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Otesteanu, Corin F; Caldelari, Reto; Heussler, Volker; Sznitman, Raphael (2024). Machine learning for predicting Plasmodium liver stage development in vitro using microscopy imaging. Computational and structural biotechnology journal, 24, pp. 334-342. Elsevier 10.1016/j.csbj.2024.04.029
Maurizio, Marina; Masid, Maria; Woods, Kerry; Caldelari, Reto; Doench, John G; Naguleswaran, Arunasalam; Joly, Denis; González-Fernández, Martín; Zemp, Jonas; Borteele, Mélanie; Hatzimanikatis, Vassily; Heussler, Volker; Rottenberg, Sven; Olias, Philipp (2024). Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites. Nature Communications, 15(1) Springer Nature 10.1038/s41467-024-50405-x
Bindschedler, Annina; Schmuckli-Maurer, Jacqueline; Buchser, Sophie; Fischer, Tara D; Wacker, Rahel; Davalan, Tim; Brunner, Jessica; Heussler, Volker T (2024). LC3B labeling of the parasitophorous vacuole membrane of Plasmodium berghei liver stage parasites depends on the V-ATPase and ATG16L1. Molecular microbiology, 121(6), pp. 1095-1111. Wiley 10.1111/mmi.15259
Beyeler, Raphael; Jordan, Melanie; Dorner, Lilian; He, Buyuan; Cyrklaff, Marek; Roques, Magali; Stanway, Rebecca; Frischknecht, Friedrich; Heussler, Volker (2024). Putative prefoldin complex subunit 5 of Plasmodium berghei is crucial for microtubule formation and parasite development in the mosquito. Molecular microbiology, 121(3), pp. 481-496. Blackwell Science 10.1111/mmi.15196
Atchou, Kodzo; Berger, Bianca Manuela; Heussler, Volker; Ochsenreiter, Torsten (2023). Pre-gelation staining expansion microscopy (PS-ExM) for visualisation of the Plasmodium liver stage. Journal of cell science, 136(22) Company of Biologists 10.1242/jcs.261377
Roques, Magali; Bindschedler, Annina; Beyeler, Raphael; Heussler, Volker T (2023). Same, same but different: Exploring Plasmodium cell division during liver stage development. PLoS pathogens, 19(3), e1011210. Public Library of Science 10.1371/journal.ppat.1011210
Romano, Patricia Silvia; Akematsu, Takahiko; Besteiro, Sébastien; Bindschedler, Annina; Carruthers, Vern B; Chahine, Zeinab; Coppens, Isabelle; Descoteaux, Albert; Alberto Duque, Thabata Lopes; He, Cynthia Y; Heussler, Volker; Le Roch, Karine G; Li, Feng-Jun; de Menezes, Juliana Perrone Bezerra; Menna-Barreto, Rubem Figueiredo Sadok; Mottram, Jeremy C; Schmuckli-Maurer, Jacqueline; Turk, Boris; Tavares Veras, Patricia Sampaio; Salassa, Betiana Nebai; ... (2023). Autophagy in protists and their hosts: When, how and why? Autophagy reports, 2(1) Taylor & Francis 10.1080/27694127.2022.2149211
Franke-Fayard, Blandine; Marin-Mogollon, Catherin; Geurten, Fiona J A; Chevalley-Maurel, Séverine; Ramesar, Jai; Kroeze, Hans; Baalbergen, Els; Wessels, Els; Baron, Ludivine; Soulard, Valérie; Martinson, Thomas; Aleshnick, Maya; Huijs, Antonius T G; Subudhi, Amit K; Miyazaki, Yukiko; Othman, Ahmad Syibli; Kolli, Surendra Kumar; Lamers, Olivia A C; Roques, Magali; Stanway, Rebecca R; ... (2022). Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver. npj vaccines, 7(1), p. 139. Nature Publishing Group 10.1038/s41541-022-00558-x
Mejia, Pedro; Treviño-Villarreal, J Humberto; De Niz, Mariana; Meibalan, Elamaran; Longchamp, Alban; Reynolds, Justin S; Turnbull, Lindsey B; Opoka, Robert O; Roussilhon, Christian; Spielmann, Tobias; Ozaki, C Keith; Heussler, Volker T.; Seydel, Karl B; Taylor, Terrie E; John, Chandy C; Milner, Danny A; Marti, Matthias; Mitchell, James R (2021). Adipose tissue parasite sequestration drives leptin production in mice and correlates with human cerebral malaria. Science Advances, 7(13) American Association for the Advancement of Science 10.1126/sciadv.abe2484
Bindschedler, Annina; Wacker, Rahel; Egli, Jessica; Eickel, Nina; Schmuckli-Maurer, Jacqueline; Franke-Fayard, Blandine M; Janse, Chris J; Heussler, Volker T. (2021). Plasmodium berghei sporozoites in nonreplicative vacuoles are eliminated by a PI3P-mediated autophagy-independent pathway. Cellular microbiology, 23(1), e13271. Wiley 10.1111/cmi.13271
Klionsky, Daniel J; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; Abildgaard, Marie H; Abudu, Yakubu Princely; Acevedo-Arozena, Abraham; Adamopoulos, Iannis E; Adeli, Khosrow; Adolph, Timon E; Adornetto, Annagrazia; Aflaki, Elma; Agam, Galila; Agarwal, Anupam; Aggarwal, Bharat B; Agnello, Maria; Agostinis, Patrizia; ... (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17(1), pp. 1-382. Taylor & Francis 10.1080/15548627.2020.1797280
De Niz, Mariana; Caldelari, Reto; Kaiser, Gesine; Zuber, Benoît; Heo, Won Do; Heussler, Volker T.; Agop-Nersesian, Carolina (2021). Hijacking of the host cell Golgi by Plasmodium berghei liver stage parasites. Journal of cell science, 134(10) Company of Biologists Limited 10.1242/jcs.252213
Putrianti, Elyzana Dewi; Schmidt-Christensen, Anja; Heussler, Volker; Matuschewski, Kai; Ingmundson, Alyssa (2020). A Plasmodium cysteine protease required for efficient transition from the liver infection stage. PLoS pathogens, 16(9), e1008891. Public Library of Science 10.1371/journal.ppat.1008891
