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Madarasz, Adrian; Xin, Li; Proulx, Steven T (2024). Clearance of erythrocytes from the subarachnoid space through cribriform plate lymphatics in female mice. EBioMedicine, 107(105295), p. 105295. Elsevier 10.1016/j.ebiom.2024.105295
Berve, Kristina; Michel, Julia; Tietz, Silvia; Blatti, Claudia; Ivan, Daniela; Enzmann, Gaby; Lyck, Ruth; Deutsch, Urban; Locatelli, Giuseppe; Engelhardt, Britta (2024). Junctional adhesion molecule-A deficient mice are protected from severe experimental autoimmune encephalomyelitis. European journal of immunology, 54(6), e2350761. Wiley-VCH 10.1002/eji.202350761
Fujisawa, Miwako (2024). [Sarcoid Peripheral Neuropathy and Myopathy: A Diagnostic and Therapeutic Challenge]. Brain and nerve = Shinkei kenkyu no shinpo, 76(5), pp. 598-604. 10.11477/mf.1416202649
Fernandez-Rojo, Manuel A; Pearen, Michael A; Burgess, Anita G; Ikonomopoulou, Maria P; Hoang-Le, Diem; Genz, Berit; Saggiomo, Silvia L; Nawaratna, Sujeevi S K; Poli, Maura; Reissmann, Regina; Gobert, Geoffrey N; Deutsch, Urban; Engelhardt, Britta; Brooks, Andrew J; Jones, Alun; Arosio, Paolo; Ramm, Grant A (2024). The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation. Science signaling, 17(830) American Association for the Advancement of Science 10.1126/scisignal.ade4335
Hansen, Cathrin E; Kamermans, Alwin; Mol, Kevin; Berve, Kristina; Rodriguez-Mogeda, Carla; Fung, Wing Ka; van Het Hof, Bert; Fontijn, Ruud D; van der Pol, Susanne M A; Michalick, Laura; Kuebler, Wolfgang M; Kenkhuis, Boyd; van Roon-Mom, Willeke; Liedtke, Wolfgang; Engelhardt, Britta; Kooij, Gijs; Witte, Maarten E; de Vries, Helga E (2024). Inflammation-induced TRPV4 channels exacerbate blood-brain barrier dysfunction in multiple sclerosis. Journal of neuroinflammation, 21(72) BioMed Central 10.1186/s12974-024-03069-9
Sáinz-Jaspeado, Miguel; Proulx, Steven T; Ring, Sarah; Richards, Mark; Martinsson, Pernilla; Li, Xiujuan; Claesson-Welsh, Lena; Ulvmar, Maria H; Jin, Yi (2024). VE-cadherin junction dynamics in initial lymphatic vessels promotes lymph node metastasis. Life science alliance, 7(3) EMBO Press 10.26508/lsa.202302168
Seillier, Célia; Lesec, Léonie; Hélie, Pauline; Marie, Charlotte; Vivien, Denis; Docagne, Fabian; Le Mauff, Brigitte; Toutirais, Olivier (2024). Tissue-plasminogen activator effects on the phenotype of splenic myeloid cells in acute inflammation. Journal of inflammation, 21(4) BioMed Central 10.1186/s12950-024-00375-0
Denes, Adam; Hansen, Cathrin E; Oezorhan, Uemit; Figuerola, Sara; de Vries, Helga E; Sorokin, Lydia; Planas, Anna M; Engelhardt, Britta; Schwaninger, Markus (2024). Endothelial cells and macrophages as allies in the healthy and diseased brain. Acta neuropathologica, 147(38) Springer-Verlag 10.1007/s00401-024-02695-0
Kelly, Louise; Brown, Christopher; Michalik, Daniel; Hawkes, Cheryl A; Aldea, Roxana; Agarwal, Nivedita; Salib, Rami; Alzetani, Aiman; Ethell, Douglas W; Counts, Scott E; de Leon, Mony; Fossati, Silvia; Koronyo-Hamaoui, Maya; Piazza, Fabrizio; Rich, Steven A; Wolters, Frank J; Snyder, Heather; Ismail, Ozama; Elahi, Fanny; Proulx, Steven T; ... (2024). Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy. Alzheimer's & dementia : the journal of the Alzheimer's Association, 20(2), pp. 1421-1435. 10.1002/alz.13512
McCloskey, Molly C; Kasap, Pelin; Trempel, Michelle; Widom, Louis P; Kuebel, Julia; Chen, Kaihua; Gaborski, Thomas R; Engelhardt, Britta; McGrath, James L (2024). Use of the MicroSiM (µSiM) Barrier Tissue Platform for Modeling the Blood-Brain Barrier. Journal of visualized experiments(203) MYJoVE Corporation 10.3791/65258
Ruef, Nora; Martínez Magdaleno, Jose; Ficht, Xenia; Purvanov, Vladimir; Palayret, Matthieu; Wissmann, Stefanie; Pfenninger, Petra; Stolp, Bettina; Thelen, Flavian; Barreto de Albuquerque, Juliana; Germann, Philipp; Sharpe, James; Abe, Jun; Legler, Daniel F; Stein, Jens V (2023). Exocrine gland-resident memory CD8+ T cells use mechanosensing for tissue surveillance. Science immunology, 8(90), eadd5724. American Association for the Advancement of Science 10.1126/sciimmunol.add5724
Johann, Lisa; Soldati, Sasha; Müller, Kristin; Lampe, Josephine; Marini, Federico; Klein, Matthias; Schramm, Eva; Ries, Nathalie; Schelmbauer, Carsten; Palagi, Ilaria; Karram, Khalad; Assmann, Julian C; Khan, Mahtab A; Wenzel, Jan; Schmidt, Mirko Hh; Körbelin, Jakob; Schlüter, Dirk; van Loo, Geert; Bopp, Tobias; Engelhardt, Britta; ... (2023). A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS. The journal of clinical investigation, 133(24) American Society for Clinical Investigation 10.1172/JCI168314
Pietilä, Riikka; Del Gaudio, Francesca; He, Liqun; Vázquez-Liébanas, Elisa; Vanlandewijck, Michael; Muhl, Lars; Mocci, Giuseppe; Bjørnholm, Katrine D; Lindblad, Caroline; Fletcher-Sandersjöö, Alexander; Svensson, Mikael; Thelin, Eric P; Liu, Jianping; van Voorden, A Jantine; Torres, Monica; Antila, Salli; Xin, Li; Karlström, Helena; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; ... (2023). Molecular anatomy of adult mouse leptomeninges. Neuron, 111(23), 3745-3764.e7. Elsevier 10.1016/j.neuron.2023.09.002
Stüdle, Chiara; Nishihara, Hideaki; Wischnewski, Sven; Kulsvehagen, Laila; Perriot, Sylvain; Ishikawa, Hiroshi; Schroten, Horst; Frank, Stephan; Deigendesch, Nikolaus; Du Pasquier, Renaud; Schirmer, Lucas; Pröbstel, Anne-Katrin; Engelhardt, Britta (2023). SARS-CoV-2 infects epithelial cells of the blood-cerebrospinal fluid barrier rather than endothelial cells or pericytes of the blood-brain barrier. Fluids and barriers of the CNS, 20(1), p. 76. BioMed Central 10.1186/s12987-023-00479-4
Garcia-Seyda, Nicolas; Song, Solene; Seveau de Noray, Valentine; David-Broglio, Luc; Matti, Christoph; Artinger, Marc; Dupuy, Florian; Biarnes-Pelicot, Martine; Valignat, Marie-Pierre; Legler, Daniel F; Bajénoff, Marc; Theodoly, Olivier (2023). Naive T lymphocytes chemotax long distance to CCL21 but not to a source of bioactive S1P. iScience, 26(10), p. 107695. Elsevier 10.1016/j.isci.2023.107695
