Jakob, Stephan

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2021

Takala, Jukka; Moser, André; Raj, Rahul; Pettilä, Ville; Irincheeva, Irina; Selander, Tuomas; Kiiski, Olli; Varpula, Tero; Reinikainen, Matti; Jakob, Stephan M. (2021). Variation in severity-adjusted resource use and outcome in intensive care units. (In Press). Intensive care medicine Springer-Verlag 10.1007/s00134-021-06546-4

Cioccari, Luca; Jakob, Stephan M.; Takala, Jukka (2021). Should Vasopressors Be Started Early in Septic Shock? Seminars in respiratory and critical care medicine, 42(5), pp. 683-688. Thieme 10.1055/s-0041-1733897

Reintam Blaser, Annika; Padar, Martin; Mändul, Merli; Elke, Gunnar; Engel, Christoph; Fischer, Krista; Giabicani, Mikhael; Gold, Thomas; Hess, Benjamin; Hiesmayr, Michael; Jakob, Stephan M.; Loudet, Cecilia I.; Meesters, Dennis M.; Mongkolpun, Wasineenart; Paugam-Burtz, Catherine; Poeze, Martijn; Preiser, Jean-Charles; Renberg, Mattias; Rooijackers, Olav; Tamme, Kadri; ... (2021). Development of the Gastrointestinal Dysfunction Score (GIDS) for critically ill patients – A prospective multicenter observational study (iSOFA study). Clinical nutrition, 40(8), pp. 4932-4940. Elsevier 10.1016/j.clnu.2021.07.015

Munch, Marie Warrer; Granholm, Anders; Myatra, Sheila Nainan; Vijayaraghavan, Bharath Kumar Tirupakuzhi; Cronhjort, Maria; Wahlin, Rebecka Rubenson; Jakob, Stephan M; Cioccari, Luca; Kjaer, Maj-Brit Nørregaard; Vesterlund, Gitte Kingo; Meyhoff, Tine Sylvest; Helleberg, Marie; Møller, Morten Hylander; Benfield, Thomas; Venkatesh, Balasubramanian; Hammond, Naomi; Micallef, Sharon; Bassi, Abhinav; John, Oommen; Jha, Vivekanand; ... (2021). Higher vs. Lower Doses of Dexamethasone in Patients with COVID-19 and Severe Hypoxia (COVID STEROID 2) trial: protocol and statistical analysis plan. Acta anaesthesiologica Scandinavica, 65(6), pp. 834-845. Wiley-Blackwell 10.1111/aas.13795

Jeitziner, Marie-Madlen; Jenni-Moser, Béatrice; Que, Yok-Ai; Thurnheer Zürcher, Maria Christine; Furrer, Hansjakob; Jakob, Stephan (2021). Importance of critical care staffing and standard intensive care therapy in the COVID-19 era: a descriptive study of the first epidemic wave at a Swiss tertiary intensive care unit. Swiss medical weekly, 151, w20529. EMH Media 10.4414/smw.2021.20529

Czerny, Martin; van den Berg, Jos; Chiesa, Roberto; Jacobs, Michael; Jakob, Stephan; Jenni, Hans-Jörg; Lorusso, Roberto; Pacini, Davide; Quintana, Eduardo; Rylski, Bartosz; Staier, Klaus; Tsilimparis, Nikolaos; Wyss, Thomas; Gottardi, Roman; Schmidli, Juerg (2021). Management of acute and chronic aortic disease during the COVID-19 pandemic-Results from a web-based ad hoc platform. Journal of cardiac surgery, 36(5), pp. 1683-1692. Wiley-Blackwell 10.1111/jocs.15093

Granholm, Anders; Munch, Marie Warrer; Myatra, Sheila Nainan; Vijayaraghavan, Bharath Kumar Tirupakuzhi; Cronhjort, Maria; Wahlin, Rebecka Rubenson; Jakob, Stephan M; Cioccari, Luca; Kjaer, Maj-Brit Nørregaard; Vesterlund, Gitte Kingo; Meyhoff, Tine Sylvest; Helleberg, Marie; Møller, Morten Hylander; Benfield, Thomas; Venkatesh, Balasubramanian; Hammond, Naomi; Micallef, Sharon; Bassi, Abhinav; John, Oommen; Jha, Vivekanand; ... (2021). Higher vs Lower Doses of Dexamethasone in Patients with COVID-19 and Severe Hypoxia (COVID STEROID 2) trial: Protocol for a secondary Bayesian analysis. Acta anaesthesiologica Scandinavica, 65(5), pp. 702-710. Wiley-Blackwell 10.1111/aas.13793

Naef, Aileen C.; Jeitziner, Marie-Madlen; Gerber, Stephan M.; Jenni-Moser, Béatrice; Müri, René M.; Jakob, Stephan M.; Nef, Tobias; Hänggi, Matthias (2021). Virtual reality stimulation to reduce the incidence of delirium in critically ill patients: study protocol for a randomized clinical trial. Trials, 22(1), p. 174. BioMed Central 10.1186/s13063-021-05090-2

Prazak, Josef; Valente, Luca; Iten, Manuela; Federer, Lea; Grandgirard, Denis; Soto, Sara; Resch, Gregory; Leib, Stephen L.; Jakob, Stephan M.; Haenggi, Matthias; Cameron, David R.; Que, Yok-Ai (2021). Benefits of aerosolized phages for the treatment of pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA): an experimental study in rats. (In Press). The journal of infectious diseases Oxford University Press 10.1093/infdis/jiab112

Sakr, Yasser; François, Bruno; Solé-Violan, Jordi; Kotfis, Katarzyna; Jaschinski, Ulrich; Estella, Angel; Leone, Marc; Jakob, Stephan M.; Wittebole, Xavier; Fontes, Luis E; de Melo Gurgel, Miguel; Midega, Thais; Vincent, Jean-Louis; Ranieri, V Marco (2021). Temporal changes in the epidemiology, management, and outcome from acute respiratory distress syndrome in European intensive care units: a comparison of two large cohorts. Critical care, 25(1), p. 87. BioMed Central 10.1186/s13054-020-03455-8

Reintam Blaser, Annika; Deane, Adam M; Preiser, Jean-Charles; Arabi, Yaseen M; Jakob, Stephan M. (2021). Enteral Feeding Intolerance: Updates in Definitions and Pathophysiology. Nutrition in clinical practice, 36(1), pp. 40-49. Wiley 10.1002/ncp.10599

Vankrunkelsven, Wouter; Gunst, Jan; Amrein, Karin; Bear, Danielle E; Berger, Mette M; Christopher, Kenneth B; Fuhrmann, Valentin; Hiesmayr, Michael; Ichai, Carole; Jakob, Stephan M; Lasocki, Sigismond; Montejo, Juan C; Oudemans-van Straeten, Heleen M; Preiser, Jean-Charles; Blaser, Annika Reintam; Rousseau, Anne-Françoise; Singer, Pierre; Starkopf, Joel; van Zanten, Arthur R; Weber-Carstens, Steffen; ... (2021). Monitoring and parenteral administration of micronutrients, phosphate and magnesium in critically ill patients: The VITA-TRACE survey. Clinical nutrition, 40(2), pp. 590-599. Elsevier 10.1016/j.clnu.2020.06.005

Schatlo, Bawarjan; Fung, Christian; Stienen, Martin N; Fathi, Ali R; Fandino, Javier; Smoll, Nicolas R; Zumofen, Daniel; Daniel, Roy Thomas; Burkhardt, Jan-Karl; Bervini, David; Marbacher, Serge; Reinert, Michael; D Alonzo, Donato; Ahlborn, Peter; Mendes Pereira, Vitor; Roethlisberger, Michel; Seule, Martin; Kerkeni, Hassen; Remonda, Luca; Weyerbrock, Astrid; ... (2021). Incidence and Outcome of Aneurysmal Subarachnoid Hemorrhage: The Swiss Study on Subarachnoid Hemorrhage (Swiss SOS). Stroke, 52(1), pp. 344-347. Wolters Kluwer Health 10.1161/STROKEAHA.120.029538

Berezowska, Sabina; Schmid, Andreas; Losmanová, Tereza; Trippel, Mafalda; Blank, Annika; Banz, Yara; Jakob, Stephan M.; Langer, Rupert (2021). Frequency and Significance of Pathologic Pulmonary Findings in Postmortem Examinations—A Single Center Experience before COVID-19. Diagnostics, 11(5) MDPI 10.3390/diagnostics11050894

2020

Corrêa, Thiago Domingos; Pereira, Adriano José; Takala, Jukka; Jakob, Stephan Mathias (2020). Regional venous-arterial CO2 to arterial-venous O2 content difference ratio in experimental circulatory shock and hypoxia. Intensive care medicine experimental, 8(1), p. 64. Springer 10.1186/s40635-020-00353-9

Berger, David; Hobi, Jan; Möller, Per W.; Haenggi, Matthias; Takala, Jukka; Jakob, Stephan M. (2020). Right ventricular stroke volume assessed by pulmonary artery pulse contour analysis. Intensive care medicine experimental, 8(1), p. 58. Springer 10.1186/s40635-020-00347-7

Bräutigam, Konstantin; Hohl, Anja; Hewer, Ekkehard; Langer, Rupert; Jakob, Stephan (2020). Myeloid Sarcoma Mimicking Endocarditis: An Autopsy Case. International journal of surgical pathology, 28(7), p. 774. Sage 10.1177/1066896919900011

Petersen, Marie Warrer; Meyhoff, Tine Sylvest; Helleberg, Marie; Kjær, Maj-Brit Nørregaard; Granholm, Anders; Hjortsø, Carl Johan Steensen; Jensen, Thomas Steen; Møller, Morten Hylander; Hjortrup, Peter Buhl; Wetterslev, Mik; Vesterlund, Gitte Kingo; Russell, Lene; Jørgensen, Vibeke Lind; Tjelle, Klaus; Benfield, Thomas; Ulrik, Charlotte Suppli; Andreasen, Anne Sofie; Mohr, Thomas; Bestle, Morten H; Poulsen, Lone Musaeus; ... (2020). Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia (COVID STEROID) trial-Protocol and statistical analysis plan. Acta anaesthesiologica Scandinavica, 64(9), pp. 1365-1375. Wiley-Blackwell 10.1111/aas.13673

Liu, Shengchen; do Amaral Campos, Pedro Paulo Zanella; Casoni, Daniela; Berger, David; Kohler, Andreas; Bloch, Andreas; Bervini, David; Setzer, Florian; Cameron, David R.; Z'Graggen, Werner; Hana, Anisa; Langer, Rupert; Corrêa, Thiago D.; Beldi, Guido; Takala, Jukka; Jakob, Stephan M. (2020). Defense mechanisms to increasing back pressure for hepatic oxygen transport and venous return in porcine fecal peritonitis. American journal of physiology - gastrointestinal and liver physiology, 319(3), G289-G302. American Physiological Society 10.1152/ajpgi.00216.2020

Pfortmüller, Carmen A.; Kindler, Manuel; Schenk, Noelle; Messmer, Anna S.; Hess, Benjamin; Jakob, Laura; Wenger, Stefanie; Waskowski, Jan; Zuercher, Patrick; Stoehr, Frederik; Jakob, Stephan M.; Englberger, Lars; Schefold, Joerg C. (2020). Hypertonic saline for fluid resuscitation in ICU patients post-cardiac surgery (HERACLES): a double-blind randomized controlled clinical trial. Intensive care medicine, 46(9), pp. 1683-1695. Springer-Verlag 10.1007/s00134-020-06132-0