Brancucci, Nicolas M.B.; Heussler, Volker T.; Grüring, Christof (2020). Targeting Plasmodium Plasmepsin V: Hitting Two Birds with One Stone. Trends in parasitology, 36(2), pp. 85-87. Elsevier Current Trends 10.1016/j.pt.2019.12.006
Burda, Paul-Christian; Bisio, Hugo; Marq, Jean-Baptiste; Soldati-Favre, Dominique; Heussler, Volker (2020). CRISPR/Cas9-Based Knockout of GNAQ Reveals Differences in Host Cell Signaling Necessary for Egress of Apicomplexan Parasites. mSphere, 5(6) American Society for Microbiology 10.1128/mSphere.01001-20
Grand, Morgane; Waqasi, Mishelle; Demarta-Gatsi, Claudia; Wei, Yu; Peronet, Roger; Commere, Pierre-Henri; Puig, Amandine; Axelrod, Jonathan; Caldelari, Reto; Heussler, Volker; Amino, Rogerio; Mecheri, Salaheddine (2020). Hepatic Inflammation Confers Protective Immunity Against Liver Stages of Malaria Parasite. Frontiers in immunology, 11, p. 585502. Frontiers Research Foundation 10.3389/fimmu.2020.585502
Valencia Lopez, Maria Jose; Schimmeck, Hanna; Gropengießer, Julia; Middendorf, Lukas; Quitmann, Melanie; Schneider, Carola; Holstermann, Barbara; Wacker, Rahel; Heussler, Volker; Reimer, Rudolph; Aepfelbacher, Martin; Ruckdeschel, Klaus (2019). Activation of the macroautophagy pathway by Yersinia enterocolitica promotes intracellular multiplication and egress of yersiniae from epithelial cells. Cellular microbiology, 21(9), e13046. Wiley 10.1111/cmi.13046
Niklaus, Livia; Agop-Nersesian, C; Schmuckli-Maurer, Jacqueline; Wacker, Rahel; Grünig, V; Heussler, Volker (2019). Deciphering host lysosome-mediated elimination of Plasmodium berghei liver stage parasites. Scientific Reports, 9(1), p. 7967. Nature Publishing Group 10.1038/s41598-019-44449-z
Stanway, Rebecca R.; Bushell, Ellen; Chiappino-Pepe, Anush; Roques, Magali; Sanderson, Theo; Franke-Fayard, Blandine; Caldelari, Reto; Golomingi, Murielle; Nyonda, Mary; Pandey, Vikash; Schwach, Frank; Chevalley, Séverine; Ramesar, Jai; Metcalf, Tom; Herd, Colin; Burda, Paul-Christian; Rayner, Julian C.; Soldati-Favre, Dominique; Janse, Chris J.; Hatzimanikatis, Vassily; ... (2019). Genome-Scale Identification of Essential Metabolic Processes for Targeting the Plasmodium Liver Stage. Cell, 179(5), 1112-1128.e26. Cell Press 10.1016/j.cell.2019.10.030
De Niz, Mariana; Heussler, Volker (2018). Rodent malaria models: insights into human disease and parasite biology. Current opinion in microbiology, 46, pp. 93-101. Elsevier 10.1016/j.mib.2018.09.003
Agop-Nersesian, Carolina; Niklaus, Livia; Wacker, Rahel; Heussler, Volker (2018). Host cell cytosolic immune response during Plasmodium liver stage development. FEMS microbiology reviews, 42(3), pp. 324-334. Blackwell Publishing Ltd 10.1093/femsre/fuy007
De Niz, Mariana; Meibalan, Elamaran; Mejia, Pedro; Ma, Siyuan; Brancucci, Nicolas M B; Agop-Nersesian, Carolina; Mandt, Rebecca; Ngotho, Priscilla; Hughes, Katie R; Waters, Andrew P; Huttenhower, Curtis; Mitchell, James R; Martinelli, Roberta; Frischknecht, Friedrich; Seydel, Karl B; Taylor, Terrie; Milner, Danny; Heussler, Volker T.; Marti, Matthias (2018). Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow. Science Advances, 4(5), eaat3775. American Association for the Advancement of Science 10.1126/sciadv.aat3775
Schnider, Cilly Bernardette; Bausch-Fluck, Damaris; Brühlmann, Francis; Heussler, Volker; Burda, Paul-Christian (2018). BioID Reveals Novel Proteins of the Parasitophorous Vacuole Membrane. mSphere, 3(1), e00522-17. American Society for Microbiology 10.1128/mSphere.00522-17
Saini, Ekta; Zeeshan, Mohammad; Brady, Declan; Pandey, Rajan; Kaiser, Gesine; Koreny, Ludek; Kumar, Pradeep; Thakur, Vandana; Tatiya, Shreyansh; Katris, Nicholas J; Limenitakis Stanway, Rebecca; Kaur, Inderjeet; Green, Judith L; Bottrill, Andrew R; Guttery, David S; Waller, Ross F; Heussler, Volker; Holder, Anthony A; Mohmmed, Asif; Malhotra, Pawan; ... (2017). Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the inner membrane complex and is required for Plasmodium parasite development. Scientific Reports, 7(1), p. 15577. Nature Publishing Group 10.1038/s41598-017-15781-z
Pino, Paco; Caldelari, Reto; Mukherjee, Budhaditya; Vahokoski, Juha; Klages, Natacha; Maco, Bohumil; Collins, Christine R; Blackman, Michael J; Kursula, Inari; Heussler, Volker; Brochet, Mathieu; Soldati-Favre, Dominique (2017). A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress. Science, 358(6362), pp. 522-528. American Association for the Advancement of Science 10.1126/science.aaf8675
Wacker, Rahel Corina; Eickel, Nina; Schmuckli, Jacqueline; Annoura, Takeshi; Niklaus, Livia; Khan, Shahid M; Guan, Jun-Lin; Heussler, Volker (2017). LC3-association with the parasitophorous vacuole membrane of Plasmodium berghei liver stages follows a noncanonical autophagy pathway. Cellular microbiology, 19(10) Wiley 10.1111/cmi.12754