Saltarin, Federico; Wegmüller, Adrian; Bejarano, Leire; Ildiz, Eco Su; Zwicky, Pascale; Vianin, Andréj; Spadin, Florentin; Soukup, Klara; Wischnewski, Vladimir; Engelhardt, Britta; Deutsch, Urban; Marques, Ines J.; Frenz, Martin; Joyce, Johanna A.; Lyck, Ruth (2023). Compromised Blood-Brain Barrier Junctions Enhance Melanoma Cell Intercalation and Extravasation. Cancers, 15(20), p. 5071. MDPI AG 10.3390/cancers15205071
Liu, Huan; Ishikawa-Ankerhold, Hellen; Winterhalter, Julia; Lorenz, Michael; Vladymyrov, Mykhailo; Massberg, Steffen; Schulz, Christian; Orban, Mathias (2023). Multiphoton In Vivo Microscopy of Embryonic Thrombopoiesis Reveals the Generation of Platelets through Budding. Cells, 12(19) MDPI 10.3390/cells12192411
Mapunda, Josephine A; Pareja, Javier; Vladymyrov, Mykhailo; Bouillet, Elisa; Hélie, Pauline; Pleskač, Petr; Barcos, Sara; Andrae, Johanna; Vestweber, Dietmar; McDonald, Donald M; Betsholtz, Christer; Deutsch, Urban; Proulx, Steven T; Engelhardt, Britta (2023). VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation. Nature communications, 14(1), p. 5837. Nature Publishing Group 10.1038/s41467-023-41580-4
Lyck, Ruth; Nishihara, Hideaki; Aydin, Sidar; Soldati, Sasha; Engelhardt, Britta (2023). Modeling Brain Vasculature Immune Interactions In Vitro. Cold Spring Harbor perspectives in medicine, 13(9), a041185. Cold Spring Harbor Laboratory Press 10.1101/cshperspect.a041185
Lazarevic, Ivana; Soldati, Sasha; Mapunda, Josephine A; Rudolph, Henriette; Rosito, Maria; de Oliveira, Alex Cardoso; Enzmann, Gaby; Nishihara, Hideaki; Ishikawa, Hiroshi; Tenenbaum, Tobias; Schroten, Horst; Engelhardt, Britta (2023). Correction to: The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis. Fluids and barriers of the CNS, 20(1), p. 55. BioMed Central 10.1186/s12987-023-00457-w
Gonzalez-Fierro, Carmen; Fonte, Coralie; Dufourd, Eloïse; Cazaentre, Vincent; Aydin, Sidar; Engelhardt, Britta; Caspi, Rachel R; Xu, Biying; Martin-Blondel, Guillaume; Spicer, Julie A; Trapani, Joseph A; Bauer, Jan; Liblau, Roland S; Bost, Chloé (2023). Effects of a Small-Molecule Perforin Inhibitor in a Mouse Model of CD8 T Cell-Mediated Neuroinflammation. Neurology: Neuroimmunology and Neuroinflammation, 10(4) Wolters Kluwer Health 10.1212/NXI.0000000000200117
Lazarevic, Ivana; Soldati, Sasha; Mapunda, Josephine A; Rudolph, Henriette; Rosito, Maria; Cardoso de Oliveira, Alex; Enzmann, Gaby; Nishihara, Hideaki; Ishikawa, Hiroshi; Tenenbaum, Tobias; Schroten, Horst; Engelhardt, Britta (2023). The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis. Fluids and barriers of the CNS, 20(1), p. 39. BioMed Central 10.1186/s12987-023-00441-4
Aydin, Sidar; Pareja, Javier; Schallenberg, Vivianne M; Klopstein, Armelle; Gruber, Thomas; Page, Nicolas; Bouillet, Elisa; Blanchard, Nicolas; Liblau, Roland; Körbelin, Jakob; Schwaninger, Markus; Johnson, Aaron J; Schenk, Mirjam; Deutsch, Urban; Merkler, Doron; Engelhardt, Britta (2023). Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown. Nature communications, 14(1), p. 3106. Nature Publishing Group 10.1038/s41467-023-38703-2
Soldati, Sasha; Bär, Alexander; Vladymyrov, Mykhailo; Glavin, Dale; McGrath, James L; Gosselet, Fabien; Nishihara, Hideaki; Goelz, Susan; Engelhardt, Britta (2023). High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro. Journal of neuroinflammation, 20(1), p. 123. BioMed Central 10.1186/s12974-023-02797-8
Matsuo, Kinya; Engelhardt, Britta; Nishihara, Hideaki (2023). Differentiation of Human Induced Pluripotent Stem Cells to Brain Microvascular Endothelial Cell-Like Cells with a Mature Immune Phenotype. Journal of visualized experiments(195) MYJoVE Corporation 10.3791/65134
Spera, Irene; Cousin, Nikola; Ries, Miriam; Kedracka, Anna; Castillo, Alina; Aleandri, Simone; Vladymyrov, Mykhailo; Mapunda, Josephine A; Engelhardt, Britta; Luciani, Paola; Detmar, Michael; Proulx, Steven T (2023). Open pathways for cerebrospinal fluid outflow at the cribriform plate along the olfactory nerves. EBioMedicine, 91(104558), p. 104558. Elsevier 10.1016/j.ebiom.2023.104558
Li, Zhilin; Antila, Salli; Nurmi, Harri; Chilov, Dmitri; Korhonen, Emilia A; Fang, Shentong; Karaman, Sinem; Engelhardt, Britta; Alitalo, Kari (2023). Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation. Science immunology, 8(82), eabq0375. American Association for the Advancement of Science 10.1126/sciimmunol.abq0375
Wishart, Claire L; Spiteri, Alanna G; Locatelli, Giuseppe; King, Nicholas J C (2023). Integrating transcriptomic datasets across neurological disease identifies unique myeloid subpopulations driving disease-specific signatures. GLIA, 71(4), pp. 904-925. Wiley-Blackwell 10.1002/glia.24314
C Ivan, Daniela; Berve, Kristina Carolin; Walthert, Sabrina; Monaco, Gianni; Borst, Katharina; Bouillet, Elisa; Ferreira, Filipa; Lee, Henry; Steudler, Jasmin; Buch, Thorsten; Prinz, Marco; Engelhardt, Britta; Locatelli, Giuseppe (2023). Insulin-like growth factor-1 receptor controls the function of CNS-resident macrophages and their contribution to neuroinflammation. Acta neuropathologica communications, 11(1), p. 35. 10.1186/s40478-023-01535-8
Locatelli, Giuseppe; Marques-Ferreira, Filipa; Katsoulas, Antonis; Kalaitzaki, Vasileia; Krueger, Martin; Ingold-Heppner, Barbara; Walthert, Sabrina; Sankowski, Roman; Prazeres da Costa, Olivia; Dolga, Amalia; Huber, Magdalena; Gold, Maike; Culmsee, Carsten; Waisman, Ari; Bechmann, Ingo; Milchevskaya, Vladislava; Prinz, Marco; Tresch, Achim; Becher, Burkhard and Buch, Thorsten (2023). IGF1R expression by adult oligodendrocytes is not required in the steady-state but supports neuroinflammation. GLIA, 71(3), pp. 616-632. Wiley-Blackwell 10.1002/glia.24299
Proulx, Steven T; Engelhardt, Britta (2023). Macrophages clear the way for CNS fluid flow. The lancet. Neurology, 22(3), pp. 194-195. Elsevier 10.1016/S1474-4422(23)00028-5
Artinger, Marc; Gerken, Oliver J; Legler, Daniel F (2023). Heparin Specifically Interacts with Basic BBXB Motifs of the Chemokine CCL21 to Define CCR7 Signaling. International journal of molecular sciences, 24(2) MDPI 10.3390/ijms24021670
Proulx, Steven T (2023). The peri-olfactory pathway: An "e-scent-ial" route for cerebrospinal fluid clearance? EBioMedicine, 87(104417), p. 104417. Elsevier 10.1016/j.ebiom.2022.104417
Sigmund, Elena C; Bauer, Aline; Jakobs, Barbara D; Tatliadim, Hazal; Tacconi, Carlotta; Thelen, Marcus; Legler, Daniel F; Halin, Cornelia (2023). Reassessing the adrenomedullin scavenging function of ACKR3 in lymphatic endothelial cells. PLoS ONE, 18(5), e0285597. Public Library of Science 10.1371/journal.pone.0285597
