Segner, Helmut

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Horn, Marianna E; Segner, Helmut; Brinkmann, Markus; Machtaler, Steven (2023). Chemically-induced trout model of acute intestinal inflammation using TNBS. Fish and shellfish immunology reports, 4, p. 100073. Elsevier 10.1016/j.fsirep.2022.100073

Bo, Jun; Zheng, Ronghui; Jiang, Yulu; Chen, Jincan; Fang, Chao; Bailey, Christyn; Zhang, Yusheng; Lee, Jae-Seong; Segner, Helmut (2023). Physiological-dependent alterations on transcriptomic and proteomic patterns of the single and combined temperature and salinity-exposed hybrid grouper, Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂. Aquaculture, 575 Elsevier 10.1016/j.aquaculture.2023.739746

Larsen, Anett Kristin; Holen, Elisabeth; Segner, Helmut (2023). Editorial: Immunity and disease of aquatic organisms under the combined impact of anthropogenic stressors: mechanisms and disease outcomes. Frontiers in Marine Science, 10 Frontiers Media 10.3389/fmars.2023.1291639

Wolf, Jeffrey C; Segner, Helmut (2023). Hazards of current concentration-setting practices in environmental toxicology studies. Critical Reviews in Toxicology, 53(5), pp. 297-310. Informa Healthcare 10.1080/10408444.2023.2229372

El Bouzidi, Chaimae; Segner, Helmut; Oufdou, Halima; Benziane, Meryem; Chiaar, Abberrahim; Bakkali, Mohammed; Hassani Zerrouk, Mounir (2023). Reproduction of Merluccius merluccius (Actinopterygii: Merlucciidae) from the northern Atlantic coasts of Morocco based on histological analysis of gonads. Scientia marina, 87(3), e069. 10.3989/scimar.05315.069

Lange, Anke; Segner, Helmut (2023). The Role of Glutathione and Sulfhydryl Groups in Cadmium Uptake by Cultures of the Rainbow Trout RTG-2 Cell Line. Cells, 12(23), p. 2720. MDPI 10.3390/cells12232720


Rubin, Aurélie; Bailey, Christyn; Strepparava, Nicole; Wahli, Thomas; Segner, Helmut; Rubin, Jean-François (2022). Reliable Field Assessment of Proliferative Kidney Disease in Wild Brown Trout, Salmo trutta, Populations: When Is the Optimal Sampling Period? Pathogens, 11(6), p. 681. MDPI AG 10.3390/pathogens11060681

Schönbächler, Katja; Segner, Helmut; Amphimaque, Bénédicte; Friker, Brian; Hofer, Andreas; Lange, Barbara; Stirn, Martina; Pantchev, Nikola; Origgi, Francesco C.; Hoby, Stefan (2022). HEALTH ASSESSMENT OF CAPTIVE AND FREE-LIVING EUROPEAN POND TURTLES (EMYS ORBICULARIS) IN SWITZERLAND. Journal of zoo and wildlife medicine, 53(1), pp. 159-172. American Association of Zoo Veterinarians 10.1638/2020-0117

Rastgar, Sara; Alijani Ardeshir, Rashid; Segner, Helmut; Tyler, Charles R; J G M Peijnenburg, Willie; Wang, Youji; Salati, Amir Parviz; Movahedinia, Abdolali (2022). Immunotoxic effects of metal-based nanoparticles in fish and bivalves. Nanotoxicology, 16(1), pp. 88-113. Taylor & Francis 10.1080/17435390.2022.2041756

Kernen, Larissa; Phan, Audrey; Bo, Jun; Herzog, Elio L.; Huynh, John; Segner, Helmut; Baumann, Lisa (2022). Estrogens as immunotoxicants: 17α-ethinylestradiol exposure retards thymus development in zebrafish (Danio rerio). Aquatic toxicology, 242, p. 106025. Elsevier 10.1016/j.aquatox.2021.106025

Strobel, Anneli; Lille-Langøy, Roger; Segner, Helmut; Burkhardt-Holm, Patricia; Goksøyr, Anders; Karlsen, Odd André (2022). Xenobiotic metabolism and its physiological consequences in high-Antarctic Notothenioid fishes. Polar biology, 45(2), pp. 345-358. Springer 10.1007/s00300-021-02992-4

Segner, Helmut; Rehberger, Kristina; Bailey, Christyn; Bo, Jun (2022). Assessing Fish Immunotoxicity by Means of In Vitro Assays: Are We There Yet? Frontiers in immunology, 13, p. 835767. Frontiers Research Foundation 10.3389/fimmu.2022.835767

Bischof, Ina; Arnot, Jon A; Jürling, Heinrich; Knipschild, Georg; Schlechtriem, Christian; Schauerte, Anna; Segner, Helmut (2022). In vitro biotransformation assays using fish liver cells: Comparing rainbow trout and carp hepatocytes. Frontiers in toxicology, 4, p. 1021880. Frontiers Media S.A. 10.3389/ftox.2022.1021880


Bailey, Christyn John; Strepparava, Nicole; Ros, Albert Frank; Wahli, Thomas; Schmidt-Posthaus, Heike; Segner, Helmut; Tafalla, Carolina (2021). It's a hard knock life for some: Heterogeneity in infection life history of salmonids influences parasite disease outcomes. Journal of animal ecology, 90(11), pp. 2573-2593. Wiley 10.1111/1365-2656.13562

Perujo, N; Van den Brink, P J; Segner, H; Mantyka-Pringle, C; Sabater, S; Birk, S; Bruder, A; Romero, F; Acuña, V (2021). A guideline to frame stressor effects in freshwater ecosystems. The Science of the total environment, 777, p. 146112. Elsevier 10.1016/j.scitotenv.2021.146112

Werner, Inge; Schneeweiss, Anke; Segner, Helmut; Junghans, Marion (2021). Environmental Risk of Pesticides for Fish in Small- and Medium-Sized Streams of Switzerland. Toxics, 9(4) MDPI 10.3390/toxics9040079

Rehberger, Kristina; Escher, Beate I; Scheidegger, Andreas; Werner, Inge; Segner, Helmut (2021). Evaluation of an in vitro assay to screen for the immunotoxic potential of chemicals to fish. Scientific reports, 11(1), p. 3167. Springer Nature 10.1038/s41598-021-82711-5

Müller, Anne-Katrin; Markert, Nele; Leser, Katharina; Kämpfer, David; Schiwy, Sabrina; Riegraf, Carolin; Buchinger, Sebastian; Gan, Lin; Abdallah, Ali T; Denecke, Bernd; Segner, Helmut; Brinkmann, Markus; Crawford, Sarah E; Hollert, Henner (2021). Bioavailability and impacts of estrogenic compounds from suspended sediment on rainbow trout (Oncorhynchus mykiss). Aquatic toxicology, 231(105719), p. 105719. Elsevier 10.1016/j.aquatox.2020.105719

Tschirren, Linda; Bachmann, David; Güler, Ali Cem; Blaser, Oliver; Rhyner, Nicola; Seitz, Andreas; Zbinden, Erich; Wahli, Thomas; Segner, Helmut; Refardt, Dominik (2021). MyFishCheck: A Model to Assess Fish Welfare in Aquaculture. Animals, 11(1) MDPI 10.3390/ani11010145


Kropf, Christian; Begnaud, Frédéric; Gimeno, Sylvia; Berthaud, Fabienne; Debonneville, Christian; Segner, Helmut (2020). In Vitro Biotransformation Assays Using Liver S9 Fractions and Hepatocytes from Rainbow Trout (Oncorhynchus mykiss): Overcoming Challenges with Difficult to Test Fragrance Chemicals. Environmental toxicology and chemistry, 39(12), pp. 2396-2408. SETAC Press 10.1002/etc.4872

Kernen, Larissa; Rieder, Jessica; Duus, Annette; Holbech, Henrik; Segner, Helmut; Bailey, Christyn (2020). Thymus development in the zebrafish (Danio rerio) from an ecoimmunology perspective. Journal of experimental zoology. Part A, Ecological and integrative physiology, 333(10), pp. 805-819. Wiley 10.1002/jez.2435

Strepparava, Nicole; Ros, Albert; Hartikainen, Hanna; Schmidt-Posthaus, Heike; Wahli, Thomas; Segner, Helmut; Bailey, Christyn (2020). Effects of parasite concentrations on infection dynamics and proliferative kidney disease pathogenesis in brown trout ( Salmo trutta ). Transboundary and emerging diseases, 67(6), pp. 2642-2652. Wiley 10.1111/tbed.13615

Song, Jun-Young; Casanova-Nakayama, Ayako; Möller, Anja-Maria; Kitamura, Shin-Ichi; Nakayama, Kei; Segner, Helmut (2020). Aryl Hydrocarbon Receptor Signaling Is Functional in Immune Cells of Rainbow Trout (Oncorhynchus mykiss). International journal of molecular sciences, 21(17), p. 6323. MDPI 10.3390/ijms21176323