Hopp, Christine S; Bennett, Brandy L; Mishra, Satish; Lehmann, Christine; Hanson, Kirsten K; Lin, Jing-Wen; Rousseau, Kimberly; Carvalho, Filomena A; van der Linden, Wouter A; Santos, Nuno C; Bogyo, Matthew; Khan, Shahid M; Heussler, Volker; Sinnis, Photini (2017). Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites. PLoS pathogens, 13(9), e1006586. Public Library of Science 10.1371/journal.ppat.1006586
Burda, Paul-Christian; Schaffner, Marco; Kaiser, Gesine; Roques, Magali Hélène Yvonne; Zuber, Benoît; Heussler, Volker (2017). A Plasmodium plasma membrane reporter reveals membrane dynamics by live-cell microscopy. Scientific Reports, 7(1), p. 9740. Nature Publishing Group 10.1038/s41598-017-09569-4
Kaiser, Gesine; De Niz Hidalgo, Mariana Isabel; Burda, Paul-Christian; Niklaus, Livia; Limenitakis Stanway, Rebecca; Heussler, Volker (2017). Generation of transgenic rodent malaria parasites by transfection of cell culture-derived merozoites. Malaria journal, 16(1), p. 305. BioMed Central 10.1186/s12936-017-1949-y
Agop Nersesian, Carolina; De Niz Hidalgo, Mariana Isabel; Niklaus, Livia; Prado, Monica; Eickel, Nina; Heussler, Volker (2017). Shedding of host autophagic proteins from the parasitophorous vacuolar membrane of Plasmodium berghei. Scientific Reports, 7(1), p. 2191. Nature Publishing Group 10.1038/s41598-017-02156-7
Burda, Paul-Christian; Caldelari, Reto; Heussler, Volker (2017). Manipulation of the Host Cell Membrane during Plasmodium Liver Stage Egress. mBio, 8(2) American Society for Microbiology 10.1128/mBio.00139-17
De Niz Hidalgo, Mariana Isabel; Burda, Paul-Christian; Kaiser, Gesine; Del Portillo, Hernando A; Spielmann, Tobias; Frischknecht, Freddy; Heussler, Volker (2017). Progress in imaging methods: insights gained into Plasmodium biology. Nature reviews. Microbiology, 15(1), pp. 37-54. Springer Nature 10.1038/nrmicro.2016.158
Schmuckli, Jacqueline; Reber, Vera; Wacker, Rahel Corina; Bindschedler, Annina; Zakher, Anthony; Heussler, Volker (2017). Inverted recruitment of autophagy proteins to the Plasmodium berghei parasitophorous vacuole membrane. PLoS ONE, 12(8), e0183797. Public Library of Science 10.1371/journal.pone.0183797
Huber, Sandra; Theiler, Romina Sarah; de Quervain, Daniel; Wiens, Olga; Karangenc, Tulin; Heussler, Volker; Dobbelaere, Dirk,; Woods, Kerry (2017). The Microtubule-Stabilizing Protein CLASP1 Associates with the Theileria annulata Schizont Surface via Its Kinetochore-Binding Domain. mSphere, 2(4) American Society for Microbiology 10.1128/mSphere.00215-17
Heussler, Volker; Rennenberg, Annika; Limenitakis Stanway, Rebecca (2016). Exoerythrocytic development of Plasmodium parasites. In: Gaur, Deepak; Chitnis, Chetan E.; Chauhan, Virander S. (eds.) Advances in Malaria research. Series on Biochemistry and Molecular Biology (pp. 9-32). Hoboken, New Jersey: Wiley & Sons, Inc.
Heussler, Volker; Spielmann, Tobias; Frischknecht, Friedrich; Gillberger, Tim (2016). Plasmodium. In: Walochnik, Julia; Duchêne, Michael (eds.) Molecular Parasitology (pp. 241-284). Wien: Springer-Verlag Wien 10.1007/978-3-7091-1416-2_9
Kaiser, Gesine; De Niz Hidalgo, Mariana Isabel; Zuber, Benoît; Burda, Paul-Christian; Kornmann, Benoît; Limenitakis Stanway, Rebecca; Heussler, Volker (2016). High resolution microscopy reveals an unusual architecture of the Plasmodium berghei endoplasmic reticulum. Molecular microbiology, 102(5), pp. 775-791. Blackwell Science 10.1111/mmi.13490
De Niz Hidalgo, Mariana Isabel; Limenitakis Stanway, Rebecca; Wacker, Rahel Corina; Keller, Derya; Heussler, Volker T. (2016). An ultrasensitive NanoLuc-based luminescence system for monitoring Plasmodium berghei throughout its life cycle. Malaria journal, 15(1), p. 232. BioMed Central 10.1186/s12936-016-1291-9
De Niz Hidalgo, Mariana Isabel; Ullrich, Ann-Katrin; Heiber, Arlett; Blancke Soares, Alexandra; Pick, Christian; Lyck, Ruth; Keller, Derya; Kaiser, Gesine; Prado, Monica; Flemming, Sven; Del Portillo, Hernando; Janse, Chris J; Heussler, Volker; Spielmann, Tobias (2016). The machinery underlying malaria parasite virulence is conserved between rodent and human malaria parasites. Nature communications, 7, p. 11659. Nature Publishing Group 10.1038/ncomms11659
Kumar, Hirdesh; Sattler, Julia Magdalena; Singer, Mirko; Heiss, Kirsten; Reinig, Miriam; Hammerschmidt-Kamper, Christiane; Heussler, Volker; Mueller, Ann-Kristin; Frischknecht, Friedrich (2016). Protective efficacy and safety of liver stage attenuated malaria parasites. Scientific Reports, 6, p. 26824. Nature Publishing Group 10.1038/srep26824
Prado, Monica; Eickel, Nina; De Niz Hidalgo, Mariana Isabel; Heitmann, Anna; Agop Nersesian, Carolina; Wacker, Rahel Corina; Schmuckli-Maurer, Jacqueline; Caldelari, Reto; Janse, Chris J; Khan, Shahid M; May, Jürgen; Meyer, Christian G; Heussler, Volker (2015). Long-term live imaging reveals cytosolic immune responses of host hepatocytes against Plasmodium infection and parasite escape mechanisms. Autophagy, 11(9), pp. 1561-1579. Landes Bioscience 10.1080/15548627.2015.1067361