van Os, Lisette; Engelhardt, Britta; Guenat, Olivier T. (2023). Integration of immune cells in organs-on-chips: a tutorial. Frontiers in Bioengineering and Biotechnology, 11, p. 1191104. Frontiers Media 10.3389/fbioe.2023.1191104
Melgrati, Serena; Gerken, Oliver J; Artinger, Marc; Radice, Egle; Szpakowska, Martyna; Chevigné, Andy; D'Uonnolo, Giulia; Antonello, Paola; Thelen, Sylvia; Pelczar, Pawel; Legler, Daniel F; Thelen, Marcus (2023). GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity. Frontiers in immunology, 14(1242531), p. 1242531. Frontiers Research Foundation 10.3389/fimmu.2023.1242531
Nishihara, Hideaki; Perriot, Sylvain; Gastfriend, Benjamin D; Steinfort, Marel; Cibien, Celine; Soldati, Sasha; Matsuo, Kinya; Guimbal, Sarah; Mathias, Amandine; Palecek, Sean P; Shusta, Eric V; Du Pasquier, Renaud; Engelhardt, Britta (2022). Intrinsic blood-brain barrier dysfunction contributes to multiple sclerosis pathogenesis. Brain : a journal of neurology, 145(12), pp. 4334-4348. Oxford University Press 10.1093/brain/awac019
Bagatella, Stefano; Haghayegh Jahromi, Neda; Monney, Camille; Polidori, Margherita; Gall, Flavio Max; Marchionatti, Emma; Serra, Fabienne; Riedl, Rainer; Engelhardt, Britta; Oevermann, Anna (2022). Bovine neutrophil chemotaxis to Listeria monocytogenes in neurolisteriosis depends on microglia-released rather than bacterial factors. Journal of neuroinflammation, 19(1), p. 304. BioMed Central 10.1186/s12974-022-02653-1
Ineichen, Benjamin V; Okar, Serhat V; Proulx, Steven T; Engelhardt, Britta; Lassmann, Hans; Reich, Daniel S (2022). Perivascular spaces and their role in neuroinflammation. Neuron, 110(21), pp. 3566-3581. Cell Press 10.1016/j.neuron.2022.10.024
Steudler, Jasmin; Ecott, Timothy; Ivan, Daniela C; Bouillet, Elisa; Walthert, Sabrina; Berve, Kristina; Dick, Tobias P; Engelhardt, Britta; Locatelli, Giuseppe (2022). Autoimmune neuroinflammation triggers mitochondrial oxidation in oligodendrocytes. GLIA, 70(11), pp. 2045-2061. Wiley-Blackwell 10.1002/glia.24235
Carare, Roxana O; Engelhardt, Britta; Perry, Victor Hugh; Kalaria, Raj (2022). In memoriam, Roy Weller (1938-2022). Acta neuropathologica, 144(5), pp. 803-806. Springer-Verlag 10.1007/s00401-022-02502-8
Kemble, Alicia M; Hornsperger, Benoit; Ruf, Iris; Richter, Hans; Benz, Jörg; Kuhn, Bernd; Heer, Dominik; Wittwer, Matthias; Engelhardt, Britta; Grether, Uwe; Collin, Ludovic (2022). A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature. PLoS ONE, 17(9), e0268590. Public Library of Science 10.1371/journal.pone.0268590
Lorusso, Girieca; Wyss, Christof B; Kuonen, François; Vannini, Nicola; Billottet, Clotilde; Duffey, Nathalie; Pineau, Raphael; Lan, Qiang; Wirapati, Pratyaksha; Barras, David; Tancredi, Alessandro; Lyck, Ruth; Lehr, Hans-Anton; Engelhardt, Britta; Delorenzi, Mauro; Bikfalvi, Andreas; Rüegg, Curzio (2022). Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation. Science translational medicine, 14(661), eaax8933. American Association for the Advancement of Science 10.1126/scitranslmed.aax8933
McCloskey, Molly C; Kasap, Pelin; Ahmad, S Danial; Su, Shiuan-Haur; Chen, Kaihua; Mansouri, Mehran; Ramesh, Natalie; Nishihara, Hideaki; Belyaev, Yury; Abhyankar, Vinay V; Begolo, Stefano; Singer, Benjamin H; Webb, Kevin F; Kurabayashi, Katsuo; Flax, Jonathan; Waugh, Richard E; Engelhardt, Britta; McGrath, James L (2022). The Modular μSiM: a Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro. Advanced healthcare materials, 11(18), e2200804. Wiley 10.1002/adhm.202200804
Rossatti, Pascal; Redpath, Gregory M I; Ziegler, Luca; Samson, Guerric P B; Clamagirand, Camille D; Legler, Daniel F; Rossy, Jérémie (2022). Rapid increase in transferrin receptor recycling promotes adhesion during T cell activation. BMC biology, 20(1), p. 189. BioMed Central 10.1186/s12915-022-01386-0
Proulx, Steven T.; Engelhardt, Britta (2022). Central nervous system zoning: How brain barriers establish subdivisions for CNS immune privilege and immune surveillance. Journal of internal medicine, 292(1), pp. 47-67. Wiley 10.1111/joim.13469
Guse, Kirsten; Hagemann, Nina; Thiele, Lisa; Remlinger, Jana; Salmen, Anke; Hoepner, Robert; Keller, Irene; Meyer, Patricia; Grandgirard, Denis; Leib, Stephen; Vassella, Erik; Locatelli, Giuseppe; Hermann, Dirk M; Chan, Andrew Hao-Kuang (2022). CNS Antigen-Specific Neuroinflammation Attenuates Ischemic Stroke With Involvement of Polarized Myeloid Cells. Neurology: neuroimmunology & neuroinflammation, 9(4) Wolters Kluwer Health 10.1212/NXI.0000000000001168
Cousins, Oliver; Hodges, Angela; Schubert, Julia; Veronese, Mattia; Turkheimer, Federico; Miyan, Jaleel; Engelhardt, Britta; Roncaroli, Federico (2022). The Blood-CSF-Brain Route of Neurological Disease: The Indirect Pathway into the Brain. Neuropathology and applied neurobiology, 48(4), e12789. Wiley 10.1111/nan.12789
Engelhardt, Britta; Comabella, Manuel; Chan, Andrew (2022). Multiple Sclerosis: Immunopathological heterogeneity and its implications. European journal of immunology, 52(6), pp. 869-881. Wiley-VCH 10.1002/eji.202149757
Artinger, Marc; Gerken, Oliver J; Purvanov, Vladimir; Legler, Daniel F (2022). Distinct Fates of Chemokine and Surrogate Molecule Gradients: Consequences for CCR7-Guided Dendritic Cell Migration. Frontiers in immunology, 13, p. 913366. Frontiers Research Foundation 10.3389/fimmu.2022.913366
Patel, Monica; Matti, Christoph; Grimsey, Natasha L; Legler, Daniel F; Javitch, Jonathan A; Finlay, David B; Glass, Michelle (2022). Delineating the interactions between the cannabinoid CB2 receptor and its regulatory effectors; β-arrestins and GPCR kinases. British journal of pharmacology, 179(10), pp. 2223-2239. Wiley 10.1111/bph.15748
Gerken, Oliver J; Artinger, Marc; Legler, Daniel F (2022). Shifting CCR7 towards Its Monomeric Form Augments CCL19 Binding and Uptake. Cells, 11(9) MDPI 10.3390/cells11091444
Dzung, Andreas; Saltari, Annalisa; Tiso, Natascia; Lyck, Ruth; Dummer, Reinhard; Levesque, Mitchell P (2022). STK11 Prevents Invasion Through STAT3/5 and FAK Repression in Cutaneous Melanoma. Journal of investigative dermatology, 142(4), 1171-1182.e10. Elsevier 10.1016/j.jid.2021.09.035
