmar; Engelhardt, Britta (2014). β2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier. Journal of immunology, 192(1), pp. 324-337. American Association of Immunologists 10.4049/jimmunol.1300858
Cecchelli, Romeo; Aday, Sezin; Sevin, Emmanuel; Almeida, Catarina; Culot, Maxime; Dehouck, Lucie; Coisne, Caroline Marie; Engelhardt, Britta; Dehouck, Marie-Pierre; Ferreira, Lino (2014). A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells. PLoS ONE, 9(6), e99733. Public Library of Science 10.1371/journal.pone.0099733
Minten, Carsten; Alt, Carsten; Gentner, Melanie; Frei, Elisabeth; Deutsch, Urban; Lyck, Ruth; Schaeren-Wiemers, Nicole; Rot, Antal; Engelhardt, Britta (2014). DARC shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous system inflammation. Brain, 137(Pt 5), pp. 1454-1469. Oxford University Press 10.1093/brain/awu045
Moretti, Federico A.; Moser, Markus; Lyck, Ruth; Abadier, Michael Magdy Labib; Ruppert, Raphael; Engelhardt, Britta; Fässler, Reinhard (2013). Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 110(42), pp. 17005-17010. National Academy of Sciences NAS 10.1073/pnas.1316032110
Paolinelli, Roberta; Corada, Monica; Ferrarini, Luca; Devraj, Kavi; Artus, Cédric; Czupalla, Cathrin J.; Rudini, Noemi; Maddaluno, Luigi; Papa, Eleanna; Engelhardt, Britta; Couraud, Pierre Olivier; Liebner, Stefan; Dejana, Elisabetta (2013). Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro. PLoS ONE, 8(8), e70233. Public Library of Science 10.1371/journal.pone.0070233
Enzmann, Gaby; Mysiorek, Caroline; Gorina, Roser; Cheng, Yu-Jung; Ghavampour, Sharang; Hannocks, Melanie-Jane; Prinz, Vincent; Dirnagl, Ulrich; Endres, Matthias; Prinz, Marco; Beschorner, Rudi; Harter, Patrick N.; Mittelbronn, Michel; Engelhardt, Britta; Sorokin, Lydia (2013). The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury. Acta neuropathologica, 125(3), pp. 395-412. Berlin: Springer-Verlag 10.1007/s00401-012-1076-3
Coisne, Caroline; Lyck, Ruth; Engelhardt, Britta (2013). Live cell imaging techniques to study T cell trafficking across the blood-brain barrier in vitro and in vivo. Fluids and barriers of the CNS, 10(1), p. 7. London: BioMed Central
Muldoon, Leslie L; Alvarez, Jorge I; Begley, David J; Boado, Ruben J; Del Zoppo, Gregory J; Doolittle, Nancy D; Engelhardt, Britta; Hallenbeck, John M; Lonser, Russell R; Ohlfest, John R; Prat, Alexandre; Scarpa, Maurizio; Smeyne, Richard J; Drewes, Lester R; Neuwelt, Edward A (2013). Immunologic privilege in the central nervous system and the blood-brain barrier. Journal of cerebral blood flow and metabolism, 33(1), pp. 13-21. New York, N.Y.: Nature Publishing Group 10.1038/jcbfm.2012.153
Kronstein, Romy; Seebach, Jochen; Grossklaus, Sylvia; Minten, Carsten; Engelhardt, Britta; Drab, Marek; Liebner, Stefan; Arsenijevic, Yvan; Taha, Abdallah Abu; Afanasieva, Tatiana; Schnittler, Hans-Joachim (2012). Caveolin-1 opens endothelial cell junctions by targeting catenins. Cardiovascular research, 93(1), pp. 130-40. Oxford: Oxford University Press 10.1093/cvr/cvr256
Wyss, Lena; Schäfer, Julia; Liebner, Stefan; Mittelbronn, Michel; Deutsch, Urban; Enzmann, Gaby; Adams, Ralf H.; Aurrand-Lions, Michel; Plate, Karl H.; Imhof, Beat A.; Engelhardt, Britta (2012). Junctional adhesion molecule (JAM)-C deficient C57BL/6 mice develop a severe hydrocephalus. PLoS ONE, 7(9), e45619. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0045619