Burda, Paul-Christian; Rölli, Matthias; Schaffner, Marco; Khan, Shahid M; Janse, Chris J; Heussler, Volker (2015). A Plasmodium phospholipase is involved in disruption of the liver stage parasitophorous vacuole membrane. PLoS pathogens, 11(3), e1004760. Public Library of Science 10.1371/journal.ppat.1004760
De Niz, Mariana; Helm, Susanne; Horstmann, Sebastian; Annoura, Takeshi; Del Portillo, Hernando A; Khan, Shahid M; Heussler, Volker (2015). In vivo and in vitro characterization of a Plasmodium liver stage-specific promoter. PLoS ONE, 10(4), e0123473. Public Library of Science 10.1371/journal.pone.0123473
Lehmann, Christine; Heitmann, Anna; Mishra, Satish; Burda, Paul-Christian; Singer, Mirko; Prado, Monica; Niklaus, Livia; Lacroix, Céline; Ménard, Robert; Frischknecht, Friedrich; Stanway, Rebecca; Sinnis, Photini; Heussler, Volker (2014). A cysteine protease inhibitor of plasmodium berghei is essential for exo-erythrocytic development. PLoS pathogens, 10(8), e1004336. Public Library of Science 10.1371/journal.ppat.1004336
Ferrer, Mireia; Martin-Jaular, Lorena; De Niz Hidalgo, Mariana Isabel; Khan, Shahid M; Janse, Chris J; Calvo, Maria; Heussler, Volker; del Portillo, Hernando A (2014). Imaging of the spleen in malaria. Parasitology international, 63(1), pp. 195-205. Elsevier 10.1016/j.parint.2013.08.014
Wiens, Olga; Xia, Dong; Von Schubert, Conrad; Wastling, Jonathan M; Dobbelaere, Dirk,; Heussler, Volker; Woods, Kerry (2014). Cell cycle-dependent phosphorylation of Theileria annulata schizont surface proteins. PLoS ONE, 9(7), e103821. Public Library of Science 10.1371/journal.pone.0103821
Espinoza Mora, Maria del Rosario; Steeg, Christiane; Tartz, Susanne; Heussler, Volker; Sparwasser, Tim; Link, Andreas; Fleischer, Bernhard; Jacobs, Thomas (2014). Depletion of regulatory T cells augments a vaccine-induced T effector cell response against the liver-stage of malaria but fails to increase memory. PLoS ONE, 9(8), e104627. Public Library of Science 10.1371/journal.pone.0104627
Falkard, Brie; Kumar, T R Santha; Hecht, Leonie-Sophie; Matthews, Krista A; Henrich, Philipp P; Gulati, Sonia; Lewis, Rebecca E; Manary, Micah J; Winzeler, Elizabeth A; Sinnis, Photini; Prigge, Sean T; Heussler, Volker; Deschermeier, Christina; Fidock, David (2013). A key role for lipoic acid synthesis during Plasmodium liver stage development. Cellular microbiology, 15(9), pp. 1585-604. Blackwell 10.1111/cmi.12137
Nagel, Andreas; Prado, Monica; Heitmann, Anna; Tartz, Susanne; Jacobs, Thomas; Deschermeier, Christina; Helm, Susanne; Stanway, Rebecca; Heussler, Volker (2013). A new approach to generate a safe double-attenuated Plasmodium liver stage vaccine. International journal for parasitology, 43(6), pp. 503-514. Elsevier 10.1016/j.ijpara.2013.01.010
Eickel, Nina; Kaiser, Gesine; Prado, Monica; Burda, Paul-Christian; Roelli, Matthias; Stanway, Rebecca R.; Heussler, Volker (2013). Features of autophagic cell death in Plasmodium liver-stage parasites. Autophagy, 9(4), pp. 568-580. Landes Bioscience 10.4161/auto.23689
Wierk, Jannika Katharina; Langbehn, Annette; Kamper, Maria; Richter, Stefanie; Burda, Paul-Christian; Heussler, Volker; Deschermeier, Christina (2013). Plasmodium berghei MAPK1 displays differential and dynamic subcellular localizations during liver stage development. PLoS ONE, 8(3), e59755. Public Library of Science 10.1371/journal.pone.0059755
Tartz, Susanne; Deschermeier, Christina; Retzlaff, Silke; Heussler, Volker; Sebo, Peter; Fleischer, Bernhard; Jacobs, Thomas (2013). Plasmodium berghei sporozoite challenge of vaccinated BALB/c mice leads to the induction of humoral immunity and improved function of CD8(+) memory T cells. European journal of immunology, 43(3), pp. 693-704. Wiley-VCH 10.1002/eji.201142262
Stanway, Rebecca R.; Schmuckli-Maurer, Jacqueline; Heussler, Volker (2013). Analysis of liver stage development in and merozoite release from hepatocytes. In: Ménard, Robert (ed.) Malaria, Methods and Protocols. Methods in Molecular Biology: Vol. 923 (pp. 411-427). Humana Press 10.1007/978-1-62703-026-7_29
Graewe, S.; Stanway, R. R.; Rennenberg, A.; Heussler, Volker (2012). Chronicle of a death foretold: Plasmodium liver stage parasites decide on the fate of the host cell. FEMS microbiology reviews, 36(1), pp. 111-130. Malden, Mass.: Blackwell Publishing Ltd 10.1111/j.1574-6976.2011.00297.x
Kolbaum, J; Tartz, S; Hartmann, W; Helm, S; Nagel, A; Heussler, Volker; Sebo, P; Fleischer, B; Jacobs, T; Breloer, M (2012). Nematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration. European journal of immunology, 42(4), pp. 890-900. Weinheim: Wiley-VCH 10.1002/eji.201141955
Kono, M; Herrmann, S; Loughran, NB; Cabera, A; Engelberg, K; Lehmann, C; Sinha, D; Prinz, B; Ruch, U; Heussler, Volker; Spielmann, T; Parkinson, J; Gilberger, TW (2012). Evolution and Architecture of the Inner Membrane Complex in Asexual and Sexual Stages of the Malaria Parasite. Molecular Biology and Evolution, 29(9), pp. 2113-2132. Oxford: Oxford University Press 10.1093/molbev/mss081