Holder, Brianna M; Tolan, Shaina E; Heinrich, Kaleb K; Miller, Kaitlin C; Hudson, Natalie; Nehra, Geetika; Pizzo, Michelle E; Storck, Steffen E; Elmquist, William F; Engelhardt, Britta; Loryan, Irena; Toborek, Michal; Bauer, Bjoern; Hartz, Anika M S; Kim, Brandon J (2022). Brain barriers virtual: an interim solution or future opportunity? Fluids and barriers of the CNS, 19(1), p. 19. BioMed Central 10.1186/s12987-022-00314-2
Mapunda, Josephine A; Tibar, Houyam; Regragui, Wafa; Engelhardt, Britta (2022). How Does the Immune System Enter the Brain? Frontiers in immunology, 13(805657), p. 805657. Frontiers Research Foundation 10.3389/fimmu.2022.805657
Martinez-Salazar, Maria; Holwerda, Melle; Stüdle, Chiara; Piragyte, Indre; Mercader, Nadia; Engelhardt, Britta; Rieben, Robert; Döring, Yvonne (2022). COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences. Frontiers in cell and developmental biology, 10, p. 824851. Frontiers 10.3389/fcell.2022.824851
Decker, Yann; Krämer, Jonas; Xin, Li; Müller, Andreas; Scheller, Anja; Fassbender, Klaus; Proulx, Steven T. (2022). Magnetic resonance imaging of cerebrospinal fluid outflow after low-rate lateral ventricle infusion in mice. JCI insight, 7(3) JCI Insight 10.1172/jci.insight.150881
Friess, Mona C; Kritikos, Ioannis; Schineis, Philipp; Medina-Sanchez, Jessica Danielly; Gkountidi, Anastasia-Olga; Vallone, Angela; Sigmund, Elena C; Schwitter, Corina; Vranova, Martina; Matti, Christoph; Arasa, Jorge; Saygili Demir, Cansaran; Bovay, Esther; Proulx, Steven T; Tomura, Michio; Rot, Antal; Legler, Daniel F; Petrova, Tatiana V; Halin, Cornelia (2022). Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics. Cell reports, 38(5), p. 110334. Cell Press 10.1016/j.celrep.2022.110334
Spiteri, Alanna G; Wishart, Claire L; Pamphlett, Roger; Locatelli, Giuseppe; King, Nicholas J C (2022). Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function. Acta neuropathologica, 143(2), pp. 179-224. Springer-Verlag 10.1007/s00401-021-02384-2
Marchetti, Luca; Francisco, David; Soldati, Sasha; Haghayegh Jahromi, Neda; Barcos, Sara; Gruber, Isabelle; Pareja R., Javier; Thiriot, Aude; von Andrian, Ulrich; Deutsch, Urban; Lyck, Ruth; Bruggmann, Rémy; Engelhardt, Britta (2022). ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro. European journal of immunology, 52(1), pp. 161-177. Wiley 10.1002/eji.202149238
Nishihara, Hideaki; Engelhardt, Britta (2022). Brain Barriers and Multiple Sclerosis: Novel Treatment Approaches from a Brain Barriers Perspective. Handbook of experimental pharmacology, 273, pp. 295-329. Springer 10.1007/164_2020_407
Galoppin, Manon; Kari, Saniya; Soldati, Sasha; Pal, Arindam; Rival, Manon; Engelhardt, Britta; Astier, Anne; Thouvenot, Eric (2022). Full spectrum of vitamin D immunomodulation in multiple sclerosis: mechanisms and therapeutic implications. Brain Communications, 4(4), fcac171. Oxford University Press 10.1093/braincomms/fcac171
Seumen, Clovis H T; Tomasiunaite, Urte; Legler, Daniel F; Hauck, Christof R (2021). Elimination of negative feedback in TLR signalling allows rapid and hypersensitive detection of microbial contaminants. Scientific reports, 11(1), p. 24414. Springer Nature 10.1038/s41598-021-03618-9
Gastfriend, Benjamin D; Nishihara, Hideaki; Canfield, Scott G; Foreman, Koji L; Engelhardt, Britta; Palecek, Sean P; Shusta, Eric V (2021). Wnt signaling mediates acquisition of blood-brain barrier properties in naïve endothelium derived from human pluripotent stem cells. eLife, 10 eLife Sciences Publications 10.7554/eLife.70992
Uetz-von Allmen, Edith; Samson, Guerric P. B.; Purvanov, Vladimir; Maeda, Takahiro; Legler, Daniel F. (2021). CAL-1 as Cellular Model System to Study CCR7-Guided Human Dendritic Cell Migration. Frontiers in immunology, 12, p. 702453. Frontiers Research Foundation 10.3389/fimmu.2021.702453
Thomsen, Tanja; Reissmann, Regina; Kaba, Elisa; Engelhardt, Britta; Klok, Harm-Anton (2021). Covalent and Noncovalent Conjugation of Degradable Polymer Nanoparticles to T Lymphocytes. Biomacromolecules, 22(8), pp. 3416-3430. American Chemical Society 10.1021/acs.biomac.1c00488
Engelhardt, Britta (2021). Private immune protection at the border of the central nervous system. Nature, 596(7870), pp. 38-40. Springer Nature 10.1038/d41586-021-01962-4
Nishihara, Hideaki; Gastfriend, Benjamin D; Kasap, Pelin; Palecek, Sean P; Shusta, Eric V; Engelhardt, Britta (2021). Differentiation of human pluripotent stem cells to brain microvascular endothelial cell-like cells suitable to study immune cell interactions. STAR protocols, 2(2), p. 100563. Elsevier 10.1016/j.xpro.2021.100563
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Abadier, Michael Magdy Labib; Haghayegh Jahromi, Neda; Cardoso Alves, Ludmila; Boscacci, Rémy; Vestweber, Dietmar; Barnum, Scott; Deutsch, Urban; Engelhardt, Britta; Lyck, Ruth (2015). Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier. European journal of immunology, 45(4), pp. 1043-1058. Wiley-VCH 10.1002/eji.201445125
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Moalli, Federica; Proulx, Steven T; Schwendener, Reto; Detmar, Michael; Schlapbach, Christoph; Stein, Jens Volker (2015). Intravital and whole-organ imaging reveals capture of melanoma-derived antigen by lymph node subcapsular macrophages leading to widespread deposition on follicular dendritic cells. Frontiers in immunology, 6(114), p. 114. Frontiers Research Foundation 10.3389/fimmu.2015.00114
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Ackerknecht, Markus; Hauser, Mark A; Legler, Daniel F; Stein, Jens Volker (2015). In vivo TCR Signaling in CD4(+) T Cells Imprints a Cell-Intrinsic, Transient Low-Motility Pattern Independent of Chemokine Receptor Expression Levels, or Microtubular Network, Integrin, and Protein Kinase C Activity. Frontiers in immunology, 6, p. 297. Frontiers Research Foundation 10.3389/fimmu.2015.00297
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Bianchi, Roberta; Teijeira, Alvaro; Proulx, Steven T; Christiansen, Ailsa J; Seidel, Catharina D; Rülicke, Thomas; Mäkinen, Taija; Hägerling, René; Halin, Cornelia; Detmar, Michael (2015). A transgenic Prox1-Cre-tdTomato reporter mouse for lymphatic vessel research. PLoS ONE, 10(4), e0122976. Public Library of Science 10.1371/journal.pone.0122976