Kropf, Christian; Fent, Karl; Fischer, Stephan; Casanova, Ayako; Segner, Helmut (2020). ABC transporters in gills of rainbow trout (Oncorhynchus mykiss). Journal of Experimental Biology, 223(Pt 15) Company of Biologists 10.1242/jeb.221069

Demir, Veysel; Bucher, Jan; Kropf, Christian; Arenz, Matthias; Segner, Helmut (2020). Comparative study of cytotoxicity by platinum nanoparticles and ions in vitro systems based on fish cell lines. Toxicology in vitro, 66, p. 104859. Elsevier 10.1016/j.tiv.2020.104859

Müller, Anne-Katrin; Markert, Nele; Leser, Katharina; Kämpfer, David; Crawford, Sarah E; Schäffer, Andreas; Segner, Helmut; Hollert, Henner (2020). Assessing endocrine disruption in freshwater fish species from a "hotspot" for estrogenic activity in sediment. Environmental pollution, 257, p. 113636. Elsevier Science 10.1016/j.envpol.2019.113636

Wheeler, James R; Segner, Helmut; Weltje, Lennart; Hutchinson, Thomas H (2020). Interpretation of sexual secondary characteristics (SSCs) in regulatory testing for endocrine activity in fish. Chemosphere, 240, p. 124943. Elsevier 10.1016/j.chemosphere.2019.124943

Baumann, Lisa; Holbech, Henrik; Schmidt-Posthaus, Heike; Moissl, Angela P; Hennies, Mark; Tiedemann, Janina; Weltje, Lennart; Segner, Helmut; Braunbeck, Thomas (2020). Does hepatotoxicity interfere with endocrine activity in zebrafish (Danio rerio)? Chemosphere, 238, p. 124589. Elsevier 10.1016/j.chemosphere.2019.124589

Bailey, Christyn; Segner, Helmut; Wahli, Thomas; Tafalla, Carolina (2020). Back From the Brink: Alterations in B and T Cell Responses Modulate Recovery of Rainbow Trout From Chronic Immunopathological Tetracapsuloides bryosalmonae Infection. Frontiers in immunology, 11(1093) Frontiers Research Foundation 10.3389/fimmu.2020.01093

Rehberger, Kristina; Wernicke von Siebenthal, Elena; Bailey, Christyn; Bregy, Patrick; Fasel, Melanie; Herzog, Elio L.; Neumann, Silvia; Schmidt-Posthaus, Heike; Segner, Helmut (2020). Long-term exposure to low 17α-ethinylestradiol (EE2) concentrations disrupts both the reproductive and the immune system of juvenile rainbow trout, Oncorhynchus mykiss. Environment International, 142, p. 105836. Elsevier 10.1016/j.envint.2020.105836

Bernet, Daniel; Wahli, Thomas; Küng, Christoph; Segner, Helmut (2020). Zooplankton Feeding Induces Macroscopical Gonad Malformations in Whitefish (Coregonus ssp.) from Lake Thun, Switzerland. Fishes, 5(3), p. 26. MDPI 10.3390/fishes5030026


Bo, Jun; Yang, Ying; Zheng, Ronghui; Fang, Chao; Jiang, Yulu; Liu, Jie; Chen, Mengyun; Hong, Fukun; Bailey, Christyn; Segner, Helmut; Wang, Kejian (2019). Antimicrobial activity and mechanisms of multiple antimicrobial peptides isolated from rockfish Sebastiscus marmoratus. Fish & shellfish immunology, 93, pp. 1007-1017. Elsevier Science 10.1016/j.fsi.2019.08.054

Bailey, Christyn; Wernicke von Siebenthal, Elena; Rehberger, Kristina; Segner, Helmut (2019). Transcriptomic analysis of the impacts of ethinylestradiol (EE2) and its consequences for proliferative kidney disease outcome in rainbow trout (Oncorhynchus mykiss). Comparative biochemistry and physiology. Part C - toxicology and pharmacology, 222, pp. 31-48. Elsevier 10.1016/j.cbpc.2019.04.009

Baumann, Lisa; Segner, Helmut; Ros, Albert; Knapen, Dries; Vergauwen, Lucia (2019). Thyroid Hormone Disruptors Interfere with Molecular Pathways of Eye Development and Function in Zebrafish. International journal of molecular sciences, 20(7) Molecular Diversity Preservation International MDPI 10.3390/ijms20071543

Woźny, Maciej; Obremski, Kazimierz; Hliwa, Piotr; Gomułka, Piotr; Różyński, Rafał; Wojtacha, Paweł; Florczyk, Maciej; Segner, Helmut; Brzuzan, Paweł (2019). Feed contamination with zearalenone promotes growth but affects the immune system of rainbow trout. Fish & shellfish immunology, 84, pp. 680-694. Elsevier Science 10.1016/j.fsi.2018.10.032

Bailey, Christyn; Strepparava, Nicole; Wahli, Thomas; Segner, Helmut (2019). Exploring the immune response, tolerance and resistance in proliferative kidney disease of salmonids. Developmental and Comparative Immunology, 90, pp. 165-175. Elsevier 10.1016/j.dci.2018.09.015

Rubin, Aurélie; de Coulon, Pauline; Bailey, Christyn; Segner, Helmut; Wahli, Thomas; Rubin, Jean-François (2019). Keeping an Eye on Wild Brown Trout (Salmo trutta) Populations: Correlation Between Temperature, Environmental Parameters, and Proliferative Kidney Disease. Frontiers in veterinary science, 6, p. 281. Frontiers Media 10.3389/fvets.2019.00281


Wernicke von Siebenthal, Elena; Rehberger, Kristina; Bailey, Christyn John; Ros, Albert Frank; Herzog, Elio Luca; Segner, Helmut (2018). Trade-Offs Underwater: Physiological Plasticity of Rainbow Trout (Oncorhynchus mykiss) Confronted by Multiple Stressors. Fishes, 3(4), p. 49. MDPI 10.3390/fishes3040049

Bailey, Christyn John; Rubin, Aurélie; Strepparava, Nicole; Segner, Helmut; Rubin, Jean-François; Wahli, Thomas (2018). Do fish get wasted? Assessing the influence of effluents on parasitic infection of wild fish. PeerJ, 6, e5956. PeerJ, Ltd 10.7717/peerj.5956

Norberg-King, Teresa J; Embry, Michelle R; Belanger, Scott E; Braunbeck, Thomas; Butler, Joshua D; Dorn, Phil B; Farr, Brianna; Guiney, Patrick D; Hughes, Sarah A; Jeffries, Marlo; Journel, Romain; Lèonard, Marc; McMaster, Mark; Oris, James T; Ryder, Kathy; Segner, Helmut; Senac, Thomas; Van Der Kraak, Glen; Whale, Graham and Wilson, Peter (2018). An International Perspective on the Tools and Concepts for Effluent Toxicity Assessments in the Context of Animal Alternatives: Reduction in Vertebrate Use. Environmental toxicology and chemistry, 37(11), pp. 2745-2757. SETAC Press 10.1002/etc.4259

Ye, Roy R; Peterson, Drew R; Kitamura, Shin-Ichi; Segner, Helmut; Seemann, Frauke; Au, Doris W T (2018). Sex-specific immunomodulatory action of the environmentalestrogen 17α-ethynylestradiol alongside with reproductive impairment in fish. Aquatic toxicology, 203, pp. 95-106. Elsevier 10.1016/j.aquatox.2018.07.019

Van den Brink, Paul J; Boxall, Alistair B A; Maltby, Lorraine; Brooks, Bryan W; Rudd, Murray A; Backhaus, Thomas; Spurgeon, David; Verougstraete, Violaine; Ajao, Charmaine; Ankley, Gerald T; Apitz, Sabine E; Arnold, Kathryn; Brodin, Tomas; Cañedo-Argüelles, Miguel; Chapman, Jennifer; Corrales, Jone; Coutellec, Marie-Agnès; Fernandes, Teresa F; Fick, Jerker; Ford, Alex T; ... (2018). Toward sustainable environmental quality: Priority research questions for Europe. Environmental toxicology and chemistry, 37(9), pp. 2281-2295. SETAC Press 10.1002/etc.4205

Nichols, John; Fay, Kellie; Bernhard, Mary Jo; Bischof, Ina; Davis, John; Halder, Marlies; Hu, Jing; Johanning, Karla; Laue, Heike; Nabb, Diane; Schlechtriem, Christian; Segner, Helmut; Swintek, Joe; Weeks, John; Embry, Michelle (2018). Reliability of In Vitro Methods Used to Measure Intrinsic Clearance of Hydrophobic Organic Chemicals by Rainbow Trout: Results of an International Ring Trial. Toxicological sciences, 164(2), pp. 563-575. Oxford University Press 10.1093/toxsci/kfy113