Deschermeier, C.; Hecht, L.S.; Bach, F.; Rützel, K.; Stanway, R.R.; Nagel, A.; Seeber, F.; Heussler, Volker (2012). Mitochondrial lipoic acid scavenging is essential for Plasmodium berghei liver stage development. Cellular microbiology, 14(3), pp. 416-430. Oxford: Blackwell 10.1111/j.1462-5822.2011.01729.x
Amino, R.; Bassat, Q.; Baum, J.; Billker, O.; Bogyo, M.; Bousema, T.; Christophides, G.; Deitsch, K.; Dinglasan, R.; Djimde, A.; Duraisingh, M.; Dzinjalamala, F.; Happi, C.; Heussler, Volker; Kramarik, J.; de Koning-Ward, T.; Lacerda, M.; Laufer, M.; Lim, P.; Llinas, M.; ... (2011). A research agenda for malaria eradication: basic science and enabling technologies. PLoS medicine, 8(1), e1000399. San Francisco, Calif.: Public Library of Science 10.1371/journal.pmed.1000399
Graewe, Stefanie; Rankin, Kathleen E.; Lehmann, Christine; Deschermeier, Christina; Hecht, Leonie; Froehlke, Ulrike; Stanway, Rebecca R.; Heussler, Volker (2011). Hostile takeover by Plasmodium: reorganization of parasite and host cell membranes during liver stage egress. PLoS pathogens, 7(9), e1002224. San Francisco, Calif.: Public Library of Science 10.1371/journal.ppat.1002224
Hansen, G.; Heitmann, A.; Witt, T.; Li, H.; Jiang, H.; Shen, X.; Heussler, Volker; Rennenberg, A.; Hilgenfeld, R. (2011). Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium. Structure, 19(7), pp. 919-929. Cambridge, Mass.: Cell Press 10.1016/j.str.2011.03.025
Hansen, G.; Schwarzloh, B.; Rennenberg, A.; Heussler, Volker; Hilgenfeld, R. (2011). The macromolecular complex of ICP and falcipain-2 from Plasmodium: preparation, crystallization and preliminary X-ray diffraction analysis. Acta crystallographica. Section F - Structural biology and crystallization communications online, 67(Pt 11), pp. 1406-10. Oxford: Wiley-Blackwell 10.1107/S1744309111034592
Martin-Jaular, L.; Ferrer, M.; Calvo, M.; Rosanas-Urgell, A.; Kalko, S.; Graewe, S.; Soria, G.; Cortadellas, N.; Ordi, J.; Planas, A.; Burns, J.; Heussler, Volker; del Portillo, H. A. (2011). Strain-specific spleen remodelling in Plasmodium yoelii infections in Balb/c mice facilitates adherence and spleen macrophage-clearance escape. Cellular microbiology, 13(1), pp. 109-122. Oxford: Blackwell 10.1111/j.1462-5822.2010.01523.x
Sicard, A.; Semblat, J. P.; Doerig, C.; Hamelin, R.; Moniatte, M.; Dorin-Semblat, D.; Spicer, J. A.; Srivastava, A.; Retzlaff, S.; Heussler, Volker; Waters, A. P.; Doerig, C. (2011). Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes. Cellular microbiology, 13(6), pp. 836-845. Oxford: Blackwell 10.1111/j.1462-5822.2011.01582.x
Stanway, R. R.; Mueller, N.; Zobiak, B.; Graewe, S.; Froehlke, U.; Zessin, P. J.; Aepfelbacher, M.; Heussler, Volker (2011). Organelle segregation into Plasmodium liver stage merozoites. Cellular microbiology, 13(11), pp. 1768-82. Oxford: Blackwell 10.1111/j.1462-5822.2011.01657.x
Putrianti, Elyzana D; Schmidt-Christensen, Anja; Arnold, Iris; Heussler, Volker; Matuschewski, Kai; Silvie, Olivier (2010). The Plasmodium serine-type SERA proteases display distinct expression patterns and non-essential in vivo roles during life cycle progression of the malaria parasite. Cellular microbiology, 12(6), pp. 725-739. Blackwell 10.1111/j.1462-5822.2009.01419.x
Rankin, Kathleen E; Graewe, Stefanie; Heussler, Volker; Stanway, Rebecca R (2010). Imaging liver-stage malaria parasites. Cellular microbiology, 12(5), pp. 569-579. Blackwell 10.1111/j.1462-5822.2010.01454.x
Rennenberg, Annika; Lehmann, Christine; Heitmann, Anna; Witt, Tina; Hansen, Guido; Nagarajan, Krishna; Deschermeier, Christina; Turk, Vito; Hilgenfeld, Rolf; Heussler, Volker (2010). Exoerythrocytic Plasmodium Parasites Secrete a Cysteine Protease Inhibitor Involved in Sporozoite Invasion and Capable of Blocking Cell Death of Host Hepatocytes. PLoS pathogens, 6(3), e1000825. Public Library of Science 10.1371/journal.ppat.1000825
Helm, Susanne; Lehmann, Christine; Nagel, Andreas; Stanway, Rebecca R; Horstmann, Sebastian; Llinas, Manuel; Heussler, Volker (2010). Identification and characterization of a liver stage-specific promoter region of the malaria parasite Plasmodium. PLoS ONE, 5(10), e13653. Public Library of Science 10.1371/journal.pone.0013653
Doerig, C; Baker, D; Billker, O; Blackman, M J; Chitnis, C; Dhar Kumar, S; Heussler, Volker; Holder, A A; Kocken, C; Krishna, S; Langsley, G; Lasonder, E; Menard, R; Meissner, M; Pradel, G; Ranford-Cartwright, L; Sharma, A; Sharma, P; Tardieux, T; Tatu, U; ... (2009). Signalling in malaria parasites. The MALSIG consortium. Parasite, 16(3), pp. 169-182. Princeps Editions 10.1051/parasite/2009163169
Stanway, Rebecca R; Witt, Tina; Zobiak, Bernd; Aepfelbacher, Martin; Heussler, Volker (2009). GFP-targeting allows visualization of the apicoplast throughout the life cycle of live malaria parasites. Biology of the cell, 101(7), pp. 415-430. Wiley 10.1042/BC20080202