Moalli, Federica; Cupovic, Jovana; Thelen, Flavian; Halbherr, Pascal; Fukui, Yoshinori; Narumiya, Shuh; Ludewig, Burkhard; Stein, Jens Volker (2014). Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell-dendritic cell interactions. The Journal of experimental medicine, 211(13), pp. 2507-2517. Rockefeller Univ. Press 10.1084/jem.20140137
Lee, Kit M; Danuser, Renzo; Stein, Jens Volker; Graham, Delyth; Nibbs, Robert J B; Graham, Gerard J (2014). The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density. EMBO journal, 33(21), pp. 2564-2580. Nature Publishing Group 10.15252/embj.201488887
Steiner, Esther; Enzmann, Gaby; Lyck, Ruth; Lin, Shuo; Rüegg, Markus A; Kröger, Stephan; Engelhardt, Britta (2014). The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions. Cell and tissue research, 358(2), pp. 465-479. Springer 10.1007/s00441-014-1969-7
Liu, Ju; Deutsch, Urban; Fung, Iris; Lobe, Corrinne G (2014). Conditional and inducible transgene expression in endothelial and hematopoietic cells using Cre/loxP and tetracycline-off systems. Experimental and therapeutic medicine, 8(5), pp. 1351-1356. Spandidos Publ. 10.3892/etm.2014.1965
Liu, Ju; Dong, Fengyun; Fung, Iris; Chen, Edwin; Allen, Thaddeus D; Deutsch, Urban; Lobe, Corrinne G (2014). Postnatal Notch1 activation induces T‑cell malignancy in conditional and inducible mouse models. International journal of oncology, 45(5), pp. 1997-2004. Spandidos Publications 10.3892/ijo.2014.2626
Waber-Wenger, Barbara; Forterre, Franck; Kuehni-Boghenbor, Kathrin; Danuser, Renzo; Stein, Jens Volker; Stoffel, Michael Hubert (2014). Sensory innervation of the dorsal longitudinal ligament and the meninges in the lumbar spine of the dog. Histochemistry and cell biology, 142(4), pp. 433-447. Springer 10.1007/s00418-014-1218-x
Imeri, Faik; Fallegger, Daniel; Zivkovic, Aleksandra; Schwalm, Stephanie; Enzmann, Gaby; Blankenbach, Kira; Meyer zu Heringdorf, Dagmar; Homann, Thomas; Kleuser, Burkhard; Pfeilschifter, Josef; Engelhardt, Britta; Stark, Holger; Huwiler, Andrea (2014). Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice. Neuropharmacology, 85, pp. 314-327. Elsevier 10.1016/j.neuropharm.2014.05.012
Aubé, Benoit; Lévesque, Sébastien A; Paré, Alexandre; Chamma, Émilie; Kébir, Hania; Gorina Mendiz, Roser; Lécuyer, Marc-André; Alvarez, Jorge I; De Koninck, Yves; Engelhardt, Britta; Prat, Alexandre; Côté, Daniel; Lacroix, Steve (2014). Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases. Journal of immunology, 193(5), pp. 2438-2454. American Association of Immunologists 10.4049/jimmunol.1400401
Liu, Ju; Deutsch, Urban; Jeong, James; Lobe, Corrinne G (2014). Constitutive notch signaling in adult transgenic mice inhibits bFGF-induced angiogenesis and blocks ovarian follicle development. Genesis, 52(9), pp. 809-816. Wiley-Liss 10.1002/dvg.22790
Abe, Jun; Shichino, Shigeyuki; Ueha, Satoshi; Hashimoto, Shin-ichi; Tomura, Michio; Inagaki, Yutaka; Stein, Jens Volker; Matsushima, Kouji (2014). Lymph node stromal cells negatively regulate antigen-specific CD4+ T cell responses. Journal of immunology, 193(4), pp. 1636-1644. American Association of Immunologists 10.4049/jimmunol.1302946
Sathiyanadan, Karthik; Coisne, Caroline Marie; Enzmann, Gaby; Deutsch, Urban; Engelhardt, Britta (2014). PSGL-1 and E/P-selectins are essential for T-cell rolling in inflamed CNS microvessels but dispensable for initiation of EAE. European journal of immunology, 44(8), pp. 2287-2294. Wiley-VCH 10.1002/eji.201344214
Weber, Benedikt; Robert, Jérôme; Ksiazek, Agnieszka; Wyss, Yves; Frese, Laura; Slamecka, Jaroslav; Kehl, Debora; Modregger, Peter; Peter, Silvia; Stampanoni, Marco; Proulx, Steven; Falk, Volkmar; Hoerstrup, Simon P (2014). Living-engineered valves for transcatheter venous valve repair. Tissue engineering. Part C, Methods, 20(6), pp. 451-463. Mary Ann Liebert 10.1089/ten.TEC.2013.0187
Navdaev, Alexey; Subramanian, Hariharan; Petunin, Alexey; Clemetson, Kenneth John; Gambaryan, Stepan; Walter, Ulrich (2014). Echicetin coated polystyrene beads: a novel tool to investigate GPIb-specific platelet activation and aggregation. PLoS ONE, 9(4), e93569. Public Library of Science 10.1371/journal.pone.0093569
Engelhardt, Britta; Liebner, Stefan (2014). Novel insights into the development and maintenance of the blood-brain barrier. Cell and tissue research, 355(3), pp. 687-699. Springer 10.1007/s00441-014-1811-2
Mayer, Jürgen; Robert-Moreno, Alexandre; Danuser, Renzo; Stein, Jens Volker; Sharpe, James; Swoger, Jim (2014). OPTiSPIM: integrating optical projection tomography in light sheet microscopy extends specimen characterization to nonfluorescent contrasts. Optics letters, 39(4), pp. 1053-1056. Optical Society of America 10.1364/OL.39.001053
Geering, Barbara; Stoeckle, Christina; Rozman, Sasa; Oberson, Kevin; Benarafa, Charaf; Simon, Hans-Uwe (2014). DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants. Journal of leukocyte biology, 95(2), pp. 293-303. Society for Leukocyte Biology 10.1189/jlb.0813462
Gorina Mendiz, Roser; Lyck, Ruth; Vestweber, Dietmar; Engelhardt, Britta (2014). β2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier. Journal of immunology, 192(1), pp. 324-337. American Association of Immunologists 10.4049/jimmunol.1300858
de Witt, Susanne M; Swieringa, Frauke; Cavill, Rachel; Lamers, Moniek M E; van Kruchten, Roger; Mastenbroek, Tom; Baaten, Constance; Coort, Susan; Pugh, Nicholas; Schulz, Ansgar; Scharrer, Inge; Jurk, Kerstin; Zieger, Barbara; Clemetson, Kenneth John; Farndale, Richard W; Heemskerk, Johan W M; Cosemans, Judith M E M (2014). Identification of platelet function defects by multi-parameter assessment of thrombus formation. Nature communications, 5, p. 4257. Nature Publishing Group 10.1038/ncomms5257
Cecchelli, Romeo; Aday, Sezin; Sevin, Emmanuel; Almeida, Catarina; Culot, Maxime; Dehouck, Lucie; Coisne, Caroline Marie; Engelhardt, Britta; Dehouck, Marie-Pierre; Ferreira, Lino (2014). A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells. PLoS ONE, 9(6), e99733. Public Library of Science 10.1371/journal.pone.0099733