Strobel, Anneli; Mark, Felix C; Segner, Helmut; Burkhardt-Holm, Patricia (2018). Expression of aryl hydrocarbon receptor-regulated genes and superoxide dismutase in the Antarctic eelpout Pachycara brachycephalum exposed to benzo[a]pyrene. Environmental toxicology and chemistry, 37(5), pp. 1487-1495. SETAC Press 10.1002/etc.4075

Casanova, Ayako; Wernicke von Siebenthal, Elena; Kropf, Christian; Oldenberg, Elisabeth; Segner, Helmut (2018). Immune-Specific Expression and Estrogenic Regulation of the Four Estrogen Receptor Isoforms in Female Rainbow Trout (Oncorhynchus mykiss). International journal of molecular sciences, 19(4) Molecular Diversity Preservation International MDPI 10.3390/ijms19040932

Strepparava, Nicole; Segner, Helmut; Ros, Albert; Hartikainen, Hanna; Schmidt-Posthaus, Heike; Wahli, Thomas (2018). Temperature-related parasite infection dynamics: the case of proliferative kidney disease of brown trout. Parasitology, 145(3), pp. 281-291. Cambridge University Press 10.1017/S0031182017001482

Strobel, Anneli; Schmid, Peter; Burkhardt-Holm, Patricia; Segner, Helmut; Zennegg, Markus (2018). Persistent organic pollutants in red- and white-blooded High-Antarctic notothenioid fish from the remote Weddell Sea. Chemosphere, 193, pp. 213-222. Elsevier Science 10.1016/j.chemosphere.2017.11.020

Bailey, Christyn John; Schmidt-Posthaus, Heike; Segner, Helmut; Wahli, Thomas; Strepparava, Nicole (2018). Are brown trout Salmo trutta fario and rainbow trout Oncorhynchus mykiss two of a kind? A comparative study of salmonids to temperature-influenced Tetracapsuloides bryosalmonae infection. Journal of fish diseases, 41(2), pp. 191-198. Wiley-Blackwell 10.1111/jfd.12694

Rehberger, Kristina; Kropf, Christian; Segner, Helmut (2018). In vitro or not in vitro: a short journey through a long history. Environmental sciences Europe, 30(1), p. 23. Springer 10.1186/s12302-018-0151-3


Szwejser, Ewa; Pijanowski, Lukasz; Maciuszek, Magdalena; Ptak, Anna; Wartalski, Kamil; Duda, Malgorzata; Segner, Helmut; Verburg-van Kemenade, B M Lidy; Chadzinska, Magdalena (2017). Stress differentially affects the systemic and leukocyte estrogen network in common carp. Fish & shellfish immunology, 68, pp. 190-201. Elsevier Science 10.1016/j.fsi.2017.07.011

Rehberger, Kristina; Werner, Inge; Hitzfeld, Bettina; Segner, Helmut; Baumann, Lisa Annie (2017). 20 Years of fish immunotoxicology - what we know and where we are. Critical Reviews in Toxicology, 47(6), pp. 509-535. Informa Healthcare 10.1080/10408444.2017.1288024

Guevara Soto, Maricruz; Vidondo Curras, Beatriz; Vaughan, L; Rubin, J-F; Segner, Helmut; Samartin, Stéphanie; Schmidt-Posthaus, Heike (2017). Investigations into the temporal development of epitheliocystis infections in brown trout: a histological study. Journal of fish diseases, 40(6), pp. 811-819. Blackwell 10.1111/jfd.12562

Bailey, Christyn John; Segner, Helmut; Casanova, Ayako; Wahli, Thomas (2017). Who needs the hotspot? The effect of temperature on the fish host immune response to Tetracapsuloides bryosalmonae the causative agent of proliferative kidney disease. Fish & shellfish immunology, 63, pp. 424-437. Elsevier Science 10.1016/j.fsi.2017.02.039

Origgi, Francesco; Benedicenti, Ottavia; Segner, Helmut; Sattler, Ursula; Wahli, Thomas; Frey, Joachim (2017). Aeromonas salmonicida type III secretion system-effectors-mediated immune suppression in rainbow trout (Oncorhynchus mykiss). Fish & shellfish immunology, 60, pp. 334-345. Elsevier Science 10.1016/j.fsi.2016.12.006

Segner, Helmut; Verburg-van Kemenade, B M Lidy; Chadzinska, Magdalena (2017). The immunomodulatory role of the hypothalamus-pituitary-gonad axis: Proximate mechanism for reproduction-immune trade offs? Developmental and Comparative Immunology, 66, pp. 43-60. Elsevier 10.1016/j.dci.2016.07.004

Szwejser, Ewa; Maciuszek, Magdalena; Casanova, Ayako; Segner, Helmut; Verburg-van Kemenade, B M Lidy; Chadzinska, Magdalena (2017). A role for multiple estrogen receptors in immune regulation of common carp. Developmental and Comparative Immunology, 66, pp. 61-72. Elsevier 10.1016/j.dci.2016.04.003

Hawliczek - Ignarski, Alessa; Cenijn, Peter; Legler, Juliette; Segner, Helmut; Legradi, Jessica (2017). Mode of Action Assignment of Chemicals Using Toxicogenomics: A Case Study with Oxidative Uncouplers. Frontiers in Environmental Science, 5 Frontiers Media 10.3389/fenvs.2017.00080

Segner, Helmut (2017). Preface. In: Ecotoxicology in Latin America. 2017: Nova Publishers, New York


Baumann, Lisa Annie; Schmidt-Posthaus, Heike; Segner, Helmut; Wolf, Jeffrey C (2016). Comment on "Uptake and Accumulation of Polystyrene Microplastics in zebrafish (Danio rerio) and Toxic Effects in Liver". Environmental science & technology, 50(22), pp. 12521-12522. ACS Publications 10.1021/acs.est.6b04193

Strobel, Anneli; Schmid, Peter; Segner, Helmut; Burkhardt-Holm, Patricia; Zennegg, Markus (2016). Persistent organic pollutants in tissues of the white-blooded Antarctic fish Champsocephalus gunnari and Chaenocephalus aceratus. Chemosphere, 161, pp. 555-562. Elsevier Science 10.1016/j.chemosphere.2016.01.089

Bischof, Ina Bettina Petra; Köster, Jessica; Segner, Helmut; Schlechtriem, Christian (2016). Hepatocytes as in vitro test system to investigate metabolite patterns of pesticides in farmed rainbow trout and common carp: Comparison between in vivo and in vitro and across species. Comparative biochemistry and physiology. Part C - toxicology and pharmacology, 187, pp. 62-73. Elsevier 10.1016/j.cbpc.2016.05.003

Kropf, Christian; Segner, Helmut; Fent, Karl (2016). ABC transporters and xenobiotic defense systems in early life stages of rainbow trout (Oncorhynchus mykiss). Comparative biochemistry and physiology. Part C - toxicology and pharmacology, 185-186, pp. 45-56. Elsevier 10.1016/j.cbpc.2016.02.006

Quesada Garcia, Maria del Alba; Encinas, Paloma; Valdehita, Ana; Baumann, Lisa Annie; Segner, Helmut; Coll, Julio M; Navas, José M (2016). Thyroid active agents T3 and PTU differentially affect immune gene transcripts in the head kidney of rainbow trout (Oncorynchus mykiss). Aquatic toxicology, 174, pp. 159-168. Elsevier 10.1016/j.aquatox.2016.02.016

Segner, Helmut; Baumann, Lisa Annie (2016). What constitutes a model organism in ecotoxicology? Integrated environmental assessment and management, 12(1), pp. 199-200. Wiley 10.1002/ieam.1727

Guevara Soto, Maricruz; Vidondo Curras, Beatriz; Vaughan, Lloyd; Seth-Smith, Helena; Nufer, Lisbeth; Segner, Helmut; Rubin, Jean-Francois; Schmidt-Posthaus, Heike (2016). The emergence of epitheliocystis in the upper Rhone region: evidence for Chlamydiae in wild and farm salmonid populations. Archives of microbiology, 198(4), pp. 315-324. Springer 10.1007/s00203-016-1192-x

Segner, Helmut (2016). Why babies do not feel pain, or: How structure-derived functional interpretations can go wrong. Animal Sentience: An Interdisciplinary Journal on Animal Feeling, 2016.33

Baumann, Lisa Annie; Ros, Albert Frank; Rehberger, Kristina; Neuhauss, Stephan C.F.; Segner, Helmut (2016). Thyroid disruption in zebrafish (Danio rerio) larvae: Different molecular response patterns lead to impaired eye development and visual functions. Aquatic toxicology, 172, pp. 44-55. Elsevier 10.1016/j.aquatox.2015.12.015