Graewe, Stefanie; Retzlaff, Silke; Struck, Nicole; Janse, Chris J; Heussler, Volker (2009). Going live: a comparative analysis of the suitability of the RFP derivatives RedStar, mCherry and tdTomato for intravital and in vitro live imaging of Plasmodium parasites. Biotechnology journal, 4(6), pp. 895-902. Wiley 10.1002/biot.200900035
Sturm, Angelika; Graewe, Stefanie; Franke-Fayard, Blandine; Retzlaff, Silke; Bolte, Stefanie; Roppenser, Bernhard; Aepfelbacher, Martin; Janse, Chris; Heussler, Volker (2009). Alteration of the parasite plasma membrane and the parasitophorous vacuole membrane during exo-erythrocytic development of malaria parasites. Protist, 160(1), pp. 51-63. Elsevier 10.1016/j.protis.2008.08.002
Lüder, Carsten G K; Stanway, Rebecca R; Chaussepied, Marie; Langsley, Gordon; Heussler, Volker (2009). Intracellular survival of apicomplexan parasites and host cell modification. International journal for parasitology, 39(2), pp. 163-173. Elsevier 10.1016/j.ijpara.2008.09.013
Limenitakis Stanway, Rebecca; Graewe, Stefanie; Rennenberg, Annika; Helm, Susanne; Heussler, Volker T. (2009). Highly efficient subcloning of rodent malaria parasites by injection of single merosomes or detached cells. Nature protocols, 4(10), pp. 1433-1439. Nature Publishing Group 10.1038/nprot.2009.172
Ménard, Robert; Heussler, Volker; Yuda, Masao; Nussenzweig, Victor (2008). Plasmodium pre-erythrocytic stages: what's new? Trends in parasitology, 24(12), pp. 564-569. Elsevier Current Trends 10.1016/j.pt.2008.08.009
Tartz, Susanne; Rüssmann, Holger; Kamanova, Jana; Sebo, Peter; Sturm, Angelika; Heussler, Volker; Fleischer, Bernhard; Jacobs, Thomas (2008). Complete protection against P. berghei malaria upon heterologous prime/boost immunization against circumsporozoite protein employing Salmonella type III secretion system and Bordetella adenylate cyclase toxoid. Vaccine, 26(47), pp. 5935-5943. Elsevier 10.1016/j.vaccine.2008.08.057
Heussler, Volker; Stanway, R R (2008). Cellular and molecular interactions between the apicomplexan parasites Plasmodium and Theileria and their host cells. Parasite, 15(3), pp. 211-218. Princeps Editions
Schmidt-Christensen, Anja; Sturm, Angelika; Horstmann, Sebastian; Heussler, Volker (2008). Expression and processing of Plasmodium berghei SERA3 during liver stages. Cellular microbiology, 10(8), pp. 1723-1734. Blackwell 10.1111/j.1462-5822.2008.01162.x
Yu, Min; Kumar, T.R. Santha; Nkrumah, Louis J.; Coppi, Alida; Retzlaff, Silke; Li, Celeste D.; Kelly, Brendan J.; Moura, Pedro A.; Lakshmanan, Viswanathan; Freundlich, Joel S.; Valderramos, Juan-Carlos; Vilcheze, Catherine; Siedner, Mark; Tsai, Jennifer H.-C.; Falkard, Brie; Sidhu, Amar bir Singh; Purcell, Lisa A.; Gratraud, Paul; Kremer, Laurent; Waters, Andrew P.; ... (2008). The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites. Cell host & microbe, 4(6), pp. 567-578. Cell Press 10.1016/j.chom.2008.11.001
Lackner, P; Burger, C; Pfaller, K; Heussler, Volker; Helbok, R; Morandell, M; Broessner, G; Tannich, E; Schmutzhard, E; Beer, R (2007). Apoptosis in experimental cerebral malaria: spatial profile of cleaved caspase-3 and ultrastructural alterations in different disease stages. Neuropathology and Applied Neurobiology, 33(5), pp. 560-571. Wiley 10.1111/j.1365-2990.2007.00833.x
Sturm, Angelika; Heussler, Volker (2007). Live and let die: manipulation of host hepatocytes by exoerythrocytic Plasmodium parasites. Medical microbiology and immunology, 196(3), pp. 127-133. Springer 10.1007/s00430-007-0044-3
Sturm, Angelika; Amino, Rogerio; van de Sand, Claudia; Regen, Tommy; Retzlaff, Silke; Rennenberg, Annika; Krueger, Andreas; Pollok, Jörg-Matthias; Menard, Robert; Heussler, Volker (2006). Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids. Science, 313(5791), pp. 1287-1290. American Association for the Advancement of Science 10.1126/science.1129720
Heussler, Volker; Doerig, Christian (2006). In vivo imaging enters parasitology. Trends in parasitology, 22(5), pp. 192-195. Elsevier Current Trends 10.1016/j.pt.2006.03.001
Tartz, Susanne; Kamanova, Jana; Simsova, Marcela; Sebo, Peter; Bolte, Stefanie; Heussler, Volker; Fleischer, Bernhard; Jacobs, Thomas (2006). Immunization with a circumsporozoite epitope fused to Bordetella pertussis adenylate cyclase in conjunction with cytotoxic T-lymphocyte-associated antigen 4 blockade confers protection against Plasmodium berghei liver-stage malaria. Infection and immunity, 74(4), pp. 2277-2285. American Society for Microbiology 10.1128/IAI.74.4.2277-2285.2006
Lackner, P; Beer, R; Heussler, Volker; Goebel, G; Rudzki, D; Helbok, R; Tannich, E; Schmutzhard, E (2006). Behavioural and histopathological alterations in mice with cerebral malaria. Neuropathology and Applied Neurobiology, 32(2), pp. 177-188. Wiley 10.1111/j.1365-2990.2006.00706.x