Cioccari, Luca; Luethi, Nora; Bailey, Michael; Shehabi, Yahya; Howe, Belinda; Messmer, Anna S.; Proimos, Helena K.; Peck, Leah; Young, Helen; Eastwood, Glenn M.; Merz, Tobias M.; Takala, Jukka; Jakob, Stephan M.; Bellomo, Rinaldo (2020). The effect of dexmedetomidine on vasopressor requirements in patients with septic shock: a subgroup analysis of the Sedation Practice in Intensive Care Evaluation [SPICE III] Trial. Critical care, 24(1), p. 441. BioMed Central 10.1186/s13054-020-03115-x

Egli, Adrian; Battegay, Manuel; Büchler, Andrea C; Bühlmann, Peter; Calandra, Thierry; Eckert, Philippe; Furrer, Hansjakob; Greub, Gilbert; Jakob, Stephan M.; Kaiser, Laurent; Leib, Stephen L.; Marsch, Stephan; Meinshausen, Nicolai; Pagani, Jean-Luc; Pugin, Jerome; Rätsch, Gunnar; Schrenzel, Jacques; Schüpbach, Reto; Siegemund, Martin; Zamboni, Nicola; ... (2020). SPHN/PHRT: Forming a Swiss-Wide Infrastructure for Data-Driven Sepsis Research. Studies in health technology and informatics, 270, pp. 1163-1167. IOS Press 10.3233/SHTI200346

Bachmann, Kaspar Felix; Haenggi, Matthias; Jakob, Stephan M.; Takala, Jukka; Gattinoni, Luciano; Berger, David (2020). Gas exchange calculation may estimate changes in pulmonary blood flow during veno-arterial extracorporeal membrane oxygenation in a porcine model. American journal of physiology - lung cellular and molecular physiology, 318(6), L1211-L1221. American Physiological Society 10.1152/ajplung.00167.2019

Reintam Blaser, Annika; Preiser, Jean-Charles; Fruhwald, Sonja; Wilmer, Alexander; Wernerman, Jan; Benstoem, Carina; Casaer, Michael P; Starkopf, Joel; van Zanten, Arthur; Rooyackers, Olav; Jakob, Stephan M; Loudet, Cecilia I; Bear, Danielle E; Elke, Gunnar; Kott, Matthias; Lautenschläger, Ingmar; Schäper, Jörn; Gunst, Jan; Stoppe, Christian; Nobile, Leda; ... (2020). Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intensive Care Medicine. Critical care, 24(1), p. 224. BioMed Central 10.1186/s13054-020-02889-4

Vincent, Jean-Louis; Ferguson, Andrew; Pickkers, Peter; Jakob, Stephan M.; Jaschinski, Ulrich; Almekhlafi, Ghaleb A; Leone, Marc; Mokhtari, Majid; Fontes, Luis E; Bauer, Philippe R; Sakr, Yasser (2020). The clinical relevance of oliguria in the critically ill patient: analysis of a large observational database. Critical care, 24(1), p. 171. BioMed Central 10.1186/s13054-020-02858-x

Eggmann, Sabrina; Luder, Gere; Verra, Martin L; Irincheeva, Irina; Bastiaenen, Caroline H G; Jakob, Stephan M (2020). Functional ability and quality of life in critical illness survivors with intensive care unit acquired weakness: A secondary analysis of a randomised controlled trial. PLoS ONE, 15(3), e0229725. Public Library of Science 10.1371/journal.pone.0229725

Kjaer, Maj-Brit Nørregaard; Meyhoff, Tine Sylvest; Madsen, Martin Bruun; Hjortrup, Peter Buhl; Møller, Morten Hylander; Egerod, Ingrid; Wetterslev, Jørn; Lange, Theis; Cronhjort, Maria; Laake, Jon Henrik; Jakob, Stephan M.; Nalos, Marek; Pettilä, Ville; van der Horst, Iwan C C; Ostermann, Marlies; Mouncey, Paul; Cecconi, Maurizio; Ferrer, Ricard; L N G Malbrain, Manu; Ahlstedt, Christian; ... (2020). Long-term patient-important outcomes after septic shock: a protocol for 1-year follow-up of the CLASSIC-trial. Acta anaesthesiologica Scandinavica, 64(3), pp. 410-416. Wiley-Blackwell 10.1111/aas.13519

Schefold, Joerg C.; Bäcklund, Minna; Ala-Kokko, Tero; Zuercher, Patrick; Mukherjee, Rajat; Mistry, Satish; Mayer, Stephan A; Dziewas, Rainer; Bakker, Jan; Jakob, Stephan M. (2020). The PhINEST study - Pharyngeal ICU Novel Electrical Stimulation Therapy: Study protocol of a prospective, multi-site, randomized, sham-controlled, single-blind (outcome assessor-blinded) study. Medicine, 99(11), e19503. Wolters Kluwer 10.1097/MD.0000000000019503

Liu, Shengchen; Moller, Per W.; Kohler, Andreas; Hana, Anisa; Beldi, Guido; Obrist, Dominik; Berger, David; Takala, Jukka; Jakob, Stephan M. (2020). Effects of Trendelenburg position and increased airway pressure on hepatic regional blood flow of normal and resected liver. Journal of applied physiology, 128(3), pp. 667-680. American Physiological Society 10.1152/japplphysiol.00705.2019

Eggmann, Sabrina; Luder, Gere; Verra, Martin L; Irincheeva, Irina; Bastiaenen, Caroline H G; Jakob, Stephan M (2020). Functional ability and quality of life in critical illness survivors with intensive care unit acquired weakness: a secondary analysis of a randomised controlled trial : DATASET [Dataset].

Eggmann, Sabrina; Kindler, Angela; Perren, Andrea; Ott, Natalie; Johannes, Frauke; Vollenweider, Rahel; Balma, Théophile; Bennett, Claire; Silva, Ivo Neto; Jakob, Stephan M. (2020). Early Physical Therapist Interventions for Patients With COVID-19 in the Acute Care Hospital: A Case Report Series. Physical therapy, 101(1) Oxford University Press 10.1093/ptj/pzaa194

2019

Gerber, Stephan M.; Jeitziner, Marie-Madlen; Knobel, Samuel E. J.; Mosimann, Urs P.; Müri, René M.; Jakob, Stephan M.; Nef, Tobias (2019). Perception and Performance on a Virtual Reality Cognitive Stimulation for Use in the Intensive Care Unit: A Non-randomized Trial in Critically Ill Patients. Frontiers in medicine, 6(287), p. 287. Frontiers 10.3389/fmed.2019.00287

Prazak, Josef; Iten, Manuela; Cameron, David Robert; Save, Jonathan Florian; Grandgirard, Denis; Resch, Gregory; Göpfert, Christine; Leib, Stephen L.; Takala, Jukka; Jakob, Stephan; Que, Yok-Ai; Hänggi, Matthias (2019). Bacteriophages Improve Outcome in Experimental Staphylococcus Aureus Ventilator Associated Pneumonia. American journal of respiratory and critical care medicine, 200(9), pp. 1126-1133. American Lung Association 10.1164/rccm.201812-2372OC

Meyhoff, Tine Sylvest; Hjortrup, Peter Buhl; Møller, Morten Hylander; Wetterslev, Jørn; Lange, Theis; Kjaer, Maj-Brit Nørregaard; Jonsson, Andreas Bender; Hjortsø, Carl Johan Steensen; Cronhjort, Maria; Laake, Jon Henrik; Jakob, Stephan M.; Nalos, Marek; Pettilä, Ville; van der Horst, Iwan; Ostermann, Marlies; Mouncey, Paul; Rowan, Kathy; Cecconi, Maurizio; Ferrer, Ricard; Malbrain, Manu L N G; ... (2019). Conservative vs liberal fluid therapy in septic shock (CLASSIC) trial-Protocol and statistical analysis plan. Acta anaesthesiologica Scandinavica, 63(9), pp. 1262-1271. Wiley-Blackwell 10.1111/aas.13434

Kohler, Andreas; Moller, Per Werner; Frey, Sabrina; Tinguely, Pascale; Candinas, Daniel; Obrist, Dominik; Jakob, Stephan M.; Beldi, Guido (2019). Portal hyperperfusion after major liver resection and associated sinusoidal damage is a therapeutic target to protect the remnant liver. American journal of physiology - gastrointestinal and liver physiology, 317(3), G264-G274. American Physiological Society 10.1152/ajpgi.00113.2019

Merz, Tobias; Cioccari, Luca; Frey, Pascal Marcel; Bloch, Andreas; Berger, David; Zante, Björn; Jakob, Stephan; Takala, Jukka (2019). Correction to: Continual hemodynamic monitoring with a single-use transesophageal echocardiography probe in critically ill patients with shock: a randomized controlled clinical trial. Intensive care medicine, 45(9), p. 1330. Springer-Verlag 10.1007/s00134-019-05700-3

Merz, Tobias; Cioccari, Luca; Frey, Pascal Marcel; Bloch, Andreas; Berger, David; Zante, Björn; Jakob, Stephan; Takala, Jukka (2019). Continual hemodynamic monitoring with a single-use transesophageal echocardiography probe in critically ill patients with shock: a randomized controlled clinical trial. Intensive care medicine, 45(8), pp. 1093-1102. Springer-Verlag 10.1007/s00134-019-05670-6

Pfortmüller, Carmen; Messmer, Anna S.; Hess, Benjamin; Reineke, David; Jakob, Laura; Wenger, Stefanie; Waskowski, Jan; Zürcher, Patrick; Stöhr, Frederik; Erdös, Gabor; Lüdi, Markus M.; Jakob, Stephan M.; Englberger, Lars; Schefold, Jörg C. (2019). Hypertonic saline for fluid resuscitation after cardiac surgery (HERACLES): study protocol for a preliminary randomised controlled clinical trial. Trials, 20(1), p. 357. BioMed Central 10.1186/s13063-019-3420-6

Werner Möller, Per; Sondergaard, Soren; Jakob, Stephan; Takala, Jukka; Berger, David (2019). Effect of volume status on the estimation of mean systemic filling pressure. Journal of applied physiology, 126(6), pp. 1503-1513. American Physiological Society 10.1152/japplphysiol.00897.2018

Pfortmueller, Carmen A.; Faeh, Livia; Müller, Martin; Eberle, Balthasar; Jenni, Hansjörg; Zante, Björn; Prazak, Josef; Englberger, Lars; Takala, Jukka; Jakob, Stephan M. (2019). Fluid management in patients undergoing cardiac surgery: effects of an acetate- versus lactate-buffered balanced infusion solution on hemodynamic stability (HEMACETAT). Critical care, 23(1), p. 159. BioMed Central 10.1186/s13054-019-2423-8

Werner Möller, Per; Hana, Anisa; Heinisch, Paul Philipp; Liu, Shengchen; Djafarzadeh, Siamak; Hänggi, Matthias; Bloch, Andreas; Takala, Jukka; Jakob, Stephan; Berger, David (2019). The Effects of Vasoconstriction and Volume Expansion on Veno-Arterial ECMO Flow. Shock, 51(5), pp. 650-658. Lippincott Williams & Wilkins 10.1097/SHK.0000000000001197

Bachmann, Kaspar F.; Nebiker, Mathias; Johner, Caroline; Bregy, Rachel; Schaller, André; Novak, Urban; Jakob, Stephan M. (2019). Rare Case of Transcutaneous Oxygen Desaturation in a Cancer Patient: A Case Report and Diagnostic Approach for a Recurrent Problem. A&A practice, 12(4), pp. 96-98. Lippincott Williams & Wilkins 10.1213/XAA.0000000000000855