Guevara Soto, Maricruz; Vaughan, Lloyd; Segner, Helmut; Wahli, Thomas; Vidondo Curras, Beatriz; Schmidt-Posthaus, Heike (2016). Epitheliocystis Distribution and Characterization in Brown Trout (Salmo trutta) from the Headwaters of Two Major European Rivers, the Rhine and Rhone. Frontiers in physiology, 7(131), p. 131. Frontiers Research Foundation 10.3389/fphys.2016.00131


Baumann, Lisa Annie; Knörr, Susanne; Keiter, Susanne; Nagel, Tina; Segner, Helmut; Braunbeck, Thomas (2015). Prochloraz causes irreversible masculinization of zebrafish (Danio rerio). Environmental science and pollution research, 22(21), pp. 16417-16422. Springer 10.1007/s11356-014-3486-3

Hampel, Miriam; Blasco, Julian; Segner, Helmut (2015). Molecular and cellular effects of contamination in aquatic ecosystems. Environmental science and pollution research, 22(22), pp. 17261-17266. Springer 10.1007/s11356-015-5565-5

Brinkmann, Markus; Eichbaum, Kathrin; Reininghaus, Mathias; Koglin, Sven; Kammann, Ulrike; Baumann, Lisa Annie; Segner, Helmut; Zennegg, Markus; Buchinger, Sebastian; Reifferscheid, Georg; Hollert, Henner (2015). Towards science-based sediment quality standards-Effects of field-collected sediments in rainbow trout (Oncorhynchus mykiss). Aquatic toxicology, 166, pp. 50-62. Elsevier 10.1016/j.aquatox.2015.07.010

Becker, Richard A; Ankley, Gerald T; Edwards, Stephen W; Kennedy, Sean W; Linkov, Igor; Meek, Bette; Sachana, Magdalini; Segner, Helmut; Van Der Burg, Bart; Villeneuve, Daniel L; Watanabe, Haruna; Barton-Maclaren, Tara S (2015). Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence. Regulatory toxicology and pharmacology, 72(3), pp. 514-537. Elsevier 10.1016/j.yrtph.2015.04.004

Strobel, Anneli; Burkhardt-Holm, Patricia; Schmid, Peter; Segner, Helmut (2015). Benzo(a)pyrene Metabolism and EROD and GST Biotransformation Activity in the Liver of Red- and White-Blooded Antarctic Fish. Environmental science & technology, 49(13), pp. 8022-8032. ACS Publications 10.1021/acs.est.5b00176

Müller, Anne-Katrin; Brinkmann, Markus; Baumann, Lisa Annie; Stoffel, Michael Hubert; Segner, Helmut; Kidd, Karen A; Hollert, Henner (2015). Morphological alterations in the liver of yellow perch (Perca flavescens) from a biological mercury hotspot. Environmental science and pollution research, 22(22), pp. 17330-17342. Springer 10.1007/s11356-015-4177-4

Connolly, Mona; Fernandez-Cruz, Maria-Luisa; Quesada-Garcia, Alba; Alte, Luis; Segner, Helmut; Navas, Jose M (2015). Comparative Cytotoxicity Study of Silver Nanoparticles (AgNPs) in a Variety of Rainbow Trout Cell Lines (RTL-W1, RTH-149, RTG-2) and Primary Hepatocytes. International journal of environmental research and public health, 12(5), pp. 5386-5405. Molecular Diversity Preservation International MDPI 10.3390/ijerph120505386

Ryser-Degiorgis, Marie-Pierre; Segner, Helmut (2015). National competence center for wildlife diseases in Switzerland: Mandate, development and current strategies. Schweizer Archiv für Tierheilkunde, 157(5), pp. 255-266. Huber 10.17236/sat00019

Segner, Helmut (2015). In vitro methodologies in ecotoxicological hazard assessment: the case of bioaccumulation testing for fish. ATLA - alternatives to laboratory animals, 43(2), P14-P16. FRAME

Altenburger, Rolf; Ait-Aissa, Selim; Antczak, Philipp; Backhaus, Thomas; Barceló, Damià; Seiler, Thomas-Benjamin; Brion, Francois; Busch, Wibke; Chipman, Kevin; López de Alda, Miren; Umbuzeiro, Gisela de Aragão; Escher, Beate I; Falciani, Francesco; Faust, Michael; Focks, Andreas; Hilscherova, Klara; Hollender, Juliane; Hollert, Henner; Jäger, Felix; Jahnke, Annika; ... (2015). Future water quality monitoring--adapting tools to deal with mixtures of pollutants in water resource management. Science of the total environment, 512-513, pp. 540-551. Elsevier 10.1016/j.scitotenv.2014.12.057

Wolf, Jeffrey C; Baumgartner, Wes A; Blazer, Vicki S; Camus, Alvin C; Engelhardt, Jeffery A; Fournie, John W; Frasca, Salvatore; Groman, David B; Kent, Michael L; Khoo, Lester H; Law, Jerry M; Lombardini, Eric D; Ruehl-Fehlert, Christine; Segner, Helmut; Smith, Stephen A; Spitsbergen, Jan M; Weber, Klaus; Wolfe, Marilyn J (2015). Nonlesions, misdiagnoses, missed diagnoses, and other interpretive challenges in fish histopathology studies: a guide for investigators, authors, reviewers, and readers. Toxicologic pathology, 43(3), pp. 297-325. Sage Publications 10.1177/0192623314540229

Slootweg, Tineke; Segner, Helmut; Mayer, Philipp; Smith, Kilian; Igumnova, Elizaveta; Nikiforov, Vladimir; Dömötörová, Milena; Oehlmann, Jörg; Liebig, Markus (2015). Transfer and effects of 1,2,3,5,7-pentachloronaphthalene in an experimental food chain. Comparative biochemistry and physiology. Part C - toxicology and pharmacology, 169, pp. 46-54. Elsevier 10.1016/j.cbpc.2015.01.001

Brack, Werner; Altenburger, Rolf; Schüürmann, Gerrit; Krauss, Martin; López Herráez, David; van Gils, Jos; Slobodnik, Jaroslav; Munthe, John; Gawlik, Bernd Manfred; van Wezel, Annemarie; Schriks, Merijn; Hollender, Juliane; Tollefsen, Knut Erik; Mekenyan, Ovanes; Dimitrov, Saby; Bunke, Dirk; Cousins, Ian; Posthuma, Leo; van den Brink, Paul J; López de Alda, Miren; ... (2015). The SOLUTIONS project: challenges and responses for present and future emerging pollutants in land and water resources management. Science of the total environment, 503-504, pp. 22-31. Elsevier 10.1016/j.scitotenv.2014.05.143

Floehr, Tilman; Scholz-Starke, B; Xiao, H; Hercht, H; Wu, L; Hou, J; Schmidt-Posthaus, Heike; Segner, Helmut; Kammann, U; Yuan, X; Roß-Nickoll, M; Schäffer, A; Hollert, H (2015). Linking Ah receptor mediated effects of sediments and impacts on fish to key pollutants in the Yangtze Three Gorges Reservoir, China – A comprehensive perspective. Science of the total environment, 538, pp. 191-211. Elsevier 10.1016/j.scitotenv.2015.07.044

Batista Linhares, Mainity; Belloy, Luc; Origgi, Francesco; Lechner, Isabel; Segner, Helmut; Ryser-Degiorgis, Marie-Pierre (2015). Investigating the role of free-ranging wild boar (Sus scrofa) in the re-emergence of enzootic pneumonia in domestic pig herds: a pathological, prevalence and risk-factor study. PLoS ONE, 10(3), e0119060. Public Library of Science 10.1371/journal.pone.0119060

Fay, Kellie A; Nabb, Diane L; Mingoia, Robert T; Bischof, Ina Bettina Petra; Nichols, John W; Segner, Helmut; Johanning, Karla; Han, Xing (2015). Determination of Metabolic Stability Using Cryopreserved Hepatocytes from Rainbow Trout (Oncorhynchus mykiss). Current protocols in toxicology, 65(4.42), pp. 1-29. Wiley 10.1002/0471140856.tx0442s65

Sabater, Sergi; Segner, Helmut; Posthuma, Leo; Barceló, Damià (2015). In response : The evidence-What actions are needed to effectively transfer from science to policy? An academic perspective. Environmental toxicology and chemistry, 34(6), pp. 1208-1210. SETAC Press 10.1002/etc.2983


Schubert, Sara; Peter, Armin; Schönenberger, René; Suter, Marc J-F; Segner, Helmut; Burkhardt-Holm, Patricia (2014). Transient exposure to environmental estrogen affects embryonic development of brown trout (Salmo trutta fario). Aquatic toxicology, 157, pp. 141-149. Elsevier 10.1016/j.aquatox.2014.10.007