Heussler, Volker; Sturm, A; Langsley, G (2006). Regulation of host cell survival by intracellular Plasmodium and Theileria parasites. Parasitology, 132(Suppl S1), S49-S60. Cambridge University Press 10.1017/S0031182006000850
van de Sand, Claudia; Horstmann, Sebastian; Schmidt, Anja; Sturm, Angelika; Bolte, Stefanie; Krueger, Andreas; Lütgehetmann, Marc; Pollok, Jörg-Matthias; Libert, Claude; Heussler, Volker (2005). The liver stage of Plasmodium berghei inhibits host cell apoptosis. Molecular microbiology, 58(3), pp. 731-742. Blackwell Science 10.1111/j.1365-2958.2005.04888.x
van Dijk, Melissa R; Douradinha, Bruno; Franke-Fayard, Blandine; Heussler, Volker; van Dooren, Maaike W; van Schaijk, Ben; van Gemert, Geert-Jan; Sauerwein, Robert W; Mota, Maria M; Waters, Andrew P; Janse, Chris J (2005). Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 102(34), pp. 12194-12199. National Academy of Sciences NAS 10.1073/pnas.0500925102
Lindenthal, C; Weich, N; Chia, Y S; Heussler, Volker; Klinkert, M Q (2005). The proteasome inhibitor MLN-273 blocks exoerythrocytic and erythrocytic development of Plasmodium parasites. Parasitology, 131(Pt 1), pp. 37-44. Cambridge University Press 10.1017/S003118200500747X
Huber, Stephan M; Duranton, Christophe; Henke, Guido; Van De Sand, Claudia; Heussler, Volker; Shumilina, Ekaterina; Sandu, Ciprian D; Tanneur, Valerie; Brand, Verena; Kasinathan, Ravi S; Lang, Karl S; Kremsner, Peter G; Hübner, Christian A; Rust, Marco B; Dedek, Karin; Jentsch, Thomas J; Lang, Florian (2004). Plasmodium induces swelling-activated ClC-2 anion channels in the host erythrocyte. Journal of biological chemistry, 279(40), pp. 41444-41452. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M407618200
Waldvogel, A S; Lepage, M-F; Zakher, Anthony; Reichel, M P; Eicher, R; Heussler, Volker (2004). Expression of interleukin 4, interleukin 4 splice variants and interferon gamma mRNA in calves experimentally infected with Fasciola hepatica. Veterinary immunology and immunopathology, 97(1-2), pp. 53-63. Elsevier 10.1016/j.vetimm.2003.08.002
Saeftel, Michael; Krueger, Andreas; Arriens, Sandra; Heussler, Volker; Racz, Paul; Fleischer, Bernhard; Brombacher, Frank; Hoerauf, Achim (2004). Mice deficient in interleukin-4 (IL-4) or IL-4 receptor alpha have higher resistance to sporozoite infection with Plasmodium berghei (ANKA) than do naive wild-type mice. Infection and immunity, 72(1), pp. 322-331. American Society for Microbiology
Waldvogel, Andreas S; Zakher, Anthony; Guionaud, Christophe T; Fernandez, Paula; Heussler, Volker (2002). Regulation of bovine IL-12R beta 2 subunit mRNA expression in bovine lymph node cells. Gene, 289(1-2), pp. 61-67. Elsevier 10.1016/S0378-1119(02)00464-X
Heussler, Volker; Rottenberg, S; Schwab, R; Küenzi, P; Fernandez, PC; McKellar, S; Shiels, B; Chen, ZJ; Orth, K; Wallach, D; Dobbelaere, Dirk, (2002). Hijacking of host cell IKK signalosomes by the transforming parasite Theileria. Science, 5595(298), pp. 1033-1036. Washington, D.C.: American Association for the Advancement of Science 10.1126/science.1075462
Rottenberg, S; Schmuckli-Maurer, J; Grimm, S; Heussler, Volker; Dobbelaere, Dirk, (2002). Characterization of the bovine IkappaB kinases (IKK)alpha and IKKbeta, the regulatory subunit NEMO and their substrate IkappaBalpha. Gene, 299(1-2), pp. 293-300. Amsterdam: Elsevier 10.1016/S0378-1119(02)01011-9
Heussler, Volker; Küenzi, P; Rottenberg, S (2001). Inhibition of apoptosis by intracellular protozoan parasites. International journal for parasitology, 31(11), pp. 1166-1176. Elsevier 10.1016/S0020-7519(01)00271-5
Heussler, Volker; Küenzi, P; Fraga, F; Schwab, R A; Hemmings, B A; Dobbelaere, D A (2001). The Akt/PKB pathway is constitutively activated in Theileria-transformed leucocytes, but does not directly control constitutive NF-kappaB activation. Cellular microbiology, 3(8), pp. 537-550. Blackwell 10.1046/j.1462-5822.2001.00134.x
Waldvogel, A S; Hediger-Weithaler, B M; Eicher, R; Zakher, Anthony; Zarlenga, D S; Gasbarre, L C; Heussler, Volker (2000). Interferon-gamma and interleukin-4 mRNA expression by peripheral blood mononuclear cells from pregnant and non-pregnant cattle seropositive for bovine viral diarrhea virus. Veterinary immunology and immunopathology, 77(3-4), pp. 201-212. Elsevier 10.1016/S0165-2427(00)00240-3
Dobbelaere, D A; Fernandez, P C; Heussler, Volker (2000). Theileria parva: taking control of host cell proliferation and survival mechanisms. Cellular microbiology, 2(2), pp. 91-99. Blackwell 10.1046/j.1462-5822.2000.00045.x
Dobbelaere, D; Fernandez, P; Machado, J; Botteron, C; Heussler, Volker (1999). Interference by the intracellular parasite Theileria parva with T-cell signal transduction pathways induces transformation and protection against apoptosis. Veterinary immunology and immunopathology, 72(1-2), pp. 95-100. Elsevier 10.1016/S0165-2427(99)00121-X