Schefold, Joerg C.; Messmer, Anna S.; Wenger, Stefanie; Müller, Lionel; von Haehling, Stephan; Doehner, Wolfram; McPhee, Jamie S; Fux, Michaela; Rösler, Kai M; Scheidegger, Olivier; Olariu, Radu; Z'Graggen, Werner; Rezzi, Serge; Grathwohl, Dominik; Konz, Tobias; Takala, Jukka; Cuenoud, Bernard; Jakob, Stephan M. (2019). Nutrient pattern analysis in critically ill patients using Omics technology (NAChO) - Study protocol for a prospective observational study. Medicine, 98(1), e13937. Lippincott Williams & Wilkins 10.1097/MD.0000000000013937

Gerber, Stephan M; Jeitziner, Marie-Madlen; Sänger, Simon D; Knobel, Samuel E J; Marchal-Crespo, Laura; Müri, René M; Schefold, Jörg C; Jakob, Stephan M; Nef, Tobias (2019). Comparing the Relaxing Effects of Different Virtual Reality Environments in the Intensive Care Unit: Observational Study. JMIR perioperative medicine, 2(2), e15579. JMIR Publications 10.2196/15579

2018

Krag, Mette; Marker, Søren; Perner, Anders; Wetterslev, Jørn; Wise, Matt P; Schefold, Joerg C.; Keus, Frederik; Guttormsen, Anne B; Bendel, Stepani; Borthwick, Mark; Lange, Theis; Rasmussen, Bodil S; Siegemund, Martin; Bundgaard, Helle; Elkmann, Thomas; Jensen, Jacob V; Nielsen, Rune D; Liboriussen, Lisbeth; Bestle, Morten H; Elkjær, Jeanie M; ... (2018). Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU. The New England journal of medicine, 379(23), pp. 2199-2208. Massachusetts Medical Society 10.1056/NEJMoa1714919

Bloch, Andreas; Glas, Michael; Kohler, Andreas; Baumann, Ulrich; Jakob, Stephan (2018). Non-Invasive Assessment of Intra-Abdominal Pressure Using Ultrasound Guided Tonometry - a Proof-of-Concept Study. Shock, 50(6), pp. 684-688. Lippincott Williams & Wilkins 10.1097/SHK.0000000000001085

Gorrasi, José Antonio; Jakob, Stephan; Tovar, Luis Antonio; Balsiger, Bruno Markus; Brandt, Sebastian; Brügger, Lukas; Bracht, Hendrik; Takala, Jukka (2018). Perioperative Fluid Accumulation Impairs Intestinal Contractility to a Smilar Extent as Peritonitis and Endotoxemia. Shock, 50(6), pp. 735-740. Lippincott Williams & Wilkins 10.1097/SHK.0000000000001088

Cioccari, Luca; Zante, Bjoern; Bloch, Andreas; Berger, David; Limacher, Andreas; Jakob, Stephan M; Takala, Jukka; Merz, Tobias M (2018). Correction to: Effects of hemodynamic monitoring using a single-use transesophageal echocardiography probe in critically ill patients - study protocol for a randomized controlled trial. [correction]. Trials, 19(1), p. 587. BioMed Central 10.1186/s13063-018-3001-0

Cioccari, Luca; Zante, Bjoern; Bloch, Andreas; Berger, David; Limacher, Andreas; Jakob, Stephan M; Takala, Jukka; Merz, Tobias M (2018). Effects of hemodynamic monitoring using a single-use transesophageal echocardiography probe in critically ill patients - study protocol for a randomized controlled trial. Trials, 19(1), p. 362. BioMed Central 10.1186/s13063-018-2714-4

Perner, Anders; Cecconi, Maurizio; Cronhjort, Maria; Darmon, Michael; Jakob, Stephan; Pettilä, Ville; van der Horst, Iwan C C (2018). Expert statement for the management of hypovolemia in sepsis. Intensive care medicine, 44(6), pp. 791-798. Springer-Verlag 10.1007/s00134-018-5177-x

Boërio, Delphine; Corrêa, Thiago D; Jakob, Stephan; Ackermann, Karin A; Bostock, Hugh; Z'Graggen, Werner Josef (2018). Muscle membrane properties in A pig sepsis model: Effect of norepinephrine. Muscle & nerve, 57(5), pp. 808-813. John Wiley & Sons 10.1002/mus.26013

Vincent, Jean-Louis; Jaschinski, Ulrich; Wittebole, Xavier; Lefrant, Jean-Yves; Jakob, Stephan; Almekhlafi, Ghaleb A; Pellis, Tommaso; Tripathy, Swagata; Rubatto Birri, Paolo N; Sakr, Yasser (2018). Worldwide audit of blood transfusion practice in critically ill patients. Critical care, 22(1), p. 102. BioMed Central 10.1186/s13054-018-2018-9

Erdös, Gabor; Uehlinger, Dominik E; Kobel, Beatrice; Stucki, Monika Pia; Wiest, Roland; Stüber, Frank; Fankhauser, Niklaus; Jakob, Stephan; Schefold, Joerg C. (2018). Cerebral microembolism in the critically ill with acute kidney injury (COMET-AKI trial): study protocol for a randomized controlled clinical trial. Trials, 19(1), p. 189. BioMed Central 10.1186/s13063-018-2561-3

Bloch, Andreas; Tomaschett, Corina; Jakob, Stephan; Schwinghammer, Andreas; Schmid, Timo (2018). Compression sonography for non-invasive measurement of lower leg compartment pressure in an animal model. Injury - international journal of the care of the injured, 49(3), pp. 532-537. Elsevier 10.1016/j.injury.2017.11.036

Sommerstein, Rami; Merz, Tobias; Jakob, Stephan; Takala, Jukka; Marschall, Jonas (2018). Decontamination of Extracorporeal Membrane Oxygenator Devices With an Intensified Disinfection Protocol: How Strict Is Too Strict? Infection control and hospital epidemiology, 39(3), pp. 366-367. Cambridge University Press 10.1017/ice.2017.283

Gahl, Brigitta; Göber, Volkhard; Odutayo, Ayodele; Tevaearai Stahel, Hendrik T; Da Costa, Bruno R; Jakob, Stephan M; Fiedler, G Martin; Chan, Olivia; Carrel, Thierry P; Jüni, Peter (2018). Prognostic Value of Early Postoperative Troponin T in Patients Undergoing Coronary Artery Bypass Grafting. Journal of the American Heart Association, 7(5), e007743. American Heart Association 10.1161/JAHA.117.007743

Glas, Michael; Frick, Tamara; Springe, Dirk; Putzu, Alessandro; Zürcher, Patrick; Grandgirard, Denis; Leib, Stephen; Jakob, Stephan; Takala, Jukka; Hänggi, Matthias (2018). Neuroprotection with the P53-Inhibitor Pifithrin-μ After Cardiac Arrest in a Rodent Model. Shock, 49(2), pp. 229-234. Lippincott Williams & Wilkins 10.1097/SHK.0000000000000917

Eggmann, Sabrina; Verra, Martin L.; Luder, Gere; Takala, Jukka; Jakob, Stephan (2018). Effects of early, combined endurance and resistance training in mechanically ventilated, critically ill patients: A randomised controlled trial. PLoS ONE, 13(11), e0207428. Public Library of Science 10.1371/journal.pone.0207428

2017

Schefold, Joerg C.; Berger, David; Zürcher, Patrick; Lensch, Michael; Perren, Andrea; Jakob, Stephan; Parviainen, Ilkka; Takala, Jukka (2017). Dysphagia in Mechanically Ventilated ICU Patients (DYnAMICS): A Prospective Observational Trial. Critical care medicine, 45(12), pp. 2061-2069. Lippincott Williams & Wilkins 10.1097/CCM.0000000000002765

Jakob, Stephan; Takala, Jukka (2017). Subcellular Energetics and Metabolism: A Cross-Species Framework. Anesthesia and analgesia, 125(6), p. 2160. Lippincott Williams & Wilkins 10.1213/ANE.0000000000002476

Bauer, Philippe R; Gajic, Ognjen; Nanchal, Rahul; Kashyap, Rahul; Martin-Loeches, Ignacio; Sakr, Yasser; Jakob, Stephan; François, Bruno; Wittebole, Xavier; Wunderink, Richard G; Vincent, Jean-Louis (2017). Association between timing of intubation and outcome in critically ill patients: A secondary analysis of the ICON audit. Journal of critical care, 42, pp. 1-5. Elsevier 10.1016/j.jcrc.2017.06.010

Gerber, Stephan Moreno; Jeitziner, Marie-Madlen; Wyss, Patric; Chesham, Alvin; Urwyler, Prabitha; Müri, René Martin; Jakob, Stephan; Nef, Tobias (2017). Visuo-acoustic stimulation that helps you to relax: A virtual reality setup for patients in the intensive care unit. Scientific Reports, 7(1), pp. 1-10. Nature Publishing Group 10.1038/s41598-017-13153-1

Werner Möller, Per; Winkler, Berhard; Hurni, Samuel; Heinisch, Paul Philipp; Bloch, Andreas; Sondergaard, Soren; Jakob, Stephan; Takala, Jukka; Berger, David (2017). Right atrial pressure and venous return during cardiopulmonary bypass. American journal of physiology - heart and circulatory physiology, 313(2), H408-H420. American Physiological Society 10.1152/ajpheart.00081.2017

Bloch, Andreas; Kohler, Andreas; Posthaus, Horst; Berger, David; Santos, Laura; Jakob, Stephan; Takala, Jukka; Hänggi, Matthias (2017). Gastrointestinal Impedance Spectroscopy to Detect Hypoperfusion During Hemorrhage. Shock, 48(2), pp. 185-195. Lippincott Williams & Wilkins 10.1097/SHK.0000000000000824

Lobo, Suzana M; De Simoni, Flávio H B; Jakob, Stephan; Estella, Angel; Vadi, Sonali; Bluethgen, Andreas; Martin-Loeches, Ignacio; Sakr, Yasser; Vincent, Jean-Louis (2017). Decision-Making on Withholding or Withdrawing Life Support in the ICU: A Worldwide Perspective. Chest, 152(2), pp. 321-329. American College of Chest Physicians 10.1016/j.chest.2017.04.176

Jakob, Stephan M; Bütikofer, Lukas; Berger, David; Coslovsky, Michael; Takala, Jukka (2017). A randomized controlled pilot study to evaluate the effect of an enteral formulation designed to improve gastrointestinal tolerance in the critically ill patient-the SPIRIT trial. Critical care, 21(1), p. 140. BioMed Central 10.1186/s13054-017-1730-1

De Marchis, Gian Marco; Schaad, Chris; Fung, Christian; Beck, Jürgen; Gralla, Jan; Takala, Jukka; Jakob, Stephan (2017). Gender-related differences in aneurysmal subarachnoid hemorrhage: A hospital based study. Clinical neurology and neurosurgery, 157, pp. 82-87. Elsevier 10.1016/j.clineuro.2017.04.009

Corrêa, Thiago Domingos; Pereira, Adriano José; Brandt, Sebastian; Vuda, Madhusudanarao; Djafarzadeh, Siamak; Takala, Jukka; Jakob, Stephan (2017). Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis. Critical care, 21(1), p. 105. BioMed Central 10.1186/s13054-017-1691-4

Schneider, Christoph; Wicki, Simone; Graeter, Stefanie; Maneva Timcheva, Tankica; Keller, Christian W; Quast, Isaak; Leontyev, Danila; Djoumerska-Alexieva, Iglika K; Käsermann, Fabian; Jakob, Stephan; Dimitrova, Petya A; Branch, Donald R; Cummings, Richard D; Lünemann, Jan D; Kaufmann, Thomas; Simon, Hans-Uwe; von Gunten, Stephan (2017). IVIG regulates the survival of human but not mouse neutrophils. Scientific Reports, 7(1), p. 1296. Nature Publishing Group 10.1038/s41598-017-01404-0