Baumann, Lisa Annie; Knörr, Susanne; Keiter, Susanne; Nagel, Tina; Rehberger, Kristina; Volz, Sina; Oberrauch, Sophia; Schiller, Viktoria; Fenske, Martina; Holbech, Henrik; Segner, Helmut; Braunbeck, Thomas (2014). Persistence of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the androgen 17β-trenbolone. Environmental toxicology and chemistry, 33(11), pp. 2488-2496. SETAC Press 10.1002/etc.2698

Lombardo, Anna; Roncaglioni, Alessandra; Benfenati, Emilio; Nendza, Monika; Segner, Helmut; Jeram, Sonja; Pauné, Eduard; Schüürmann, Gerrit (2014). Optimizing the aquatic toxicity assessment under REACH through an integrated testing strategy (ITS). Environmental research, 135, pp. 156-164. Elsevier 10.1016/j.envres.2014.09.002

Möller, Anja-Maria; Korytář, Tomáš; Köllner, Bernd; Schmidt-Posthaus, Heike; Segner, Helmut (2014). The teleostean liver as an immunological organ: Intrahepatic immune cells (IHICs) in healthy and benzo[a]pyrene challenged rainbow trout (Oncorhynchus mykiss). Developmental and Comparative Immunology, 46(2), pp. 518-529. Elsevier 10.1016/j.dci.2014.03.020

Wenger, Michael; Shved, Natallia; Akgül, Gülfirde; Caelers, Antje; Casanova, Ayako; Segner, Helmut; Eppler, Elisabeth (2014). Developmental oestrogen exposure differentially modulates IGF-I and TNF-α expression levels in immune organs of Yersinia ruckeri-challenged young adult rainbow trout (Oncorhynchus mykiss). General and comparative endocrinology, 205, pp. 168-175. Elsevier 10.1016/j.ygcen.2014.05.022

Baumann, Lisa Annie; Knörr, Susanne; Keiter, Susanne; Rehberger, Kristina; Volz, Sina; Schiller, Viktoria; Fenske, Martina; Holbech, Henrik; Segner, Helmut; Braunbeck, Thomas (2014). Reversibility of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the estrogen 17α-ethinylestradiol. Toxicology and Applied Pharmacology, 278(3), pp. 230-237. Elsevier 10.1016/j.taap.2014.04.025

Lombardo, Anna; Roncaglioni, Alessandra; Benfentati, Emilio; Nendza, Monika; Segner, Helmut; Fernández, Alberto; Kühne, Ralph; Franco, Antonio; Pauné, Eduard; Schüürmann, Gerrit (2014). Integrated testing strategy (ITS) for bioaccumulation assessment under REACH. Environment International, 69, pp. 40-50. Elsevier 10.1016/j.envint.2014.04.005

Segner, Helmut; Schmitt-Jansen, M; Sabater, S (2014). Assessing the impact of multiple stressors on aquatic biota: the receptor's side matters. Environmental science & technology, 48(14), pp. 7690-7696. ACS Publications 10.1021/es405082t

Fay, Kellie A; Mingoia, Robert T; Goeritz, Ina; Nabb, Diane L; Hoffman, Alex D; Ferrell, Barbra D; Peterson, Heather M; Nichols, John W; Segner, Helmut; Han, Xing (2014). Intra- and interlaboratory reliability of a cryopreserved trout hepatocyte assay for the prediction of chemical bioaccumulation potential. Environmental science & technology, 48(14), pp. 8170-8178. ACS Publications 10.1021/es500952a

Depiereux, Sophie; Liagre, Mélanie; Danis, Lorraine; De Meulder, Bertrand; Depiereux, Eric; Segner, Helmut; Kestemont, Patrick (2014). Intersex occurrence in rainbow trout (Oncorhynchus mykiss) male fry chronically exposed to ethynylestradiol. PLoS ONE, 9(7), e98531. Public Library of Science 10.1371/journal.pone.0098531

Quesada Garcia, Maria del Alba; Valdehita, A; Kropf, Christian; Casanova-Nakayama, Ayako; Segner, Helmut; Navas, J M (2014). Thyroid signaling in immune organs and cells of the teleost fish rainbow trout (Oncorhynchus mykiss). Fish & shellfish immunology, 38(1), pp. 166-174. Elsevier Science 10.1016/j.fsi.2014.03.016

Chambers, Janice E; Greim, Helmut; Kendall, Ronald J; Segner, Helmut; Sharpe, Richard M; Van Der Kraak, Glen (2014). Human and ecological risk assessment of a crop protection chemical: a case study with the azole fungicide epoxiconazole. Critical Reviews in Toxicology, 44(2), pp. 176-210. Informa Healthcare 10.3109/10408444.2013.855163

Wolf, Jeffrey C.; Ruehl-Fehlert, Christine; Segner, Helmut E.; Weber, Klaus; Hardisty, Jerry F. (2014). Pathology working group review of histopathologic specimens from three laboratory studies of diclofenac in trout. Aquatic toxicology, 146, pp. 127-136. Elsevier 10.1016/j.aquatox.2013.10.033

Möller, Anja-Maria; Hermsen, Corinna; Floehr, Tilman; Lamoree, Marja H; Segner, Helmut (2014). Tissue-specific metabolism of benzo[a]pyrene in rainbow trout (Oncorhynchus mykiss): a comparison between the liver and immune organs. Drug metabolism and disposition, 42(1), pp. 111-118. American Society for Pharmacology and Experimental Therapeutics 10.1124/dmd.113.053777

Ohe, Peter C.; Apitz, Sabine E.; Arbačiauskas, Kęstutis; Beketov, Mikhail A.; Borchardt, Dietrich; Zwart, Dick; Goedkoop, Willem; Hein, Michaela; Hellsten, Seppo; Hering, Daniel; Kefford, Ben J.; Panov, Vadim E.; Schäfer, Ralf B.; Segner, Helmut; Gils, Jos; Vegter, Joop J.; Wetzel, Markus A.; Brack, Werner (2014). Status and Causal Pathway Assessments Supporting River Basin Management. In: Risk-Informed Management of European River Basins. The Handbook of Environmental Chemistry: Vol. 29 (pp. 53-149). Berlin, Heidelberg: Springer 10.1007/978-3-642-38598-8_3

Ohe, Peter C.; Zwart, Dick; Semenzin, Elena; Apitz, Sabine E.; Gottardo, Stefania; Harris, Bob; Hein, Michaela; Marcomini, Antonio; Posthuma, Leo; Schäfer, Ralf B.; Segner, Helmut; Brack, Werner (2014). Monitoring Programmes, Multiple Stress Analysis and Decision Support for River Basin Management. In: Risk-informed management of European river basins. Monitoring Programmes, Multiple Stress: Vol. 29 (pp. 151-182). Berlin, Heidelberg: Springer 10.1007/978-3-642-38598-8_4

Strepparava, Nicole; Wahli, Thomas; Segner, Helmut; Petrini, Orlando (2014). Detection and quantification of Flavobacterium psychrophilum in water and fish tissue samples by quantitative real time PCR. BMC microbiology, 14, p. 105. BioMed Central 10.1186/1471-2180-14-105

Segner, Helmut (2014). Hormone als Schadstoffe? Biologie in unserer Zeit, 44(4), pp. 232-241. Wiley-VCH 10.1002/biuz.201410540


Groh, Ksenia J; Schönenberger, René; Eggen, Rik I L; Segner, Helmut; Suter, Marc J-F (2013). Analysis of protein expression in zebrafish during gonad differentiation by targeted proteomics. General and comparative endocrinology, 193, pp. 210-220. Elsevier 10.1016/j.ygcen.2013.07.020

Segner, Helmut; Casanova-Nakayama, Ayako; Kase, Robert; Tyler, Charles R. (2013). Impact of environmental estrogens on Yfish considering the diversity of estrogen signaling. General and comparative endocrinology, 191, pp. 190-201. Elsevier 10.1016/j.ygcen.2013.05.015

Strepparava, Nicole; Nicolas, Pierre; Wahli, Thomas; Segner, Helmut; Petrini, Orlando (2013). Molecular epidemiology of Flavobacterium psychrophilum from Swiss fish farms. Diseases of aquatic organisms, 105(3), pp. 203-210. Inter-Research 10.3354/dao02609

Hamers, Timo; Legler, Juliette; Blaha, Ludek; Hylland, Ketil; Marigomez, Ionan; Schipper, Cor A.; Segner, Helmut; Vethaak, A. Dick; Witters, Hilda; de Zwart, Dick; Leonards, Pim E. G. (2013). Expert opinion on toxicity profiling--report from a NORMAN expert group meeting. Integrated environmental assessment and management, 9(2), pp. 185-191. Wiley 10.1002/ieam.1395