Lyck, Ruth; Engelhardt, Britta (2012). Going against the tide--how encephalitogenic T cells breach the blood-brain barrier. Journal of vascular research, 49(6), pp. 497-509. Basel: Karger 10.1159/000341232
Engelhardt, Britta; Ransohoff, Richard M (2012). Capture, crawl, cross: the T cell code to breach the blood-brain barriers. Trends in immunology, 33(12), pp. 579-89. Oxford: Elsevier Current Trends 10.1016/j.it.2012.07.004
Ransohoff, Richard M; Engelhardt, Britta (2012). The anatomical and cellular basis of immune surveillance in the central nervous system. Nature reviews - immunology, 12(9), pp. 623-35. London: Nature Publishing Group 10.1038/nri3265
Steiner, Esther; Enzmann, Gaby U; Lin, Shuo; Ghavampour, Sharang; Hannocks, Melanie-Jane; Zuber, Benoît; Rüegg, Markus A; Sorokin, Lydia; Engelhardt, Britta (2012). Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation. GLIA, 60(11), pp. 1646-59. Hoboken, N.J.: Wiley-Blackwell 10.1002/glia.22383
Lélu, Karine; Laffont, Sophie; Delpy, Laurent; Paulet, Pierre-Emmanuel; Périnat, Therese; Tschanz, Stefan A.; Pelletier, Lucette; Engelhardt, Britta; Guéry, Jean-Charles (2011). Estrogen Receptor α Signaling in T Lymphocytes Is Required for Estradiol-Mediated Inhibition of Th1 and Th17 Cell Differentiation and Protection against Experimental Autoimmune Encephalomyelitis. Journal of immunology, 187(5), pp. 2386-93. Bethesda, Md.: American Association of Immunologists 10.4049/jimmunol.1101578
Pfeiffer, Friederike; Schäfer, Julia; Lyck, Ruth; Makrides, Victoria; Brunner, Sarah; Schaeren-Wiemers, Nicole; Deutsch, Urban; Engelhardt, Britta (2011). Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis. Acta neuropathologica, 122(5), pp. 601-14. Berlin: Springer-Verlag 10.1007/s00401-011-0883-2
Engelhardt, Britta; Coisne, Caroline (2011). Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle. Fluids and barriers of the CNS, 8(1), p. 4. London: BioMed Central 10.1186/2045-8118-8-4
Coisne, Caroline; Engelhardt, Britta (2010). Preclinical testing of strategies for therapeutic targeting of human T-cell trafficking in vivo. Methods in molecular biology, 616, pp. 268-281. Totowa, N.J.: Humana Press 10.1007/978-1-60761-461-6_17
Engelhardt, Britta (2010). Negotiating the brain barriers: Access of immune cells and pathogens into the CNS. In: Kilpatrick, Trevor; Ransohoff, Richard M; Wesselingh, Steven (eds.) Inflammatory Diseases of the Central Nervous System (pp. 35-46). Cambridge: Cambridge University Press
Rossy, Jérémie; Schlicht, Dominique; Engelhardt, Britta; Niggli, Verena (2009). Flotillins interact with PSGL-1 in neutrophils and, upon stimulation, rapidly organize into membrane domains subsequently accumulating in the uropod. PLoS ONE, 4(4), e5403. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0005403
Engelhardt, Britta; Sorokin, Lydia (2009). The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction. Seminars in immunopathology, 31(4), pp. 497-511. Berlin: Springer-Verlag 10.1007/s00281-009-0177-0
Wolburg-Buchholz, Karen; Mack, Andreas F; Steiner, Esther; Pfeiffer, Friederike; Engelhardt, Britta; Wolburg, Hartwig (2009). Loss of astrocyte polarity marks blood-brain barrier impairment during experimental autoimmune encephalomyelitis. Acta neuropathologica, 118(2), pp. 219-33. Berlin: Springer 10.1007/s00401-009-0558-4