Jakob, Stephan; Takala, Jukka (2017). Comments on Teboul and Scheeren: understanding the Haldane effect. Intensive care medicine, 43(4), p. 597. Springer 10.1007/s00134-017-4697-0

Berger, David; Werner Möller, Per; Blöchlinger, Stefan; Bloch, Andreas; Jakob, Stephan; Takala, Jukka (21 March 2017). P106 Methodological issues for the determination of mean systemic filling pressure at the end of life. Critical care, 21(Suppl1), p. 41. BioMed Central

Werner Möller, Per; Jakob, Stephan; Takala, Jukka; Berger, David (21 March 2017). P108 Right atrial pressure as back-pressure to venous return. Critical care, 21(Suppl 1), pp. 41-42. BioMed Central

Djafarzadeh, Siamak; Jakob, Stephan (2017). Isolation of Intact Mitochondria from Skeletal Muscle by Differential Centrifugation for High-resolution Respirometry Measurements. Journal of visualized experiments(121) MYJoVE Corporation 10.3791/55251

Djafarzadeh, Siamak; Jakob, Stephan (2017). High-resolution Respirometry to Assess Mitochondrial Function in Permeabilized and Intact Cells. Journal of visualized experiments(120) MYJoVE Corporation 10.3791/54985

Varis, Elina; Pettilä, Ville Yrjö Olavi; Poukkanen, Meri; Jakob, Stephan; Karlsson, Sari; Perner, Anders; Takala, Jukka; Wilkman, Erika (2017). Evolution of Blood Lactate and 90-Day Mortality in Septic Shock. A Post Hoc Analysis of the Finnaki Study. Shock, 47(5), pp. 574-581. Lippincott Williams & Wilkins 10.1097/SHK.0000000000000772

Reintam Blaser, Annika; Starkopf, Joel; Alhazzani, Waleed; Berger, Mette M.; Casaer, Michael P.; Deane, Adam M.; Fruhwald, Sonja; Hiesmayr, Michael; Ichai, Carole; Jakob, Stephan; Loudet, Cecilia I.; Malbrain, Manu L. N. G.; Montejo González, Juan C.; Paugam-Burtz, Catherine; Poeze, Martijn; Preiser, Jean-Charles; Singer, Pierre; van Zanten, Arthur R.H.; De Waele, Jan; Wendon, Julia; ... (2017). Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines. Intensive care medicine, 43(3), pp. 380-398. Springer 10.1007/s00134-016-4665-0

Merz, Tobias; Pereira, Adriano J; Schürch, Roger; Schefold, Joerg C.; Jakob, Stephan; Takala, Jukka; Djafarzadeh, Siamak (2017). Mitochondrial function of immune cells in septic shock: A prospective observational cohort study. PLoS ONE, 12(6), e0178946. Public Library of Science 10.1371/journal.pone.0178946

Kessler, Ulf; Schlapbach, Luregn J.; Klimek, Peter Michael; Jakob, Stephan (2017). Low L-Ficolin associated with disease severity during sepsis in adult ICU patients. Liver international, 37(9), p. 1409. Blackwell Munksgaard 10.1111/liv.13448

2016

Nobile, Leda; Taccone, Fabio S; Szakmany, Tamas; Sakr, Yasser; Jakob, Stephan; Pellis, Tommaso; Antonelli, Massimo; Leone, Marc; Wittebole, Xavier; Pickkers, Peter; Vincent, Jean-Louis (2016). The impact of extracerebral organ failure on outcome of patients after cardiac arrest: an observational study from the ICON database. Critical care, 20(1), p. 368. BioMed Central 10.1186/s13054-016-1528-6

Bhaskar, Monica; Jakob, Stephan; Djafarzadeh, Siamak (2 November 2016). Effect of cytomix and sedative drugs on mitochondrial electron transport chain of cultured primary human astrocytes (Unpublished). In: Day of Clinical Research 2016.

Pettilä, Ville Yrjö Olavi; Jakob, Stephan; Takala, Jukka (2016). The new sepsis/septic shock-3 definition is just not enough - more detailed research is needed. Acta anaesthesiologica Scandinavica, 60(10), pp. 1344-1346. Wiley-Blackwell 10.1111/aas.12777

Martin-Loeches, Ignacio; Wunderink, Richard G; Nanchal, Rahul; Lefrant, Jean Yves; Kapadia, Farhad; Sakr, Yasser; Vincent, Jean-Louis; Jakob, Stephan (2016). Determinants of time to death in hospital in critically ill patients around the world. Intensive care medicine, 42(9), pp. 1454-1460. Springer 10.1007/s00134-016-4479-0

Eggmann, Sabrina; Verra, Martin L; Luder, Gere; Takala, Jukka; Jakob, Stephan (2016). Effects of early, combined endurance and resistance training in mechanically ventilated, critically ill patients: a study protocol for a randomised controlled trial. Trials, 17, p. 403. BioMed Central 10.1186/s13063-016-1533-8

Djafarzadeh, Siamak; Vuda, Madhusudanarao; Jeger, Victor; Takala, Jukka; Jakob, Stephan (2016). The Effects of Fentanyl on Hepatic Mitochondrial Function. Anesthesia and analgesia, 123(2), pp. 311-325. International Anesthesia Research Society 10.1213/ANE.0000000000001280

Pettilä, Ville Yrjö Olavi; Hjortrup, Peter Buhl; Jakob, Stephan; Wilkman, Erika; Perner, Anders; Takala, Jukka (2016). Control groups in recent septic shock trials: a systematic review. Intensive care medicine, 42(12), pp. 1912-1921. Springer 10.1007/s00134-016-4444-y

Berger, David; Werner Möller, Per; Weber, Alberto; Bloch, Andreas; Bloechlinger, Stefan; Hänggi, Matthias; Sondergaard, Soren; Jakob, Stephan; Magder, Sheldon; Takala, Jukka (2016). Effect of PEEP, blood volume, and inspiratory hold maneuvers on venous return. American journal of physiology - heart and circulatory physiology, 311(3), H794-H806. American Physiological Society 10.1152/ajpheart.00931.2015

Takala, Jukka; Jakob, Stephan (2016). Oxygen transport in the critically ill. In: Webb, Andrew; Angus, Derek; Finfer, Simon; Gattinoni, Luciano; Singer, Mervyn (eds.) Oxford Textbook of Critical Care (pp. 636-639). Oxford University Press

Reintam Blaser, Annika; Jakob, Stephan; Starkopf, Joel (2016). Gastrointestinal failure in the ICU. Current opinion in critical care, 22(2), pp. 128-141. Lippincott Williams & Wilkins 10.1097/MCC.0000000000000286

Basciani, Reto Marco; Rindlisbacher, Antje; Begert, Esther; Brander, Luc; Jakob, Stephan; Etter, Reto; Carrel, Thierry; Eberle, Balthasar (2016). Anaesthetic induction with etomidate in cardiac surgery: A randomised controlled trial. European journal of anaesthesiology, 33(6), pp. 417-424. Lippincott Williams & Wilkins 10.1097/EJA.0000000000000434

Zürcher, Patrick; Springe, Dirk; Grandgirard, Denis; Leib, Stephen; Grossholz, Marius; Jakob, Stephan; Takala, Jukka; Hänggi, Matthias (2016). A randomized trial of the effects of the noble gases helium and argon on neuroprotection in a rodent cardiac arrest model. BMC neurology, 16, p. 43. BioMed Central 10.1186/s12883-016-0565-8

Pettilä, Ville Yrjö Olavi; Merz, Tobias Michael; Wilkman, Erika; Perner, Anders; Karlsson, Sari; Lange, Theis; Hästbacka, Johanna; Hjortrup, Peter Buhl; Kuitunen, Anne; Jakob, Stephan; Takala, Jukka (2016). Targeted tissue perfusion versus macrocirculation-guided standard care in patients with septic shock (TARTARE-2S): study protocol and statistical analysis plan for a randomized controlled trial. Trials, 17(384), p. 384. BioMed Central 10.1186/s13063-016-1515-x

2015

Zubler, Frederic; Koenig, Christa; Steimer, Andreas; Jakob, Stephan; Schindler, Kaspar Anton; Gast, Heidemarie (2015). Prognostic and diagnostic value of EEG signal coupling measures in coma. Clinical neurophysiology, 127(8), pp. 2942-2952. Elsevier 10.1016/j.clinph.2015.08.022

Fung, Christian; Inglin, Fabienne; Murek, Michael Konrad; Balmer, Mathias; Abu-Isa, Janine; Z'Graggen, Werner Josef; Ozdoba, Christoph; Gralla, Jan; Jakob, Stephan; Takala, Jukka; Beck, Jürgen; Raabe, Andreas (2015). Reconsidering the logic of World Federation of Neurosurgical Societies grading in patients with severe subarachnoid hemorrhage. Journal of neurosurgery, 124(2), pp. 299-304. American Association of Neurological Surgeons 10.3171/2015.2.JNS14614

Merz, Tobias Michael; Pichler Hefti, Jacqueline Renée; Hefti, Urs; Huber, Andreas; Jakob, Stephan; Takala, Jukka; Djafarzadeh, Siamak (2015). Changes in mitochondrial enzymatic activities of monocytes during prolonged hypobaric hypoxia and influence of antioxidants: A randomized controlled study. Redox report, 20(5), pp. 234-240. Maney Publishing 10.1179/1351000215Y.0000000007

Bloechlinger, Stefan; Berger, David; Bryner, Jürg; Roost, Eva; Jakob, Stephan; Dünser, Martin W; Takala, Jukka (2015). Changes in Left Ventricular Torsion Early Postoperatively After Aortic Valve Replacement and at Long-Term Follow-up. Journal of cardiothoracic and vascular anesthesia, 29(4), pp. 860-867. Elsevier 10.1053/j.jvca.2015.01.010

Jakob, Stephan; Groeneveld, A B Johan; Teboul, Jean-Louis (2015). Venous-arterial CO2 to arterial-venous O2 difference ratio as a resuscitation target in shock states? Intensive care medicine, 41(5), pp. 936-938. Springer 10.1007/s00134-015-3778-1

Bänziger, B; Regueira, T; Vogt, R; Brandt, S; Vandevelde, M; Jakob, Stephan (2015). Neurohistological abnormalities during early porcine endotoxemia. Acta anaesthesiologica Scandinavica, 59(5), pp. 586-597. Wiley-Blackwell 10.1111/aas.12512

Bendel, Stepani; Springe, Dirk; Pereira, Adriano José; Grandgirard, Denis; Leib, Stephen; Putzu, Alessandro; Schlickeiser, Jannis; Jakob, Stephan M.; Takala, Jukka; Hänggi, Matthias (2015). Do different anesthesia regimes affect hippocampal apoptosis and neurologic deficits in a rodent cardiac arrest model? BMC anesthesiology, 15(2), p. 2. BioMed Central 10.1186/1471-2253-15-2

Fung, Christian; Balmer, Mathias; Murek, Michael; Z'Graggen, Werner Josef; Abu-Isa, Janine; Ozdoba, Christoph; Hänggi, Matthias; Jakob, Stephan; Raabe, Andreas; Beck, Jürgen (2015). Impact of early-onset seizures on grading and outcome in patients with subarachnoid hemorrhage. Journal of neurosurgery, 122(2), pp. 408-413. American Association of Neurological Surgeons 10.3171/2014.10.JNS14163