Burki, Richard; Krasnov, Aleksei; Bettge, Kathrin; Rexroad, Caird E.; Afanasyev, Sergey; Antikainen, Miia; Burkhardt-Holm, Patricia; Wahli, Thomas; Segner, Helmut (2013). Molecular crosstalk between a chemical and a biological stressor and consequences on disease manifestation in rainbow trout. Aquatic toxicology, 127, pp. 2-8. Elsevier 10.1016/j.aquatox.2012.02.026

Fehr, Alexander; Walther, Elisabeth; Schmidt-Posthaus, Heike; Nufer, Lisbeth; Wilson, Anthony; Svercel, Miroslav; Richter, Denis; Segner, Helmut; Pospischil, Andreas; Vaughan, Lloyd (2013). Candidatus Syngnamydia venezia, a novel member of the phylum Chlamydiae from the broad nosed pipefish, Syngnathus typhle. PLoS ONE, 8(8), e70853. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0070853

Gallana, Milena; Ryser-Degiorgis, Marie-Pierre; Wahli, Thomas; Segner, Helmut (2013). Climate change and infectious diseases of wildlife: Altered interactions between pathogens, vectors and hosts. Current zoology, 59(3), pp. 427-437. Chinese Academy of sciences


Schmidt-Posthaus, Heike; Bettge, K; Forster, U; Segner, Helmut; Wahli, Thomas (2012). Kidney pathology and parasite intensity in rainbow trout Oncorhynchus mykiss surviving proliferative kidney disease: time course and influence of temperature. Diseases of aquatic organisms, 97(3), pp. 207-218. Inter-Research 10.3354/dao02417

Burki, Richard; Krasnov, A.; Bettge, Kathrin; Rexroad, C. E.; Afanasyev, S.; Antikainen, M.; Burkhardt-Holm, P.; Wahli, Thomas; Segner, Helmut (2012). Pathogenic infection confounds induction of the estrogenic biomarker vitellogenin in rainbow trout. Environmental toxicology and chemistry, 31(10), pp. 2318-23. SETAC Press 10.1002/etc.1966

Hawliczek, Alessa; Nota, B.; Cenijn, P.; Kamstra, J.; Pieterse, B.; Winter, R.; Winkens, K.; Hollert, H.; Segner, Helmut; Legler, J. (2012). Developmental toxicity and endocrine disrupting potency of 4-azapyrene, benzo[b]fluorene and retene in the zebrafish Danio rerio. Reproductive Toxicology, 33(2), pp. 213-23. Elsevier 10.1016/j.reprotox.2011.11.001

Johanning, K.; Hancock, G.; Escher, B.; Adekola, A.; Bernhard, M. J.; Cowan-Ellsberry, C.; Domoradzki, J.; Dyer, S.; Eickhoff, C.; Embry, M.; Erhardt, S.; Fitzsimmons, P.; Halder, M.; Hill, J.; Holden, D.; Johnson, R.; Rutishauser, S.; Segner, Helmut; Schultz, I. and Nichols, J. (2012). Assessment of metabolic stability using the rainbow trout (Oncorhynchus mykiss) liver S9 fraction. In: Current Protocols in Toxicology Chapter 14 (Unit 14.10.1-28). Wiley 10.1002/0471140856.tx1410s53

Lahti, M.; Brozinski, J. M.; Segner, Helmut; Kronberg, L.; Oikari, A. (2012). Bioavailability of pharmaceuticals in waters close to wastewater treatment plants: use of fish bile for exposure assessment. Environmental toxicology and chemistry, 31(8), pp. 1831-1837. SETAC Press 10.1002/etc.1879

Segner, Helmut; Möller, Anja Maria; Wenger, Michael; Casanova-Nakayama, Ayako (2012). Fish immunotoxicology: research at the crossroads of immunology, ecology and toxicology. In: Kawaguchi, M.; Misaki, K.; Sato, H.; Yokokawa, T.; Itai, T.; Nguyen, T. M.; Ono, J.; Tanabe, S. (eds.) Advanced Environmental Studies by Young Scientists. Interdisciplinary Studies on Environmental Chemistry: Vol. 6 (pp. 1-12). Tokyo: Terra Scientific Publishing Company

Segner, Helmut; Sundh, H.; Buchmann, K.; Douxfils, J.; Sundell, K. S.; Mathieu, C.; Ruane, N.; Jutfelt, F.; Toften, H.; Vaughan, L. (2012). Health of farmed fish: its relation to fish welfare and its utility as welfare indicator. FISH PHYSIOLOGY AND BIOCHEMISTRY, 38(1), pp. 85-105. Springer Netherlands 10.1007/s10695-011-9517-9

Segner, Helmut; Wenger, Michael; Möller, Anja-Maria; Kollner, B.; Casanova-Nakayama, Ayako (2012). Immunotoxic effects of environmental toxicants in fish - how to assess them? Environmental science and pollution research, 19(7), pp. 2465-2476. Springer-Verlag 10.1007/s11356-012-0978-x

Strepparava, N.; Wahli, Thomas; Segner, Helmut; Polli, B.; Petrini, O. (2012). Fluorescent In Situ hybridization: a new tool for the direct identification and detection of F. psychrophilum. PLoS ONE, 7(11), e49280. Public Library of Science 10.1371/journal.pone.0049280

Wenger, Michael; Krasnov, A.; Skugor, S.; Goldschmidt-Clermont, E.; Sattler, Ursula; Afanasyev, S.; Segner, Helmut (2012). Estrogen Modulates Hepatic Gene Expression and Survival of Rainbow Trout Infected with Pathogenic Bacteria Yersinia ruckeri. Marine Biotechnoloy, 14(5), pp. 530-543. Springer 10.1007/s10126-012-9473-0

Ye, Roy R.; Lei, Elva N. Y.; Lam, Michael H. W.; Chan, Alice K. Y.; Bo, Jun; van de Merwe, Jason P.; Fong, Amy C. C.; Yang, Michael M. S.; Lee, J. S.; Segner, Helmut E.; Wong, Chris K. C.; Wu, Rudolf S. S.; Au, Doris W. T. (2012). Gender-specific modulation of immune system complement gene expression in marine medaka Oryzias melastigma following dietary exposure of BDE-47. Environmental science and pollution research, 19(7), pp. 2477-2487. Springer 10.1007/s11356-012-0887-z

Bonnineau, Chloé; Möller, Anja-Maria; Barata, Carlos; Bonet, Berta; Proia, Lorenzo; Sans-Piché, Frédéric; Schmitt-Jansen, Mechthild; Guasch, Helena; Segner, Helmut (2012). Advances in the Multibiomarker Approach for Risk Assessment in Aquatic Ecosystems. In: Guasch, Helena; Ginebreda, Antoni; Geiszinger, Anita (eds.) Emerging and Priority Pollutants in Rivers. Bringing Science into River Management Plans. The Handbook of Environmental Chemistry: Vol. 19 (pp. 147-179). Berlin, Heidelberg: Springer Berlin Heidelberg 10.1007/978-3-642-25722-3_6

Segner, Helmut (2012). Fish. Nociception and pain. A biological perspective. Contributions to Ethics and Biotechnology: Vol. 9. Bern: Federal Office for Buildings and Logistics (FOBL)

Origgi, Francesco; Plattet, Philippe; Sattler, Ursula; Robert, N.; Casaubon, J.; Mavrot, Fabien; Pewsner, Mirjam Lea; Wu, Natacha; Giovannini, Samoa; Oevermann, Anna; Stoffel, Michael Hubert; Gaschen, Véronique; Segner, Helmut; Ryser-Degiorgis, Marie-Pierre (2012). Emergence of Canine Distemper Virus Strains With Modified Molecular Signature and Enhanced Neuronal Tropism Leading to High Mortality in Wild Carnivores. Veterinary pathology, 49(6), pp. 913-929. American College of Veterinary Pathologists 10.1177/0300985812436743


Bittner, David; Cossins, Andrew R; Segner, Helmut; Excoffier, Laurent; Largiadèr, Carlo R (2011). Identification of candidate genes and physiological pathways involved in gonad deformation in whitefish (Coregonus spp.) from Lake Thun, Switzerland. International journal of environmental research and public health, 8(7), pp. 2706-33. Basel: Molecular Diversity Preservation International MDPI 10.3390/ijerph8072706

Bernet, D; Wahli, T; Gerecke, A; Segner, H (2011). Exposure of whitefish (Coregonus lavaretus) eggs to native or chemically spiked sediments from Lake Thun does not lead to abnormal gonad development. Environmental biotechnology, 7(1), pp. 17-29. Offenburg: Hochschule Offenburg

Segner, Helmut (2011). Moving beyond a descriptive aquatic toxicology: the value of biological process and trait information. Aquatic toxicology, 105(3-4 Suppl), pp. 50-5. Amsterdam: Elsevier 10.1016/j.aquatox.2011.06.016