Minten, Carsten; Alt, Carsten; Gentner, Melanie; Frei, Elisabeth; Deutsch, Urban; Lyck, Ruth; Schaeren-Wiemers, Nicole; Rot, Antal; Engelhardt, Britta (2014). DARC shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous system inflammation. Brain, 137(Pt 5), pp. 1454-1469. Oxford University Press 10.1093/brain/awu045
Blum, Katrin S; Karaman, Sinem; Proulx, Steven T; Ochsenbein, Alexandra M; Luciani, Paola; Leroux, Jean-Christophe; Wolfrum, Christian; Detmar, Michael (2014). Chronic high-fat diet impairs collecting lymphatic vessel function in mice. PLoS ONE, 9(4), e94713. Public Library of Science 10.1371/journal.pone.0094713
Proulx, Steven T; Luciani, Paola; Dieterich, Lothar C; Karaman, Sinem; Leroux, Jean-Christophe; Detmar, Michael (2013). Expansion of the lymphatic vasculature in cancer and inflammation: new opportunities for in vivo imaging and drug delivery. Journal of controlled release, 172(2), pp. 550-557. Elsevier 10.1016/j.jconrel.2013.04.027
Cremona, Tiziana P.; Tschanz, Stefan A.; von Garnier, Christophe; Benarafa, Charaf (2013). SerpinB1 deficiency is not associated with increased susceptibility to pulmonary emphysema in mice. American journal of physiology - lung cellular and molecular physiology, 305(12), L981-L989. American Physiological Society 10.1152/ajplung.00181.2013
Moretti, Federico A.; Moser, Markus; Lyck, Ruth; Abadier, Michael Magdy Labib; Ruppert, Raphael; Engelhardt, Britta; Fässler, Reinhard (2013). Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 110(42), pp. 17005-17010. National Academy of Sciences NAS 10.1073/pnas.1316032110
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Stephens, G; Yan, Y; Jandrot-Perrus, M; Villeval, JL; Clemetson, KJ; Phillips, DR (2005). Platelet activation induces metalloproteinase-dependent GP VI cleavage to down-regulate platelet reactivity to collagen. Blood, 105(1), pp. 186-91. Washington, D.C.: American Society of Hematology 10.1182/blood-2004-07-2842
Liang, HP; Morel-Kopp, MC; Clemetson, JM; Clemetson, KJ; Kekomaki, R; Kroll, H; Michaelides, K; Tuddenham, EG; Vanhoorelbeke, K; Ward, CM (2005). A common ancestral glycoprotein (GP) 9 1828A>G (Asn45Ser) gene mutation occurring in European families from Australia and Northern Europe with Bernard-Soulier Syndrome (BSS). Thrombosis and haemostasis, 94(3), pp. 599-605. Stuttgart: Schattauer 10.1160/TH05-03-0165
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Hamm, Stefan; Dehouck, Bénédicte; Kraus, Jörg; Wolburg-Buchholz, Karen; Wolburg, Hartwig; Risau, Werner; Cecchelli, Roméo; Engelhardt, Britta; Dehouck, Marie-Pierre (2004). Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contacts. Cell and tissue research, 315(2), pp. 157-166. Springer 10.1007/s00441-003-0825-y
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Chavakis, T; Santoso, S; Clemetson, KJ; Sachs, UJ; Isordia-Salas, I; Pixley, RA; Nawroth, PP; Colman, RW; Preissner, KT (2003). High molecular weight kininogen regulates platelet-leukocyte interactions by bridging Mac-1 and glycoprotein Ib. Journal of biological chemistry, 46(278), pp. 45375-81. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M304344200
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Fiedler, U; Krissl, T; Koidl, S; Weiss, C; Koblizek, T; Deutsch, U; Martiny-Baron, G; Marmé, D; Augustin, HG (2003). Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats. Journal of biological chemistry, 3(278), pp. 1721-7. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M208550200
Alberio, L; Friese, P; Clemetson, KJ; Dale, GL (2002). Collagen response and glycoprotein VI function decline progressively as canine platelets age in vivo. Thrombosis and haemostasis, 88(3), pp. 510-6. Stuttgart: Schattauer
Navdaev, A; Clemetson, KJ (2002). Glycoprotein Ib cross-linking/ligation on echicetin-coated surfaces or echicetin-IgMkappa in stirred suspension activates platelets by cytoskeleton modulated calcium release. Journal of biological chemistry, 48(277), pp. 45928-34. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M206129200
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Du, Xiao-Yan; Magnenat, E; Wells, TN; Clemetson, KJ (2002). Alboluxin, a snake C-type lectin from Trimeresurus albolabris venom is a potent platelet agonist acting via GPIb and GPVI. Thrombosis and haemostasis, 87(4), pp. 692-8. Stuttgart: Schattauer
Dale, GL; Friese, P; Batar, P; Hamilton, SF; Reed, GL; Jackson, KW; Clemetson, KJ; Alberio, L (2002). Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface. Nature, 6868(415), pp. 175-9. London: Macmillan Journals Ltd. 10.1038/415175a
Du, XY; Clemetson, JM; Navdaev, A; Magnenat, EM; Wells, TN; Clemetson, KJ (2002). Ophioluxin, a convulxin-like C-type lectin from Ophiophagus hannah (King cobra) is a powerful platelet activator via glycoprotein VI. Journal of biological chemistry, 38(277), pp. 35124-32. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M204372200
Uff, S; Clemetson, JM; Harrison, T; Clemetson, KJ; Emsley, J (2002). Crystal structure of the platelet glycoprotein Ib(alpha) N-terminal domain reveals an unmasking mechanism for receptor activation. Journal of biological chemistry, 38(277), pp. 35657-63. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M205271200
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Nawroth, R; Poell, G; Ranft, A; Kloep, S; Samulowitz, U; Fachinger, G; Golding, M; Shima, DT; Deutsch, U; Vestweber, D (2002). VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. EMBO journal, 18(21), pp. 4885-95. London: Nature Publishing Group 10.1093/emboj/cdf497
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Boehlen, F; Clemetson, KJ (2001). Platelet chemokines and their receptors: what is their relevance to platelet storage and transfusion practice? Transfusion medicine, 11(6), pp. 403-17. Oxford: Blackwell Scientific Publications 10.1046/j.1365-3148.2001.00340.x
Clemetson, KJ (2001). Platelet receptors for adhesion and activation. Variability as a factor in susceptibility to cardiovascular diseases. Italian heart journal, 2(11), pp. 816-8. Roma: Centro Editoriale Pubblicitario Italiano CEPI
Clemetson, KJ (2001). Platelet glycoproteins and their role in diseases. Transfusion clinique et biologique, 8(3), pp. 155-62. Paris: Elsevier Masson SAS 10.1016/S1246-7820(01)00184-7