Marbacher, Serge; Fathi, Ali Reza; Muroi, Carl; Coluccia, Daniel; Andereggen, Lukas; Neuschmelting, Volker; Widmer, Hans Rudolf; Jakob, Stephan; Fandino, Javier (2015). The rabbit blood shunt subarachnoid haemorrhage model. Acta neurochirurgica - supplementa, 120, pp. 337-342. Springer 10.1007/978-3-319-04981-6_58

Ackermann, Karin; Brander, Lukas; Tuchscherer, Daniel; Schröder, Ralph; Jakob, Stephan; Takala, Jukka; Z'Graggen, Werner Josef (2015). Esophageal versus surface recording of diaphragm compound muscle action potential. Muscle & nerve, 51(4), pp. 598-600. John Wiley & Sons 10.1002/mus.24577

Corrêa, Thiago Domingos; Takala, Jukka; Jakob, Stephan (2015). Is lactate clearance impaired in septic shock? Critical care, 19(306), p. 306. BioMed Central 10.1186/s13054-015-1039-x

Corrêa, Thiago Domingos; Jakob, Stephan; Takala, Jukka (2015). Arterial blood pressure targets in septic shock: is it time to move to an individualized approach? Critical care, 19(264), p. 264. BioMed Central 10.1186/s13054-015-0958-x

Turunen, Heidi; Jakob, Stephan; Ruokonen, Esko; Kaukonen, Kirsi-Maija; Sarapohja, Toni; Apajasalo, Marjo; Takala, Jukka (2015). Dexmedetomidine versus standard care sedation with propofol or midazolam in intensive care: an economic evaluation. Critical care, 19(67), p. 67. BioMed Central 10.1186/s13054-015-0787-y

Corrêa, Thiago D; Takala, Jukka; Jakob, Stephan (2015). Angiotensin II in septic shock. Critical care, 19(98), p. 98. BioMed Central 10.1186/s13054-015-0802-3

Jeger, Victor; Brandt, Sebastian; Porta, Francesca; Jakob, Stephan; Takala, Jukka; Djafarzadeh, Siamak (2015). Dose response of endotoxin on hepatocyte and muscle mitochondrial respiration in vitro. BioMed research international, 2015, p. 353074. Hindawi Publishing Corporation 10.1155/2015/353074

2014

Marbacher, Serge; Nevzati, Edin; Croci, Davide; Erhardt, Salome; Muroi, Carl; Jakob, Stephan; Fandino, Javier (2014). The Rabbit Shunt Model of Subarachnoid Haemorrhage. Translational stroke research, 5(6), pp. 669-680. Springer 10.1007/s12975-014-0369-3

Marbacher, Serge; Neuschmelting, Volker; Andereggen, Lukas; Widmer, Hans Rudolf; von Gunten, Michael; Takala, Jukka; Jakob, Stephan; Fandino, Javier (2014). Early brain injury linearly correlates with reduction in cerebral perfusion pressure during the hyperacute phase of subarachnoid hemorrhage. Intensive care medicine experimental, 2(1), p. 30. Springer 10.1186/s40635-014-0030-1

Andereggen, Lukas; Neuschmelting, Volker; von Gunten, Michael; Widmer, Hans Rudolf; Takala, Jukka; Jakob, Stephan; Fandino, Javier; Marbacher, Serge (2014). The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects. Journal of visualized experiments(92), e52132. MYJoVE Corporation 10.3791/52132

Hänggi, Matthias; Jakob, Stephan; Takala, Jukka (2014). Sedation level and prevalence of delirium: response to Brummel and Ely. Intensive care medicine, 40(1), p. 136. Springer 10.1007/s00134-013-3092-8

Pereira, A. J.; Jeger, V.; Fahrner, R.; Djafarzadeh, Siamak; Lensch, Michael; Takala, Jukka; Jakob, Stephan (2014). Interference of angiotensin II and enalapril with hepatic blood flow regulation. American journal of physiology - gastrointestinal and liver physiology, 307(6), G655-G663. American Physiological Society 10.1152/ajpgi.00150.2014

Corrêa, Thiago D.; Jeger, Victor; Pereira, Adriano José; Takala, Jukka; Djafarzadeh, Siamak; Jakob, Stephan (2014). Angiotensin II in Septic Shock: effects on tissue perfusion, organ function, and mitochondrial respiration in a porcine model of fecal peritonitis. Critical care medicine, 42(8), e550-e559. Lippincott Williams & Wilkins 10.1097/CCM.0000000000000397

Ackermann, Karin; Bostock, Hugh; Brander, Lukas; Schröder, Ralph; Djafarzadeh, Siamak; Tuchscherer, Daniel; Jakob, Stephan; Takala, Jukka; Z'Graggen, Werner Josef (2014). Early changes of muscle membrane properties in porcine faecal peritonitis. Critical care, 18(4), p. 484. BioMed Central 10.1186/s13054-014-0484-2

Jakob, Stephan; Ruokonen, E.; Takala, Jukka (2014). Efficacy of dexmedetomidine compared with midazolam for sedation in adult intensive care patients. British journal of anaesthesia, 112(3), pp. 581-582. Oxford University Press 10.1093/bja/aeu032

2013

Gorrasi, José; Eleftheriadis, Anestis; Takala, Jukka; Brandt, Sebastian; Djafarzadeh, Siamak; Brügger, Lukas; Bracht, Hendrik; Jakob, Stephan (2013). Different Contribution of Splanchnic Organs to Hyperlactatemia in Fecal Peritonitis and Cardiac Tamponade. BioMed research international, 2013, pp. 1-8. Hindawi Publishing Corporation 10.1155/2013/251084

Astin, Ronan; Bentham, Robert; Djafarzadeh, Siamak; Horscroft, James A.; Kuc, Rhoda E.; Leung, Po Sing; Skipworth, James R. A.; Vicencio, Jose M.; Davenport, Anthony P.; Murray, Andrew J.; Takala, Jukka; Jakob, Stephan; Montgomery, Hugh; Szabadkai, Gyorgy (2013). No evidence for a local renin-angiotensin system in liver mitochondria. Scientific Reports, 3(1), p. 2467. Nature Publishing Group 10.1038/srep02467

Corrêa, Thiago Domingos; Takala, Jukka; Jakob, Stephan (2013). Target blood pressure in sepsis: between a rock and a hard place. Critical care, 17(3), p. 433. BioMed Central 10.1186/cc12692

Jeger, Victor; Djafarzadeh, Siamak; Jakob, Stephan; Takala, Jukka (2013). Mitochondrial function in sepsis. European journal of clinical investigation, 43(5), pp. 532-542. Wiley-Blackwell 10.1111/eci.12069

Corrêa, Thiago Domingos; Vuda, Madhusudanarao; Takala, Jukka; Djafarzadeh, Siamak; Silva, Eliézer; Jakob, Stephan (2013). Increasing mean arterial blood pressure in sepsis: effects on fluid balance, vasopressor load and renal function. Critical care, 17(1), R21. BioMed Central 10.1186/cc12495

Lehmann, Laura; Bendel, Stepani; Uehlinger, Dominik E; Takala, Jukka; Schafer, Margaret; Reinert, Michael; Jakob, Stephan M (2013). Randomized, Double-Blind Trial of the Effect of Fluid Composition on Electrolyte, Acid-Base, and Fluid Homeostasis in Patients Early After Subarachnoid Hemorrhage. Neurocritical care, 18(1), pp. 5-12. New York, N.Y.: Springer 10.1007/s12028-012-9764-3

Torgersen, Christian-Erik; Meichtry, Jurka; Schmittinger, Christian A; Blöchlinger, Stefan; Jakob, Stephan M; Takala, Jukka; Dünser, Martin Wolfgang (2013). Haemodynamic variables and functional outcome in hypothermic patients following out-of-hospital cardiac arrest. Resuscitation, 84(6), pp. 798-804. Shannon: Elsevier Science Ireland 10.1016/j.resuscitation.2012.10.012

Hänggi, Matthias; Blum, Sina; Brechbuehl, Ruth; Brunello, Anna; Jakob, Stephan; Takala, Jukka (2013). Effect of sedation level on the prevalence of delirium when assessed with CAM-ICU and ICDSC. Intensive care medicine, 39(12), pp. 2171-2179. Springer Berlin Heidelberg 10.1007/s00134-013-3034-5

2012

Vuda, Madhusudanarao; Brander, Lukas; Schröeder, Ralph; Jakob, Stephan M; Takala, Jukka; Djafarzadeh, Siamak (2012). Effects of catecholamines on hepatic and skeletal muscle mitochondrial respiration after prolonged exposure to faecal peritonitis in pigs. Innate immunity, 18(2), pp. 217-30. Los Angeles, Calif.: Sage Publications 10.1177/1753425911398279

Fung, Christian; Z'graggen, Werner J; Beck, Jürgen; Gralla, Jan; Jakob, Stephan M; Schucht, Philippe; Raabe, Andreas (2012). Traumatic subarachnoid hemorrhage, basal ganglia hematoma and ischemic stroke caused by a torn lenticulostriate artery. Acta neurochirurgica, 154(1), pp. 59-62. Wien: Springer Vienna 10.1007/s00701-011-1162-7

Jakob, Stephan M; Bracht, Hendrik; Porta, Francesca; Balsiger, Bruno M; Brander, Lukas; Knuesel, Rafael; Feng, Hong-Qiang; Kolarova, Anna; Ma, Yingmin; Takala, Jukka (2012). Effects of cardiac preload reduction and dobutamine on hepatosplanchnic blood flow regulation in porcine endotoxemia. American journal of physiology - gastrointestinal and liver physiology, 303(2), G247-55. Bethesda, Md.: American Physiological Society 10.1152/ajpgi.00433.2011

Chiusa, Manuel; Hool, Sara-Lynn; Truetsch, Petra; Djafarzadeh, Siamak; Jakob, Stephan M; Seifriz, Franziska; Scherer, Stefan J; Suter, Thomas M; Zuppinger, Christian; Zbinden, Stephan (2012). Cancer therapy modulates VEGF signaling and viability in adult rat cardiac microvascular endothelial cells and cardiomyocytes. Journal of molecular and cellular cardiology, 52(5), pp. 1164-75. Oxford: Elsevier 10.1016/j.yjmcc.2012.01.022

Jakob, Stephan M; Ruokonen, Esko; Grounds, R Michael; Sarapohja, Toni; Garratt, Chris; Pocock, Stuart J; Bratty, J Raymond; Takala, Jukka; Dexmedetomidine for Long-Term Sedation, Investigators (2012). Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA - the journal of the American Medical Association, 307(11), pp. 1151-60. Chicago, Ill.: American Medical Association 10.1001/jama.2012.304

Jeitziner, M-M; Schwendimann, R; Hamers, J P H; Rohrer, O; Hantikainen, V; Jakob, S M (2012). Assessment of pain in sedated and mechanically ventilated patients: an observational study. Acta anaesthesiologica Scandinavica, 56(5), pp. 645-54. Oxford: Wiley-Blackwell 10.1111/j.1399-6576.2012.02660.x

Reintam Blaser, Annika; Malbrain, Manu L N G; Starkopf, Joel; Fruhwald, Sonja; Jakob, Stephan M; De Waele, Jan; Braun, Jan-Peter; Poeze, Martijn; Spies, Claudia (2012). Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems. Intensive care medicine, 38(3), pp. 384-94. Berlin: Springer-Verlag 10.1007/s00134-011-2459-y