Casanova-Nakayama, A.; Wenger, M.; Burki, R.; Eppler, E.; Krasnov, A.; Segner, H. (2011). Endocrine disrupting compounds: can they target the immune system of fish? Marine pollution bulletin, 63(5-12), pp. 412-6. Oxford: Elsevier 10.1016/j.marpolbul.2011.05.007

Escher, B I; Cowan-Ellsberry, C E; Dyer, S; Embry, M R; Erhardt, S; Halder, M; Kwon, J H; Johanning, K; Oosterwijk, M T; Rutishauser, S; Segner, H; Nichols, J (2011). Protein and lipid binding parameters in rainbow trout (Oncorhynchus mykiss) blood and liver fractions to extrapolate from an in vitro metabolic degradation assay to in vivo bioaccumulation potential of hydrophobic organic chemicals. Chemical research in toxicology, 24(7), pp. 1134-43. Washington, D.C.: American Chemical Society 10.1021/tx200114y

Schmidt-Posthaus, Heike; Polkinghorne, A; Nufer, L; Schifferli, A; Zimmermann, D R; Segner, Helmut; Steiner, P; Vaughan, L (2011). A natural freshwater origin for two chlamydial species, Candidatus Piscichlamydia salmonis and Candidatus Clavochlamydia salmonicola, causing mixed infections in wild brown trout (Salmo trutta). Environmental microbiology, 14(8), pp. 2048-2057. Malden, Mass.: Wiley-Blackwell 10.1111/j.1462-2920.2011.02670.x

Segner, Helmut (2011). Reproductive and developmental toxicity in fishes. In: Gupta, Ramesh C. (ed.) Reproductive and Developmental Toxicology (pp. 1145-1166). Amsterdam: Elsevier

Wenger, M.; Sattler, U.; Goldschmidt-Clermont, E.; Segner, H. (2011). 17Beta-estradiol affects the response of complement components and survival of rainbow trout (Oncorhynchus mykiss) challenged by bacterial infection. Fish & shellfish immunology, 31(1), pp. 90-7. London: Elsevier Science 10.1016/j.fsi.2011.04.007

Schmitt-Janssen, M.; von der Ohe, P.C.; Franz, S.; Rotter, S.; Sabater, S.; de Zwart, D.; Segner, Helmut (2011). Ecological relevance of key toxicants in aquatic systems. In: Brack, Werner (ed.) Effect-Directed Analysis of Complex Environmental Contamination. The Handbook of Environmental Chemistry: Vol. 15 (pp. 315-339). Heidelberg: Springer Verlag 10.1007/978-3-642-18384-3_13


Bittner, D; Bernet, D; Wahli, Thomas; Segner, Helmut; Kueng, C; Largiadèr, Carlo R. (2009). How normal is abnormal? - Discriminating between deformations and natural variation in gonad morphology of European whitefish Coregonus lavaretus. Journal of fish biology, 74(7), pp. 1594-1614. Oxford: Blackwell 10.1111/j.1095-8649.2009.02233.x

Bettge, K.; Segner, Helmut; Burki, R.; Schmidt-Posthaus, Heike; Wahli, Thomas (2009). Proliferative kidney disease (PKD) of rainbow trout: temperature- and time-related changes of Tetracapsuloides bryosalmonae DNA in the kidney. Parasitology, 136(6), pp. 615-25. London: Cambridge University Press 10.1017/S0031182009005800

Bettge, K.; Wahli, Thomas; Segner, Helmut; Schmidt-Posthaus, Heike (2009). Proliferative kidney disease in rainbow trout: time- and temperature-related renal pathology and parasite distribution. Diseases of aquatic organisms, 83(1), pp. 67-76. Oldendorf (Luhe) (D): Inter-Research 10.3354/dao01989

Froehlicher, M.; Liedtke, A.; Groh, K.; Lopez-Schier, H.; Neuhauss, S.C.; Segner, H.; Eggen, R.I. (2009). Estrogen receptor subtype beta2 is involved in neuromast development in zebrafish (Danio rerio) larvae. Developmental biology, 330(1), pp. 32-43. San Diego, Calif.: Elsevier 10.1016/j.ydbio.2009.03.005

Hrovat, M.; Segner, Helmut; Jeram, S. (2009). Variability of in vivo fish acute toxicity data. Regulatory toxicology and pharmacology, 54(3), pp. 294-300. Amsterdam: Elsevier 10.1016/j.yrtph.2009.05.013

Jos, A.; Camean, A.M.; Pflugmacher, S.; Segner, Helmut (2009). The antioxidant glutathione in the fish cell lines EPC and BCF-2: response to model pro-oxidants as measured by three different fluorescent dyes. Toxicology in vitro, 23(3), pp. 546-53. Oxford: Elsevier 10.1016/j.tiv.2009.01.013

Kipfer, S.; Segner, Helmut; Wenger, M.; Wahli, Thomas; Bernet, Daniel (2009). Long-term estrogen exposure of whitefish Coregonus lavaretus induces intersex but not Lake Thun-typical gonad malformations. Diseases of aquatic organisms, 84(1), pp. 43-56. Oldendorf (Luhe) (D): Inter-Research 10.3354/dao02031

Ortiz-Delgado, J.B.; Segner, Helmut; Sarasquete, C. (2009). Brain CYP1A in seabream, Sparus aurata exposed to benzo(a)pyrene. Histology and histopathology, 24(10), pp. 1263-73. Murcia: Gutenberg

Segner, Helmut (2009). Zebrafish (Danio rerio) as a model organism for investigating endocrine disruption. Comparative biochemistry and physiology. Part C - toxicology and pharmacology, 149(2), pp. 187-195. New York, N.Y.: Elsevier 10.1016/j.cbpc.2008.10.099

Vonk, J.A.; Benigni, R.; Hewitt, M.; Nendza, M.; Segner, Helmut; van de Meent, D.; Cronin, M.T. (2009). The use of mechanisms and modes of toxic action in integrated testing strategies: the report and recommendations of a workshop held as part of the European Union OSIRIS Integrated Project. ATLA - alternatives to laboratory animals, 37(5), pp. 557-71. Nottingham, UK: FRAME

Weisbrod, A.V.; Sahi, J.; Segner, Helmut; James, M.O.; Nichols, J.; Schultz, I.; Erhardt, S.; Cowan-Ellsberry, C.; Bonnell, M.; Hoeger, B. (2009). The state of in vitro science for use in bioaccumulation assessments for fish. Environmental toxicology and chemistry, 28(1), pp. 86-96. Pensacola, Fla.: SETAC Press 10.1897/08-015.1

Froehlicher, M.; Liedtke, A.; Groh, K.J.; Neuhauss, S.C.; Segner, Helmut; Eggen, R.I. (2009). Zebrafish (Danio rerio) neuromast: promising biological endpoint linking developmental and toxicological studies. Aquatic toxicology, 95(4), pp. 307-319. Amsterdam: Elsevier 10.1016/j.aquatox.2009.04.007


Rossteuscher, Stefanie; Schmidt-Posthaus, Heike; Schäfers, Christoph; Teigeler, Matthias; Segner, Helmut (2008). Background pathology of the ovary in a laboratory population of zebrafish Danio rerio. Diseases of aquatic organisms, 79(2), pp. 169-172. Inter-Research 10.3354/dao01893

Cheshenko, Ksenia; Pakdel, Farzad; Segner, Helmut; Kah, Olivier; Eggen, Rik I L (2008). Interference of endocrine disrupting chemicals with aromatase CYP19 expression or activity, and consequences for reproduction of teleost fish. General and comparative endocrinology, 155(1), pp. 31-62. San Diego, Calif.: Elsevier 10.1016/j.ygeen.2007.03.005

Ortiz-Delgado, J B; Behrens, A; Segner, H; Sarasquete, C (2008). Tissue-specific induction of EROD activity and CYP1A protein in Sparus aurata exposed to B(a)P and TCDD. Ecotoxicology and environmental safety, 69(1), pp. 80-8. Amsterdam: Elsevier 10.1016/j.ecoenv.2006.12.021

Schubert, Sara; Peter, Armin; Burki, Richard; Schönenberger, René; Suter, Marc J.-F.; Segner, Helmut; Burkhardt-Holm, Patricia (2008). Sensitivity of brown trout reproduction to long-term estrogenic exposure. Aquatic toxicology, 90(1), pp. 65-72. Amsterdam: Elsevier 10.1016/j.aquatox.2008.08.002

Shved, Natallia; Berishvili, Giorgi; Baroiller, Jean-François; Segner, Helmut; Reinecke, Manfred (2008). Environmentally Relevant Concentrations of 17α-Ethinylestradiol (EE2) Interfere With the Growth Hormone (GH)/Insulin-Like Growth Factor (IGF)-I System in Developing Bony Fish. Toxicological sciences, 106(1), pp. 93-102. Oxford University Press 10.1093/toxsci/kfn150