Fernandez, P C; Machado, J; Heussler, Volker; Botteron, C; Palmer, G H; Dobbelaere, D A (1999). The inhibition of NF-kappaB activation pathways and the induction of apoptosis by dithiocarbamates in T cells are blocked by the glutathione precursor N-acetyl-L-cysteine. Biological chemistry, 380(12), pp. 1383-1394. De Gruyter 10.1515/BC.1999.178
Heussler, Volker; Machado, J; Fernandez, P C; Botteron, C; Chen, C G; Pearse, M J; Dobbelaere, D A (1999). The intracellular parasite Theileria parva protects infected T cells from apoptosis. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 96(13), pp. 7312-7317. National Academy of Sciences NAS 10.1073/pnas.96.13.7312
Heussler, Volker; Fernandez, P C; Machado, J; Botteron, C; Dobbelaere, D A (1999). N-acetylcysteine blocks apoptosis induced by N-alpha-tosyl-L-phenylalanine chloromethyl ketone in transformed T-cells. Cell death and differentiation, 6(4), pp. 342-350. Nature Publishing Group 10.1038/sj.cdd.4400501
Dobbelaere, D; Heussler, Volker (1999). Transformation of leukocytes by Theileria parva and T. annulata. Annual review of microbiology, 53, pp. 1-42. Annual Reviews 10.1146/annurev.micro.53.1.1
Weynants, V; Gilson, D; Furger, A; Collins, R A; Mertens, P; De Bolle, X; Heussler, Volker; Roditi, Isabel; Howard, C J; Dobbelaere, A E; Letesson, J J (1998). Production and characterisation of monoclonal antibodies specific for bovine interleukin-4. Veterinary immunology and immunopathology, 66(2), pp. 99-112. Elsevier 10.1016/S0165-2427(98)00184-6
Heussler, Volker; Kaufmann, H; Glaser, I; Ducommun, D; Müller, C; Dobbelaere, D (1998). A DNA probe for the detection of Dicrocoelium dendriticum in ants of Formica spp. and Lasius spp. Parasitology research, 84(6), pp. 505-508. Springer 10.1007/s004360050437
Gentschev, I; Glaser, I; Goebel, W; McKeever, D J; Musoke, A; Heussler, Volker (1998). Delivery of the p67 sporozoite antigen of Theileria parva by using recombinant Salmonella dublin: secretion of the product enhances specific antibody responses in cattle. Infection and immunity, 66(5), pp. 2060-2064. American Society for Microbiology
Heussler, Volker; Taracha, E L; Musoke, A; Duchateau, L; McKeever, D J (1998). Immunisation with live attenuated Salmonella dublin expressing a sporozoite protein confers partial protection against Theileria parva. Vaccine, 16(8), pp. 834-841. Elsevier 10.1016/S0264-410X(97)00263-6
Palmer, G H; Machado, J; Fernandez, P; Heussler, Volker; Perinat, T; Dobbelaere, D A (1997). Parasite-mediated nuclear factor kappaB regulation in lymphoproliferation caused by Theileria parva infection. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 94(23), pp. 12527-12532. National Academy of Sciences NAS
Daubenberger, C; Heussler, Volker; Gobright, E; Wijngaard, P; Clevers, H C; Wells, C; Tsuji, N; Musoke, A; McKeever, D (1997). Molecular characterisation of a cognate 70 kDa heat shock protein of the protozoan Theileria parva. Molecular and biochemical parasitology, 85(2), pp. 265-269. Elsevier 10.1016/S0166-6851(97)02831-4
Estes, D M; Hirano, A; Heussler, Volker; Dobbelaere, D A; Brown, W C (1995). Expression and biological activities of bovine interleukin 4: effects of recombinant bovine interleukin 4 on T cell proliferation and B cell differentiation and proliferation in vitro. Cellular immunology, 163(2), pp. 268-279. Elsevier 10.1006/cimm.1995.1126
Heussler, Volker; Dobbelaere, D A (1994). Cloning of a protease gene family of Fasciola hepatica by the polymerase chain reaction. Molecular and biochemical parasitology, 64(1), pp. 11-23. Elsevier 10.1016/0166-6851(94)90130-9
Eichhorn, M; Prospero, T D; Heussler, Volker; Dobbelaere, D A (1993). Antibodies against major histocompatibility complex class II antigens directly inhibit the growth of T cells infected with Theileria parva without affecting their state of activation. Journal of experimental medicine, 178(3), pp. 769-776. Rockefeller University Press 10.1084/jem.178.3.769
Heussler, Volker; Kaufmann, H; Strahm, D; Liz, J; Dobbelaere, D (1993). DNA probes for the detection of Fasciola hepatica in snails. Molecular and cellular probes, 7(4), pp. 261-267. Elsevier 10.1006/mcpr.1993.1039
Brown, W C; Zhao, S; Woods, V M; Tripp, C A; Tetzlaff, C L; Heussler, Volker; Dobbelaere, D A; Rice-Ficht, A C (1993). Identification of two Th1 cell epitopes on the Babesia bovis-encoded 77-kilodalton merozoite protein (Bb-1) by use of truncated recombinant fusion proteins. Infection and immunity, 61(1), pp. 236-244. American Society for Microbiology
Heussler, Volker; Eichhorn, M; Reeves, R; Magnuson, N S; Williams, R O; Dobbelaere, D A (1992). Constitutive IL-2 mRNA expression in lymphocytes, infected with the intracellular parasite Theileria parva. Journal of immunology, 149(2), pp. 562-567. American Association of Immunologists
Heussler, Volker; Eichhorn, M; Dobbelaere, D A (1992). Cloning of a full-length cDNA encoding bovine interleukin 4 by the polymerase chain reaction. Gene, 114(2), pp. 273-278. Elsevier 10.1016/0378-1119(92)90587-F