Brügger, Lukas E; Beldi, Guido; Stalder, Michael; Porta, Francesca; Candinas, Daniel; Takala, Jukka; Jakob, Stephan M (2012). Postoperative splanchnic blood flow redistribution in response to fluid challenges in the presence and absence of endotoxemia in a porcine model. Shock, 37(1), pp. 116-21. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/SHK.0b013e31823917eb

Corrêa, Thiago D; Vuda, Madhusudanarao; Blaser, Annika Reintam; Takala, Jukka; Djafarzadeh, Siamak; Dünser, Martin W; Silva, Eliézer; Lensch, Michael; Wilkens, Ludwig; Jakob, Stephan M (2012). Effect of treatment delay on disease severity and need for resuscitation in porcine fecal peritonitis. Critical care medicine, 40(10), pp. 2841-9. Baltimore, Md.: Lippincott Williams & Wilkins 10.1097/CCM.0b013e31825b916b

Marbacher, Serge; Andereggen, Lukas; Neuschmelting, Volker; Widmer, Hans Rudolf; von Gunten, Michael; Takala, Jukka; Jakob, Stephan M; Fandino, Javier (2012). A new rabbit model for the study of early brain injury after subarachnoid hemorrhage. Journal of neuroscience methods, 208(2), pp. 138-45. Amsterdam: Elsevier 10.1016/j.jneumeth.2012.05.010

Regueira, T; Djafarzadeh, S; Brandt, S; Gorrasi, J; Borotto, E; Porta, F; Takala, J; Bracht, H; Shaw, S; Lepper, P M; Jakob, S M (2012). Oxygen transport and mitochondrial function in porcine septic shock, cardiogenic shock, and hypoxaemia. Acta anaesthesiologica Scandinavica, 56(7), pp. 846-59. Oxford: Wiley-Blackwell 10.1111/j.1399-6576.2012.02706.x

Ganter, C C; Hochuli, R; Bossard, M; Etter, Reto; Takala, J; Uehlinger, D E; Jakob, S M (2012). Forced fluid removal in critically ill patients with acute kidney injury. Acta anaesthesiologica Scandinavica, 56(9), pp. 1183-90. Oxford: Wiley-Blackwell 10.1111/j.1399-6576.2012.02734.x

Shafighi, Maziar; Olariu, Radu; Brun, Claudio; Fathi, Ali R; Djafarzadeh, Siamak; Jakob, Stephan M; Hunger, Robert E; Banic, Andrej; Constantinescu, Mihai A (2012). The role of androgens on hypoxia-inducible factor (HIF)-1α-induced angiogenesis and on the survival of ischemically challenged skin flaps in a rat model. Microsurgery, 32(6), pp. 475-81. New York, N.Y.: Wiley-Liss 10.1002/micr.21996

Djafarzadeh, Siamak; Vuda, Madhusudanarao; Takala, Jukka; Jakob, Stephan M (2012). Effect of remifentanil on mitochondrial oxygen consumption of cultured human hepatocytes. PLoS ONE, 7(9), e45195. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0045195

2011

Banz, Vanessa M; Jakob, Stephan M; Inderbitzin, Daniel (2011). Improving Outcome After Major Surgery: Pathophysiological Considerations. Anesthesia and analgesia, 112(5), pp. 1147-55. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1213/ANE.0b013e3181ed114e

Djafarzadeh, Siamak; Vuda, Madhusudanarao; Takala, Jukka; Ochs, Matthias; Jakob, Stephan M (2011). Toll-like receptor-3-induced mitochondrial dysfunction in cultured human hepatocytes. Mitochondrion, 11(1), pp. 83-8. Amsterdam: Elsevier 10.1016/j.mito.2010.07.010

Haenggi, Matthias; Barthelmes, Daniel; Ulmer, Hanno; Takala, Jukka; Jakob, Stephan M (2011). Comparison of non-calibrated pulse-contour analysis with continuous thermodilution for cardiac output assessment in patients with induced hypothermia after cardiac arrest. Resuscitation, 82(4), pp. 423-6. Shannon: Elsevier Science Ireland 10.1016/j.resuscitation.2010.12.015

Marbacher, Serge; Sherif, Camillo; Neuschmelting, Volker; Schläppi, Janine-Ai; Takala, Jukka; Jakob, Stephan; Fandino, Javier (2011). Preliminary results of an ICP-controlled subarachnoid hemorrhage rabbit model for the study of delayed cerebral vasospasm. Acta neurochirurgica - supplementa, 110(Pt 1), pp. 163-5. Wien: Springer 10.1007/978-3-7091-0353-1_28

Torgersen, Christian; Dünser, Martin W; Schmittinger, Christian A; Pettilä, Ville; Ruokonen, Esko; Wenzel, Volker; Jakob, Stephan M; Takala, Jukka (2011). Current approach to the haemodynamic management of septic shock patients in European intensive care units: a cross-sectional, self-reported questionnaire-based survey. European journal of anaesthesiology, 28(4), pp. 284-90. Philadelphia, Pa.: Lippincott Williams & Wilkins 10.1097/EJA.0b013e3283405062

Fathi, Ali Reza; Marbacher, Serge; Graupner, Thilo; Wehrli, Felix; Jakob, Stephan M; Schroth, Gerhard; Fandino, Javier (2011). Continuous intrathecal glyceryl trinitrate prevents delayed cerebral vasospasm in the single-SAH rabbit model in vivo. Acta neurochirurgica, 153(8), 1669-75; discussion 1675. Wien: Springer Vienna 10.1007/s00701-011-1049-7

Takala, Jukka; Ruokonen, Esko; Tenhunen, Jyrki J; Parviainen, Ilkka; Jakob, Stephan M (2011). Early non-invasive cardiac output monitoring in hemodynamically unstable intensive care patients: A multi-center randomized controlled trial. Critical care, 15(3), R148. London: BioMed Central 10.1186/cc10273

Kessler, Ulf; Grau, Tamar; Gronchi, Fabrizio; Berger, Steffen; Brandt, Sebastian; Bracht, Hendrik; Marcucci, Carlo; Zachariou, Zacharias; Jakob, Stephan M (2011). Comparison of porcine and human coagulation by thrombelastometry. Thrombosis research, 128(5), pp. 477-82. Amsterdam: Elsevier 10.1016/j.thromres.2011.03.013

Shafighi, Maziar; Olariu, Radu; Fathi, Ali R; Djafarzadeh, Siamak; Jakob, Stephan M; Banic, Andrej; Constantinescu, Mihai A (2011). Dimethyloxalylglycine stabilizes HIF-1α in cultured human endothelial cells and increases random-pattern skin flap survival in vivo. Plastic and reconstructive surgery, 128(2), pp. 415-422. Lippincott Williams & Wilkins 10.1097/PRS.0b013e31821e6e69

Hofmann, Eveline; Marbach, Serge; Jakob, Stephan M; Takala, Jukka; Remonda, Luca; Fandino, Javier (2011). Incidence of vasospasm, outcome, and quality of life after endovascular and surgical treatment of ruptured intracranial aneurysms: results of a single-center prospective study in Switzerland. ISRN vascular medicine, 2011 New York, N.Y.: International Scholarly Research Network ISRN

2010

Brunello, Anna-Giulia; Haenggi, Matthias; Wigger, Oliver; Porta, Francesca; Takala, Jukka; Jakob, Stephan M (2010). Usefulness of a clinical diagnosis of ICU-acquired paresis to predict outcome in patients with SIRS and acute respiratory failure. Intensive care medicine, 36(1), pp. 66-74. Berlin: Springer-Verlag 10.1007/s00134-009-1645-7

Spirig, Rolf; Djafarzadeh, Siamak; Regueira, Tomas; Shaw, Sidney G; von Garnier, Christophe; Takala, Jukka; Jakob, Stephan M; Rieben, Robert; Lepper, Philipp M (2010). Effects of TLR agonists on the hypoxia-regulated transcription factor HIF-1alpha and dendritic cell maturation under normoxic conditions. PLoS ONE, 5(6), e0010983. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0010983

Jakob, Stephan M; Stanga, Zeno (2010). Perioperative metabolic changes in patients undergoing cardiac surgery. Nutrition, 26(4), pp. 349-53. New York, N.Y.: Elsevier 10.1016/j.nut.2009.07.014

Daudel, Fritz; Gorrasi, José; Bracht, Hendrik; Brandt, Sebastian; Krejci, Vladimir; Jakob, Stephan M; Takala, Jukka; Rothen, Hans Ulrich (2010). Effects of lung recruitment maneuvers on splanchnic organ perfusion during endotoxin-induced pulmonary arterial hypertension. Shock, 34(5), pp. 488-94. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/SHK.0b013e3181e03bfb

Brügger, Lukas E; Beldi, Guido; Beck, Mario; Porta, Francesca; Bracht, Hendrik; Candinas, Daniel; Takala, Jukka; Jakob, Stephan M (2010). Splanchnic vasoregulation after major abdominal surgery in pigs. World journal of surgery, 34(9), pp. 2057-63. New York, N.Y.: Springer

Barthelmes, D; Jakob, S M; Laitinen, S; Rahikainen, S; Ahonen, H; Takala, J (2010). Effect of site of lactate infusion on regional lactate exchange in pigs. British journal of anaesthesia, 105(5), pp. 627-34. Oxford: Oxford University Press 10.1093/bja/aeq214

Wyler von Ballmoos, Moritz; Takala, Jukka; Roeck, Margareta; Porta, Francesca; Tueller, David; Ganter, Christoph C; Schröder, Ralph; Bracht, Hendrik; Baenziger, Bertram; Jakob, Stephan M (2010). Pulse-pressure variation and hemodynamic response in patients with elevated pulmonary artery pressure: a clinical study. Critical care, 14(3), R111. London: BioMed Central 10.1186/cc9060

Passath, Christina; Takala, Jukka; Tuchscherer, Daniel; Jakob, Stephan M; Sinderby, Christer; Brander, Lukas (2010). Physiologic response to changing positive end-expiratory pressure during neurally adjusted ventilatory assist in sedated, critically ill adults. Chest, 138(3), pp. 578-87. Northbrook, Ill.: American College of Chest Physicians 10.1378/chest.10-0286

Dahlqvist, Mats B; Andres, Robert H; Raabe, Andreas; Jakob, Stephan M; Takala, Jukka; Dünser, Martin W (2010). Brain herniation in a patient with apparently normal intracranial pressure: a case report. Journal of medical case reports, 4, p. 297. London: BioMed Central

Daudel, Fritz; Tüller, David; Krähenbühl, Stefanie; Jakob, Stephan M; Takala, Jukka (2010). Pulse pressure variation and volume responsiveness during acutely increased pulmonary artery pressure: an experimental study. Critical care, 14(3), R122. London: BioMed Central 10.1186/cc9080

Torgersen, C; Schmittinger, C A; Takala, J; Jakob, S M; Dünser, M W (2010). The association between early hemodynamic variables and outcome in normothermic comatose patients following cardiac arrest. Acta anaesthesiologica Scandinavica, 54(8), pp. 1027-35. Oxford: Wiley-Blackwell 10.1111/j.1399-6576.2010.02273.x

Marbacher, Serge; Sherif, Camillo; Neuschmelting, Volker; Schläppi, Janine-Ai; Takala, Jukka; Jakob, Stephan M; Fandino, Javier (2010). Extra-intracranial blood shunt mimicking aneurysm rupture: intracranial-pressure-controlled rabbit subarachnoid hemorrhage model. Journal of neuroscience methods, 191(2), pp. 227-33. Amsterdam: Elsevier 10.1016/j.jneumeth.2010.07.004