Du, XY; Navdaev, A; Clemetson, JM; Magnenat, E; Wells, TN; Clemetson, KJ (2001). Bilinexin, a snake C-type lectin from Agkistrodon bilineatus venom agglutinates platelets via GPIb and alpha2beta1. Thrombosis and haemostasis, 86(5), pp. 1277-83. Stuttgart: Schattauer
Furihata, K; Clemetson, KJ; Deguchi, H; Kunicki, TJ (2001). Variation in human platelet glycoprotein VI content modulates glycoprotein VI-specific prothrombinase activity. Arteriosclerosis, thrombosis, and vascular biology, 21(11), pp. 1857-63. Philadelphia, Pa.: Lippincott Williams & Wilkins 10.1161/hq1001.096643
Clemetson, KJ; Clemetson, JM (2001). Platelet collagen receptors. Thrombosis and haemostasis, 86(1), pp. 189-97. Stuttgart: Schattauer
Navdaev, A; Dörmann, D; Clemetson, JM; Clemetson, KJ (2001). Echicetin, a GPIb-binding snake C-type lectin from Echis carinatus, also contains a binding site for IgMkappa responsible for platelet agglutination in plasma and inducing signal transduction. Blood, 97(8), pp. 2333-41. Washington, D.C.: American Society of Hematology 10.1182/blood.V97.8.2333
Navdaev, A; Clemetson, JM; Polgar, J; Kehrel, BE; Glauner, M; Magnenat, E; Wells, TN; Clemetson, KJ (2001). Aggretin, a heterodimeric C-type lectin from Calloselasma rhodostoma (malayan pit viper), stimulates platelets by binding to alpha 2beta 1 integrin and glycoprotein Ib, activating Syk and phospholipase Cgamma 2, but does not involve the glycoprotein VI/Fc receptor gamma chain collagen receptor. Journal of biological chemistry, 24(276), pp. 20882-9. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M101585200
Dörmann, D; Clemetson, JM; Navdaev, A; Kehrel, BE; Clemetson, KJ (2001). Alboaggregin A activates platelets by a mechanism involving glycoprotein VI as well as glycoprotein Ib. Blood, 97(4), pp. 929-36. Washington, D.C.: American Society of Hematology 10.1182/blood.V97.4.929
Eiberger, J; Degen, J; Romualdi, A; Deutsch, U; Willecke, K; Söhl, G (2001). Connexin genes in the mouse and human genome. Cell communication & adhesion, 8(4-6), pp. 163-5. Basingstoke, UK: Taylor & Francis 10.3109/15419060109080717
Adams, RH; Diella, F; Hennig, S; Helmbacher, F; Deutsch, U; Klein, R (2001). The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration. Cell, 104(1), pp. 57-69. Cambridge, Mass.: Cell Press 10.1016/S0092-8674(01)00191-X
Theis, M; de Wit, C; Schlaeger, TM; Eckardt, D; Krüger, O; Döring, B; Risau, W; Deutsch, U; Pohl, U; Willecke, K (2001). Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene. Genesis, 29(1), pp. 1-13. Hoboken, N.J.: Wiley-Liss 10.1002/1526-968X(200101)29:1<1::AID-GENE1000>3.0.CO;2-0
Clemetson, KJ (2000). Vascular biology--XIth International Meeting. 5-9 September 2000, Geneva, Switzerland. IDrugs, 3(11), pp. 1307-11. London: Thomson Scientific
Dörmann, D; Clemetson, KJ; Kehrel, BE (2000). The GPIb thrombin-binding site is essential for thrombin-induced platelet procoagulant activity. Blood, 96(7), pp. 2469-78. Washington, D.C.: American Society of Hematology
Alberio, L; Safa, O; Clemetson, KJ; Esmon, CT; Dale, GL (2000). Surface expression and functional characterization of alpha-granule factor V in human platelets: effects of ionophore A23187, thrombin, collagen, and convulxin. Blood, 95(5), pp. 1694-702. Washington, D.C.: American Society of Hematology
Clemetson, KJ; Clemetson, JM; Proudfoot, AE; Power, CA; Baggiolini, M; Wells, TN (2000). Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets. Blood, 96(13), pp. 4046-54. Washington, D.C.: American Society of Hematology
Ruan, J; Schmugge, M; Clemetson, KJ; Cazes, E; Combrie, R; Bourre, F; Nurden, AT (1999). Homozygous Cys542-->Arg substitution in GPIIIa in a Swiss patient with type I Glanzmann's thrombasthenia. British journal of haematology, 2(105), pp. 523-31. Oxford: Wiley-Blackwell 10.1111/j.1365-2141.1999.01376.x
Jandrot-Perrus, M; Clemetson, KJ; Guillin, MC; Bouton, MC (1999). Binding of heparin to platelet membrane glycoprotein Ib: functional effects. Thrombosis and haemostasis, 81(2), pp. 316-7. Stuttgart: Schattauer
Clemetson, KJ (1999). Primary haemostasis: sticky fingers cement the relationship. Current Biology, 3(9), R110-2. Cambridge, Mass.: Cell Press 10.1016/S0960-9822(99)80063-3
Clemetson, JM; Polgar, J; Magnenat, E; Wells, TN; Clemetson, KJ (1999). The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors. Journal of biological chemistry, 41(274), pp. 29019-24. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.274.41.29019
Clemetson, KJ (1999). Platelet collagen receptors: a new target for inhibition? Haemostasis, 29(1), pp. 16-26. Basel: Karger
Fachinger, G; Deutsch, U; Risau, W (1999). Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2. Oncogene, 43(18), pp. 5948-53. Basingstoke, UK: Nature Publishing Group 10.1038/sj.onc.1202992
Adams, RH; Wilkinson, GA; Weiss, C; Diella, F; Gale, NW; Deutsch, U; Risau, W; Klein, R (1999). Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes & development, 13(3), pp. 295-306. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press 10.1101/gad.13.3.295
Polgár, J; Magnenat, E; Wells, TN; Clemetson, KJ (1998). Platelet glycoprotein Ia* is the processed form of multimerin--isolation and determination of N-terminal sequences of stored and released forms. Thrombosis and haemostasis, 80(4), pp. 645-8. Stuttgart: Schattauer
Schmitz, G; Rothe, G; Ruf, A; Barlage, S; Tschöpe, D; Clemetson, KJ; Goodall, AH; Michelson, AD; Nurden, AT; Shankey, TV (1998). European Working Group on Clinical Cell Analysis: Consensus protocol for the flow cytometric characterisation of platelet function. Thrombosis and haemostasis, 79(5), pp. 885-96. Stuttgart: Schattauer
Polgár, J; Eichler, P; Greinacher, A; Clemetson, KJ (1998). Adenosine diphosphate (ADP) and ADP receptor play a major role in platelet activation/aggregation induced by sera from heparin-induced thrombocytopenia patients. Blood, 91(2), pp. 549-54. Washington, D.C.: American Society of Hematology
Kehrel, B; Wierwille, S; Clemetson, KJ; Anders, O; Steiner, M; Knight, CG; Farndale, RW; Okuma, M; Barnes, MJ (1998). Glycoprotein VI is a major collagen receptor for platelet activation: it recognizes the platelet-activating quaternary structure of collagen, whereas CD36, glycoprotein IIb/IIIa, and von Willebrand factor do not. Blood, 91(2), pp. 491-9. Washington, D.C.: American Society of Hematology