Dodelet-Devillers, Aurore; Cayrol, Romain; van Horssen, Jack; Haqqani, Arsalan S; de Vries, Helga E; Engelhardt, Britta; Greenwood, John; Prat, Alexandre (2009). Functions of lipid raft membrane microdomains at the blood-brain barrier. Journal of molecular medicine JMM, 87(8), pp. 765-74. Berlin: Springer 10.1007/s00109-009-0488-6
Sellner, Johann; Greeve, Isabell; Findling, Oliver; Kamm, Christian P.; Minten, Carsten; Engelhardt, Britta; Grandgirard, Denis; Leib, Stephen L.; Mattle, Heinrich P (2008). Effect of interferon-beta and atorvastatin on Th1/Th2 cytokines in multiple sclerosis. Neurochemistry international, 53(1-2), pp. 17-21. Amsterdam: Elsevier 10.1016/j.neuint.2008.04.004
Endres, Matthias; Engelhardt, Britta; Koistinaho, Jari; Lindvall, Olle; Meairs, Stephen; Mohr, Jay P; Planas, Anna; Rothwell, Nancy; Schwaninger, Markus; Schwab, Martin E; Vivien, Denis; Wieloch, Tadeusz; Dirnagl, Ulrich (2008). Improving outcome after stroke: overcoming the translational roadblock. Cerebrovascular diseases, 25(3), pp. 268-78. Basel: Karger 10.1159/000118039
Engelhardt, Britta; Kappos, Ludwig (2008). Natalizumab: targeting alpha4-integrins in multiple sclerosis. Neurodegenerative diseases, 5(1), pp. 16-22. Basel: Karger 10.1159/000109933
Engelhardt, B. (2008). Adhesion and signalling molecules controlling the extravasation of leukocytes accross the endothelium. Transfusion medicine and hemotherapy, 35(2), pp. 73-75. Basel: Karger 10.1159/000119115
Engelhardt, Britta (2006). Immune cell migration across the blood–brain barrier: molecular mechanisms and therapeutic targeting. Future neurology, 1(1), 47 - 56. London: Future Medicine Ltd 10.2217/14796708.1.1.47
Meairs, Stephen; Wahlgren, Nils; Dirnagl, Ulrich; Lindvall, Olle; Rothwell, Peter; Baron, Jean-Claude; Hossmann, Konstantin; Engelhardt, Britta; Ferro, José; McCulloch, James; Kaste, Markku; Endres, Matthias; Koistinaho, Jari; Planas, Anna; Vivien, Denis; Dijkhuizen, Rick; Czlonkowska, Anna; Hagen, Arne; Evans, Alan; De Libero, Gennaro; ... (2006). Stroke research priorities for the next decade--A representative view of the European scientific community. Cerebrovascular diseases, 22(2-3), pp. 75-82. Basel: Karger 10.1159/000093098
Engelhardt, B (2006). Molecular mechanisms involved in T cell migration across the blood-brain barrier. Journal of neural transmission, 113(4), pp. 477-85. Wien: Springer 10.1007/s00702-005-0409-y
Walter, Silke; Doering, Axinia; Letiembre, Maryse; Liu, Yang; Hao, Wenlin; Diem, Ricarda; Bernreuther, Christian; Glatzel, Markus; Engelhardt, Britta; Fassbender, Klaus (2006). The LPS receptor, CD14, in experimental autoimmune encephalomyelitis and multiple sclerosis. Cellular physiology and biochemistry, 17(3-4), pp. 167-72. Basel: Karger 10.1159/000092078
Engelhardt, Britta (2006). Physiologie der Blut-Hirn-Schranke – Bedeutung für die Neuroimmunmodulation. In: Straub, Rainer H (ed.) Lehrbuch der klinischen Pathophysiologie komplexer chronischer Erkrankungen. Band 1 (pp. 150-159). Göttingen: Vandenhoeck & Ruprecht V&R unipress
Hamm, Stefan; Dehouck, Bénédicte; Kraus, Jörg; Wolburg-Buchholz, Karen; Wolburg, Hartwig; Risau, Werner; Cecchelli, Roméo; Engelhardt, Britta; Dehouck, Marie-Pierre (2004). Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contacts. Cell and tissue research, 315(2), pp. 157-166. Springer 10.1007/s00441-003-0825-y