Jakob, (2010). Does hypercapnic acidosis preserve mucosal oxygenation during hemorrhage? Shock, 34(6), pp. 649-50. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/SHK.0b013e3181e86ec8

Jakob, Stephan M; Knuesel, Rafael; Tenhunen, Jyrki J; Pradl, Richard; Takala, Jukka (2010). Increasing abdominal pressure with and without PEEP: effects on intra-peritoneal, intra-organ and intra-vascular pressures. BMC gastroenterology, 10, p. 70. London: BioMed Central 10.1186/1471-230X-10-70

Jeger, Victor; Jakob, Stephan M; Fontana, Stefano; Wolf, Martin; Zimmermann, Heinz; Exadaktylos, Aristomenis K (2010). 500 ml of blood loss does not decrease non-invasive tissue oxygen saturation (StO2) as measured by near infrared spectroscopy - A hypothesis generating pilot study in healthy adult women. Journal of trauma management & outcomes, 4, p. 5. London: BioMed Central 10.1186/1752-2897-4-5

Jakob, Stephan (2010). The effects of mechanical ventilation on hepato-splanchnic perfusion. Current opinion in critical care, 16(2), pp. 165-168. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/MCC.0b013e3283374b1c

2009

Ruokonen, Esko; Parviainen, Ilkka; Jakob, Stephan M; Nunes, Silvia; Kaukonen, Maija; Shepherd, Stephen T; Sarapohja, Toni; Bratty, J Raymond; Takala, Jukka (2009). Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation. Intensive care medicine, 35(2), pp. 282-90. Berlin: Springer-Verlag 10.1007/s00134-008-1296-0

Ganter, Christoph; Buser, Christof; Haenggi, Matthias; Mattes, Hanswilly; Takala, Jukka; Jakob, Stephan (2009). Inverse thermodilution with conventional pulmonary artery catheters for the assessment of cerebral, hepatic, renal, and femoral blood flow. Shock, 32(2), pp. 194-200. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/SHK.0b013e318194c73a

Neuschmelting, Volker; Fathi, Ali-Reza; Hidalgo Staub, Eveline Teresa; Marbacher, Serge; Schroth, Gerhard; Takala, Jukka; Jakob, Stephan M; Fandino, Javier (2009). Norepinephrine-induced hypertension dilates vasospastic basilar artery after subarachnoid haemorrhage in rabbits. Acta neurochirurgica, 151(5), pp. 487-93. Wien: Springer Vienna 10.1007/s00701-009-0287-4

von Gunten, Stephan; Jakob, Stephan M; Geering, Barbara; Takala, Jukka; Simon, Hans-Uwe (2009). Different patterns of Siglec-9-mediated neutrophil death responses in septic shock. Shock, 32(4), pp. 386-92. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/SHK.0b013e3181a1bc98

Haenggi, Matthias; Ypparila-Wolters, Heidi; Buerki, Sarah; Schlauri, Rebekka; Korhonen, Ilkka; Takala, Jukka; Jakob, Stephan M (2009). Auditory event-related potentials, bispectral index, and entropy for the discrimination of different levels of sedation in intensive care unit patients. Anesthesia and analgesia, 109(3), pp. 807-16. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1213/ane.0b013e3181acc85d

Neuschmelting, Volker; Marbacher, Serge; Fathi, Ali-Reza; Jakob, Stephan M; Fandino, Javier (2009). Elevated level of endothelin-1 in cerebrospinal fluid and lack of nitric oxide in basilar arterial plasma associated with cerebral vasospasm after subarachnoid haemorrhage in rabbits. Acta neurochirurgica, 151(7), 795-801; discussion 801. Wien: Springer Vienna 10.1007/s00701-009-0350-1

Barthelmes, Daniel; Parviainen, Ilkka; Vainio, Pauli; Vanninen, Ritva; Takala, Jukka; Ikonen, Aki; Tueller, David; Jakob, Stephan M (2009). Assessment of splanchnic blood flow using magnetic resonance imaging. European journal of gastroenterology & hepatology, 21(6), pp. 693-700. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/MEG.0b013e32831a86e0

Brander, Lukas; Haltmeier, Tobias; Suter, Anna; Studer, Peter; Inderbitzin, Daniel; Candinas, Daniel; Vogt, Andreas; Henzen, Christoph; Takala, Jukka; Jakob, Stephan M (2009). Peri-operative adrenocortical response to low-dose (1 microg) ACTH and relation to postoperative complications in patients undergoing elective abdominal surgery. Surgery, 146(1), pp. 88-99. New York, N.Y.: Elsevier 10.1016/j.surg.2009.01.018

Regueira, Tomas; Lepper, Philipp M; Brandt, Sebastian; Ochs, Matthias; Vuda, Madhusudanarao; Takala, Jukka; Jakob, Stephan M; Djafarzadeh, Siamak (2009). Hypoxia inducible factor-1 alpha induction by tumour necrosis factor-alpha, but not by toll-like receptor agonists, modulates cellular respiration in cultured human hepatocytes. Liver international, 29(10), pp. 1582-92. Oxford: Blackwell Munksgaard 10.1111/j.1478-3231.2009.02109.x

Daudel, Fritz; Kessler, Ulf; Folly, Hélène; Lienert, Jasmin S; Takala, Jukka; Jakob, Stephan M (2009). Thromboelastometry for the assessment of coagulation abnormalities in early and established adult sepsis: a prospective cohort study. Critical care, 13(2), R42. London: BioMed Central 10.1186/cc7765

Dünser, Martin W; Takala, Jukka; Ulmer, Hanno; Mayr, Viktoria D; Luckner, Günter; Jochberger, Stefan; Daudel, Fritz; Lepper, Philipp; Hasibeder, Walter R; Jakob, Stephan M (2009). Arterial blood pressure during early sepsis and outcome. Intensive care medicine, 35(7), pp. 1225-33. Berlin: Springer-Verlag 10.1007/s00134-009-1427-2

Dünser, Martin W; Ruokonen, Esko; Pettilä, Ville; Ulmer, Hanno; Torgersen, Christian; Schmittinger, Christian A; Jakob, Stephan; Takala, Jukka (2009). Association of arterial blood pressure and vasopressor load with septic shock mortality: a post hoc analysis of a multicenter trial. Critical care, 13(6), R181. London: BioMed Central 10.1186/cc8167

Dünser, Martin W; Bataar, Otgon; Tsenddorj, Ganbat; Lundeg, Ganbold; Jochberger, Stefan; Jakob, Stephan (2009). Intensive care medicine in Mongolia's 3 largest cities: outlining the needs. Journal of critical care, 24(3), 469.e1-6. New York, N.Y.: Elsevier 10.1016/j.jcrc.2008.06.014

Haenggi, Matthias; Ypparila-Wolters, Heidi; Hauser, Kathrin; Caviezel, Claudio; Takala, Jukka; Korhonen, Ilkka; Jakob, Stephan M (2009). Intra- and inter-individual variation of BIS-index and Entropy during controlled sedation with midazolam/remifentanil and dexmedetomidine/remifentanil in healthy volunteers: an interventional study. Critical care, 13(1), R20. London: BioMed Central 10.1186/cc7723

Torgersen, Christian; Schmittinger, Christian A; Wagner, Sarah; Ulmer, Hanno; Takala, Jukka; Jakob, Stephan M; Dünser, Martin W (2009). Hemodynamic variables and mortality in cardiogenic shock: a retrospective cohort study. Critical care, 13(5), R157. London: BioMed Central 10.1186/cc8114

Farese, Stefan; Jakob, Stephan M; Kalicki, Robert; Frey, Felix J; Uehlinger, Dominik E (2009). Treatment of acute renal failure in the intensive care unit: lower costs by intermittent dialysis than continuous venovenous hemodiafiltration. Artificial organs, 33(8), pp. 634-40. Malden, Mass.: Wiley-Blackwell 10.1111/j.1525-1594.2009.00794.x

Jakob, Stephan (2009). Septic shock resuscitation: what goals and how to achieve them? Critical care, 13(3), p. 147. London: BioMed Central 10.1186/cc7870

Arnberger, Michael; Vogt, Andreas; Studer, Peter; Inderbitzin, Daniel; Pulver, Carole; Röhrig, Bernd; Jakob, Stephan M; Greif, Robert (2009). Evaluation of physical and mental recovery status after elective liver resection. European journal of anaesthesiology, 26(7), pp. 559-65. Philadelphia, Pa.: Lippincott Williams & Wilkins 10.1097/EJA.0b013e328328f552

Jakob, Stephan M; Takala, Jukka (2009). Physical and occupational therapy during sedation stops. Lancet, 373(9678), pp. 1824-6. London: Elsevier 10.1016/S0140-6736(09)60866-7

Takala, Jukka; Jakob, Stephan M (2009). Shedding light on microcirculation? Intensive care medicine, 35(3), pp. 394-6. Berlin: Springer-Verlag 10.1007/s00134-008-1386-z

Jakob, Stephan M; Parviainen, Ilkka; Ruokonen, Esko; Hinder, Raffael; Uusaro, Ari; Takala, Jukka (2009). Increased splanchnic oxygen extraction because of routine nursing procedures. Critical care medicine, 37(2), pp. 483-9. Baltimore, Md.: Lippincott Williams & Wilkins 10.1097/CCM.0b013e3181958821

Porta, Francesca; Bracht, Hendrik; Weikert, Christian; Beck, Mario; Takala, Jukka; Brandt, Sebastian; Hiltebrand, Luzius B; Jakob, Stephan M (2009). Effects of endotoxin and catecholamines on hepatic mitochondrial respiration. Inflammation, 32(5), pp. 315-21. New York, N.Y.: Springer US; http://www.springer-ny.com 10.1007/s10753-009-9138-y

2008

Nyberg, A; Jakob, S M; Seeman-Lodding, H; Porta, F; Bracht, H; Bischofberger, H; Jern, C; Takala, J; Aneman, A (2008). Time- and dose-related regional fluxes of tissue-type plasminogen activator in anesthetized endotoxemic pigs. Acta anaesthesiologica Scandinavica, 52(1), pp. 57-64. Oxford: Wiley-Blackwell 10.1111/j.1399-6576.2007.01481.x

Bracht, Hendrik; Krejci, Vladimir; Hiltebrand, Luzius; Brandt, Sebastian; Sigurdsson, Gisli; Ali, Syed Z; Takala, Jukka; Jakob, Stephan M (2008). Orthogonal polarization spectroscopy to detect mesenteric hypoperfusion. Intensive care medicine, 34(10), pp. 1883-90. Berlin: Springer-Verlag 10.1007/s00134-008-1130-8

Taniguchi, Yoshie; Bracht, Hendrik; Porta, Francesca; Krejci, Vladimir; Ali, Sayed Z; Beck, Mario; Mettler, Daniel; Takala, Jukka; Jakob, Stephan M (2008). Thermodilution and esophageal Doppler ultrasound in the assessment of blood flow changes induced by endotoxin and dobutamine. Journal of trauma - injury, infection, and critical care, 65(1), pp. 175-82. Baltimore, Md.: Lippincott, Williams, & Wilkins 10.1097/TA.0b013e31815eb0ff

Ali, Syed Z; Bracht, Hendrik; Krejci, Vladimir; Beck, Mario; Stalder, Michael; Hiltebrand, Luzius; Takala, Jukka; Brandt, Sebastian; Jakob, Stephan M (2008). The immediate and sustained effects of volume challenge on regional blood flows in pigs. Anesthesia and analgesia, 106(2), 595-600, table of contents. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1213/ane.0b013e31816064d2