Clemetson, KJ; Polgár, J; Clemetson, JM (1998). Snake venom C-type lectins as tools in platelet research. Platelets, 9(3-4), pp. 165-9. London: Informa Healthcare 10.1080/09537109876636
Clemetson, KJ; Clemetson, JM (1998). Integrins and cardiovascular disease. Cellular and molecular life sciences, 6(54), pp. 502-13. Basel: Springer 10.1007/s000180050179
Reiss, Y; Hoch, G; Deutsch, U; Engelhardt, B (1998). T cell interaction with ICAM-1-deficient endothelium in vitro: essential role for ICAM-1 and ICAM-2 in transendothelial migration of T cells. European journal of immunology, 28(10), pp. 3086-99. Weinheim: Wiley-VCH 10.1002/(SICI)1521-4141(199810)28:10<3086::AID-IMMU3086>3.0.CO;2-Z
Knies, UE; Behrensdorf, HA; Mitchell, CA; Deutsch, U; Risau, W; Drexler, HC; Clauss, M (1998). Regulation of endothelial monocyte-activating polypeptide II release by apoptosis. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 95(21), pp. 12322-7. Washington, D.C.: National Academy of Sciences NAS 10.1073/pnas.95.21.12322
Koblizek, TI; Weiss, C; Yancopoulos, GD; Deutsch, U; Risau, W (1998). Angiopoietin-1 induces sprouting angiogenesis in vitro. Current Biology, 9(8), pp. 529-32. Cambridge, Mass.: Cell Press 10.1016/S0960-9822(98)70205-2
Walz, Alfred; Schmutz, Peter; Mueller, Christoph; Schnyder-Candrian, Silvia (1997). Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease. Journal of leukocyte biology, 62(5), pp. 604-611. Society for Leukocyte Biology 10.1002/jlb.62.5.604
Polgár, J; Kramer, RM; Um, SL; Jakubowski, JA; Clemetson, KJ (1997). Human group II 14 kDa phospholipase A2 activates human platelets. Biochemical journal, 327(Pt 1), pp. 259-65. London: Portland Press
Clemetson, KJ (1997). Platelet GPIb-V-IX complex. Thrombosis and haemostasis, 78(1), pp. 266-70. Stuttgart: Schattauer
Polgár, J; Magnenat, EM; Peitsch, MC; Wells, TN; Saqi, MS; Clemetson, KJ (1997). Amino acid sequence of the alpha subunit and computer modelling of the alpha and beta subunits of echicetin from the venom of Echis carinatus (saw-scaled viper). Biochemical journal, 323(Pt 2), pp. 533-7. London: Portland Press
Polgár, J; Clemetson, JM; Kehrel, BE; Wiedemann, M; Magnenat, EM; Wells, TN; Clemetson, KJ (1997). Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor. Journal of biological chemistry, 21(272), pp. 13576-83. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.272.21.13576
Mayr, T; Deutsch, U; Kühl, M; Drexler, HC; Lottspeich, F; Deutzmann, R; Wedlich, D; Risau, W (1997). Fritz: a secreted frizzled-related protein that inhibits Wnt activity. Mechanisms of development, 63(1), pp. 109-25. Shannon: Elsevier 10.1016/S0925-4773(97)00035-X
Schlaeger, TM; Bartunkova, S; Lawitts, JA; Teichmann, G; Risau, W; Deutsch, U; Sato, TN (1997). Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 94(7), pp. 3058-63. Washington, D.C.: National Academy of Sciences NAS 10.1073/pnas.94.7.3058
Koblizek, TI; Runting, AS; Stacker, SA; Wilks, AF; Risau, W; Deutsch, U (1997). Tie2 receptor expression and phosphorylation in cultured cells and mouse tissues. European journal of biochemistry, 244(3), pp. 774-9. Cambridge: Blackwell Science 10.1111/j.1432-1033.1997.00774.x
Bichsel, Verena E.; Walz, Alfred; Bickel, Matthias (1997). Identification of proteins binding specifically to the 3′-untranslated region of granulocyte/macrophagecolony stimulating factor mRNA. Nucleic acids research, 25(12), pp. 2417-2423. Oxford University Press 10.1093/nar/25.12.2417
Seitz, M.; Loetscher, P.; Dewald, B.; Towbin, H.; Rordorf, C.; Gallati, H.; Baggiolini, M.; Gerber, N. J. (1995). METHOTREXATE ACTION IN RHEUMATOID ARTHRITIS: STIMULATION OF CYTOKINE INHIBITOR AND INHIBITION OF CHEMOKINE PRODUCTION BY PERIPHERAL BLOOD MONONUCLEAR CELLS. Rheumatology, 34(7), pp. 602-609. Oxford University Press 10.1093/rheumatology/34.7.602
Abadier, Michael Magdy Labib; Lyck, Ruth (2017). Pathways across the blood-brain barrier. In: Lyck, Ruth; Enzmann, Gaby (eds.) The Blood Brain Barrier and Inflammation. Progress in Inflammation Research (pp. 187-211). Springer 10.1007/978-3-319-45514-3_9
Stein, Jens Volker; Moalli, Federica; Ackerknecht, Markus (2016). Basic Rules of T Cell Migration. In: Donnadieu, Emmanuel (ed.) Defects in T cell Trafficking and Resistance to Cancer Immunotherapy. Resistance to Targeted Anti-Cancer Therapeutics: Vol. 9 (pp. 1-19). Springer 10.1007/978-3-319-42223-7_1
Benarafa, Charaf (2015). Regulation of Neutrophil Serine Proteases by Intracellular Serpins. In: Geiger, Margarethe; Wahlmüller, Felix; Furtmüller, Margareta (eds.) The Serpin Family. Proteins with Multiple Functions in Health and Disease (pp. 59-76). Cham: Springer 10.1007/978-3-319-22711-5_5
Engelhardt, Britta (2010). Negotiating the brain barriers: Access of immune cells and pathogens into the CNS. In: Kilpatrick, Trevor; Ransohoff, Richard M; Wesselingh, Steven (eds.) Inflammatory Diseases of the Central Nervous System (pp. 35-46). Cambridge: Cambridge University Press
Clemetson, Kenneth John; Clemetson, Jeannine (2007). Platelet Receptors. In: Michelson, Alan D (ed.) Platelets, Second Edition (pp. 117-144). Fribourg: Elsevier
Engelhardt, Britta (2006). Development of the Blood-Brain Interface. In: Dermietzel, Rolf; Spray, David C; Nedergaard, Maiken (eds.) Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (pp. 9-39). Weinheim: Wiley-VCH 10.1002/9783527611225.ch1
Engelhardt, Britta (2006). Physiologie der Blut-Hirn-Schranke – Bedeutung für die Neuroimmunmodulation. In: Straub, Rainer H (ed.) Lehrbuch der klinischen Pathophysiologie komplexer chronischer Erkrankungen. Band 1 (pp. 150-159). Göttingen: Vandenhoeck & Ruprecht V&R unipress
Parakkatel, Dixy; Ruprecht, Nico; von Tengg-Kobligk, Hendrik; Engelhardt, Britta; Heverhagen, Johannes (June 2024). Investigating the role of peripheral blood mononuclear cells in gadolinium deposition in the brain (Unpublished). In: Swiss Congress of Radiology 2024 (SCR'24). Geneva. June 2024.
Prange, L.; Villiger, A.; Schaer, S.; Dach, R.; Sidorov, D.; Beutler, G.; Jäggi, A. (4 May 2020). CODE IGS reference products including Galileo (Unpublished). In: EGU General Assembly 2020, Sharing Geosciences Online. Vienna, Austria. 04-08 May 2020.