Nakayama, Ayako; Riesen, Ivan; Köllner, Bernd; Eppler, Elisabeth; Segner, Helmut (2008). Surface Marker-Defined Head Kidney Granulocytes and B Lymphocytes of Rainbow Trout Express Benzo[a]pyrene-Inducible Cytochrome P4501A Protein. Toxicological sciences, 103(1), pp. 86-96. Oxford University Press 10.1093/toxsci/kfn024


Kallivretaki, Evangelina; Eggen, Rik I L; Neuhauss, Stephan C F; Kah, Olivier; Segner, Helmut (2007). The zebrafish, brain-specific, aromatase cyp19a2 is neither expressed nor distributed in a sexually dimorphic manner during sexual differentiation. Developmental dynamics, 236(11), pp. 3155-66. New York, N.Y.: John Wiley & Sons 10.1002/dvdy.21344

Knüsel, R; Bergmann, S M; Einer-Jensen, K; Casey, J; Segner, H; Wahli, Thomas (2007). Virus isolation vs RT-PCR: which method is more successful in detecting VHSV and IHNV in fish tissue sampled under field conditions? Journal of fish diseases, 30(9), pp. 559-68. Oxford: Blackwell 10.1111/j.1365-2761.2007.00842.x

Jos, A; Segner, Helmut; Herradón, B; Repetto, G; Navas, J M (2007). Induction of EROD activity by 1-phenylimidazole and beta-naphthoflavone in rainbow trout cultured hepatocytes: a comparative study. Toxicology in vitro, 21(7), pp. 1307-10. Oxford: Elsevier 10.1016/j.tiv.2007.03.017

Cheshenko, Ksenia; Brion, Francois; Le Page, Yann; Hinfray, Nathalie; Pakdel, Farzad; Kah, Olivier; Segner, Helmut; Eggen, Rik I L (2007). Expression of zebra fish aromatase cyp19a and cyp19b genes in response to the ligands of estrogen receptor and aryl hydrocarbon receptor. Toxicological sciences, 96(2), pp. 255-67. Oxford: Oxford University Press 10.1093/toxsci/kfm003

Köhler, Heinz-R; Sandu, Cristina; Scheil, Volker; Nagy-Petric¿, Erika M; Segner, Helmut; Telcean, Ilie; Stan, Gheorghe; Triebskorn, Rita (2007). Monitoring pollution in river Mure , Romania, Part III: biochemical effect markers in fish and integrative reflection. Environmental monitoring and assessment, 127(1-3), pp. 47-54. Dordrecht: Kluwer 10.1007/s10661-006-9257-y

Ortiz-Delgado, J B; Segner, Helmut; Arellano, J M; Sarasquete, C (2007). Histopathological alterations, EROD activity, CYP1A protein and biliary metabolites in gilthead seabream Sparus aurata exposed to benzo(a)pyrene. Histology and histopathology, 22(4), pp. 417-32. Murcia: Gutenberg

Schäfers, C; Teigeler, M; Wenzel, A; Maack, G; Fenske, M; Segner, Helmut (2007). Concentration- and time-dependent effects of the synthetic estrogen, 17alpha-ethinylestradiol, on reproductive capabilities of the zebrafish, Danio rerio. Journal of toxicology and environmental health. Part A - current issues, 70(9), pp. 768-79. London: Taylor & Francis 10.1080/15287390701236470

Shved, Natallia; Berishvili, Giorgi; D'Cotta, Helena; Baroiller, Jean-François; Segner, Helmut; Eppler, Elisabeth; Reinecke, Manfred (2007). Ethinylestradiol differentially interferes with IGF-I in liver and extrahepatic sites during development of male and female bony fish. Journal of endocrinology, 195(3), pp. 513-23. Bristol: BioScientifica 10.1677/JOE-07-0295

Burkhardt-Holm, Patricia; Segner, Helmut (2007). Lebenswissenschaften und allgemeine Ökologie: Gemeinsamkeiten, Unterschiede und gegenseitige Beeinflussung. In: Di Giulio, Antonietta; Defila, Rico; Hammer, Thomas; Bruppacher, Susanne (eds.) Allgemeine Ökologie. Innovationen in Wissenschaft und Gesellschaft. Festschrift für Ruth Kaufmann-Hayoz (pp. 103-125). Bern: Haupt

Segner, H. (2007). Ecotoxicology - how to asses the impact of toxicants in a multifactorial environment? In: Mothersill C, Mosse I (ed.) Multiple Stressors: A Challenge for the Future. NATO Science for Peace and Security Series C: Environmental Security (pp. 39-56). Heidelberg: Springer Verlag 10.1007/978-1-4020-6335-0_4

Nichols, J; Erhardt, S; Dyer, S; James, M; Moore, M; Plotzke, K; Segner, Helmut; Schultz, I; Thomas, K; Vasiluk, L; Weisbrod, A (2007). Use of in vitro absorption, distribution, metabolism, and excretion (ADME) data in bioaccumulation assessments for fish. Human and ecological risk assessment, 13(6), pp. 1164-1191. Boca Raton, Fla.: CRC Press 10.1080/10807030701655897

Zimmerli, Simone; Bernet, Daniel; Burckhardt-Holm, P; Schmidt-Posthaus, Heike; Volanthen, P; Wahli, Thomas; Segner, Helmut (2007). Assessment of fish health status in four Swiss rivers showing a decline of brown trouth catches. Aquatic Sciences, 69(1), pp. 11-25. Basel: Birkhäuser-Verlag; www.birkhä 10.1007/s00027-006-0844-3


Navas, José M; Segner, Helmut (2006). Vitellogenin synthesis in primary cultures of fish liver cells as endpoint for in vitro screening of the (anti)estrogenic activity of chemical substances. Aquatic toxicology, 80(1), pp. 1-22. Amsterdam: Elsevier 10.1016/j.aquatox.2006.07.013

Burki, Richard; Vermeirssen, Etiënne L M; Körner, Oliver; Joris, Caroline; Burkhardt-Holm, Patricia; Segner, Helmut (2006). Assessment of estrogenic exposure in brown trout (Salmo trutta) in a Swiss midland river: integrated analysis of passive samplers, wild and caged fish, and vitellogenin mRNA and protein. Environmental toxicology and chemistry, 25(8), pp. 2077-86. Pensacola, Fla.: SETAC Press 10.1897/05-545R.1

Hutchinson, Thomas H; Ankley, Gerald T; Segner, Helmut; Tyler, Charles R (2006). Screening and testing for endocrine disruption in fish-biomarkers as "signposts," not "traffic lights," in risk assessment. Environmental health perspectives, 114 Suppl 1(Suppl 1), pp. 106-114. Research Triangle Park, N.C.: National Institute of Environmental Health Sciences 10.1289/ehp.8062

Kallivretaki, Evangelina; Eggen, Rik; Neuhauss, Stephan; Alberti, Martin; Kausch, Ulf; Segner, Helmut (2006). Aromatase in zebrafish: a potential target for endocrine disrupting chemicals. Marine environmental research, 62 Suppl, S187-S190. London: Applied Science Publ. Ltd. 10.1016/j.marenvres.2006.04.003

Segner, Helmut (2006). Comment on "Lessons from endocrine disruption and their application to other issues concerning trace organics in the aquatic environment". Environmental science & technology, 40(3), 1084-5; author reply 1086. Washington, D.C.: ACS Publications 10.1021/es051791d

Berishvili, Giorgi; D'Cotta, Helena; Baroiller, Jean-François; Segner, Helmut; Reinecke, Manfred (2006). Differential expression of IGF-I mRNA and peptide in the male and female gonad during early development of a bony fish, the tilapia Oreochromis niloticus. General and comparative endocrinology, 146(3), pp. 204-10. San Diego, Calif.: Elsevier 10.1016/j.ygcen.2005.11.008

Segner, Helmut; Eppler, Elisabeth; Reinecke, Manfred (2006). The impact of environmental hormonally active substances on the endocrine and immune system of fish. In: Kapoor, B.G. (ed.) Fish Endocrinology 1 (pp. 879-882). New Hampshire: Science Publishers


Segner, Helmut (2003). Need for establishing integrated programs to monitor endocrine active compounds. Pure and Applied Chemistry, 75(11-12), pp. 2435-2444. De Gruyter 10.1351/pac200375112435


Schmidt-Posthaus, Heike; Wahli, Thomas; Bernet, Daniel; Bernet, Daniel; Segner, Helmut; Knüsel, Ralph; Escher, Matthias; Pugovkin, Dimtri; Burkhardt-Holm, Patricia (2002). Proliferative kidney disease (PKD) in Switzerland: Current state of knowledge. Journal of fish diseases, 25(8), pp. 491-500. Blackwell 10.1046/j.1365-2761.2002.00401.x

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