Regueira, Tomas; Bänziger, Bertram; Djafarzadeh, Siamak; Brandt, Sebastian; Gorrasi, Jose; Takala, Jukka; Lepper, Philipp M; Jakob, Stephan M (2008). Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration. Critical care, 12(4), R88. London: BioMed Central 10.1186/cc6956

Marbacher, Serge; Neuschmelting, Volker; Graupner, Thilo; Jakob, Stephan M; Fandino, Javier (2008). Prevention of delayed cerebral vasospasm by continuous intrathecal infusion of glyceroltrinitrate and nimodipine in the rabbit model in vivo. Intensive care medicine, 34(5), pp. 932-8. Berlin: Springer-Verlag 10.1007/s00134-008-0995-x

Jakob, Stephan (2008). It makes a difference! Wiener klinische Wochenschrift, 120(19-20), pp. 581-2. Wien: Springer Vienna 10.1007/s00508-008-1082-6

Hänggi, Matthias; Ypparila-Wolters, Heidi; Bieri, Christine; Steiner, Carola; Takala, Jukka; Korhonen, Ilkka; Jakob, Stephan M (2008). Entropy and bispectral index for assessment of sedation, analgesia and the effects of unpleasant stimuli in critically ill patients: an observational study. Critical care, 12(5), R119. London: BioMed Central 10.1186/cc7015

Takala, Jukka; Dellinger, R Philip; Koskinen, Kati; St Andre, Arthur; Read, Martyn; Levy, Mitchell; Jakob, Stephan M; Mello, Patricia Veiga C; Friolet, Raymond; Ruokonen, Esko (2008). Development and simultaneous application of multiple care protocols in critical care: a multicenter feasibility study. Intensive care medicine, 34(8), pp. 1401-10. Berlin: Springer-Verlag 10.1007/s00134-008-1084-x

Lötscher, S; Wermelinger, VR; Jakob, SM; Merz, TM (2008). Hämophagozytose-Syndrom mit massivem capillary leak. Schweizerisches Medizin-Forum SMF / Swiss medical forum / Forum médical suisse FMS, -8(46), pp. 898-900. Basel: EMH Editores Medicorum Helveticorum

Regueira, Tomas Emilio; Jakob, Stephan; Djafarzadeh, Siamak (2008). Regulation of mitochondrial function by hypoxia and inflammation in sepsis: A putative role for hypoxia inducible factor. In: Vincent, Jean-Louis (ed.) Yearbook of Intensive Care and Emergency Medicine 2008 (pp. 385-394). Heidelberg: Springer 10.1007/978-3-540-77290-3_36

2007

Plock, Jan; Frese, Steffen; Keogh, Adrian; Bisch-Knaden, Sonja; Ayuni, Erick; Corazza, Nadia; Weikert, Christian; Jakob, Stephan; Erni, Dominique; Dufour, Jean-François; Brunner, Thomas; Candinas, Daniel; Stroka, Deborah (2007). Activation of non-ischemic, hypoxia-inducible signalling pathways up-regulate cytoprotective genes in the murine liver. Journal of hepatology, 47(4), pp. 538-45. Amsterdam: Elsevier 10.1016/j.jhep.2007.04.016

Krejci, Vladimir; Hiltebrand, Luzius B; Jakob, Stephan M; Takala, Jukka; Sigurdsson, Gisli H (2007). Vasopressin in septic shock: effects on pancreatic, renal, and hepatic blood flow. Critical care, 11(6), R129. London: BioMed Central 10.1186/cc6197

Jakob, Stephan M; Parviainen, Ilkka; Ruokonen, Esko; Kogan, Alexander; Takala, Jukka (2007). TONOMETRY REVISITED: PERFUSION-RELATED, METABOLIC, AND RESPIRATORY COMPONENTS OF GASTRIC MUCOSAL ACIDOSIS IN ACUTE CARDIORESPIRATORY FAILURE. Shock, 29(5), pp. 543-548. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/SHK.0b013e31815d0c10

Jakob, Stephan M; Lubszky, Szabina; Friolet, Raymond; Rothen, Hans Ulrich; Kolarova, Anna; Takala, Jukka (2007). Sedation and weaning from mechanical ventilation: effects of process optimization outside a clinical trial. Journal of critical care, 22(3), pp. 219-28. New York, N.Y.: Elsevier 10.1016/j.jcrc.2007.01.001

Knuesel, Rafael; Takala, Jukka; Brander, Lukas; Haenggi, Matthias; Bracht, Hendrik; Porta, Francesca; Jakob, Stephan M (2007). Intraperitoneal microdialysis: critique of an editorial. Critical care medicine, 35(7), 1802; discussion 1802. Baltimore, Md.: Lippincott Williams & Wilkins 10.1097/01.CCM.0000269345.99949.3D

Hiltebrand, Luzius B; Krejci, Vladimir; Jakob, Stephan M; Takala, Jukka; Sigurdsson, Gisli H (2007). Effects of vasopressin on microcirculatory blood flow in the gastrointestinal tract in anesthetized pigs in septic shock. Anesthesiology, 106(6), pp. 1156-67. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/01.anes.0000267599.02140.86

Contaldo, C; Harder, Y; Plock, J; Banic, A; Jakob, S M; Erni, D (2007). The influence of local and systemic preconditioning on oxygenation, metabolism and survival in critically ischaemic skin flaps in pigs. Journal of plastic, reconstructive & aesthetic surgery, 60(11), pp. 1182-92. Amsterdam: Elsevier 10.1016/j.bjps.2007.02.011

Bracht, Hendrik; Hänggi, Matthias; Jeker, Barbara; Wegmüller, Ninja; Porta, Francesca; Tüller, David; Takala, Jukka; Jakob, Stephan M (2007). Incidence of low central venous oxygen saturation during unplanned admissions in a multidisciplinary intensive care unit: an observational study. Critical care, 11(1), R2. London: BioMed Central 10.1186/cc5144

Fandino, J; Fathi, A R; Graupner, T; Jakob, S; Landolt, H (2007). [Perspectives in the treatment of subarachnoid-hemorrhage-induced cerebral vasospasm]. Neurocirugía, 18(1), pp. 16-27. Madrid: Siglo

2006

Porta, Francesca; Takala, Jukka; Weikert, Christian; Bracht, Hendrik; Kolarova, Anna; Lauterburg, Bernhard H; Borotto, Erika; Jakob, Stephan M (2006). Effects of prolonged endotoxemia on liver, skeletal muscle and kidney mitochondrial function. Critical care, 10(4), R118. London: BioMed Central 10.1186/cc5013

Fux, Christoph A; Bianchetti, Mario G; Jakob, Stephan M; Remonda, Luca (2006). Reversible encephalopathy complicating post-streptococcal glomerulonephritis. Pediatric infectious disease journal, 25(1), pp. 85-7. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/01.imf.0000195614.66987.2f

Krejci, Vladimir; Hiltebrand, Luzius; Büchi, Conradin; Ali, Syed Z; Contaldo, Claudio; Takala, Jukka; Sigurdsson, Gisli H; Jakob, Stephan M (2006). Decreasing gut wall glucose as an early marker of impaired intestinal perfusion. Critical care medicine, 34(9), pp. 2406-14. Baltimore, Md.: Lippincott Williams & Wilkins 10.1097/01.CCM.0000233855.34344.29

Luginbühl, M; Rüfenacht, M; Korhonen, I; Gils, M; Jakob, S; Petersen-Felix, S. (2006). Stimulation induced variability of pulse plethysmography does not discriminate responsiveness to intubation. British journal of anaesthesia, 96(3), pp. 323-329. Oxford: Oxford University Press 10.1093/bja/aei315

Knuesel, Rafael; Takala, Jukka; Brander, Lukas; Haenggi, Matthias; Bracht, Hendrik; Porta, Francesca; Jakob, Stephan M (2006). Membrane microdialysis: Evaluation of a new method to assess splanchnic tissue metabolism. Critical care medicine, 34(10), pp. 2638-45. Baltimore, Md.: Lippincott Williams & Wilkins 10.1097/01.CCM.0000239430.73826.23

Brander, Lukas; Jakob, Stephan M; Knuesel, Rafael; Savolainen, Hannu; Widmer, Matthias K; Schmidli, Juerg; Takala, Jukka (2006). Effects of low abdominal blood flow and dobutamine on blood flow distribution and on the hepatic arterial buffer response in anaesthetized pigs. Shock, 25(4), pp. 402-13. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/01.0000217813.50104.5d

Ganter, CG; Jakob, SM; Takala, J (2006). Pulmonary capillary pressure. A review. Minerva anestesiologica, 72(1-2), pp. 21-36. Torino: Minerva Medica

Haenggi, Matthias; Ypparila, Heidi; Hauser, Kathrin; Caviezel, Claudio; Korhonen, Ilkka; Takala, Jukka; Jakob, Stephan M (2006). The effects of dexmedetomidine/remifentanil and midazolam/remifentanil on auditory-evoked potentials and electroencephalogram at light-to-moderate sedation levels in healthy subjects. Anesthesia and analgesia, 103(5), pp. 1163-9. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1213/01.ane.0000237394.21087.85

Porta, Francesca; Takala, Jukka; Weikert, Christian; Kaufmann, Priska; Krahenbuhl, Stephan; Jakob, Stephan M (2006). Effect of endotoxin, dobutamine and dopamine on muscle mitochondrial respiration in vitro. Journal of endotoxin research, 12(6), pp. 358-66. London: Sage 10.1179/096805106X153952

Collaborative Study Group on Perioperative ScvO2 Monitoring (KIM, H; Haenggi, M; Jakob, SM; Loher, S; Raeber, C; Takala, J) (2006). Multicentre study on peri- and postoperative central venous oxygen saturation in high-risk surgical patients. Critical care, 10(6), R158. London: BioMed Central 10.1186/cc5094

Parviainen, I; Jakob, SM; Suistomaa, M; Takala, J; The, Scandinavian Society of Anaesthesiology; Intensive, Care Medicine (SSAI) (2006). Practical sources of error in measuring pulmonary artery occlusion pressure: a study in participants of a special intensivist training program of The Scandinavian Society of Anaesthesiology and Intensive Care Medicine (SSAI). Acta anaesthesiologica Scandinavica, 50(5), pp. 600-3. Oxford: Wiley-Blackwell 10.1111/j.1399-6576.2006.01008.x

Braun, Jan-Peter; Jakob, Stephan M; Volk, Thomas; Doepfmer, Ulrich R; Moshirzadeh, Maryam; Stegmann, Shirin; Dohmen, Pascal M; Spies, Claudia (2006). Arterio-venous gradients of free energy change for assessment of systemic and splanchnic perfusion in cardiac surgery patients. Perfusion, 21(6), pp. 353-60. London: Sage 10.1177/0267659106074004

Gorrasi, J; Takala, J; Jakob, S (2006). The vascular bed during critical illness: evaluation in animal models. In: , (ed.) (119-128.). Heidelberg: Springer Verlag

2003

Knüsel, Rafael Matthias; Jakob, Stephan M.; Brander, Lukas; Bracht, Hendrik; Siegenthaler, Andreas; Takala, Jukka (2003). Changes in regional blood flow and pCO2 gradients during isolated abdominal aortic blood flow reduction. Intensive care medicine, 29(12), pp. 2255-2265. Springer-Verlag 10.1007/s00134-003-1954-1

Röck, Margareta Anna; Jakob, Stephan M.; Böhlen, Thomas; Brander, Lukas; Knuesel, Rafael; Takala, Jukka (2003). Change in stroke volume in response to fluid challenge: assessment using esophageal Doppler. Intensive care medicine, 29(10), pp. 1729-1735. Springer-Verlag 10.1007/s00134-003-1720-4

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